Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PTCH1
  • Mouse genes Ptch1
  • Rat genes Ptch1
  • Zfish genes ptch1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ptch1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0015485	cholesterol binding	PTCH1	IDA		Human	PMID:21931618
Molecular Function	GO:0030332	cyclin binding	PTCH1	IPI	UniProtKB:P13350	Human	PMID:11331587
Molecular Function	GO:0030332	cyclin binding	PTCH1	IPI	UniProtKB:P14635	Human	PMID:11331587
Molecular Function	GO:0030332	cyclin binding	Ptch1	IPI	UniProtKB:P13350	Mouse	MGI:MGI:5306326|PMID:11331587
Molecular Function	GO:0097108	hedgehog family protein binding	PTCH1	IPI	UniProtKB:P97812	Human	PMID:9811851
Molecular Function	GO:0097108	hedgehog family protein binding	PTCH1	IPI	UniProtKB:Q61488	Human	PMID:9811851
Molecular Function	GO:0097108	hedgehog family protein binding	PTCH1	IPI	UniProtKB:Q62226	Human	PMID:9811851
Molecular Function	GO:0008201	heparin binding	Ptch1	IDA		Mouse	MGI:MGI:3687672|PMID:10500113
Molecular Function	GO:0005113	patched binding	Ptch1	IDA		Mouse	MGI:MGI:3687672|PMID:10500113
Molecular Function	GO:0005515	protein binding	PTCH1	IPI	UniProtKB:P14635	Human	PMID:19502428
Molecular Function	GO:0005515	protein binding	PTCH1	IPI	UniProtKB:P21146	Human	PMID:19502428
Molecular Function	GO:0005515	protein binding	PTCH1	IPI	UniProtKB:P25098	Human	PMID:19502428
Molecular Function	GO:0005515	protein binding	PTCH1	IPI	UniProtKB:Q15465	Human	PMID:19561609
Molecular Function	GO:0005515	protein binding	PTCH1	IPI	UniProtKB:O35158	Human	PMID:21802063
Molecular Function	GO:0005515	protein binding	PTCH1	IPI	UniProtKB:Q4KMG0	Human	PMID:21802063
Molecular Function	GO:0005515	protein binding	PTCH1	IPI	UniProtKB:P46937	Human	PMID:25283809
Molecular Function	GO:0005515	protein binding	PTCH1	IPI	UniProtKB:P46937	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	Ptch1	IPI	UniProtKB:Q62226	Mouse	MGI:MGI:3687672|PMID:10500113
Molecular Function	GO:0005515	protein binding	Ptch1	IPI	UniProtKB:Q14623	Mouse	MGI:MGI:5508726|PMID:21537345
Molecular Function	GO:0005515	protein binding	Ptch1	IPI	UniProtKB:Q96EY1	Mouse	MGI:MGI:3699985|PMID:17230190
Molecular Function	GO:0005515	protein binding	Ptch1	IPI	PR:Q62226	Mouse	PMID:29118110
Molecular Function	GO:0005515	protein binding	Ptch1	IPI	PR:Q9JJS0	Mouse	PMID:25639508
Molecular Function	GO:0005515	protein binding	Ptch1	IPI	PR:Q99JG2	Mouse	PMID:24062445
Molecular Function	GO:0044877	protein-containing complex binding	Ptch1	IDA		Mouse	MGI:MGI:5306326|PMID:11331587
Molecular Function	GO:0005119	smoothened binding	PTCH1	IPI	UniProtKB:Q99835	Human	PMID:11278759
Molecular Function	GO:0005119	smoothened binding	PTCH1	IPI	UniProtKB:Q99835	Human	PMID:9811851
Cellular Component	GO:0045177	apical part of cell	PTCH1	IDA		Human	PMID:17850284
Cellular Component	GO:0044295	axonal growth cone	Ptch1	IDA		Rat	PMID:21618238|RGD:5509937
Cellular Component	GO:0005901	caveola	PTCH1	IDA		Human	PMID:11278759
Cellular Component	GO:0005929	cilium	Ptch1	IDA		Mouse	PMID:19684112
Cellular Component	GO:0005929	cilium	Ptch1	IDA		Mouse	PMID:19654211
Cellular Component	GO:0044294	dendritic growth cone	Ptch1	IDA		Rat	PMID:21618238|RGD:5509937
Cellular Component	GO:0005794	Golgi apparatus	PTCH1	IDA		Human	PMID:11278759
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	PTCH1	IDA		Human	PMID:11278759
Cellular Component	GO:0030496	midbody	Ptch1	IDA		Mouse	MGI:MGI:4942244|PMID:15166316
Cellular Component	GO:0005634	nucleus	Ptch1	IDA		Rat	PMID:26210874|RGD:12832755
Cellular Component	GO:0048471	perinuclear region of cytoplasm	PTCH1	IDA		Human	PMID:11278759
Cellular Component	GO:0005886	plasma membrane	PTCH1	IDA		Human	PMID:11278759
Cellular Component	GO:0005886	plasma membrane	PTCH1	IDA		Human	PMID:12635140
Cellular Component	GO:0005886	plasma membrane	Ptch1	IDA		Mouse	MGI:MGI:5306540|PMID:21931618
Cellular Component	GO:0005886	plasma membrane	Ptch1	IDA		Mouse	MGI:MGI:5306326|PMID:11331587
Cellular Component	GO:0005886	plasma membrane	Ptch1	IDA		Mouse	PMID:24062445
Cellular Component	GO:0014069	postsynaptic density	Ptch1	IDA		Rat	PMID:21618238|RGD:5509937
Biological Process	GO:0009887	animal organ morphogenesis	Ptch1	IMP	MGI:MGI:1857447	Mouse	PMID:12917290
Biological Process	GO:0007420	brain development	Ptch1	IMP		Mouse	MGI:MGI:5142377|PMID:11517919
Biological Process	GO:0001658	branching involved in ureteric bud morphogenesis	Ptch1	IMP	MGI:MGI:1857447	Mouse	PMID:19809516
Biological Process	GO:0010002	cardioblast differentiation	ptch1	IGI	ZFIN:ZDB-GENO-080728-6	Zfish	PMID:18842815
Biological Process	GO:0061005	cell differentiation involved in kidney development	Ptch1	IGI	MGI:MGI:95729	Mouse	PMID:19809516
Biological Process	GO:0001709	cell fate determination	Ptch1	IGI	MGI:MGI:1095405	Mouse	PMID:24492243
Biological Process	GO:0072203	cell proliferation involved in metanephros development	Ptch1	IMP	MGI:MGI:1857447	Mouse	PMID:19809516
Biological Process	GO:0071397	cellular response to cholesterol	PTCH1	IMP		Human	PMID:11278759
Biological Process	GO:0071397	cellular response to cholesterol	Ptch1	IEP		Mouse	MGI:MGI:5306540|PMID:21931618
Biological Process	GO:0071679	commissural neuron axon guidance	Ptch1	IMP		Rat	PMID:19946319|RGD:12879429
Biological Process	GO:0021904	dorsal/ventral neural tube patterning	Ptch1	IMP	MGI:MGI:1857447	Mouse	PMID:9262482
Biological Process	GO:0009953	dorsal/ventral pattern formation	Ptch1	IGI	MGI:MGI:1341847	Mouse	PMID:15576403
Biological Process	GO:0030326	embryonic limb morphogenesis	Ptch1	IGI	MGI:MGI:98297	Mouse	PMID:11389830
Biological Process	GO:0030326	embryonic limb morphogenesis	Ptch1	IMP	MGI:MGI:1856954	Mouse	PMID:11784021
Biological Process	GO:0048568	embryonic organ development	Ptch1	IGI	MGI:MGI:2144467	Mouse	PMID:24302887
Biological Process	GO:0009957	epidermal cell fate specification	Ptch1	IGI	MGI:MGI:1095405	Mouse	PMID:24492243
Biological Process	GO:0008544	epidermis development	Ptch1	IMP	MGI:MGI:1856954	Mouse	PMID:17631878
Biological Process	GO:0050673	epithelial cell proliferation	Ptch1	IMP	MGI:MGI:1856954	Mouse	PMID:17631878
Biological Process	GO:0042593	glucose homeostasis	Ptch1	IMP	MGI:MGI:1857447	Mouse	PMID:11044404
Biological Process	GO:0003007	heart morphogenesis	Ptch1	IMP	MGI:MGI:1857447	Mouse	PMID:9262482
Biological Process	GO:0035137	hindlimb morphogenesis	Ptch1	IMP	MGI:MGI:1857447	Mouse	PMID:9262482
Biological Process	GO:0001701	in utero embryonic development	Ptch1	IGI	MGI:MGI:2384818	Mouse	PMID:21406566
Biological Process	GO:0001957	intramembranous ossification	ptch1	IMP	ZFIN:ZDB-GENO-100507-1	Zfish	PMID:22627283
Biological Process	GO:0043616	keratinocyte proliferation	Ptch1	IMP	MGI:MGI:1856954	Mouse	PMID:17631878
Biological Process	GO:0035108	limb morphogenesis	PTCH1	IMP		Human	PMID:8681379
Biological Process	GO:0097421	liver regeneration	Ptch1	IEP		Rat	PMID:22024090|RGD:12911223
Biological Process	GO:0030879	mammary gland development	Ptch1	IMP	MGI:MGI:1857447	Mouse	PMID:10529434
Biological Process	GO:0060603	mammary gland duct morphogenesis	Ptch1	IMP	MGI:MGI:1857447	Mouse	PMID:10529434
Biological Process	GO:0060644	mammary gland epithelial cell differentiation	Ptch1	IMP	MGI:MGI:1857447	Mouse	PMID:10529434
Biological Process	GO:0072205	metanephric collecting duct development	PTCH1	IEP		Human	PMID:17850284
Biological Process	GO:0051782	negative regulation of cell division	Ptch1	IMP		Mouse	MGI:MGI:5306326|PMID:11331587
Biological Process	GO:0008285	negative regulation of cell population proliferation	Ptch1	IMP		Mouse	MGI:MGI:5306326|PMID:11331587
Biological Process	GO:0008285	negative regulation of cell population proliferation	Ptch1	IMP	MGI:MGI:2675356	Mouse	PMID:16489008
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	PTCH1	IMP		Human	PMID:16229683
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Ptch1	IMP		Mouse	MGI:MGI:5619427|PMID:24548465
Biological Process	GO:0050680	negative regulation of epithelial cell proliferation	Ptch1	IMP	MGI:MGI:1856954	Mouse	PMID:17631878
Biological Process	GO:0010839	negative regulation of keratinocyte proliferation	Ptch1	IMP	MGI:MGI:1856954	Mouse	PMID:17631878
Biological Process	GO:0040015	negative regulation of multicellular organism growth	Ptch1	IMP	MGI:MGI:1856954	Mouse	PMID:11784021
Biological Process	GO:0048635	negative regulation of muscle organ development	ptch1	IGI	ZFIN:ZDB-MRPHLNO-050308-1,ZFIN:ZDB-MRPHLNO-061130-1,ZFIN:ZDB-MRPHLNO-061130-2	Zfish	PMID:16765934
Biological Process	GO:0045668	negative regulation of osteoblast differentiation	PTCH1	IMP		Human	PMID:16229683
Biological Process	GO:0045879	negative regulation of smoothened signaling pathway	Ptch1	IGI	UniProtKB:Q62226	Mouse	MGI:MGI:5306540|PMID:21931618
Biological Process	GO:0045879	negative regulation of smoothened signaling pathway	Ptch1	IDA		Mouse	PMID:11493558
Biological Process	GO:0045879	negative regulation of smoothened signaling pathway	Ptch1	IMP	MGI:MGI:2153143	Mouse	PMID:11784021
Biological Process	GO:0045879	negative regulation of smoothened signaling pathway	Ptch1	IGI	MGI:MGI:1916147	Mouse	PMID:15269168
Biological Process	GO:0045879	negative regulation of smoothened signaling pathway	Ptch1	IDA		Mouse	PMID:9006067
Biological Process	GO:0045879	negative regulation of smoothened signaling pathway	Ptch1	IMP	MGI:MGI:1857447	Mouse	PMID:19684112
Biological Process	GO:0045879	negative regulation of smoothened signaling pathway	Ptch1	IGI	MGI:MGI:2142166	Mouse	PMID:19004860
Biological Process	GO:0045879	negative regulation of smoothened signaling pathway	Ptch1	IMP	MGI:MGI:1857447	Mouse	PMID:19809516
Biological Process	GO:0045879	negative regulation of smoothened signaling pathway	ptch1	IMP	ZFIN:ZDB-GENO-980202-1296	Zfish	PMID:16121254
Biological Process	GO:2000647	negative regulation of stem cell proliferation	Ptch1	IMP	MGI:MGI:1856954	Mouse	PMID:17631878
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	PTCH1	IMP		Human	PMID:16229683
Biological Process	GO:0021997	neural plate axis specification	Ptch1	IMP		Mouse	MGI:MGI:5142377|PMID:11517919
Biological Process	GO:0001843	neural tube closure	Ptch1	IMP	MGI:MGI:1857447	Mouse	PMID:9262482
Biological Process	GO:0001841	neural tube formation	Ptch1	IDA		Mouse	MGI:MGI:3687672|PMID:10500113
Biological Process	GO:0021532	neural tube patterning	PTCH1	IMP		Human	PMID:8681379
Biological Process	GO:0001649	osteoblast differentiation	ptch1	IMP	ZFIN:ZDB-GENO-100507-1	Zfish	PMID:19906866
Biological Process	GO:0007389	pattern specification process	Ptch1	IMP	MGI:MGI:1857447	Mouse	PMID:9262482
Biological Process	GO:0060037	pharyngeal system development	PTCH1	IMP		Human	PMID:8681379
Biological Process	GO:0060037	pharyngeal system development	PTCH1	IMP		Human	PMID:8981943
Biological Process	GO:0010875	positive regulation of cholesterol efflux	PTCH1	IDA		Human	PMID:21931618
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Ptch1	IMP		Mouse	MGI:MGI:5619427|PMID:24548465
Biological Process	GO:0045606	positive regulation of epidermal cell differentiation	Ptch1	IGI	MGI:MGI:1095405	Mouse	PMID:24492243
Biological Process	GO:0030850	prostate gland development	Ptch1	IEP		Rat	PMID:15328011|RGD:1303367
Biological Process	GO:0072659	protein localization to plasma membrane	PTCH1	IDA		Human	PMID:11278759
Biological Process	GO:0016485	protein processing	Ptch1	IMP	MGI:MGI:1857447	Mouse	PMID:16061793
Biological Process	GO:0042127	regulation of cell population proliferation	Ptch1	IMP	MGI:MGI:1857447	Mouse	PMID:19809516
Biological Process	GO:0040008	regulation of growth	Ptch1	IMP	MGI:MGI:1857447	Mouse	PMID:9262482
Biological Process	GO:0007346	regulation of mitotic cell cycle	Ptch1	IMP	MGI:MGI:2675356	Mouse	PMID:16489008
Biological Process	GO:0032880	regulation of protein localization	Ptch1	IDA		Mouse	MGI:MGI:5306326|PMID:11331587
Biological Process	GO:0032880	regulation of protein localization	Ptch1	IMP	MGI:MGI:2675356	Mouse	PMID:16489008
Biological Process	GO:0010157	response to chlorate	Ptch1	IDA		Mouse	PMID:11476578
Biological Process	GO:0032355	response to estradiol	Ptch1	IEP		Rat	PMID:17109907|RGD:1601055
Biological Process	GO:0009612	response to mechanical stimulus	Ptch1	IEP		Rat	PMID:16943241|RGD:2303055
Biological Process	GO:0014070	response to organic cyclic compound	Ptch1	IEP		Rat	PMID:18772241|RGD:2303053
Biological Process	GO:0032526	response to retinoic acid	Ptch1	IEP		Rat	PMID:17307727|RGD:2303054
Biological Process	GO:0009410	response to xenobiotic stimulus	Ptch1	IEP		Rat	PMID:18772241|RGD:2303053
Biological Process	GO:0060041	retina development in camera-type eye	ptch1	IMP	ZFIN:ZDB-GENO-110629-4	Zfish	PMID:19840373
Biological Process	GO:0060042	retina morphogenesis in camera-type eye	ptch1	IMP	ZFIN:ZDB-GENO-110629-4	Zfish	PMID:22003118
Biological Process	GO:0007165	signal transduction	Ptch1	IDA		Mouse	MGI:MGI:3687672|PMID:10500113
Biological Process	GO:0048745	smooth muscle tissue development	PTCH1	IEP		Human	PMID:17850284
Biological Process	GO:0061053	somite development	PTCH1	IMP		Human	PMID:8681379
Biological Process	GO:0061053	somite development	Ptch1	IMP		Mouse	MGI:MGI:5142377|PMID:11517919
Biological Process	GO:0007286	spermatid development	Ptch1	IEP		Rat	PMID:21893610|RGD:150573809
Biological Process	GO:0021522	spinal cord motor neuron differentiation	Ptch1	IGI	MGI:MGI:107736	Mouse	PMID:21552265
Biological Process	GO:0072089	stem cell proliferation	Ptch1	IMP	MGI:MGI:1856954	Mouse	PMID:17631878

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern