Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PTPN22
  • Mouse genes Ptpn22
  • Rat genes Ptpn22
  • Zfish genes ptpn22
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ptpn22

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0019900	kinase binding	Ptpn22	IPI	UniProtKB:P32577	Mouse	MGI:MGI:4942270|PMID:8890164
Molecular Function	GO:0016791	phosphatase activity	PTPN22	IDA		Human	PMID:23991106
Molecular Function	GO:0005515	protein binding	PTPN22	IPI	UniProtKB:P22681	Human	PMID:10068674
Molecular Function	GO:0005515	protein binding	PTPN22	IPI	UniProtKB:P62993	Human	PMID:11882361
Molecular Function	GO:0005515	protein binding	PTPN22	IPI	UniProtKB:P06239	Human	PMID:16461343
Molecular Function	GO:0005515	protein binding	PTPN22	IPI	UniProtKB:P20963	Human	PMID:16461343
Molecular Function	GO:0005515	protein binding	PTPN22	IPI	UniProtKB:P43403	Human	PMID:16461343
Molecular Function	GO:0005515	protein binding	PTPN22	IPI	UniProtKB:P06239	Human	PMID:19167335
Molecular Function	GO:0005515	protein binding	PTPN22	IPI	UniProtKB:O75563	Human	PMID:21719704
Molecular Function	GO:0005515	protein binding	PTPN22	IPI	UniProtKB:P06239	Human	PMID:21719704
Molecular Function	GO:0005515	protein binding	PTPN22	IPI	UniProtKB:Q3UND0	Human	PMID:21719704
Molecular Function	GO:0005515	protein binding	PTPN22	IPI	UniProtKB:Q13114	Human	PMID:23871208
Molecular Function	GO:0005515	protein binding	PTPN22	IPI	UniProtKB:Q60803	Human	PMID:23871208
Molecular Function	GO:0005515	protein binding	PTPN22	IPI	UniProtKB:P00533	Human	PMID:24658140
Molecular Function	GO:0005515	protein binding	PTPN22	IPI	UniProtKB:O43586	Human	PMID:25040622
Molecular Function	GO:0005515	protein binding	PTPN22	IPI	UniProtKB:P00533	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	Ptpn22	IPI	UniProtKB:Q99N69	Mouse	MGI:MGI:5306581|PMID:15786712
Molecular Function	GO:1990782	protein tyrosine kinase binding	Ptpn22	IPI	RGD:1308800	Rat	PMID:25505293|RGD:9835029
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	PTPN22	IDA		Human	PMID:10068674
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	PTPN22	IDA		Human	PMID:16461343
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	PTPN22	IDA		Human	PMID:18056643
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	PTPN22	IDA		Human	PMID:27043286
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	Ptpn22	IDA		Mouse	MGI:MGI:5792478|PMID:27043286
Molecular Function	GO:0017124	SH3 domain binding	Ptpn22	IPI	UniProtKB:P32577	Mouse	MGI:MGI:4942270|PMID:8890164
Molecular Function	GO:0031625	ubiquitin protein ligase binding	PTPN22	IPI	UniProtKB:Q13114	Human	PMID:23871208
Cellular Component	GO:0005737	cytoplasm	PTPN22	IDA		Human	PMID:10068674
Cellular Component	GO:0005737	cytoplasm	PTPN22	IDA		Human	PMID:10940933
Cellular Component	GO:0005737	cytoplasm	Ptpn22	IDA		Mouse	MGI:MGI:4942261|PMID:10940933
Cellular Component	GO:0005737	cytoplasm	Ptpn22	IDA		Mouse	MGI:MGI:4942270|PMID:8890164
Cellular Component	GO:0005737	cytoplasm	Ptpn22	IDA		Rat	PMID:24998229|RGD:11532752
Cellular Component	GO:0009898	cytoplasmic side of plasma membrane	PTPN22	IDA		Human	PMID:10940933
Cellular Component	GO:0009898	cytoplasmic side of plasma membrane	Ptpn22	IDA		Mouse	MGI:MGI:4942261|PMID:10940933
Cellular Component	GO:0005634	nucleus	PTPN22	IDA		Human	PMID:10940933
Cellular Component	GO:0005634	nucleus	Ptpn22	IDA		Mouse	MGI:MGI:4942261|PMID:10940933
Cellular Component	GO:0048471	perinuclear region of cytoplasm	PTPN22	IDA		Human	PMID:10068674
Biological Process	GO:0071225	cellular response to muramyl dipeptide	PTPN22	IDA		Human	PMID:23991106
Biological Process	GO:0071225	cellular response to muramyl dipeptide	Ptpn22	IDA		Mouse	MGI:MGI:5640942|PMID:23991106
Biological Process	GO:0031663	lipopolysaccharide-mediated signaling pathway	PTPN22	IMP		Human	PMID:23991106
Biological Process	GO:0010507	negative regulation of autophagy	PTPN22	IMP		Human	PMID:23991106
Biological Process	GO:0010629	negative regulation of gene expression	PTPN22	IMP		Human	PMID:23991106
Biological Process	GO:0010629	negative regulation of gene expression	Ptpn22	IMP		Mouse	MGI:MGI:5640942|PMID:23991106
Biological Process	GO:0010629	negative regulation of gene expression	Ptpn22	IMP		Mouse	MGI:MGI:5562517|PMID:23871208
Biological Process	GO:0032715	negative regulation of interleukin-6 production	PTPN22	IMP		Human	PMID:23991106
Biological Process	GO:0032715	negative regulation of interleukin-6 production	Ptpn22	IMP		Mouse	MGI:MGI:5640942|PMID:23991106
Biological Process	GO:0032717	negative regulation of interleukin-8 production	PTPN22	IMP		Human	PMID:23991106
Biological Process	GO:0032717	negative regulation of interleukin-8 production	Ptpn22	IMP		Mouse	MGI:MGI:5640942|PMID:23991106
Biological Process	GO:0043508	negative regulation of JUN kinase activity	PTPN22	IMP		Human	PMID:23991106
Biological Process	GO:0070433	negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway	PTPN22	IMP		Human	PMID:23991106
Biological Process	GO:0070433	negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway	Ptpn22	IMP		Mouse	MGI:MGI:5640942|PMID:23991106
Biological Process	GO:1903753	negative regulation of p38MAPK cascade	PTPN22	IMP		Human	PMID:23991106
Biological Process	GO:1903753	negative regulation of p38MAPK cascade	Ptpn22	IMP		Mouse	MGI:MGI:5640942|PMID:23991106
Biological Process	GO:0050868	negative regulation of T cell activation	PTPN22	IMP		Human	PMID:18299186
Biological Process	GO:0050868	negative regulation of T cell activation	Ptpn22	IMP		Mouse	MGI:MGI:4946183|PMID:21044313
Biological Process	GO:0050860	negative regulation of T cell receptor signaling pathway	PTPN22	IDA		Human	PMID:18056643
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	PTPN22	IMP		Human	PMID:23991106
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	Ptpn22	IMP		Mouse	MGI:MGI:5640942|PMID:23991106
Biological Process	GO:0035644	phosphoanandamide dephosphorylation	Ptpn22	IDA		Mouse	MGI:MGI:4943401|PMID:16938887
Biological Process	GO:2000566	positive regulation of CD8-positive, alpha-beta T cell proliferation	Ptpn22	IMP		Mouse	MGI:MGI:5562517|PMID:23871208
Biological Process	GO:0002230	positive regulation of defense response to virus by host	Ptpn22	IMP		Mouse	MGI:MGI:5562517|PMID:23871208
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PTPN22	IMP		Human	PMID:23991106
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	Ptpn22	IMP		Mouse	MGI:MGI:5640942|PMID:23991106
Biological Process	GO:0010628	positive regulation of gene expression	PTPN22	IMP		Human	PMID:23871208
Biological Process	GO:0010628	positive regulation of gene expression	PTPN22	IMP		Human	PMID:23991106
Biological Process	GO:0010628	positive regulation of gene expression	Ptpn22	IMP		Mouse	MGI:MGI:5640942|PMID:23991106
Biological Process	GO:0010628	positive regulation of gene expression	Ptpn22	IMP		Mouse	MGI:MGI:5562517|PMID:23871208
Biological Process	GO:0071663	positive regulation of granzyme B production	Ptpn22	IMP		Mouse	MGI:MGI:5562517|PMID:23871208
Biological Process	GO:0032727	positive regulation of interferon-alpha production	Ptpn22	IMP		Mouse	MGI:MGI:5562517|PMID:23871208
Biological Process	GO:0032728	positive regulation of interferon-beta production	Ptpn22	IMP		Mouse	MGI:MGI:5562517|PMID:23871208
Biological Process	GO:1900227	positive regulation of NLRP3 inflammasome complex assembly	PTPN22	IDA		Human	PMID:27043286
Biological Process	GO:1900227	positive regulation of NLRP3 inflammasome complex assembly	Ptpn22	IDA		Mouse	MGI:MGI:5792478|PMID:27043286
Biological Process	GO:0042307	positive regulation of protein import into nucleus	Ptpn22	IMP		Mouse	MGI:MGI:5562517|PMID:23871208
Biological Process	GO:1902523	positive regulation of protein K63-linked ubiquitination	PTPN22	IMP		Human	PMID:23871208
Biological Process	GO:1902523	positive regulation of protein K63-linked ubiquitination	Ptpn22	IMP		Mouse	MGI:MGI:5562517|PMID:23871208
Biological Process	GO:0034141	positive regulation of toll-like receptor 3 signaling pathway	PTPN22	IMP		Human	PMID:23871208
Biological Process	GO:0034141	positive regulation of toll-like receptor 3 signaling pathway	Ptpn22	IMP		Mouse	MGI:MGI:5562517|PMID:23871208
Biological Process	GO:0034145	positive regulation of toll-like receptor 4 signaling pathway	PTPN22	IMP		Human	PMID:23871208
Biological Process	GO:0034145	positive regulation of toll-like receptor 4 signaling pathway	Ptpn22	IMP		Mouse	MGI:MGI:5562517|PMID:23871208
Biological Process	GO:0034157	positive regulation of toll-like receptor 7 signaling pathway	Ptpn22	IMP		Mouse	MGI:MGI:5562517|PMID:23871208
Biological Process	GO:0034165	positive regulation of toll-like receptor 9 signaling pathway	Ptpn22	IMP		Mouse	MGI:MGI:5562517|PMID:23871208
Biological Process	GO:0032481	positive regulation of type I interferon production	PTPN22	IMP		Human	PMID:23871208
Biological Process	GO:0032729	positive regulation of type II interferon production	PTPN22	IMP		Human	PMID:23991106
Biological Process	GO:0006470	protein dephosphorylation	PTPN22	IDA		Human	PMID:10068674
Biological Process	GO:0006470	protein dephosphorylation	Ptpn22	IMP		Mouse	MGI:MGI:80190|PMID:1373816
Biological Process	GO:0006470	protein dephosphorylation	Ptpn22	IMP	MGI:MGI:3043469	Mouse	PMID:14752163
Biological Process	GO:1903169	regulation of calcium ion transmembrane transport	Ptpn22	IMP		Rat	PMID:25505293|RGD:9835029
Biological Process	GO:0002685	regulation of leukocyte migration	Ptpn22	IMP		Mouse	MGI:MGI:5562517|PMID:23871208
Biological Process	GO:0032817	regulation of natural killer cell proliferation	PTPN22	IDA		Human	PMID:20522204
Biological Process	GO:1901222	regulation of NIK/NF-kappaB signaling	PTPN22	IMP		Human	PMID:23991106
Biological Process	GO:1901222	regulation of NIK/NF-kappaB signaling	Ptpn22	IMP		Mouse	MGI:MGI:5640942|PMID:23991106
Biological Process	GO:0050730	regulation of peptidyl-tyrosine phosphorylation	Ptpn22	IMP		Rat	PMID:25505293|RGD:9835029
Biological Process	GO:0032496	response to lipopolysaccharide	PTPN22	IMP		Human	PMID:23871208
Biological Process	GO:0030217	T cell differentiation	Ptpn22	IMP	MGI:MGI:3043469	Mouse	PMID:14752163
Biological Process	GO:0050852	T cell receptor signaling pathway	Ptpn22	IMP	MGI:MGI:3043469	Mouse	PMID:14752163

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern