Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PTHLH
  • Mouse genes Pthlh
  • Rat genes Pthlh
  • Zfish genes pthlha,pthlhb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pthlh

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005179	hormone activity	Pthlh	IDA		Rat	PMID:3175653|RGD:729903
Molecular Function	GO:0051428	peptide hormone receptor binding	PTHLH	IDA		Human	PMID:19674967
Molecular Function	GO:0005515	protein binding	PTHLH	IPI	UniProtKB:Q03431	Human	PMID:19674967
Cellular Component	GO:0005829	cytosol	PTHLH	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005794	Golgi apparatus	PTHLH	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005622	intracellular anatomical structure	Pthlh	IDA		Mouse	PMID:8895385
Cellular Component	GO:0005654	nucleoplasm	PTHLH	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	Pthlh	IDA		Mouse	MGI:MGI:5788801|PMID:26859332
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	PTHLH	IDA		Human	PMID:9832460
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	Pthlh	IDA		Rat	PMID:3175653|RGD:729903
Biological Process	GO:0030282	bone mineralization	Pthlh	IMP	MGI:2665181	Mouse	PMID:19968565
Biological Process	GO:0030282	bone mineralization	Pthlh	IMP	MGI:1889069	Mouse	PMID:19968565
Biological Process	GO:0030282	bone mineralization	pthlha	IMP	ZFIN:ZDB-MRPHLNO-130111-2	Zfish	PMID:22761277
Biological Process	GO:0002062	chondrocyte differentiation	Pthlh	IMP	MGI:MGI:2154515	Mouse	PMID:8895385
Biological Process	GO:0035907	dorsal aorta development	pthlha	IMP	ZFIN:ZDB-MRPHLNO-150625-5	Zfish	PMID:23559631
Biological Process	GO:0048701	embryonic cranial skeleton morphogenesis	pthlha	IMP	ZFIN:ZDB-MRPHLNO-130111-2	Zfish	PMID:22761277
Biological Process	GO:0048701	embryonic cranial skeleton morphogenesis	pthlhb	IMP	ZFIN:ZDB-MRPHLNO-130122-3	Zfish	PMID:22761277
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	pthlhb	IMP	ZFIN:ZDB-MRPHLNO-130122-3	Zfish	PMID:22761277
Biological Process	GO:0001958	endochondral ossification	Pthlh	IMP	MGI:MGI:2154515	Mouse	PMID:8895385
Biological Process	GO:0007492	endoderm development	Pthlh	IDA		Mouse	PMID:9921650
Biological Process	GO:0048286	lung alveolus development	Pthlh	IMP	MGI:MGI:2154515	Mouse	PMID:15162506
Biological Process	GO:0060487	lung epithelial cell differentiation	Pthlh	IMP	MGI:MGI:2154515	Mouse	PMID:15162506
Biological Process	GO:0060649	mammary gland bud elongation	Pthlh	IMP	MGI:MGI:2154515	Mouse	PMID:9477327
Biological Process	GO:0061182	negative regulation of chondrocyte development	PTHLH	IDA		Human	PMID:90087
Biological Process	GO:0032331	negative regulation of chondrocyte differentiation	PTHLH	IDA		Human	PMID:90087
Biological Process	GO:0032331	negative regulation of chondrocyte differentiation	Pthlh	IMP	MGI:MGI:2154515	Mouse	PMID:8895385
Biological Process	GO:0032331	negative regulation of chondrocyte differentiation	Pthlh	IDA		Mouse	PMID:17328886
Biological Process	GO:0032331	negative regulation of chondrocyte differentiation	Pthlh	IGI	MGI:MGI:95728	Mouse	PMID:17328886
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	Pthlh	IDA		Mouse	PMID:17328886
Biological Process	GO:0060659	nipple sheath formation	Pthlh	IMP	MGI:MGI:2154515	Mouse	PMID:9477327
Biological Process	GO:0002076	osteoblast development	Pthlh	IMP	MGI:MGI:2154515	Mouse	PMID:9832460
Biological Process	GO:0008284	positive regulation of cell population proliferation	Pthlh	IDA		Mouse	PMID:17328886
Biological Process	GO:0016485	protein processing	Pthlh	IDA		Mouse	PMID:17328886
Biological Process	GO:0010468	regulation of gene expression	PTHLH	IDA		Human	PMID:90087
Biological Process	GO:0001501	skeletal system development	PTHLH	IDA		Human	PMID:9008714
Biological Process	GO:0001501	skeletal system development	Pthlh	IMP	MGI:MGI:2154515	Mouse	PMID:8314082
Biological Process	GO:0001501	skeletal system development	Pthlh	IMP	MGI:MGI:2154515	Mouse	PMID:11606467
Biological Process	GO:0043129	surfactant homeostasis	Pthlh	IMP	MGI:MGI:2154515	Mouse	PMID:15162506

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern