Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PTN
  • Mouse genes Ptn
  • Rat genes Ptn
  • Zfish genes ptn
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ptn

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0030246	carbohydrate binding	PTN	EXP		Human	PMID:26896299
Molecular Function	GO:0035374	chondroitin sulfate binding	PTN	IDA		Human	PMID:26896299
Molecular Function	GO:0035373	chondroitin sulfate proteoglycan binding	Ptn	IPI	RGD:2431	Rat	PMID:20369290|RGD:9831444
Molecular Function	GO:0005539	glycosaminoglycan binding	Ptn	IDA		Rat	PMID:7925491|RGD:9834943
Molecular Function	GO:0008083	growth factor activity	PTN	IDA		Human	PMID:1733956
Molecular Function	GO:0008083	growth factor activity	Ptn	IDA		Rat	PMID:16226713|RGD:9834996
Molecular Function	GO:0008083	growth factor activity	ptn	IMP		Zfish	PMID:15358204
Molecular Function	GO:1904399	heparan sulfate binding	Ptn	IPI	CHEBI:28815	Rat	PMID:8567685|RGD:9834944
Molecular Function	GO:0008201	heparin binding	PTN	IDA		Human	PMID:1733956
Molecular Function	GO:0008201	heparin binding	Ptn	IDA		Rat	PMID:16226713|RGD:9834996
Molecular Function	GO:0008201	heparin binding	Ptn	IPI	CHEBI:28304	Rat	PMID:8567685|RGD:9834944
Molecular Function	GO:0005178	integrin binding	PTN	IPI	UniProtKB:P05106,UniProtKB:P08648	Human	PMID:19141530
Molecular Function	GO:0140677	molecular function activator activity	PTN	IPI	UniProtKB:P05106	Human	PMID:21344482
Molecular Function	GO:0005515	protein binding	PTN	IPI	UniProtKB:P23471	Human	PMID:10706604
Molecular Function	GO:0005515	protein binding	PTN	IPI	UniProtKB:P23471,UniProtKB:P35222	Human	PMID:10706604
Molecular Function	GO:0005515	protein binding	PTN	IPI	UniProtKB:P23471	Human	PMID:19141530
Molecular Function	GO:0005515	protein binding	PTN	IPI	UniProtKB:P05106	Human	PMID:21344482
Molecular Function	GO:0005515	protein binding	PTN	IPI	UniProtKB:P11215	Human	PMID:28939773
Molecular Function	GO:0005515	protein binding	PTN	IPI	UniProtKB:Q12797-6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PTN	IPI	UniProtKB:P17612	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PTN	IPI	UniProtKB:P37173	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PTN	IPI	UniProtKB:P50454	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PTN	IPI	UniProtKB:Q92876	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Ptn	IPI	RGD:621486	Rat	PMID:8175719|RGD:10043820
Molecular Function	GO:0019901	protein kinase binding	PTN	IPI	UniProtKB:Q9HC98	Human	PMID:20873783
Molecular Function	GO:0004864	protein phosphatase inhibitor activity	PTN	IDA		Human	PMID:27445335
Molecular Function	GO:0043394	proteoglycan binding	Ptn	IPI	UniProtKB:P51653	Rat	PMID:27671118|RGD:14397577
Molecular Function	GO:0043394	proteoglycan binding	Ptn	IPI	RGD:3455	Rat	PMID:8702927|RGD:9589111
Molecular Function	GO:0045545	syndecan binding	Ptn	IPI	UniProtKB:P33671	Rat	PMID:9817766|RGD:14397563
Molecular Function	GO:0038085	vascular endothelial growth factor binding	Ptn	IPI	RGD:619991	Rat	PMID:17881084|RGD:2292001
Cellular Component	GO:0005604	basement membrane	Ptn	IDA		Rat	PMID:9990431|RGD:10044215
Cellular Component	GO:0009986	cell surface	Ptn	IDA		Rat	PMID:8812110|RGD:10043837
Cellular Component	GO:0005737	cytoplasm	Ptn	IDA		Rat	PMID:9570800|RGD:9831440
Cellular Component	GO:0005783	endoplasmic reticulum	PTN	IDA		Human	GO_REF:0000054
Cellular Component	GO:0005576	extracellular region	Ptn	IDA		Mouse	MGI:MGI:6294181|PMID:19442624
Cellular Component	GO:0005576	extracellular region	Ptn	IDA		Rat	PMID:12057922|RGD:727382
Cellular Component	GO:0005576	extracellular region	Ptn	IDA		Rat	PMID:17881084|RGD:2292001
Cellular Component	GO:0005615	extracellular space	PTN	IDA		Human	PMID:1733956
Cellular Component	GO:0016020	membrane	Ptn	IDA		Rat	PMID:15632143|RGD:9834998
Cellular Component	GO:0031594	neuromuscular junction	Ptn	IDA		Rat	PMID:8812110|RGD:10043837
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Ptn	IDA		Rat	PMID:16226713|RGD:9834996
Cellular Component	GO:0098794	postsynapse	Ptn	IDA		Rat	PMID:7955321|RGD:13702269
Cellular Component	GO:0098793	presynapse	Ptn	IDA		Rat	PMID:7955321|RGD:13702269
Cellular Component	GO:0032991	protein-containing complex	PTN	IDA		Human	PMID:20873783
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	Ptn	IMP		Mouse	PMID:12093164
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	Ptn	IDA		Mouse	PMID:12093164
Biological Process	GO:0030282	bone mineralization	Ptn	IDA		Mouse	PMID:12413943
Biological Process	GO:0007420	brain development	Ptn	IEP		Rat	PMID:2270483|RGD:9831441
Biological Process	GO:0071456	cellular response to hypoxia	Ptn	IEP		Rat	PMID:16226713|RGD:9834996
Biological Process	GO:0071456	cellular response to hypoxia	Ptn	IEP		Rat	PMID:17925408|RGD:10044023
Biological Process	GO:0071407	cellular response to organic cyclic compound	Ptn	IEP		Rat	PMID:12057922|RGD:727382
Biological Process	GO:0036120	cellular response to platelet-derived growth factor stimulus	Ptn	IEP		Rat	PMID:16226713|RGD:9834996
Biological Process	GO:0034644	cellular response to UV	Ptn	IEP		Rat	PMID:17925408|RGD:10044023
Biological Process	GO:0071305	cellular response to vitamin D	Ptn	IEP		Rat	PMID:21153232|RGD:9831436
Biological Process	GO:0021549	cerebellum development	Ptn	IEP		Rat	PMID:8653419|RGD:10043831
Biological Process	GO:0046697	decidualization	Ptn	IMP		Mouse	MGI:MGI:6294220|PMID:28657144
Biological Process	GO:0140059	dendrite arborization	Ptn	IMP		Mouse	MGI:MGI:6269048|PMID:30497772
Biological Process	GO:0031104	dendrite regeneration	Ptn	IDA		Rat	PMID:27671118|RGD:14397577
Biological Process	GO:0045446	endothelial cell differentiation	Ptn	IEP		Rat	PMID:20830586|RGD:9686141
Biological Process	GO:0044849	estrous cycle	Ptn	IMP		Mouse	MGI:MGI:3718185|PMID:17121547
Biological Process	GO:0044849	estrous cycle	Ptn	IEP		Rat	PMID:9846168|RGD:10044015
Biological Process	GO:0007507	heart development	Ptn	IEP		Rat	PMID:17925408|RGD:10044023
Biological Process	GO:0030902	hindbrain development	Ptn	IEP		Rat	PMID:9749725|RGD:9831452
Biological Process	GO:0007229	integrin-mediated signaling pathway	PTN	IDA		Human	PMID:19141530
Biological Process	GO:0007612	learning	Ptn	IMP		Mouse	MGI:MGI:5619038|PMID:25000129
Biological Process	GO:0007612	learning	Ptn	IMP	MGI:MGI:2183157	Mouse	PMID:12093164
Biological Process	GO:0007612	learning	Ptn	IEP		Rat	PMID:24069387|RGD:9999367
Biological Process	GO:0002232	leukocyte chemotaxis involved in inflammatory response	Ptn	IMP		Mouse	MGI:MGI:3606557|PMID:15482347
Biological Process	GO:0001889	liver development	Ptn	IEP		Rat	PMID:12057922|RGD:727382
Biological Process	GO:0060291	long-term synaptic potentiation	Ptn	IEP		Rat	PMID:8904779|RGD:9831451
Biological Process	GO:0030324	lung development	Ptn	IEP		Rat	PMID:2270483|RGD:9831441
Biological Process	GO:0007613	memory	Ptn	IMP		Mouse	MGI:MGI:5619038|PMID:25000129
Biological Process	GO:0050804	modulation of chemical synaptic transmission	Ptn	IMP		Mouse	PMID:12093164
Biological Process	GO:0050804	modulation of chemical synaptic transmission	Ptn	IDA		Mouse	PMID:12093164
Biological Process	GO:0016525	negative regulation of angiogenesis	Ptn	IMP		Rat	PMID:17881084|RGD:2292001
Biological Process	GO:0030336	negative regulation of cell migration	Ptn	IMP		Rat	PMID:17881084|RGD:2292001
Biological Process	GO:0050680	negative regulation of epithelial cell proliferation	Ptn	IDA		Rat	PMID:8812110|RGD:10043837
Biological Process	GO:0060253	negative regulation of glial cell proliferation	Ptn	IMP		Rat	PMID:17881084|RGD:2292001
Biological Process	GO:1900272	negative regulation of long-term synaptic potentiation	Ptn	IMP		Mouse	MGI:MGI:2181835|PMID:12093164
Biological Process	GO:1900272	negative regulation of long-term synaptic potentiation	Ptn	IMP		Mouse	MGI:MGI:2136679|PMID:11414790
Biological Process	GO:0045837	negative regulation of membrane potential	Ptn	IDA		Rat	PMID:9753126|RGD:9831450
Biological Process	GO:0072201	negative regulation of mesenchymal cell proliferation	Ptn	IDA		Rat	PMID:8812110|RGD:10043837
Biological Process	GO:0007406	negative regulation of neuroblast proliferation	Ptn	IMP		Mouse	MGI:MGI:3045656|PMID:15121180
Biological Process	GO:1904397	negative regulation of neuromuscular junction development	Ptn	IDA		Rat	PMID:7722643|RGD:9834945
Biological Process	GO:0007399	nervous system development	ptn	IMP		Zfish	PMID:15358204
Biological Process	GO:0048477	oogenesis	Ptn	IMP		Mouse	MGI:MGI:3718185|PMID:17121547
Biological Process	GO:0001503	ossification	Ptn	IDA		Mouse	PMID:12413943
Biological Process	GO:0043932	ossification involved in bone remodeling	PTN	IDA		Human	PMID:19442624
Biological Process	GO:0043065	positive regulation of apoptotic process	Ptn	IMP		Rat	PMID:17925408|RGD:10044023
Biological Process	GO:0048680	positive regulation of axon regeneration	Ptn	IDA		Rat	PMID:27671118|RGD:14397577
Biological Process	GO:0030501	positive regulation of bone mineralization	Ptn	IMP		Mouse	MGI:MGI:6294181|PMID:19442624
Biological Process	GO:0045597	positive regulation of cell differentiation	Ptn	IMP		Mouse	MGI:MGI:6294220|PMID:28657144
Biological Process	GO:0008284	positive regulation of cell population proliferation	PTN	IDA		Human	PMID:1733956
Biological Process	GO:0010811	positive regulation of cell-substrate adhesion	Ptn	IDA		Rat	PMID:7925491|RGD:9834943
Biological Process	GO:1900006	positive regulation of dendrite development	Ptn	IMP		Mouse	MGI:MGI:6269048|PMID:30497772
Biological Process	GO:2000347	positive regulation of hepatocyte proliferation	Ptn	IMP		Mouse	MGI:MGI:3606557|PMID:15482347
Biological Process	GO:2000347	positive regulation of hepatocyte proliferation	Ptn	IDA		Rat	PMID:16226713|RGD:9834996
Biological Process	GO:0002690	positive regulation of leukocyte chemotaxis	Ptn	IMP		Mouse	MGI:MGI:3606557|PMID:15482347
Biological Process	GO:0010976	positive regulation of neuron projection development	Ptn	IDA		Rat	PMID:27671118|RGD:14397577
Biological Process	GO:0010976	positive regulation of neuron projection development	Ptn	IDA		Rat	PMID:7955315|RGD:10043822
Biological Process	GO:0010976	positive regulation of neuron projection development	Ptn	IDA		Rat	PMID:9749725|RGD:9831452
Biological Process	GO:0048714	positive regulation of oligodendrocyte differentiation	PTN	IDA		Human	PMID:27445335
Biological Process	GO:0048714	positive regulation of oligodendrocyte differentiation	PTN	IMP		Human	PMID:30667096
Biological Process	GO:0045778	positive regulation of ossification	Ptn	IMP		Rat	PMID:9817766|RGD:14397563
Biological Process	GO:1904395	positive regulation of skeletal muscle acetylcholine-gated channel clustering	Ptn	IDA		Rat	PMID:7722643|RGD:9834945
Biological Process	GO:2000738	positive regulation of stem cell differentiation	Ptn	IMP		Mouse	MGI:MGI:3045656|PMID:15121180
Biological Process	GO:0043113	receptor clustering	PTN	IDA		Human	PMID:27445335
Biological Process	GO:0008360	regulation of cell shape	Ptn	IMP		Rat	PMID:17881084|RGD:2292001
Biological Process	GO:1903706	regulation of hemopoiesis	Ptn	IMP		Mouse	MGI:MGI:5293574|PMID:21791434
Biological Process	GO:0031641	regulation of myelination	Ptn	IMP		Mouse	MGI:MGI:5805301|PMID:27445335
Biological Process	GO:2000036	regulation of stem cell population maintenance	Ptn	IMP		Mouse	MGI:MGI:5293574|PMID:21791434
Biological Process	GO:0048167	regulation of synaptic plasticity	Ptn	IMP		Mouse	MGI:MGI:2136679|PMID:11414790
Biological Process	GO:0014823	response to activity	Ptn	IEP		Rat	PMID:21688311|RGD:9834997
Biological Process	GO:0010996	response to auditory stimulus	Ptn	IMP		Mouse	MGI:MGI:3640442|PMID:16619002
Biological Process	GO:1904391	response to ciliary neurotrophic factor	Ptn	IEP		Rat	PMID:16914133|RGD:9831439
Biological Process	GO:0032355	response to estradiol	Ptn	IEP		Rat	PMID:9846168|RGD:10044015
Biological Process	GO:1904373	response to kainic acid	Ptn	IEP		Rat	PMID:7477935|RGD:10043834
Biological Process	GO:1990089	response to nerve growth factor	Ptn	IEP		Rat	PMID:16914133|RGD:9831439
Biological Process	GO:0032570	response to progesterone	Ptn	IEP		Rat	PMID:9846168|RGD:10044015
Biological Process	GO:0009410	response to xenobiotic stimulus	Ptn	IEP		Rat	PMID:7970205|RGD:9831446
Biological Process	GO:0060041	retina development in camera-type eye	Ptn	IEP		Rat	PMID:16914133|RGD:9831439
Biological Process	GO:0060041	retina development in camera-type eye	Ptn	IEP		Rat	PMID:8453763|RGD:9831456
Biological Process	GO:0060221	retinal rod cell differentiation	Ptn	IMP		Rat	PMID:16914133|RGD:9831439
Biological Process	GO:1904389	rod bipolar cell differentiation	Ptn	IEP		Rat	PMID:16914133|RGD:9831439
Biological Process	GO:0021510	spinal cord development	Ptn	IEP		Rat	PMID:8453763|RGD:9831456
Biological Process	GO:0021794	thalamus development	Ptn	IEP		Rat	PMID:10051750|RGD:10043838
Biological Process	GO:0042246	tissue regeneration	Ptn	IMP		Mouse	MGI:MGI:3606557|PMID:15482347

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern