Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PTCH2
  • Mouse genes Ptch2
  • Rat genes Ptch2
  • Zfish genes ptch2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ptch2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0097108	hedgehog family protein binding	PTCH2	IPI	UniProtKB:P97812	Human	PMID:9811851
Molecular Function	GO:0097108	hedgehog family protein binding	PTCH2	IPI	UniProtKB:Q61488	Human	PMID:9811851
Molecular Function	GO:0097108	hedgehog family protein binding	PTCH2	IPI	UniProtKB:Q62226	Human	PMID:9811851
Molecular Function	GO:0005119	smoothened binding	PTCH2	IPI	UniProtKB:Q99835	Human	PMID:9811851
Biological Process	GO:0043010	camera-type eye development	ptch2	IMP	ZFIN:ZDB-GENO-080327-300	Zfish	PMID:30333214
Biological Process	GO:0043010	camera-type eye development	ptch2	IMP	ZFIN:ZDB-GENO-080327-300	Zfish	PMID:18479681
Biological Process	GO:0043010	camera-type eye development	ptch2	IMP	ZFIN:ZDB-MRPHLNO-050308-1	Zfish	PMID:18479681
Biological Process	GO:0010002	cardioblast differentiation	ptch2	IGI	ZFIN:ZDB-GENO-080728-6	Zfish	PMID:18842815
Biological Process	GO:0001709	cell fate determination	Ptch2	IGI	MGI:MGI:105373	Mouse	PMID:24492243
Biological Process	GO:0009957	epidermal cell fate specification	Ptch2	IGI	MGI:MGI:105373	Mouse	PMID:24492243
Biological Process	GO:0008544	epidermis development	Ptch2	IMP	MGI:MGI:3656034	Mouse	PMID:16914743
Biological Process	GO:0042633	hair cycle	Ptch2	IMP	MGI:MGI:3656034	Mouse	PMID:16914743
Biological Process	GO:0048635	negative regulation of muscle organ development	ptch2	IGI	ZFIN:ZDB-MRPHLNO-050308-3,ZFIN:ZDB-MRPHLNO-061130-1,ZFIN:ZDB-MRPHLNO-061130-2	Zfish	PMID:16765934
Biological Process	GO:0048635	negative regulation of muscle organ development	ptch2	IGI	ZFIN:ZDB-GENE-030131-4827	Zfish	PMID:16765934
Biological Process	GO:0045879	negative regulation of smoothened signaling pathway	ptch2	IMP	ZFIN:ZDB-MRPHLNO-050308-1	Zfish	PMID:19305393
Biological Process	GO:0045879	negative regulation of smoothened signaling pathway	ptch2	IMP	ZFIN:ZDB-GENO-140130-35	Zfish	PMID:23150614
Biological Process	GO:0001649	osteoblast differentiation	ptch2	IMP	ZFIN:ZDB-GENO-080728-1	Zfish	PMID:19906866
Biological Process	GO:0045606	positive regulation of epidermal cell differentiation	Ptch2	IGI	MGI:MGI:105373	Mouse	PMID:24492243
Biological Process	GO:0009954	proximal/distal pattern formation	ptch2	IMP	ZFIN:ZDB-MRPHLNO-050308-1	Zfish	PMID:18479681
Biological Process	GO:0009954	proximal/distal pattern formation	ptch2	IMP	ZFIN:ZDB-GENO-080327-300	Zfish	PMID:18479681
Biological Process	GO:0001558	regulation of cell growth	PTCH2	IMP		Human	PMID:18285427
Biological Process	GO:0031290	retinal ganglion cell axon guidance	ptch2	IMP	ZFIN:ZDB-GENO-080327-300	Zfish	PMID:9007260
Biological Process	GO:0043588	skin development	Ptch2	IMP	MGI:MGI:3656034	Mouse	PMID:16914743

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern