Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PTGIS
  • Mouse genes Ptgis
  • Rat genes Ptgis
  • Zfish genes ptgis
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ptgis

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0020037	heme binding	PTGIS	IDA		Human	PMID:17020766
Molecular Function	GO:0020037	heme binding	PTGIS	IDA		Human	PMID:18032380
Molecular Function	GO:0020037	heme binding	ptgis	IDA		Zfish	PMID:18032380|ZFIN:ZDB-PUB-120117-26
Molecular Function	GO:0008116	prostaglandin-I synthase activity	PTGIS	IDA		Human	PMID:15115769
Molecular Function	GO:0008116	prostaglandin-I synthase activity	PTGIS	IDA		Human	PMID:20122998
Molecular Function	GO:0008116	prostaglandin-I synthase activity	PTGIS	IDA		Human	PMID:21296955
Molecular Function	GO:0008116	prostaglandin-I synthase activity	Ptgis	IMP		Rat	PMID:10359560|RGD:727270
Molecular Function	GO:0008116	prostaglandin-I synthase activity	Ptgis	IDA		Rat	PMID:16094316|RGD:8693629
Molecular Function	GO:0008116	prostaglandin-I synthase activity	ptgis	IDA		Zfish	PMID:18032380|ZFIN:ZDB-PUB-120117-26
Molecular Function	GO:0005515	protein binding	PTGIS	IPI	UniProtKB:Q03135	Human	PMID:20122998
Cellular Component	GO:0005901	caveola	PTGIS	IDA		Human	PMID:20122998
Cellular Component	GO:0005737	cytoplasm	Ptgis	IDA		Mouse	PMID:10385625
Cellular Component	GO:0005783	endoplasmic reticulum	PTGIS	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005783	endoplasmic reticulum	PTGIS	IDA		Human	PMID:21035466
Cellular Component	GO:0005615	extracellular space	Ptgis	IDA		Rat	PMID:15684702|RGD:1580695
Cellular Component	GO:0005634	nucleus	PTGIS	IDA		Human	PMID:21035466
Cellular Component	GO:0005634	nucleus	Ptgis	IDA		Mouse	PMID:10385625
Biological Process	GO:0097190	apoptotic signaling pathway	PTGIS	IDA		Human	PMID:11551955
Biological Process	GO:0071456	cellular response to hypoxia	PTGIS	IDA		Human	PMID:21296955
Biological Process	GO:0071347	cellular response to interleukin-1	PTGIS	IEP		Human	PMID:8185632
Biological Process	GO:0071354	cellular response to interleukin-6	PTGIS	IEP		Human	PMID:8185632
Biological Process	GO:0046697	decidualization	Ptgis	IDA		Mouse	PMID:10385625
Biological Process	GO:0007566	embryo implantation	Ptgis	IDA		Mouse	PMID:10385625
Biological Process	GO:0006690	icosanoid metabolic process	PTGIS	IDA		Human	PMID:15115769
Biological Process	GO:0050728	negative regulation of inflammatory response	PTGIS	IDA		Human	PMID:20159982
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	PTGIS	IDA		Human	PMID:20159982
Biological Process	GO:0045019	negative regulation of nitric oxide biosynthetic process	PTGIS	IDA		Human	PMID:20159982
Biological Process	GO:0045766	positive regulation of angiogenesis	PTGIS	IMP		Human	PMID:20122998
Biological Process	GO:1900119	positive regulation of execution phase of apoptosis	PTGIS	IDA		Human	PMID:11551955
Biological Process	GO:0035360	positive regulation of peroxisome proliferator activated receptor signaling pathway	PTGIS	IDA		Human	PMID:11551955
Biological Process	GO:0001516	prostaglandin biosynthetic process	PTGIS	IDA		Human	PMID:15115769
Biological Process	GO:0001516	prostaglandin biosynthetic process	PTGIS	IDA		Human	PMID:20122998
Biological Process	GO:0001516	prostaglandin biosynthetic process	PTGIS	IDA		Human	PMID:21296955
Biological Process	GO:0001516	prostaglandin biosynthetic process	Ptgis	IDA		Rat	PMID:16094316|RGD:8693629
Biological Process	GO:0001516	prostaglandin biosynthetic process	ptgis	IDA		Zfish	PMID:18032380|ZFIN:ZDB-PUB-120117-26
Biological Process	GO:0001666	response to hypoxia	Ptgis	IMP		Rat	PMID:16094316|RGD:8693629

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern