Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Pth

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes PTH
- Mouse genes Pth
- Rat genes Pth
- Zfish genes pth1a,pth1b
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pth

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005179	hormone activity	PTH	IMP		Human	PMID:11604398
Molecular Function	GO:0005179	hormone activity	Pth	IDA		Mouse	PMID:15601870\|MGI:MGI:3525928
Molecular Function	GO:0005179	hormone activity	Pth	IDA		Mouse	PMID:11606467
Molecular Function	GO:0005179	hormone activity	Pth	IDA		Mouse	PMID:15601870
Molecular Function	GO:0005179	hormone activity	Pth	IMP		Rat	PMID:11604398\|RGD:12793028
Molecular Function	GO:0005179	hormone activity	pth1a	IDA		Zfish	PMID:14684608
Molecular Function	GO:0005179	hormone activity	pth1b	IDA		Zfish	PMID:14684608
Molecular Function	GO:0031856	parathyroid hormone receptor binding	Pth	IDA		Rat	PMID:11554727\|RGD:729887
Molecular Function	GO:0051428	peptide hormone receptor binding	PTH	IMP		Human	PMID:11604398
Molecular Function	GO:0051428	peptide hormone receptor binding	PTH	IDA		Human	PMID:19674967
Molecular Function	GO:0051428	peptide hormone receptor binding	Pth	IMP		Rat	PMID:11604398\|RGD:12793028
Molecular Function	GO:0005515	protein binding	PTH	IMP		Human	PMID:11604398
Molecular Function	GO:0005515	protein binding	PTH	IPI	UniProtKB:Q03431	Human	PMID:19674967
Molecular Function	GO:0005515	protein binding	PTH	IPI	UniProtKB:Q12797-6	Human	PMID:32296183
Molecular Function	GO:0048018	receptor ligand activity	PTH	IMP		Human	PMID:11604398
Molecular Function	GO:0048018	receptor ligand activity	Pth	IMP		Rat	PMID:11604398\|RGD:12793028
Molecular Function	GO:0031857	type 1 parathyroid hormone receptor binding	PTH	IMP		Human	PMID:11604398
Molecular Function	GO:0031857	type 1 parathyroid hormone receptor binding	Pth	IMP		Rat	PMID:11604398\|RGD:12793028
Molecular Function	GO:0031857	type 1 parathyroid hormone receptor binding	Pth	IDA		Rat	PMID:9054374\|RGD:7207455
Cellular Component	GO:0005615	extracellular space	Pth	IDA		Mouse	PMID:11606467
Cellular Component	GO:0005615	extracellular space	Pth	IDA		Mouse	PMID:24259513
Cellular Component	GO:0005615	extracellular space	Pth	IDA		Rat	PMID:23094155\|RGD:7242729
Biological Process	GO:0007202	activation of phospholipase C activity	PTH	IMP		Human	PMID:11604398
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	PTH	IDA		Human	PMID:90087
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	PTH	IMP		Human	PMID:11604398
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	Pth	IDA		Mouse	PMID:19723499
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	Pth	IDA		Rat	PMID:9832460\|RGD:1601517
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	Pth	IMP		Rat	PMID:11604398\|RGD:12793028
Biological Process	GO:0030282	bone mineralization	Pth	IMP	MGI:1889069	Mouse	PMID:19968565
Biological Process	GO:0030282	bone mineralization	Pth	IMP	MGI:2665181	Mouse	PMID:19968565
Biological Process	GO:0055074	calcium ion homeostasis	Pth	IMP	MGI:1889069	Mouse	PMID:19968565
Biological Process	GO:0055074	calcium ion homeostasis	Pth	IMP	MGI:2665181	Mouse	PMID:19968565
Biological Process	GO:0055074	calcium ion homeostasis	pth1a	IMP	ZFIN:ZDB-MRPHLNO-140425-3	Zfish	PMID:24169558
Biological Process	GO:0007267	cell-cell signaling	Pth	IDA		Rat	PMID:22696456\|RGD:7242895
Biological Process	GO:0009913	epidermal cell differentiation	pth1a	IMP	ZFIN:ZDB-MRPHLNO-150916-1	Zfish	PMID:25872007
Biological Process	GO:0048873	homeostasis of number of cells within a tissue	Pth	IGI	MGI:MGI:95560	Mouse	PMID:21048959
Biological Process	GO:0006874	intracellular calcium ion homeostasis	Pth	IDA		Mouse	PMID:12488435
Biological Process	GO:0006874	intracellular calcium ion homeostasis	Pth	IDA		Rat	PMID:9832460\|RGD:1601517
Biological Process	GO:0009059	macromolecule biosynthetic process	PTH	IDA		Human	PMID:19723499
Biological Process	GO:0010960	magnesium ion homeostasis	Pth	IMP	MGI:2665181	Mouse	PMID:19968565
Biological Process	GO:0010960	magnesium ion homeostasis	Pth	IMP	MGI:1889069	Mouse	PMID:19968565
Biological Process	GO:0071866	negative regulation of apoptotic process in bone marrow cell	Pth	IGI	MGI:MGI:95560	Mouse	PMID:21048959
Biological Process	GO:1900158	negative regulation of bone mineralization involved in bone maturation	Pth	IMP		Rat	PMID:11604398\|RGD:12793028
Biological Process	GO:0032331	negative regulation of chondrocyte differentiation	Pth	IMP		Rat	PMID:11604398\|RGD:12793028
Biological Process	GO:0010629	negative regulation of gene expression	PTH	IDA		Human	PMID:17696759
Biological Process	GO:0055062	phosphate ion homeostasis	Pth	IMP	MGI:2665181	Mouse	PMID:19968565
Biological Process	GO:0055062	phosphate ion homeostasis	Pth	IMP	MGI:1889069	Mouse	PMID:19968565
Biological Process	GO:0030501	positive regulation of bone mineralization	PTH	IDA		Human	PMID:17696759
Biological Process	GO:0030501	positive regulation of bone mineralization	Pth	IDA		Rat	PMID:15758479\|RGD:7207452
Biological Process	GO:0030501	positive regulation of bone mineralization	Pth	IDA		Rat	PMID:22445539\|RGD:7242906
Biological Process	GO:0071864	positive regulation of cell proliferation in bone marrow	Pth	IGI	MGI:MGI:95560	Mouse	PMID:21048959
Biological Process	GO:0071864	positive regulation of cell proliferation in bone marrow	Pth	IGI	MGI:MGI:96559	Mouse	PMID:21048959
Biological Process	GO:0010628	positive regulation of gene expression	Pth	IMP		Rat	PMID:8603605\|RGD:151665808
Biological Process	GO:0046326	positive regulation of glucose import	PTH	IDA		Human	PMID:21076856
Biological Process	GO:0045725	positive regulation of glycogen biosynthetic process	PTH	IDA		Human	PMID:21076856
Biological Process	GO:0060732	positive regulation of inositol phosphate biosynthetic process	PTH	IMP		Human	PMID:11604398
Biological Process	GO:0045778	positive regulation of ossification	Pth	IDA		Rat	PMID:15758479\|RGD:7207452
Biological Process	GO:0090290	positive regulation of osteoclast proliferation	Pth	IGI	MGI:MGI:95560	Mouse	PMID:21048959
Biological Process	GO:0009967	positive regulation of signal transduction	Pth	IMP		Mouse	PMID:15910753
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	PTH	IDA		Human	PMID:19723499
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Pth	IDA		Mouse	PMID:15910753
Biological Process	GO:0010468	regulation of gene expression	PTH	IDA		Human	PMID:90087
Biological Process	GO:0010468	regulation of gene expression	Pth	IDA		Mouse	PMID:15910753
Biological Process	GO:0046686	response to cadmium ion	Pth	IEP		Rat	PMID:22708652\|RGD:7242891
Biological Process	GO:0045471	response to ethanol	Pth	IEP		Rat	PMID:23376407\|RGD:7242792
Biological Process	GO:0071774	response to fibroblast growth factor	Pth	IEP		Rat	PMID:23467972\|RGD:7242791
Biological Process	GO:0010288	response to lead ion	Pth	IEP		Rat	PMID:23376407\|RGD:7242792
Biological Process	GO:0031667	response to nutrient levels	Pth	IEP		Rat	PMID:22677883\|RGD:7242898
Biological Process	GO:0071107	response to parathyroid hormone	Pth	IEP		Rat	PMID:9639577\|RGD:7242931
Biological Process	GO:0033280	response to vitamin D	Pth	IEP		Rat	PMID:22926202\|RGD:7242796
Biological Process	GO:0009410	response to xenobiotic stimulus	Pth	IEP		Rat	PMID:22260362\|RGD:7242929
Biological Process	GO:0007266	Rho protein signal transduction	Pth	IMP		Rat	PMID:15476589\|RGD:1601516
Biological Process	GO:0007165	signal transduction	Pth	IMP		Mouse	PMID:15910753
Biological Process	GO:0006366	transcription by RNA polymerase II	Pth	IDA		Mouse	PMID:15910753

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.