Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PTK7
  • Mouse genes Ptk7
  • Rat genes Ptk7
  • Zfish genes ptk7a,ptk7b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ptk7

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	PTK7	IPI	UniProtKB:P35222	Human	PMID:21132015
Molecular Function	GO:0005515	protein binding	PTK7	IPI	UniProtKB:P0DPK4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PTK7	IPI	UniProtKB:P60410	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PTK7	IPI	UniProtKB:Q5JR59-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PTK7	IPI	UniProtKB:Q8IUG1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PTK7	IPI	UniProtKB:Q99750	Human	PMID:32296183
Cellular Component	GO:0005911	cell-cell junction	PTK7	IDA		Human	PMID:20837484
Cellular Component	GO:0005911	cell-cell junction	Ptk7	IDA		Mouse	PMID:20215345
Cellular Component	GO:0005925	focal adhesion	PTK7	HDA		Human	PMID:21423176
Cellular Component	GO:0016020	membrane	Ptk7	IDA		Mouse	PMID:20704721
Cellular Component	GO:0005886	plasma membrane	Ptk7	IDA		Mouse	PMID:20215345
Biological Process	GO:0031532	actin cytoskeleton reorganization	PTK7	IMP		Human	PMID:20837484
Biological Process	GO:0003401	axis elongation	Ptk7	IMP	MGI:MGI:3640803	Mouse	PMID:20704721
Biological Process	GO:0016477	cell migration	PTK7	IMP		Human	PMID:20837484
Biological Process	GO:0071300	cellular response to retinoic acid	PTK7	IMP		Human	PMID:17910947
Biological Process	GO:0090660	cerebrospinal fluid circulation	ptk7a	IMP	ZFIN:ZDB-GENO-130506-2	Zfish	PMID:27284198
Biological Process	GO:0090103	cochlea morphogenesis	Ptk7	IMP	MGI:MGI:3640803	Mouse	PMID:20704721
Biological Process	GO:0060026	convergent extension	Ptk7	IMP	MGI:MGI:3640803	Mouse	PMID:20704721
Biological Process	GO:0060026	convergent extension	ptk7b	IGI	ZFIN:ZDB-MRPHLNO-081029-4,ZFIN:ZDB-MRPHLNO-081029-5,ZFIN:ZDB-MRPHLNO-101124-1	Zfish	PMID:20837484
Biological Process	GO:0060026	convergent extension	ptk7b	IMP	ZFIN:ZDB-MRPHLNO-101124-1	Zfish	PMID:20837484
Biological Process	GO:0060976	coronary vasculature development	Ptk7	IMP		Mouse	PMID:25807483
Biological Process	GO:0045198	establishment of epithelial cell apical/basal polarity	Ptk7	IMP	MGI:MGI:3046905	Mouse	PMID:15229603
Biological Process	GO:0001736	establishment of planar polarity	Ptk7	IMP	MGI:MGI:3640803	Mouse	PMID:20704721
Biological Process	GO:0007507	heart development	Ptk7	IMP		Mouse	PMID:25807483
Biological Process	GO:0001822	kidney development	Ptk7	IMP	MGI:MGI:5552948	Mouse	PMID:27002738
Biological Process	GO:0060484	lung-associated mesenchyme development	Ptk7	IMP	MGI:MGI:3640803	Mouse	PMID:20704721
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	ptk7a	IDA		Zfish	PMID:23533179
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	ptk7a	IMP	ZFIN:ZDB-GENO-130506-2	Zfish	PMID:23533179
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	ptk7a	IGI	ZFIN:ZDB-GENE-980526-332	Zfish	PMID:23533179
Biological Process	GO:0001843	neural tube closure	Ptk7	IGI	MGI:MGI:2135272	Mouse	PMID:15229603
Biological Process	GO:0001843	neural tube closure	Ptk7	IMP	MGI:MGI:3640803	Mouse	PMID:20704721
Biological Process	GO:0001843	neural tube closure	Ptk7	IMP	MGI:MGI:3046905	Mouse	PMID:15229603
Biological Process	GO:0003402	planar cell polarity pathway involved in axis elongation	ptk7a	IDA		Zfish	PMID:23533179
Biological Process	GO:0090179	planar cell polarity pathway involved in neural tube closure	Ptk7	IGI	MGI:MGI:1100883	Mouse	PMID:20704721
Biological Process	GO:0090179	planar cell polarity pathway involved in neural tube closure	Ptk7	IGI	MGI:MGI:2135272	Mouse	PMID:20704721
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	PTK7	IMP		Human	PMID:21132015
Biological Process	GO:0010976	positive regulation of neuron projection development	PTK7	IMP		Human	PMID:17910947
Biological Process	GO:2000040	regulation of planar cell polarity pathway involved in axis elongation	ptk7a	IMP	ZFIN:ZDB-GENO-130506-2	Zfish	PMID:23533179
Biological Process	GO:0035282	segmentation	ptk7a	IMP	ZFIN:ZDB-GENO-141215-1	Zfish	PMID:25182715
Biological Process	GO:0001501	skeletal system development	ptk7a	IMP	ZFIN:ZDB-GENO-141215-1	Zfish	PMID:25182715
Biological Process	GO:0003281	ventricular septum development	Ptk7	IMP		Mouse	PMID:25807483
Biological Process	GO:0042060	wound healing	Ptk7	IGI	MGI:MGI:2145950	Mouse	PMID:20643356
Biological Process	GO:0042060	wound healing	Ptk7	IGI	MGI:MGI:2655333	Mouse	PMID:20643356
Biological Process	GO:0042060	wound healing	Ptk7	IGI	MGI:MGI:1100883	Mouse	PMID:20643356
Biological Process	GO:0042060	wound healing	Ptk7	IGI	MGI:MGI:2135272	Mouse	PMID:20643356

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern