Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PTEN
  • Mouse genes Pten
  • Rat genes Pten
  • Zfish genes ptena,ptenb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pten

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0010997	anaphase-promoting complex binding	PTEN	IPI	UniProtKB:P30260	Human	PMID:21241890
Molecular Function	GO:0010997	anaphase-promoting complex binding	PTEN	IPI	UniProtKB:Q9UJX3	Human	PMID:21241890
Molecular Function	GO:0010997	anaphase-promoting complex binding	PTEN	IPI	UniProtKB:Q9UJX4	Human	PMID:21241890
Molecular Function	GO:0010997	anaphase-promoting complex binding	PTEN	IPI	UniProtKB:Q9UJX5	Human	PMID:21241890
Molecular Function	GO:0019899	enzyme binding	PTEN	IPI	UniProtKB:Q93009	Human	PMID:16845383
Molecular Function	GO:0042802	identical protein binding	PTEN	IPI	UniProtKB:P60484	Human	PMID:24766807
Molecular Function	GO:0051717	inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity	PTEN	IDA		Human	PMID:9593664
Molecular Function	GO:0035255	ionotropic glutamate receptor binding	Pten	IDA		Rat	PMID:15102920|RGD:12802359
Molecular Function	GO:0042577	lipid phosphatase activity	ptena	IDA		Zfish	PMID:17704803
Molecular Function	GO:0042577	lipid phosphatase activity	ptena	IMP	ZFIN:ZDB-MRPHLNO-060214-1	Zfish	PMID:16193492
Molecular Function	GO:0042577	lipid phosphatase activity	ptenb	IMP	ZFIN:ZDB-MRPHLNO-060214-7	Zfish	PMID:16193492
Molecular Function	GO:0042577	lipid phosphatase activity	ptenb	IDA		Zfish	PMID:17704803
Molecular Function	GO:0030165	PDZ domain binding	PTEN	IPI	UniProtKB:Q12959	Human	PMID:10646847
Molecular Function	GO:0030165	PDZ domain binding	PTEN	IPI	UniProtKB:Q6P0Q8	Human	PMID:10646847
Molecular Function	GO:0030165	PDZ domain binding	PTEN	IPI	UniProtKB:Q86UL8	Human	PMID:10760291
Molecular Function	GO:0030165	PDZ domain binding	Pten	IPI	RGD:68424	Rat	PMID:20628354|RGD:4144068
Molecular Function	GO:0016791	phosphatase activity	ptena	IDA		Zfish	PMID:19515017
Molecular Function	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	PTEN	IDA		Human	PMID:9593664
Molecular Function	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	PTEN	IDA		Human	PMID:9811831
Molecular Function	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	Pten	IDA		Mouse	PMID:9778245
Molecular Function	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	Pten	IDA		Rat	PMID:17324556|RGD:12802336
Molecular Function	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	Pten	IMP		Rat	PMID:20628354|RGD:4144068
Molecular Function	GO:0051800	phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity	PTEN	IDA		Human	PMID:9811831
Molecular Function	GO:0004438	phosphatidylinositol-3-phosphate phosphatase activity	PTEN	IDA		Human	PMID:9811831
Molecular Function	GO:0004721	phosphoprotein phosphatase activity	PTEN	IDA		Human	PMID:21241890
Molecular Function	GO:0005161	platelet-derived growth factor receptor binding	Pten	IDA		Rat	PMID:14718524|RGD:1358422
Molecular Function	GO:0005515	protein binding	PTEN	IPI	UniProtKB:Q9NZM5	Human	PMID:15355975
Molecular Function	GO:0005515	protein binding	PTEN	IPI	UniProtKB:O60307	Human	PMID:15951562
Molecular Function	GO:0005515	protein binding	PTEN	IPI	UniProtKB:O88382	Human	PMID:15951562
Molecular Function	GO:0005515	protein binding	PTEN	IPI	UniProtKB:Q60592	Human	PMID:15951562
Molecular Function	GO:0005515	protein binding	PTEN	IPI	UniProtKB:Q62696	Human	PMID:15951562
Molecular Function	GO:0005515	protein binding	PTEN	IPI	UniProtKB:Q9JK71	Human	PMID:15951562
Molecular Function	GO:0005515	protein binding	PTEN	IPI	UniProtKB:Q9R1L5	Human	PMID:15951562
Molecular Function	GO:0005515	protein binding	PTEN	IPI	UniProtKB:O14745	Human	PMID:16456542
Molecular Function	GO:0005515	protein binding	PTEN	IPI	UniProtKB:P09619	Human	PMID:16456542
Molecular Function	GO:0005515	protein binding	PTEN	IPI	UniProtKB:Q15599	Human	PMID:16456542
Molecular Function	GO:0005515	protein binding	PTEN	IPI	UniProtKB:Q9JHL1	Human	PMID:16456542
Molecular Function	GO:0005515	protein binding	PTEN	IPI	UniProtKB:O14745	Human	PMID:17242191
Molecular Function	GO:0005515	protein binding	PTEN	IPI	UniProtKB:Q15599	Human	PMID:17242191
Molecular Function	GO:0005515	protein binding	PTEN	IPI	UniProtKB:P62136	Human	PMID:17274640
Molecular Function	GO:0005515	protein binding	PTEN	IPI	UniProtKB:P42685	Human	PMID:19345329
Molecular Function	GO:0005515	protein binding	PTEN	IPI	UniProtKB:P46934	Human	PMID:19345329
Molecular Function	GO:0005515	protein binding	PTEN	IPI	UniProtKB:Q06830	Human	PMID:19369943
Molecular Function	GO:0005515	protein binding	PTEN	IPI	UniProtKB:P98170	Human	PMID:19473982
Molecular Function	GO:0005515	protein binding	PTEN	IPI	UniProtKB:P35226	Human	PMID:19903340
Molecular Function	GO:0005515	protein binding	PTEN	IPI	UniProtKB:P30260	Human	PMID:21241890
Molecular Function	GO:0005515	protein binding	PTEN	IPI	UniProtKB:Q9NRD5	Human	PMID:21653829
Molecular Function	GO:0005515	protein binding	PTEN	IPI	UniProtKB:Q9P0U4	Human	PMID:21653829
Molecular Function	GO:0005515	protein binding	PTEN	IPI	UniProtKB:O14745	Human	PMID:21804599
Molecular Function	GO:0005515	protein binding	PTEN	IPI	UniProtKB:Q9Y6Q9	Human	PMID:23514585
Molecular Function	GO:0005515	protein binding	PTEN	IPI	UniProtKB:Q16643	Human	PMID:23940795
Molecular Function	GO:0005515	protein binding	PTEN	IPI	UniProtKB:O14745	Human	PMID:24012959
Molecular Function	GO:0005515	protein binding	PTEN	IPI	UniProtKB:P09619	Human	PMID:24012959
Molecular Function	GO:0005515	protein binding	PTEN	IPI	UniProtKB:O43791	Human	PMID:24656772
Molecular Function	GO:0005515	protein binding	PTEN	IPI	UniProtKB:Q96T49	Human	PMID:25007873
Molecular Function	GO:0005515	protein binding	PTEN	IPI	UniProtKB:P09619	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	Pten	IPI	UniProtKB:P02340	Mouse	MGI:MGI:5462485|PMID:23123091
Molecular Function	GO:0005515	protein binding	Pten	IPI	UniProtKB:Q9JHL1	Mouse	MGI:MGI:3617099|PMID:16456542
Molecular Function	GO:0005515	protein binding	Pten	IPI	UniProtKB:B1AZ99	Mouse	MGI:MGI:5700270|PMID:26280536
Molecular Function	GO:0005515	protein binding	Pten	IPI	UniProtKB:Q6A4J8	Mouse	MGI:MGI:3815264|PMID:18716620
Molecular Function	GO:0005515	protein binding	Pten	IPI	UniProtKB:P70441|UniProtKB:Q9JHL1	Mouse	MGI:MGI:3617099|PMID:16456542
Molecular Function	GO:0005515	protein binding	Pten	IPI	UniProtKB:P49452	Mouse	MGI:MGI:3706446|PMID:17218262
Molecular Function	GO:0005515	protein binding	Pten	IPI	UniProtKB:P70441	Mouse	MGI:MGI:4943390|PMID:18190691
Molecular Function	GO:0005515	protein binding	Pten	IPI	PR:P02340	Mouse	PMID:18332125
Molecular Function	GO:0005515	protein binding	Pten	IPI	PR:Q811D0	Mouse	PMID:20448149
Molecular Function	GO:0005515	protein binding	Pten	IPI	RGD:2848	Rat	PMID:16474401|RGD:2292548
Molecular Function	GO:0005515	protein binding	Pten	IPI	UniProtKB:Q9Z340	Rat	PMID:18082612|RGD:8553352
Molecular Function	GO:0005515	protein binding	Pten	IPI	UniProtKB:Q9Z340	Rat	PMID:18550519|RGD:8554471
Molecular Function	GO:0005515	protein binding	Pten	IPI	UniProtKB:P31016	Rat	PMID:20628354|RGD:4144068
Molecular Function	GO:0005515	protein binding	Pten	IPI	RGD:70885	Rat	PMID:23940795|RGD:8554403
Molecular Function	GO:0005515	protein binding	Pten	IPI	UniProtKB:Q07266	Rat	PMID:23940795|RGD:8554403
Molecular Function	GO:0019901	protein kinase binding	Pten	IPI	UniProtKB:Q60806	Mouse	MGI:MGI:5298335|PMID:20940307
Molecular Function	GO:0004722	protein serine/threonine phosphatase activity	PTEN	IDA		Human	PMID:9256433
Molecular Function	GO:1990782	protein tyrosine kinase binding	Pten	IDA		Rat	PMID:22609523|RGD:12801498
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	PTEN	IDA		Human	PMID:9256433
Molecular Function	GO:1990381	ubiquitin-specific protease binding	PTEN	IPI	UniProtKB:Q5T2D3	Human	PMID:26280536
Molecular Function	GO:1990381	ubiquitin-specific protease binding	PTEN	IPI	UniProtKB:Q92995	Human	PMID:26280536
Cellular Component	GO:0016324	apical plasma membrane	PTEN	IMP		Human	PMID:24862762
Cellular Component	GO:0042995	cell projection	PTEN	IDA		Human	PMID:10760291
Cellular Component	GO:0042995	cell projection	PTEN	IDA		Human	PMID:25007873
Cellular Component	GO:0005737	cytoplasm	PTEN	IDA		Human	PMID:10760291
Cellular Component	GO:0005737	cytoplasm	PTEN	IDA		Human	PMID:10940933
Cellular Component	GO:0005737	cytoplasm	PTEN	IDA		Human	PMID:21241890
Cellular Component	GO:0005737	cytoplasm	PTEN	IDA		Human	PMID:24862762
Cellular Component	GO:0005737	cytoplasm	PTEN	IDA		Human	PMID:9187108
Cellular Component	GO:0005737	cytoplasm	Pten	IDA		Mouse	PMID:14522255
Cellular Component	GO:0005737	cytoplasm	Pten	IDA		Mouse	PMID:18562292
Cellular Component	GO:0005737	cytoplasm	Pten	IDA		Rat	PMID:17239858|RGD:2292538
Cellular Component	GO:0009898	cytoplasmic side of plasma membrane	PTEN	IDA		Human	PMID:10940933
Cellular Component	GO:0005829	cytosol	PTEN	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	Pten	IDA		Rat	PMID:10662831|RGD:12801496
Cellular Component	GO:0043197	dendritic spine	Pten	IDA		Rat	PMID:20628354|RGD:4144068
Cellular Component	GO:0005739	mitochondrion	Pten	IDA		Rat	PMID:16502258|RGD:2292547
Cellular Component	GO:0035749	myelin sheath adaxonal region	Pten	IDA		Mouse	MGI:MGI:4441217|PMID:20237282
Cellular Component	GO:0043005	neuron projection	Pten	IMP		Mouse	MGI:MGI:5286805|PMID:21664258
Cellular Component	GO:0043005	neuron projection	Pten	IDA		Mouse	MGI:MGI:5286805|PMID:21664258
Cellular Component	GO:0043005	neuron projection	Pten	IDA		Rat	PMID:20628354|RGD:4144068
Cellular Component	GO:0005654	nucleoplasm	PTEN	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	PTEN	IDA		Human	PMID:17218261
Cellular Component	GO:0005634	nucleus	PTEN	IDA		Human	PMID:21241890
Cellular Component	GO:0005634	nucleus	PTEN	IDA		Human	PMID:24862762
Cellular Component	GO:0005634	nucleus	Pten	IDA		Mouse	PMID:14522255
Cellular Component	GO:0005634	nucleus	Pten	IDA		Mouse	PMID:18332125
Cellular Component	GO:0005634	nucleus	Pten	IDA		Mouse	PMID:18562292
Cellular Component	GO:0005634	nucleus	Pten	IDA		Rat	PMID:17239858|RGD:2292538
Cellular Component	GO:0005886	plasma membrane	PTEN	IDA		Human	PMID:10760291
Cellular Component	GO:0099524	postsynaptic cytosol	Pten	IDA		Rat	PMID:26780512|RGD:11352897
Cellular Component	GO:0099524	postsynaptic cytosol	Pten	IMP		Rat	PMID:26780512|RGD:11352897
Cellular Component	GO:0045211	postsynaptic membrane	Pten	IDA		Rat	PMID:20628354|RGD:4144068
Cellular Component	GO:0043220	Schmidt-Lanterman incisure	Pten	IDA		Mouse	MGI:MGI:4441217|PMID:20237282
Biological Process	GO:0030534	adult behavior	Pten	IMP		Mouse	MGI:MGI:3629385|PMID:16675393
Biological Process	GO:0007568	aging	Pten	IEP		Rat	PMID:18054565|RGD:2292534
Biological Process	GO:0007568	aging	Pten	IEP		Rat	PMID:25185054|RGD:12880043
Biological Process	GO:0001525	angiogenesis	Pten	IMP	MGI:MGI:2136412,MGI:MGI:2182005	Mouse	PMID:16107612
Biological Process	GO:0031103	axon regeneration	ptena	IMP	ZFIN:ZDB-MRPHLNO-150123-1	Zfish	PMID:24929056
Biological Process	GO:0042100	B cell proliferation	Pten	IMP	MGI:MGI:1857936	Mouse	PMID:16027169
Biological Process	GO:0001568	blood vessel development	ptena	IMP	ZFIN:ZDB-MRPHLNO-060214-1	Zfish	PMID:16193492
Biological Process	GO:0001568	blood vessel development	ptenb	IMP	ZFIN:ZDB-MRPHLNO-060214-7	Zfish	PMID:16193492
Biological Process	GO:0048854	brain morphogenesis	Pten	IMP		Mouse	MGI:MGI:3832995|PMID:19208814
Biological Process	GO:0060070	canonical Wnt signaling pathway	PTEN	IDA		Human	PMID:20123964
Biological Process	GO:0048738	cardiac muscle tissue development	Pten	IMP	MGI:MGI:2136412,MGI:MGI:2182005	Mouse	PMID:16107612
Biological Process	GO:0016477	cell migration	Pten	IMP	MGI:MGI:2183285	Mouse	PMID:12091320
Biological Process	GO:0008283	cell population proliferation	Pten	IMP	MGI:MGI:1857936	Mouse	PMID:16027169
Biological Process	GO:0008283	cell population proliferation	Pten	IGI	MGI:MGI:102548	Mouse	PMID:16027168
Biological Process	GO:0036294	cellular response to decreased oxygen levels	Pten	IDA		Mouse	PMID:24875179
Biological Process	GO:0071257	cellular response to electrical stimulus	PTEN	IMP		Human	PMID:27919618
Biological Process	GO:0071361	cellular response to ethanol	Pten	IDA		Rat	PMID:12700235|RGD:12801493
Biological Process	GO:0071456	cellular response to hypoxia	Pten	IDA		Mouse	PMID:24875179
Biological Process	GO:0032869	cellular response to insulin stimulus	Pten	IDA		Rat	PMID:12700235|RGD:12801493
Biological Process	GO:1990314	cellular response to insulin-like growth factor stimulus	Pten	IDA		Rat	PMID:12700235|RGD:12801493
Biological Process	GO:0044320	cellular response to leptin stimulus	Pten	IMP		Rat	PMID:24103758|RGD:12802338
Biological Process	GO:1990090	cellular response to nerve growth factor stimulus	Pten	IEP		Rat	PMID:10662831|RGD:12801496
Biological Process	GO:0007417	central nervous system development	Pten	IMP	MGI:MGI:2183285	Mouse	PMID:12091320
Biological Process	GO:0032286	central nervous system myelin maintenance	Pten	IMP		Mouse	MGI:MGI:3772418|PMID:18082964
Biological Process	GO:0021955	central nervous system neuron axonogenesis	Pten	IMP		Mouse	MGI:MGI:3629385|PMID:16675393
Biological Process	GO:0060027	convergent extension involved in gastrulation	ptenb	IMP	ZFIN:ZDB-GENO-080910-4,ZFIN:ZDB-MRPHLNO-060214-7	Zfish	PMID:21494560
Biological Process	GO:0060027	convergent extension involved in gastrulation	ptenb	IMP	ZFIN:ZDB-MRPHLNO-060214-7	Zfish	PMID:21494560
Biological Process	GO:0060027	convergent extension involved in gastrulation	ptenb	IMP	ZFIN:ZDB-MRPHLNO-060214-8	Zfish	PMID:21494560
Biological Process	GO:0060997	dendritic spine morphogenesis	Pten	IMP		Mouse	MGI:MGI:3772418|PMID:18082964
Biological Process	GO:0060997	dendritic spine morphogenesis	Pten	IMP		Mouse	MGI:MGI:5320272|PMID:21411674
Biological Process	GO:0021542	dentate gyrus development	Pten	IMP		Mouse	MGI:MGI:3759727|PMID:17706614
Biological Process	GO:0043542	endothelial cell migration	Pten	IMP	MGI:MGI:2136412,MGI:MGI:2182005	Mouse	PMID:16107612
Biological Process	GO:0048853	forebrain morphogenesis	Pten	IMP		Mouse	MGI:MGI:3629385|PMID:16675393
Biological Process	GO:0007507	heart development	Pten	IMP	MGI:MGI:3578141	Mouse	PMID:15755804
Biological Process	GO:0030097	hemopoiesis	ptena	IMP	ZFIN:ZDB-GENO-180301-1	Zfish	PMID:24124088
Biological Process	GO:0030097	hemopoiesis	ptenb	IMP	ZFIN:ZDB-GENO-180301-1	Zfish	PMID:24124088
Biological Process	GO:0030097	hemopoiesis	ptenb	IMP	ZFIN:ZDB-MRPHLNO-060214-7	Zfish	PMID:20371743
Biological Process	GO:0071545	inositol phosphate catabolic process	Pten	IDA		Rat	PMID:18056380|RGD:2292524
Biological Process	GO:0007611	learning or memory	Pten	IMP		Mouse	MGI:MGI:3629385|PMID:16675393
Biological Process	GO:0031174	lifelong otolith mineralization	ptena	IMP	ZFIN:ZDB-MRPHLNO-060214-1	Zfish	PMID:16193492
Biological Process	GO:0031174	lifelong otolith mineralization	ptenb	IMP	ZFIN:ZDB-MRPHLNO-060214-7	Zfish	PMID:16193492
Biological Process	GO:0045475	locomotor rhythm	Pten	IMP		Mouse	MGI:MGI:3759727|PMID:17706614
Biological Process	GO:0007626	locomotory behavior	Pten	IMP		Mouse	MGI:MGI:3629385|PMID:16675393
Biological Process	GO:0060292	long-term synaptic depression	Pten	IMP		Rat	PMID:20628354|RGD:4144068
Biological Process	GO:0060291	long-term synaptic potentiation	Pten	IMP		Mouse	MGI:MGI:3772418|PMID:18082964
Biological Process	GO:0060179	male mating behavior	Pten	IMP		Mouse	MGI:MGI:3629385|PMID:16675393
Biological Process	GO:0042711	maternal behavior	Pten	IMP		Mouse	MGI:MGI:3629385|PMID:16675393
Biological Process	GO:0007613	memory	Pten	IMP		Rat	PMID:15317872|RGD:2292551
Biological Process	GO:0033555	multicellular organismal response to stress	Pten	IMP		Mouse	MGI:MGI:3629385|PMID:16675393
Biological Process	GO:0042552	myelination	Pten	IMP		Mouse	PMID:20448149
Biological Process	GO:0002275	myeloid cell activation involved in immune response	ptena	IGI	ZFIN:ZDB-GENO-080916-2	Zfish	PMID:24598081
Biological Process	GO:0002275	myeloid cell activation involved in immune response	ptenb	IGI	ZFIN:ZDB-GENO-080916-2	Zfish	PMID:24598081
Biological Process	GO:0061515	myeloid cell development	ptena	IGI	ZFIN:ZDB-GENO-080916-2	Zfish	PMID:24598081
Biological Process	GO:0061515	myeloid cell development	ptenb	IGI	ZFIN:ZDB-GENO-080916-2	Zfish	PMID:24598081
Biological Process	GO:0016525	negative regulation of angiogenesis	ptena	IGI	ZFIN:ZDB-GENO-080916-2	Zfish	PMID:23720233
Biological Process	GO:0016525	negative regulation of angiogenesis	ptenb	IGI	ZFIN:ZDB-GENO-080916-2	Zfish	PMID:23720233
Biological Process	GO:0043066	negative regulation of apoptotic process	Pten	IMP		Mouse	MGI:MGI:2151077|PMID:10339565
Biological Process	GO:0043066	negative regulation of apoptotic process	Pten	IMP		Rat	PMID:30783439|RGD:150527846
Biological Process	GO:0048681	negative regulation of axon regeneration	Pten	IMP		Mouse	MGI:MGI:5694525|PMID:26203138
Biological Process	GO:0050771	negative regulation of axonogenesis	Pten	IMP		Mouse	MGI:MGI:3629385|PMID:16675393
Biological Process	GO:0030889	negative regulation of B cell proliferation	Pten	IMP	MGI:MGI:1857936	Mouse	PMID:16027169
Biological Process	GO:0060044	negative regulation of cardiac muscle cell proliferation	Pten	IGI	RNAcentral:URS000006FDD4_10090|RNAcentral:URS000013D17D_10090	Mouse	MGI:MGI:5584062|PMID:23575307
Biological Process	GO:0060044	negative regulation of cardiac muscle cell proliferation	Pten	IMP		Rat	PMID:30783439|RGD:150527846
Biological Process	GO:0045786	negative regulation of cell cycle	Pten	IMP		Rat	PMID:30783439|RGD:150527846
Biological Process	GO:1902807	negative regulation of cell cycle G1/S phase transition	PTEN	IDA		Human	PMID:10918569
Biological Process	GO:0030336	negative regulation of cell migration	PTEN	IMP		Human	PMID:17880912
Biological Process	GO:0030336	negative regulation of cell migration	PTEN	IMP		Human	PMID:21573166
Biological Process	GO:0030336	negative regulation of cell migration	PTEN	IMP		Human	PMID:9616126
Biological Process	GO:0008285	negative regulation of cell population proliferation	PTEN	IMP		Human	PMID:10468583
Biological Process	GO:0008285	negative regulation of cell population proliferation	PTEN	IMP		Human	PMID:17880912
Biological Process	GO:0008285	negative regulation of cell population proliferation	PTEN	IDA		Human	PMID:19057511
Biological Process	GO:0008285	negative regulation of cell population proliferation	Pten	IGI	MGI:MGI:102548	Mouse	PMID:16027168
Biological Process	GO:0008285	negative regulation of cell population proliferation	Pten	IDA		Rat	PMID:14656929|RGD:1358424
Biological Process	GO:0045792	negative regulation of cell size	Pten	IMP		Mouse	MGI:MGI:5320272|PMID:21411674
Biological Process	GO:0045792	negative regulation of cell size	Pten	IMP		Mouse	MGI:MGI:3629385|PMID:16675393
Biological Process	GO:2000773	negative regulation of cellular senescence	Pten	IMP		Mouse	MGI:MGI:5009768|PMID:21241890
Biological Process	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	PTEN	IDA		Human	PMID:21241890
Biological Process	GO:1900425	negative regulation of defense response to bacterium	Pten	IMP		Rat	PMID:18056380|RGD:2292524
Biological Process	GO:1903860	negative regulation of dendrite extension	Pten	IMP		Rat	PMID:23028614|RGD:151893507
Biological Process	GO:0061002	negative regulation of dendritic spine morphogenesis	Pten	IMP		Mouse	MGI:MGI:3629385|PMID:16675393
Biological Process	GO:0050680	negative regulation of epithelial cell proliferation	Pten	IMP	MGI:MGI:2183284	Mouse	PMID:15994948
Biological Process	GO:0010719	negative regulation of epithelial to mesenchymal transition	PTEN	IMP		Human	PMID:27919618
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	PTEN	IMP		Human	PMID:19962668
Biological Process	GO:0090394	negative regulation of excitatory postsynaptic potential	Pten	IMP		Mouse	MGI:MGI:5320272|PMID:21411674
Biological Process	GO:1905450	negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis	Pten	IMP		Rat	PMID:18056380|RGD:2292524
Biological Process	GO:0051895	negative regulation of focal adhesion assembly	PTEN	IMP		Human	PMID:9616126
Biological Process	GO:2000134	negative regulation of G1/S transition of mitotic cell cycle	PTEN	IDA		Human	PMID:21241890
Biological Process	GO:0051548	negative regulation of keratinocyte migration	PTEN	IMP		Human	PMID:27919618
Biological Process	GO:0031642	negative regulation of myelination	Pten	IMP		Mouse	PMID:20448149
Biological Process	GO:0010977	negative regulation of neuron projection development	Pten	IDA		Rat	PMID:28008308|RGD:14397573
Biological Process	GO:0046621	negative regulation of organ growth	Pten	IMP		Mouse	MGI:MGI:3832995|PMID:19208814
Biological Process	GO:0033137	negative regulation of peptidyl-serine phosphorylation	PTEN	IMP		Human	PMID:10918569
Biological Process	GO:1901017	negative regulation of potassium ion transmembrane transporter activity	Pten	IMP		Rat	PMID:24103758|RGD:12802338
Biological Process	GO:0051898	negative regulation of protein kinase B signaling	PTEN	IMP		Human	PMID:26280536
Biological Process	GO:0051898	negative regulation of protein kinase B signaling	PTEN	IMP		Human	PMID:10760291
Biological Process	GO:0051898	negative regulation of protein kinase B signaling	PTEN	IMP		Human	PMID:19962668
Biological Process	GO:0051898	negative regulation of protein kinase B signaling	PTEN	IMP		Human	PMID:21573166
Biological Process	GO:0051898	negative regulation of protein kinase B signaling	PTEN	IMP		Human	PMID:22879939
Biological Process	GO:0051898	negative regulation of protein kinase B signaling	Pten	IMP		Mouse	MGI:MGI:3629385|PMID:16675393
Biological Process	GO:0051898	negative regulation of protein kinase B signaling	Pten	IMP		Mouse	MGI:MGI:2151077|PMID:10339565
Biological Process	GO:0051898	negative regulation of protein kinase B signaling	Pten	IMP	MGI:MGI:2156086,MGI:MGI:5051834	Mouse	PMID:25512490
Biological Process	GO:0051898	negative regulation of protein kinase B signaling	Pten	IMP		Mouse	PMID:20448149
Biological Process	GO:0001933	negative regulation of protein phosphorylation	PTEN	IDA		Human	PMID:20123964
Biological Process	GO:0001933	negative regulation of protein phosphorylation	Pten	IMP		Mouse	MGI:MGI:5693365|PMID:19147652
Biological Process	GO:0090071	negative regulation of ribosome biogenesis	Pten	IMP		Mouse	MGI:MGI:3772418|PMID:18082964
Biological Process	GO:2000272	negative regulation of signaling receptor activity	Pten	IMP		Rat	PMID:24044036|RGD:12802358
Biological Process	GO:2000808	negative regulation of synaptic vesicle clustering	Pten	IMP		Mouse	MGI:MGI:3629385|PMID:16675393
Biological Process	GO:2000808	negative regulation of synaptic vesicle clustering	Pten	IMP		Mouse	MGI:MGI:3772418|PMID:18082964
Biological Process	GO:0042130	negative regulation of T cell proliferation	Pten	IMP	MGI:MGI:1857936	Mouse	PMID:16027169
Biological Process	GO:1904706	negative regulation of vascular associated smooth muscle cell proliferation	PTEN	IMP		Human	PMID:26208095
Biological Process	GO:1903690	negative regulation of wound healing, spreading of epidermal cells	PTEN	IMP		Human	PMID:27919618
Biological Process	GO:0031175	neuron projection development	Pten	IDA		Rat	PMID:14990793|RGD:1358423
Biological Process	GO:0007270	neuron-neuron synaptic transmission	Pten	IMP		Mouse	MGI:MGI:3772418|PMID:18082964
Biological Process	GO:0014065	phosphatidylinositol 3-kinase signaling	PTEN	IDA		Human	PMID:9593664
Biological Process	GO:0046856	phosphatidylinositol dephosphorylation	PTEN	IMP		Human	PMID:21828076
Biological Process	GO:0046856	phosphatidylinositol dephosphorylation	PTEN	IDA		Human	PMID:9593664
Biological Process	GO:0046856	phosphatidylinositol dephosphorylation	PTEN	IDA		Human	PMID:9811831
Biological Process	GO:0046856	phosphatidylinositol dephosphorylation	Pten	IDA		Rat	PMID:17324556|RGD:12802336
Biological Process	GO:0046856	phosphatidylinositol dephosphorylation	Pten	IMP		Rat	PMID:20628354|RGD:4144068
Biological Process	GO:0046856	phosphatidylinositol dephosphorylation	ptena	IDA		Zfish	PMID:17704803
Biological Process	GO:0046856	phosphatidylinositol dephosphorylation	ptena	IMP	ZFIN:ZDB-MRPHLNO-060214-1	Zfish	PMID:16193492
Biological Process	GO:0046856	phosphatidylinositol dephosphorylation	ptenb	IDA		Zfish	PMID:17704803
Biological Process	GO:0046856	phosphatidylinositol dephosphorylation	ptenb	IMP	ZFIN:ZDB-MRPHLNO-060214-7	Zfish	PMID:16193492
Biological Process	GO:0048008	platelet-derived growth factor receptor signaling pathway	Pten	IDA		Rat	PMID:14718524|RGD:1358422
Biological Process	GO:0043065	positive regulation of apoptotic process	Pten	IMP		Rat	PMID:16502258|RGD:2292547
Biological Process	GO:2001235	positive regulation of apoptotic signaling pathway	Pten	IMP	MGI:MGI:1857937	Mouse	PMID:9778245
Biological Process	GO:0010666	positive regulation of cardiac muscle cell apoptotic process	Pten	IMP		Rat	PMID:22609523|RGD:12801498
Biological Process	GO:0010666	positive regulation of cardiac muscle cell apoptotic process	Pten	IMP		Rat	PMID:30783439|RGD:150527846
Biological Process	GO:0008284	positive regulation of cell population proliferation	Pten	IMP		Mouse	MGI:MGI:5009768|PMID:21241890
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	PTEN	IMP		Human	PMID:20123964
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	Pten	IMP		Mouse	PMID:25512490
Biological Process	GO:2000463	positive regulation of excitatory postsynaptic potential	Pten	IMP		Mouse	MGI:MGI:3772418|PMID:18082964
Biological Process	GO:0010628	positive regulation of gene expression	Pten	IMP		Rat	PMID:20578043|RGD:12801497
Biological Process	GO:0032755	positive regulation of interleukin-6 production	Pten	IMP		Rat	PMID:30783439|RGD:150527846
Biological Process	GO:0045666	positive regulation of neuron differentiation	Pten	IMP		Rat	PMID:10662831|RGD:12801496
Biological Process	GO:1903984	positive regulation of TRAIL-activated apoptotic signaling pathway	PTEN	IMP		Human	PMID:19962668
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	Pten	IMP		Rat	PMID:30783439|RGD:150527846
Biological Process	GO:1904668	positive regulation of ubiquitin protein ligase activity	PTEN	IDA		Human	PMID:21241890
Biological Process	GO:1904668	positive regulation of ubiquitin protein ligase activity	Pten	IMP		Mouse	MGI:MGI:5009768|PMID:21241890
Biological Process	GO:2000060	positive regulation of ubiquitin-dependent protein catabolic process	PTEN	IDA		Human	PMID:21241890
Biological Process	GO:0097107	postsynaptic density assembly	Pten	IMP		Mouse	MGI:MGI:3772418|PMID:18082964
Biological Process	GO:0060134	prepulse inhibition	Pten	IMP		Mouse	MGI:MGI:3629385|PMID:16675393
Biological Process	GO:0060134	prepulse inhibition	Pten	IMP		Mouse	MGI:MGI:3832995|PMID:19208814
Biological Process	GO:0097105	presynaptic membrane assembly	Pten	IMP		Mouse	MGI:MGI:3772418|PMID:18082964
Biological Process	GO:0060736	prostate gland growth	Pten	IMP	MGI:MGI:2183284	Mouse	PMID:15994948
Biological Process	GO:0006470	protein dephosphorylation	PTEN	IDA		Human	PMID:9256433
Biological Process	GO:0006470	protein dephosphorylation	Pten	IMP		Rat	PMID:22609523|RGD:12801498
Biological Process	GO:0043491	protein kinase B signaling	Pten	IMP		Mouse	MGI:MGI:5298335|PMID:20940307
Biological Process	GO:0043491	protein kinase B signaling	Pten	IMP		Mouse	MGI:MGI:5693365|PMID:19147652
Biological Process	GO:0043491	protein kinase B signaling	Pten	IMP	MGI:MGI:2156086,MGI:MGI:5051834	Mouse	PMID:25512490
Biological Process	GO:0043491	protein kinase B signaling	Pten	IMP		Mouse	PMID:20448149
Biological Process	GO:0050821	protein stabilization	PTEN	IDA		Human	PMID:20123964
Biological Process	GO:0048679	regulation of axon regeneration	Pten	IGI	MGI:MGI:88190	Mouse	PMID:24733831
Biological Process	GO:0002902	regulation of B cell apoptotic process	Pten	IMP	MGI:MGI:1857466	Mouse	PMID:9990064
Biological Process	GO:0051726	regulation of cell cycle	Pten	IGI	MGI:MGI:98834	Mouse	PMID:18332125
Biological Process	GO:0032535	regulation of cellular component size	Pten	IMP		Mouse	MGI:MGI:3772418|PMID:18082964
Biological Process	GO:0060341	regulation of cellular localization	Pten	IMP		Mouse	MGI:MGI:4944030|PMID:21266327
Biological Process	GO:2000109	regulation of macrophage apoptotic process	Pten	IMP	MGI:MGI:1857466	Mouse	PMID:9990064
Biological Process	GO:0010975	regulation of neuron projection development	Pten	IMP		Mouse	MGI:MGI:4411937|PMID:19778506
Biological Process	GO:0051896	regulation of protein kinase B signaling	ptena	IMP	ZFIN:ZDB-MRPHLNO-060214-1	Zfish	PMID:16193492
Biological Process	GO:0051896	regulation of protein kinase B signaling	ptenb	IMP	ZFIN:ZDB-MRPHLNO-060214-7	Zfish	PMID:16193492
Biological Process	GO:0031647	regulation of protein stability	PTEN	IMP		Human	PMID:10866658
Biological Process	GO:0032228	regulation of synaptic transmission, GABAergic	Pten	IMP	MGI:MGI:2156086	Mouse	PMID:24875179
Biological Process	GO:0014823	response to activity	Pten	IEP		Rat	PMID:23812090|RGD:12801494
Biological Process	GO:0046685	response to arsenic-containing substance	Pten	IEP		Rat	PMID:14713550|RGD:2292552
Biological Process	GO:0033198	response to ATP	Pten	IEP		Rat	PMID:17132626|RGD:2292542
Biological Process	GO:0032355	response to estradiol	Pten	IEP		Rat	PMID:15482376|RGD:2292550
Biological Process	GO:0045471	response to ethanol	Pten	IEP		Rat	PMID:12939597|RGD:1299125
Biological Process	GO:0009749	response to glucose	Pten	IEP		Rat	PMID:16804083|RGD:2292546
Biological Process	GO:0010035	response to inorganic substance	Pten	IEP		Rat	PMID:17302912|RGD:2292536
Biological Process	GO:0007584	response to nutrient	Pten	IEP		Rat	PMID:17166883|RGD:2292540
Biological Process	GO:0014070	response to organic cyclic compound	Pten	IEP		Rat	PMID:18095365|RGD:2292523
Biological Process	GO:0010033	response to organic substance	Pten	IEP		Rat	PMID:16807353|RGD:2292544
Biological Process	GO:0009410	response to xenobiotic stimulus	Pten	IEP		Rat	PMID:16188065|RGD:2292549
Biological Process	GO:0010043	response to zinc ion	Pten	IEP		Rat	PMID:18054565|RGD:2292534
Biological Process	GO:0060024	rhythmic synaptic transmission	Pten	IMP		Mouse	MGI:MGI:3759727|PMID:17706614
Biological Process	GO:0035176	social behavior	Pten	IMP		Mouse	MGI:MGI:3832995|PMID:19208814
Biological Process	GO:0035176	social behavior	Pten	IMP		Mouse	MGI:MGI:3629385|PMID:16675393
Biological Process	GO:0007416	synapse assembly	Pten	IMP		Mouse	MGI:MGI:3629385|PMID:16675393
Biological Process	GO:0060074	synapse maturation	Pten	IMP		Mouse	MGI:MGI:3772418|PMID:18082964
Biological Process	GO:0042098	T cell proliferation	Pten	IMP	MGI:MGI:1857936	Mouse	PMID:16027169

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern