Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PTGER4
  • Mouse genes Ptger4
  • Rat genes Ptger4
  • Zfish genes ptger4a,ptger4b,ptger4c
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ptger4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004957	prostaglandin E receptor activity	PTGER4	IDA		Human	PMID:8163486
Molecular Function	GO:0004957	prostaglandin E receptor activity	Ptger4	IDA		Rat	PMID:10336471|RGD:9850259
Molecular Function	GO:0004957	prostaglandin E receptor activity	ptger4a	IDA		Zfish	PMID:23770421
Molecular Function	GO:0004957	prostaglandin E receptor activity	ptger4b	IDA		Zfish	PMID:23770421
Molecular Function	GO:0004957	prostaglandin E receptor activity	ptger4c	IDA		Zfish	PMID:23770421
Molecular Function	GO:0005515	protein binding	PTGER4	IPI	UniProtKB:Q9BSK4	Human	PMID:16424369
Cellular Component	GO:0044306	neuron projection terminus	Ptger4	IDA		Rat	PMID:15292051|RGD:10003094
Cellular Component	GO:0043025	neuronal cell body	Ptger4	IDA		Rat	PMID:15292051|RGD:10003094
Cellular Component	GO:0031965	nuclear membrane	Ptger4	IDA		Rat	PMID:10336471|RGD:9850259
Cellular Component	GO:0005886	plasma membrane	Ptger4	IDA		Rat	PMID:10336471|RGD:9850259
Biological Process	GO:0007188	adenylate cyclase-modulating G protein-coupled receptor signaling pathway	PTGER4	IDA		Human	PMID:8163486
Biological Process	GO:0060348	bone development	Ptger4	IDA		Rat	PMID:19233324|RGD:8554254
Biological Process	GO:0042074	cell migration involved in gastrulation	ptger4a	IMP	ZFIN:ZDB-MRPHLNO-060302-3	Zfish	PMID:16391234
Biological Process	GO:0042074	cell migration involved in gastrulation	ptger4a	IMP	ZFIN:ZDB-MRPHLNO-060302-4	Zfish	PMID:16391234
Biological Process	GO:0071333	cellular response to glucose stimulus	Ptger4	IEP		Rat	PMID:12888618|RGD:10043387
Biological Process	GO:0071347	cellular response to interleukin-1	Ptger4	IEP		Rat	PMID:11207665|RGD:10043377
Biological Process	GO:0071260	cellular response to mechanical stimulus	Ptger4	IEP		Mouse	MGI:MGI:5315359|PMID:14665434
Biological Process	GO:0071380	cellular response to prostaglandin E stimulus	Ptger4	IEP		Rat	PMID:11248657|RGD:10043612
Biological Process	GO:0042466	chemokinesis	Ptger4	IMP		Rat	PMID:8679543|RGD:10043355
Biological Process	GO:0097070	ductus arteriosus closure	Ptger4	IMP		Rat	PMID:16303610|RGD:10003042
Biological Process	GO:1990402	embryonic liver development	ptger4a	IGI	ZFIN:ZDB-MRPHLNO-060302-1,ZFIN:ZDB-MRPHLNO-060302-2,ZFIN:ZDB-MRPHLNO-060302-3,ZFIN:ZDB-MRPHLNO-060302-4	Zfish	PMID:24530296
Biological Process	GO:1990402	embryonic liver development	ptger4a	IMP	ZFIN:ZDB-MRPHLNO-060302-3,ZFIN:ZDB-MRPHLNO-060302-4	Zfish	PMID:24530296
Biological Process	GO:0070371	ERK1 and ERK2 cascade	Ptger4	IDA		Rat	PMID:19233324|RGD:8554254
Biological Process	GO:0031017	exocrine pancreas development	ptger4a	IGI	ZFIN:ZDB-MRPHLNO-060302-1,ZFIN:ZDB-MRPHLNO-060302-2,ZFIN:ZDB-MRPHLNO-060302-3,ZFIN:ZDB-MRPHLNO-060302-4	Zfish	PMID:24530296
Biological Process	GO:0031017	exocrine pancreas development	ptger4a	IMP	ZFIN:ZDB-MRPHLNO-060302-3,ZFIN:ZDB-MRPHLNO-060302-4	Zfish	PMID:24530296
Biological Process	GO:0007565	female pregnancy	Ptger4	IEP		Rat	PMID:10819751|RGD:10043343
Biological Process	GO:0007565	female pregnancy	Ptger4	IEP		Rat	PMID:14634592|RGD:10003032
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	ptger4c	IDA		Zfish	PMID:23770421|ZFIN:ZDB-PUB-130710-8
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	ptger4b	IDA		Zfish	PMID:23770421|ZFIN:ZDB-PUB-130710-8
Biological Process	GO:0002244	hematopoietic progenitor cell differentiation	ptger4a	IMP	ZFIN:ZDB-MRPHLNO-060302-4	Zfish	PMID:17579056
Biological Process	GO:0002244	hematopoietic progenitor cell differentiation	ptger4a	IMP	ZFIN:ZDB-MRPHLNO-060302-3	Zfish	PMID:17579056
Biological Process	GO:0006955	immune response	PTGER4	IEP		Human	PMID:8862514
Biological Process	GO:0072639	interleukin-33 production	Ptger4	IMP		Mouse	PMID:32484881
Biological Process	GO:0007254	JNK cascade	Ptger4	IDA		Rat	PMID:19233324|RGD:8554254
Biological Process	GO:0060137	maternal process involved in parturition	Ptger4	IEP		Rat	PMID:19801535|RGD:10043313
Biological Process	GO:0042322	negative regulation of circadian sleep/wake cycle, REM sleep	Ptger4	IMP		Rat	PMID:10923657|RGD:10043386
Biological Process	GO:0001818	negative regulation of cytokine production	Ptger4	IMP		Mouse	MGI:MGI:2151986|PMID:11602631
Biological Process	GO:1904336	negative regulation of ductus arteriosus closure	Ptger4	IMP		Rat	PMID:16303610|RGD:10003042
Biological Process	GO:1904471	negative regulation of endothelin production	Ptger4	IMP		Rat	PMID:15560120|RGD:10043380
Biological Process	GO:2000420	negative regulation of eosinophil extravasation	PTGER4	IDA		Human	PMID:21681739
Biological Process	GO:0010727	negative regulation of hydrogen peroxide metabolic process	Ptger4	IMP		Rat	PMID:11991626|RGD:10003093
Biological Process	GO:0050728	negative regulation of inflammatory response	PTGER4	IDA		Human	PMID:16424369
Biological Process	GO:0050728	negative regulation of inflammatory response	Ptger4	IGI	MGI:MGI:1335089	Mouse	PMID:18270204
Biological Process	GO:0050728	negative regulation of inflammatory response	Ptger4	IMP	MGI:MGI:2137850	Mouse	PMID:18270204
Biological Process	GO:0033624	negative regulation of integrin activation	PTGER4	IDA		Human	PMID:21681739
Biological Process	GO:0032690	negative regulation of interleukin-1 alpha production	Ptger4	IMP		Rat	PMID:15560120|RGD:10043380
Biological Process	GO:0051771	negative regulation of nitric-oxide synthase biosynthetic process	Ptger4	IMP		Rat	PMID:11991626|RGD:10003093
Biological Process	GO:0002792	negative regulation of peptide secretion	Ptger4	IMP		Rat	PMID:15560120|RGD:10043380
Biological Process	GO:1904348	negative regulation of small intestine smooth muscle contraction	Ptger4	IMP		Rat	PMID:11991626|RGD:10003093
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	Ptger4	IMP		Rat	PMID:15560120|RGD:10043380
Biological Process	GO:2000388	positive regulation of antral ovarian follicle growth	Ptger4	IMP		Rat	PMID:15944932|RGD:10003098
Biological Process	GO:0045780	positive regulation of bone resorption	Ptger4	IMP		Rat	PMID:11792579|RGD:729815
Biological Process	GO:1904364	positive regulation of calcitonin secretion	Ptger4	IMP		Rat	PMID:11278900|RGD:10003101
Biological Process	GO:0043950	positive regulation of cAMP-mediated signaling	Ptger4	IMP		Rat	PMID:11278900|RGD:10003101
Biological Process	GO:0045785	positive regulation of cell adhesion	Ptger4	IMP		Rat	PMID:14751573|RGD:10043372
Biological Process	GO:0008284	positive regulation of cell population proliferation	Ptger4	IMP		Rat	PMID:19233324|RGD:8554254
Biological Process	GO:1904367	positive regulation of chemokinesis	Ptger4	IMP		Rat	PMID:8679543|RGD:10043355
Biological Process	GO:0046010	positive regulation of circadian sleep/wake cycle, non-REM sleep	Ptger4	IMP		Rat	PMID:10923657|RGD:10043386
Biological Process	GO:0001819	positive regulation of cytokine production	Ptger4	IDA		Mouse	MGI:MGI:4353445|PMID:19465928
Biological Process	GO:0010628	positive regulation of gene expression	Ptger4	IMP		Rat	PMID:17673547|RGD:2300260
Biological Process	GO:1900127	positive regulation of hyaluronan biosynthetic process	Ptger4	IMP		Rat	PMID:17080198|RGD:9588632
Biological Process	GO:0050729	positive regulation of inflammatory response	Ptger4	IDA		Mouse	MGI:MGI:4353445|PMID:19465928
Biological Process	GO:0032733	positive regulation of interleukin-10 production	Ptger4	IMP		Rat	PMID:15560120|RGD:10043380
Biological Process	GO:0032757	positive regulation of interleukin-8 production	Ptger4	IMP		Rat	PMID:15944932|RGD:10003098
Biological Process	GO:1904466	positive regulation of matrix metallopeptidase secretion	Ptger4	IMP		Rat	PMID:8679543|RGD:10043355
Biological Process	GO:0070257	positive regulation of mucus secretion	Ptger4	IMP		Rat	PMID:11991626|RGD:10003093
Biological Process	GO:0070257	positive regulation of mucus secretion	Ptger4	IMP		Rat	PMID:18254372|RGD:10003046
Biological Process	GO:2000391	positive regulation of neutrophil extravasation	Ptger4	IMP		Rat	PMID:15944932|RGD:10003098
Biological Process	GO:0045778	positive regulation of ossification	Ptger4	IMP		Rat	PMID:14751573|RGD:10043372
Biological Process	GO:0045778	positive regulation of ossification	Ptger4	IMP		Rat	PMID:17106877|RGD:10045950
Biological Process	GO:0045669	positive regulation of osteoblast differentiation	Ptger4	IMP		Rat	PMID:14751573|RGD:10043372
Biological Process	GO:2000386	positive regulation of ovarian follicle development	Ptger4	IMP		Rat	PMID:15944932|RGD:10003098
Biological Process	GO:0001934	positive regulation of protein phosphorylation	Ptger4	IMP		Rat	PMID:17067562|RGD:10043389
Biological Process	GO:0050714	positive regulation of protein secretion	Ptger4	IMP		Rat	PMID:8679543|RGD:10043355
Biological Process	GO:0035815	positive regulation of renal sodium excretion	Ptger4	IMP		Rat	PMID:18287210|RGD:10003052
Biological Process	GO:0014911	positive regulation of smooth muscle cell migration	Ptger4	IMP		Rat	PMID:17080198|RGD:9588632
Biological Process	GO:1904460	positive regulation of substance P secretion	Ptger4	IMP		Rat	PMID:11278900|RGD:10003101
Biological Process	GO:1904496	positive regulation of substance P secretion, neurotransmission	Ptger4	IMP		Rat	PMID:15292051|RGD:10003094
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	Ptger4	IMP		Rat	PMID:17067562|RGD:10043389
Biological Process	GO:0035810	positive regulation of urine volume	Ptger4	IMP		Rat	PMID:18287210|RGD:10003052
Biological Process	GO:0090303	positive regulation of wound healing	Ptger4	IMP		Rat	PMID:16515909|RGD:10043388
Biological Process	GO:0048793	pronephros development	ptger4a	IMP	ZFIN:ZDB-MRPHLNO-060302-3	Zfish	PMID:27996936
Biological Process	GO:0010840	regulation of circadian sleep/wake cycle, wakefulness	Ptger4	IMP		Rat	PMID:10923657|RGD:10043386
Biological Process	GO:0030278	regulation of ossification	Ptger4	IMP	MGI:MGI:2137851	Mouse	PMID:10749873
Biological Process	GO:0051492	regulation of stress fiber assembly	Ptger4	IDA		Mouse	MGI:MGI:5315359|PMID:14665434
Biological Process	GO:0043200	response to amino acid	Ptger4	IEP		Rat	PMID:10882227|RGD:10003083
Biological Process	GO:0070555	response to interleukin-1	Ptger4	IEP		Rat	PMID:10800959|RGD:10003104
Biological Process	GO:0032496	response to lipopolysaccharide	Ptger4	IMP	MGI:MGI:2137851	Mouse	PMID:15834430
Biological Process	GO:0009612	response to mechanical stimulus	PTGER4	IEP		Human	PMID:21723865
Biological Process	GO:0009624	response to nematode	Ptger4	IMP		Mouse	PMID:32484881
Biological Process	GO:0014070	response to organic cyclic compound	Ptger4	IEP		Rat	PMID:19801535|RGD:10043313
Biological Process	GO:0032570	response to progesterone	Ptger4	IEP		Rat	PMID:19801535|RGD:10043313
Biological Process	GO:0034695	response to prostaglandin E	Ptger4	IEP		Rat	PMID:10800959|RGD:10003104
Biological Process	GO:1902074	response to salt	Ptger4	IEP		Rat	PMID:10432392|RGD:9850282
Biological Process	GO:1990785	response to water-immersion restraint stress	Ptger4	IEP		Rat	PMID:10882227|RGD:10003083
Biological Process	GO:0009410	response to xenobiotic stimulus	Ptger4	IEP		Rat	PMID:10800959|RGD:10003104
Biological Process	GO:0033077	T cell differentiation in thymus	ptger4a	IMP	ZFIN:ZDB-MRPHLNO-060302-4	Zfish	PMID:17579056
Biological Process	GO:0033077	T cell differentiation in thymus	ptger4a	IMP	ZFIN:ZDB-MRPHLNO-071226-1	Zfish	PMID:17579056
Biological Process	GO:0042093	T-helper cell differentiation	Ptger4	IDA		Mouse	MGI:MGI:4353445|PMID:19465928

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern