Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PTGS1
  • Mouse genes Ptgs1
  • Rat genes Ptgs1
  • Zfish genes ptgs1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ptgs1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004601	peroxidase activity	ptgs1	IDA		Zfish	PMID:17112475
Molecular Function	GO:0004666	prostaglandin-endoperoxide synthase activity	PTGS1	IDA		Human	PMID:1380156
Molecular Function	GO:0004666	prostaglandin-endoperoxide synthase activity	ptgs1	IMP	ZFIN:ZDB-MRPHLNO-050722-3	Zfish	PMID:15936346
Molecular Function	GO:0005515	protein binding	PTGS1	IPI	UniProtKB:P48645	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PTGS1	IPI	UniProtKB:P53801	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PTGS1	IPI	UniProtKB:Q8WZ73-3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PTGS1	IPI	UniProtKB:Q9NP61	Human	PMID:32814053
Cellular Component	GO:0005737	cytoplasm	PTGS1	IDA		Human	PMID:12355421
Cellular Component	GO:0005737	cytoplasm	Ptgs1	IDA		Mouse	PMID:12355421
Cellular Component	GO:0005737	cytoplasm	Ptgs1	IDA		Mouse	PMID:12021206
Cellular Component	GO:0005737	cytoplasm	Ptgs1	IDA		Rat	PMID:12657565|RGD:1299132
Cellular Component	GO:0070062	extracellular exosome	PTGS1	HDA		Human	PMID:18570454
Cellular Component	GO:0005794	Golgi apparatus	PTGS1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	PTGS1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005635	nuclear envelope	Ptgs1	IDA		Rat	PMID:12657565|RGD:1299132
Cellular Component	GO:0001750	photoreceptor outer segment	Ptgs1	IDA		Mouse	PMID:12355421
Biological Process	GO:0007568	aging	Ptgs1	IEP		Rat	PMID:17499644|RGD:2300265
Biological Process	GO:0071407	cellular response to organic cyclic compound	ptgs1	IDA		Zfish	PMID:17112475
Biological Process	GO:0019371	cyclooxygenase pathway	PTGS1	IDA		Human	PMID:1380156
Biological Process	GO:1990402	embryonic liver development	ptgs1	IMP	ZFIN:ZDB-MRPHLNO-050722-3,ZFIN:ZDB-MRPHLNO-050722-4	Zfish	PMID:24530296
Biological Process	GO:0031017	exocrine pancreas development	ptgs1	IMP	ZFIN:ZDB-MRPHLNO-050722-3,ZFIN:ZDB-MRPHLNO-050722-4	Zfish	PMID:24530296
Biological Process	GO:0001822	kidney development	ptgs1	IMP	ZFIN:ZDB-MRPHLNO-050722-3	Zfish	PMID:15936346
Biological Process	GO:0007612	learning	Ptgs1	IMP		Rat	PMID:21701788|RGD:5688147
Biological Process	GO:0035633	maintenance of blood-brain barrier	Ptgs1	IMP		Rat	PMID:17704356|RGD:2325928
Biological Process	GO:0007613	memory	Ptgs1	IMP		Rat	PMID:21701788|RGD:5688147
Biological Process	GO:0032811	negative regulation of epinephrine secretion	Ptgs1	IMP		Rat	PMID:18598693|RGD:2300224
Biological Process	GO:0010700	negative regulation of norepinephrine secretion	Ptgs1	IMP		Rat	PMID:18598693|RGD:2300224
Biological Process	GO:0045987	positive regulation of smooth muscle contraction	Ptgs1	IMP		Rat	PMID:18480553|RGD:2300247
Biological Process	GO:0045907	positive regulation of vasoconstriction	Ptgs1	IMP		Rat	PMID:17245358|RGD:1625725
Biological Process	GO:0045907	positive regulation of vasoconstriction	Ptgs1	IMP		Rat	PMID:18456673|RGD:2300248
Biological Process	GO:0048793	pronephros development	ptgs1	IMP	ZFIN:ZDB-MRPHLNO-050722-3	Zfish	PMID:27996936
Biological Process	GO:0001516	prostaglandin biosynthetic process	Ptgs1	IMP	MGI:MGI:1857238	Mouse	PMID:12093889
Biological Process	GO:0001516	prostaglandin biosynthetic process	Ptgs1	IMP		Rat	PMID:17673564|RGD:2300259
Biological Process	GO:0006693	prostaglandin metabolic process	Ptgs1	IMP	MGI:MGI:1857238	Mouse	PMID:10987272
Biological Process	GO:0008217	regulation of blood pressure	Ptgs1	IMP	MGI:MGI:1857238	Mouse	PMID:12093889
Biological Process	GO:0042127	regulation of cell population proliferation	Ptgs1	IGI	MGI:MGI:88039	Mouse	PMID:10987272
Biological Process	GO:0051412	response to corticosterone	Ptgs1	IEP		Rat	PMID:18584335|RGD:2300226
Biological Process	GO:0070542	response to fatty acid	Ptgs1	IEP		Rat	PMID:16983392|RGD:5688222
Biological Process	GO:0010243	response to organonitrogen compound	Ptgs1	IEP		Rat	PMID:11211925|RGD:2300269
Biological Process	GO:0019233	sensory perception of pain	Ptgs1	IMP		Rat	PMID:21362433|RGD:5508227
Biological Process	GO:0001570	vasculogenesis	ptgs1	IMP	ZFIN:ZDB-MRPHLNO-050722-3	Zfish	PMID:15936346

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern