Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PTF1A
  • Mouse genes Ptf1a
  • Rat genes Ptf1a
  • Zfish genes ptf1a
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ptf1a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	Ptf1a	IDA		Mouse	PMID:25063451
Molecular Function	GO:0003682	chromatin binding	Ptf1a	IDA		Mouse	PMID:23639443
Molecular Function	GO:0003677	DNA binding	Ptf1a	IDA		Mouse	MGI:MGI:1327626|PMID:2294404
Molecular Function	GO:0003677	DNA binding	Ptf1a	IDA		Rat	PMID:2788241|RGD:8554285
Molecular Function	GO:0003677	DNA binding	Ptf1a	IDA		Rat	PMID:8861960|RGD:633757
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Ptf1a	IDA		Mouse	PMID:19887377
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ptf1a	IGI	RefSeq:NM_003200	Zfish	PMID:15183727
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ptf1a	IPI	ZFIN:ZDB-GENE-030219-204	Zfish	PMID:19067490
Molecular Function	GO:0070888	E-box binding	Ptf1a	IDA		Mouse	PMID:22232429
Molecular Function	GO:0005515	protein binding	Ptf1a	IPI	UniProtKB:P31266	Mouse	MGI:MGI:1859633|PMID:11318877
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Ptf1a	IDA		Rat	PMID:1840677|RGD:10047301
Molecular Function	GO:0043565	sequence-specific DNA binding	Ptf1a	IDA		Mouse	PMID:17938243
Molecular Function	GO:0043565	sequence-specific DNA binding	ptf1a	IPI	ZFIN:ZDB-GENE-030219-204	Zfish	PMID:19067490
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	PTF1A	IDA		Human	PMID:28473536
Cellular Component	GO:0005737	cytoplasm	Ptf1a	IDA		Rat	PMID:1720355|RGD:8554087
Cellular Component	GO:0005622	intracellular anatomical structure	Ptf1a	IDA		Mouse	PMID:17938243
Cellular Component	GO:0005634	nucleus	Ptf1a	IDA		Rat	PMID:1720355|RGD:8554087
Cellular Component	GO:0005667	transcription regulator complex	Ptf1a	IDA		Mouse	PMID:17938243
Cellular Component	GO:0005667	transcription regulator complex	Ptf1a	IDA		Rat	PMID:1720355|RGD:8554087
Biological Process	GO:0035881	amacrine cell differentiation	Ptf1a	IMP		Mouse	MGI:MGI:3691257|PMID:17075007
Biological Process	GO:0035881	amacrine cell differentiation	Ptf1a	IMP	MGI:MGI:3701996	Mouse	PMID:17301087
Biological Process	GO:0035881	amacrine cell differentiation	ptf1a	IMP	ZFIN:ZDB-GENO-170105-7	Zfish	PMID:23416047
Biological Process	GO:0035881	amacrine cell differentiation	ptf1a	IMP	ZFIN:ZDB-GENO-170105-7,ZFIN:ZDB-MRPHLNO-070531-6,ZFIN:ZDB-MRPHLNO-070531-9	Zfish	PMID:23416047
Biological Process	GO:0009887	animal organ morphogenesis	ptf1a	IMP		Zfish	PMID:15031114
Biological Process	GO:0009887	animal organ morphogenesis	ptf1a	IMP		Zfish	PMID:15183727
Biological Process	GO:0030154	cell differentiation	ptf1a	IMP		Zfish	PMID:15183727
Biological Process	GO:0045165	cell fate commitment	Ptf1a	IMP	MGI:MGI:2387804	Mouse	PMID:12185368
Biological Process	GO:0045165	cell fate commitment	Ptf1a	IMP	MGI:MGI:2387804,MGI:MGI:3771319	Mouse	PMID:17938243
Biological Process	GO:0021549	cerebellum development	PTF1A	IMP		Human	PMID:15543146
Biological Process	GO:0021549	cerebellum development	Ptf1a	IMP		Mouse	MGI:MGI:3703683|PMID:15543146
Biological Process	GO:0006351	DNA-templated transcription	Ptf1a	IDA		Mouse	MGI:MGI:4438526|PMID:19887377
Biological Process	GO:0031017	exocrine pancreas development	Ptf1a	IDA		Rat	PMID:10768861|RGD:8554373
Biological Process	GO:0031017	exocrine pancreas development	ptf1a	IMP	ZFIN:ZDB-MRPHLNO-070531-6,ZFIN:ZDB-MRPHLNO-070531-9	Zfish	PMID:17223324
Biological Process	GO:0048699	generation of neurons	Ptf1a	IDA		Mouse	MGI:MGI:1859633|PMID:11318877
Biological Process	GO:0048699	generation of neurons	Ptf1a	IMP	MGI:MGI:2387804	Mouse	PMID:23616538
Biological Process	GO:0030902	hindbrain development	Ptf1a	IDA		Mouse	MGI:MGI:1859633|PMID:11318877
Biological Process	GO:0030182	neuron differentiation	Ptf1a	IMP	MGI:MGI:3701996	Mouse	PMID:17301087
Biological Process	GO:0048663	neuron fate commitment	Ptf1a	IDA		Mouse	PMID:16039563
Biological Process	GO:0031016	pancreas development	PTF1A	IMP		Human	PMID:15543146
Biological Process	GO:0031016	pancreas development	Ptf1a	IMP	MGI:MGI:2387804,MGI:MGI:3771319	Mouse	PMID:17938243
Biological Process	GO:0031016	pancreas development	ptf1a	IMP	ZFIN:ZDB-MRPHLNO-070531-6	Zfish	PMID:18519637
Biological Process	GO:0031016	pancreas development	ptf1a	IMP	ZFIN:ZDB-GENO-090122-3	Zfish	PMID:18519637
Biological Process	GO:0031016	pancreas development	ptf1a	IMP	ZFIN:ZDB-MRPHLNO-070531-7	Zfish	PMID:18519637
Biological Process	GO:0031016	pancreas development	ptf1a	IMP	ZFIN:ZDB-MRPHLNO-070531-7,ZFIN:ZDB-MRPHLNO-070531-8	Zfish	PMID:17335795
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Ptf1a	IDA		Mouse	MGI:MGI:3694141|PMID:11279116
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Ptf1a	IDA		Mouse	PMID:17938243
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ptf1a	IGI	ZFIN:ZDB-GENE-030219-204	Zfish	PMID:19067490
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Ptf1a	IDA		Mouse	PMID:19887377
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Ptf1a	IMP	MGI:MGI:2387812	Mouse	PMID:19887377
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Ptf1a	IDA		Mouse	PMID:23639443
Biological Process	GO:0006355	regulation of DNA-templated transcription	Ptf1a	IDA		Mouse	MGI:MGI:3703683|PMID:15543146
Biological Process	GO:0006355	regulation of DNA-templated transcription	Ptf1a	IMP		Mouse	PMID:22232429
Biological Process	GO:0006355	regulation of DNA-templated transcription	Ptf1a	IMP	MGI:MGI:2152066	Mouse	PMID:9851981
Biological Process	GO:0006355	regulation of DNA-templated transcription	Ptf1a	IDA		Rat	PMID:2788241|RGD:8554285
Biological Process	GO:0061074	regulation of neural retina development	Ptf1a	IMP		Mouse	MGI:MGI:3691257|PMID:17075007
Biological Process	GO:0010842	retina layer formation	Ptf1a	IMP		Mouse	MGI:MGI:3691257|PMID:17075007
Biological Process	GO:0060042	retina morphogenesis in camera-type eye	Ptf1a	IMP	MGI:MGI:3701996	Mouse	PMID:17301087
Biological Process	GO:0048384	retinoic acid receptor signaling pathway	Ptf1a	IDA		Mouse	MGI:MGI:1859633|PMID:11318877
Biological Process	GO:0009888	tissue development	PTF1A	IDA		Human	PMID:12185368
Biological Process	GO:0006366	transcription by RNA polymerase II	Ptf1a	IMP	MGI:MGI:2387812	Mouse	PMID:19887377
Biological Process	GO:0006366	transcription by RNA polymerase II	Ptf1a	IDA		Mouse	PMID:23639443

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern