About   Help   FAQ
Comparative GO Graph (mouse, human, rat, zebrafish)
Source
Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Ptpn6

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

Molecular Function


Cellular Component


Biological Process



Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ptpn6
Category ID Classification term Gene Evidence Inferred from Organism Reference
Molecular FunctionGO:0050839cell adhesion molecule bindingPtpn6IPIUniProtKB:P16573MouseMGI:MGI:5770065|PMID:19948503
Molecular FunctionGO:0005126cytokine receptor bindingPtpn6IPIRGD:2425RatPMID:11157073|RGD:1302222
Molecular FunctionGO:0005126cytokine receptor bindingPtpn6IPIRGD:2543RatPMID:11157073|RGD:1302222
Molecular FunctionGO:0046703natural killer cell lectin-like receptor bindingPtpn6IPIRGD:727903RatPMID:12782717|RGD:1299590
Molecular FunctionGO:0140031phosphorylation-dependent protein bindingPTPN6IPIUniProtKB:Q96LA5HumanPMID:11162587
Molecular FunctionGO:0140031phosphorylation-dependent protein bindingPTPN6IPIUniProtKB:Q96LC7HumanPMID:12163025
Molecular FunctionGO:0001784phosphotyrosine residue bindingPTPN6IPIUniProtKB:Q96RL6HumanPMID:11986327
Molecular FunctionGO:0001784phosphotyrosine residue bindingPTPN6IMPHumanPMID:12051764
Molecular FunctionGO:0001784phosphotyrosine residue bindingPTPN6IPIUniProtKB:Q96P31HumanPMID:12051764
Molecular FunctionGO:0001784phosphotyrosine residue bindingPtpn6IPIUniProtKB:P27812MousePMID:10229828
Molecular FunctionGO:0005515protein bindingPTPN6IPIUniProtKB:P20138HumanPMID:10206955
Molecular FunctionGO:0005515protein bindingPTPN6IPIUniProtKB:Q9UGN4HumanPMID:10540326
Molecular FunctionGO:0005515protein bindingPTPN6IPIUniProtKB:P20138HumanPMID:10556798
Molecular FunctionGO:0005515protein bindingPTPN6IPIUniProtKB:P62993HumanPMID:10660620
Molecular FunctionGO:0005515protein bindingPTPN6IPIUniProtKB:Q6GTX8HumanPMID:10660620
Molecular FunctionGO:0005515protein bindingPTPN6IPIUniProtKB:Q9UKJ0HumanPMID:10660620
Molecular FunctionGO:0005515protein bindingPTPN6IPIUniProtKB:Q9UKJ1HumanPMID:10660620
Molecular FunctionGO:0005515protein bindingPTPN6IPIUniProtKB:Q6GTX8HumanPMID:10764762
Molecular FunctionGO:0005515protein bindingPTPN6IPIUniProtKB:P20138HumanPMID:10887109
Molecular FunctionGO:0005515protein bindingPTPN6IPIUniProtKB:Q9BZW8HumanPMID:11489943
Molecular FunctionGO:0005515protein bindingPTPN6IPIUniProtKB:Q8NHL6HumanPMID:11907092
Molecular FunctionGO:0005515protein bindingPTPN6IPIUniProtKB:Q9UGN4HumanPMID:16254138
Molecular FunctionGO:0005515protein bindingPTPN6IPIUniProtKB:Q9UGN4HumanPMID:16339535
Molecular FunctionGO:0005515protein bindingPTPN6IPIUniProtKB:Q8NHJ6HumanPMID:16493035
Molecular FunctionGO:0005515protein bindingPTPN6IPIUniProtKB:P08922HumanPMID:17416557
Molecular FunctionGO:0005515protein bindingPTPN6IPIUniProtKB:Q2HXU8HumanPMID:17562706
Molecular FunctionGO:0005515protein bindingPTPN6IPIUniProtKB:P20138HumanPMID:17947393
Molecular FunctionGO:0005515protein bindingPTPN6IPIUniProtKB:Q14790HumanPMID:18086677
Molecular FunctionGO:0005515protein bindingPTPN6IPIUniProtKB:P35968HumanPMID:18377662
Molecular FunctionGO:0005515protein bindingPTPN6IPIUniProtKB:P13688HumanPMID:18424730
Molecular FunctionGO:0005515protein bindingPTPN6IPIUniProtKB:P43626HumanPMID:18604210
Molecular FunctionGO:0005515protein bindingPTPN6IPIUniProtKB:O75022HumanPMID:18802077
Molecular FunctionGO:0005515protein bindingPTPN6IPIUniProtKB:Q8N423HumanPMID:18802077
Molecular FunctionGO:0005515protein bindingPTPN6IPIUniProtKB:Q8NHJ6HumanPMID:18802077
Molecular FunctionGO:0005515protein bindingPTPN6IPIUniProtKB:Q8NHL6HumanPMID:18802077
Molecular FunctionGO:0005515protein bindingPTPN6IPIUniProtKB:P06239HumanPMID:19167335
Molecular FunctionGO:0005515protein bindingPTPN6IPIUniProtKB:P46527HumanPMID:19838216
Molecular FunctionGO:0005515protein bindingPTPN6IPIUniProtKB:Q96P31HumanPMID:19843936
Molecular FunctionGO:0005515protein bindingPTPN6IPIUniProtKB:O94916-1HumanPMID:20351292
Molecular FunctionGO:0005515protein bindingPTPN6IPIUniProtKB:Q6DN72HumanPMID:20933011
Molecular FunctionGO:0005515protein bindingPTPN6IPIUniProtKB:P11049HumanPMID:22624718
Molecular FunctionGO:0005515protein bindingPTPN6IPIUniProtKB:B7UM99HumanPMID:23001144
Molecular FunctionGO:0005515protein bindingPTPN6IPIUniProtKB:Q7DB77HumanPMID:23001144
Molecular FunctionGO:0005515protein bindingPTPN6IPIUniProtKB:O95866HumanPMID:23112346
Molecular FunctionGO:0005515protein bindingPTPN6IPIUniProtKB:P13688HumanPMID:23696226
Molecular FunctionGO:0005515protein bindingPTPN6IPIUniProtKB:P20138HumanPMID:24216507
Molecular FunctionGO:0005515protein bindingPTPN6IPIUniProtKB:Q9BZW8HumanPMID:24642916
Molecular FunctionGO:0005515protein bindingPTPN6IPIUniProtKB:Q13643HumanPMID:25416956
Molecular FunctionGO:0005515protein bindingPTPN6IPIUniProtKB:P62993HumanPMID:25535246
Molecular FunctionGO:0005515protein bindingPTPN6IPIUniProtKB:Q8N1K5HumanPMID:25535246
Molecular FunctionGO:0005515protein bindingPTPN6IPIUniProtKB:O35274HumanPMID:25785436
Molecular FunctionGO:0005515protein bindingPTPN6IPIUniProtKB:Q6DKI7HumanPMID:26755705
Molecular FunctionGO:0005515protein bindingPTPN6IPIUniProtKB:P08069HumanPMID:28065597
Molecular FunctionGO:0005515protein bindingPTPN6IPIUniProtKB:P35968HumanPMID:28065597
Molecular FunctionGO:0005515protein bindingPTPN6IPIUniProtKB:Q9H492HumanPMID:35044719
Molecular FunctionGO:0005515protein bindingPTPN6IPIUniProtKB:P19235HumanPMID:7228577
Molecular FunctionGO:0005515protein bindingPTPN6IPIUniProtKB:P19235HumanPMID:7528537
Molecular FunctionGO:0005515protein bindingPTPN6IPIUniProtKB:P19235HumanPMID:7528577
Molecular FunctionGO:0005515protein bindingPTPN6IPIUniProtKB:P06239HumanPMID:8114715
Molecular FunctionGO:0005515protein bindingPTPN6IPIUniProtKB:P43628HumanPMID:8574854
Molecular FunctionGO:0005515protein bindingPTPN6IPIUniProtKB:P31994HumanPMID:8577729
Molecular FunctionGO:0005515protein bindingPTPN6IPIUniProtKB:P20273HumanPMID:8627166
Molecular FunctionGO:0005515protein bindingPTPN6IPIUniProtKB:P43628HumanPMID:8648092
Molecular FunctionGO:0005515protein bindingPTPN6IPIUniProtKB:P43626HumanPMID:8691146
Molecular FunctionGO:0005515protein bindingPTPN6IPIUniProtKB:P43628HumanPMID:8691154
Molecular FunctionGO:0005515protein bindingPTPN6IPIUniProtKB:P31994HumanPMID:9148918
Molecular FunctionGO:0005515protein bindingPTPN6IPIUniProtKB:P43628HumanPMID:9148918
Molecular FunctionGO:0005515protein bindingPTPN6IPIUniProtKB:Q8NHL6HumanPMID:9285411
Molecular FunctionGO:0005515protein bindingPTPN6IPIUniProtKB:P31994HumanPMID:9603468
Molecular FunctionGO:0005515protein bindingPTPN6IPIUniProtKB:P16284HumanPMID:9774457
Molecular FunctionGO:0005515protein bindingPTPN6IPIUniProtKB:Q8N423HumanPMID:9842885
Molecular FunctionGO:0005515protein bindingPTPN6IPIUniProtKB:Q8NHL6HumanPMID:9842885
Molecular FunctionGO:0005515protein bindingPtpn6IPIUniProtKB:Q64281MouseMGI:MGI:6827313|PMID:9973385
Molecular FunctionGO:0005515protein bindingPtpn6IPIUniProtKB:P48025MouseMGI:MGI:5478702|PMID:22496641
Molecular FunctionGO:0005515protein bindingPtpn6IPIUniProtKB:P35329MouseMGI:MGI:2153585|PMID:11551923
Molecular FunctionGO:0005515protein bindingPtpn6IPIUniProtKB:P31809|UniProtKB:P40223MouseMGI:MGI:4837548|PMID:21029969
Molecular FunctionGO:0005515protein bindingPtpn6IPIUniProtKB:D7PDD4MouseMGI:MGI:5512895|PMID:23112346
Molecular FunctionGO:0005515protein bindingPtpn6IPIUniProtKB:B7UM99MouseMGI:MGI:5441117|PMID:23001144
Molecular FunctionGO:0005515protein bindingPtpn6IPIUniProtKB:P42225MouseMGI:MGI:5561193|PMID:24360797
Molecular FunctionGO:0005515protein bindingPtpn6IPIUniProtKB:E9BTJ1MouseMGI:MGI:6094794|PMID:18028878
Molecular FunctionGO:0005515protein bindingPtpn6IPIUniProtKB:Q91YS8MouseMGI:MGI:5918010|PMID:25915125
Molecular FunctionGO:0005515protein bindingPtpn6IPIUniProtKB:Q95VF2MouseMGI:MGI:6103758|PMID:12646217
Molecular FunctionGO:0005515protein bindingPtpn6IPIUniProtKB:Q3TB92MouseMGI:MGI:4461821|PMID:20526344
Molecular FunctionGO:0005515protein bindingPtpn6IPIUniProtKB:P35329MouseMGI:MGI:5508302|PMID:9890995
Molecular FunctionGO:0005515protein bindingPtpn6IPIUniProtKB:Q64281MouseMGI:MGI:6827314|PMID:10026201
Molecular FunctionGO:0005515protein bindingPtpn6IPIUniProtKB:P97797MouseMGI:MGI:3760575|PMID:17954568
Molecular FunctionGO:0005515protein bindingPtpn6IPIUniProtKB:Q9Z1S8MouseMGI:MGI:3837242|PMID:19171907
Molecular FunctionGO:0005515protein bindingPtpn6IPIPR:Q68SN8MousePMID:23509253
Molecular FunctionGO:0005515protein bindingPtpn6IPIPR:Q62120MousePMID:8943354
Molecular FunctionGO:0005515protein bindingPtpn6IPIUniProtKB:Q99JB4MousePMID:10229823
Molecular FunctionGO:0005515protein bindingPtpn6IPIPR:Q62245MousePMID:8632004
Molecular FunctionGO:0005515protein bindingPtpn6IPIPR:000044464MousePMID:9047385
Molecular FunctionGO:0005515protein bindingPtpn6IPIPR:Q60631MousePMID:8632004
Molecular FunctionGO:0005515protein bindingPtpn6IPIPR:P27870MousePMID:8632004
Molecular FunctionGO:0005515protein bindingPtpn6IPIPR:P31809-1MousePMID:9867848
Molecular FunctionGO:0005515protein bindingPtpn6IPIPR:Q6SJQ0MousePMID:12893283
Molecular FunctionGO:0005515protein bindingPtpn6IPIPR:P13379MousePMID:9064344
Molecular FunctionGO:0005515protein bindingPtpn6IPIUniProtKB:P97710RatPMID:16055727|RGD:13792550
Molecular FunctionGO:0019901protein kinase bindingPTPN6IPIUniProtKB:Q78DX7HumanPMID:11266449
Molecular FunctionGO:0030291protein serine/threonine kinase inhibitor activityPtpn6IDAMousePMID:27830702
Molecular FunctionGO:0004725protein tyrosine phosphatase activityPTPN6IMPHumanPMID:10206955
Molecular FunctionGO:0004725protein tyrosine phosphatase activityPTPN6IMPHumanPMID:17562706
Molecular FunctionGO:0004725protein tyrosine phosphatase activityPtpn6IDAMouseMGI:MGI:6294631|PMID:10556798
Molecular FunctionGO:0004725protein tyrosine phosphatase activityPtpn6IDAMousePMID:27830702
Molecular FunctionGO:0004725protein tyrosine phosphatase activityPtpn6IDAMousePMID:10585470
Molecular FunctionGO:0004725protein tyrosine phosphatase activityPtpn6IDAMousePMID:8943354
Molecular FunctionGO:0004725protein tyrosine phosphatase activityPtpn6IDAMousePMID:9064344
Molecular FunctionGO:0004725protein tyrosine phosphatase activityPtpn6IDAMousePMID:8632004
Molecular FunctionGO:0042169SH2 domain bindingPtpn6IDAMousePMID:8632004
Molecular FunctionGO:0017124SH3 domain bindingPtpn6IDAMousePMID:8632004
Molecular FunctionGO:0005001transmembrane receptor protein tyrosine phosphatase activityPTPN6IDAHumanPMID:11266449
Cellular ComponentGO:0042105alpha-beta T cell receptor complexPtpn6IDAMousePMID:9064344
Cellular ComponentGO:0097440apical dendritePtpn6IDARatPMID:11157073|RGD:1302222
Cellular ComponentGO:0005911cell-cell junctionPtpn6IDAMousePMID:23793062
Cellular ComponentGO:0005737cytoplasmPTPN6IDAHumanPMID:10940933
Cellular ComponentGO:0005737cytoplasmPTPN6IDAHumanPMID:19838216
Cellular ComponentGO:0005737cytoplasmPtpn6IDAMousePMID:27830702
Cellular ComponentGO:0070062extracellular exosomePTPN6HDAHumanPMID:19056867
Cellular ComponentGO:0070062extracellular exosomePTPN6HDAHumanPMID:20458337
Cellular ComponentGO:0005730nucleolusPTPN6IDAHumanGO_REF:0000052
Cellular ComponentGO:0005654nucleoplasmPTPN6IDAHumanGO_REF:0000052
Cellular ComponentGO:0005634nucleusPTPN6IDAHumanPMID:19838216
Cellular ComponentGO:0032991protein-containing complexPTPN6IMPHumanPMID:17562706
Biological ProcessGO:0050853B cell receptor signaling pathwayPtpn6IMPMGI:MGI:1856074MousePMID:9254656
Biological ProcessGO:0050853B cell receptor signaling pathwayPtpn6IGIMGI:MGI:3053558MousePMID:23509253
Biological ProcessGO:0030154cell differentiationPTPN6IDAHumanPMID:11266449
Biological ProcessGO:0036006cellular response to macrophage colony-stimulating factor stimulusPtpn6IEPRatPMID:11157073|RGD:1302222
Biological ProcessGO:1905867epididymis developmentPtpn6IMPMouseMGI:MGI:1930880|PMID:11266449
Biological ProcessGO:0002244hematopoietic progenitor cell differentiationPtpn6IMPMousePMID:24029230
Biological ProcessGO:0045087innate immune responseptpn6IMPZFIN:ZDB-MRPHLNO-140506-1ZfishPMID:23335748
Biological ProcessGO:0035556intracellular signal transductionPtpn6IDAMousePMID:10229828
Biological ProcessGO:0000165MAPK cascadePtpn6IMPMGI:MGI:1856074MousePMID:9064344
Biological ProcessGO:0000165MAPK cascadePtpn6IMPMGI:MGI:1856074MousePMID:9254656
Biological ProcessGO:0035855megakaryocyte developmentPtpn6IMPMGI:MGI:3719625MousePMID:23509158
Biological ProcessGO:0042267natural killer cell mediated cytotoxicityPtpn6IMPMGI:MGI:1856073MousePMID:6971254
Biological ProcessGO:0002924negative regulation of humoral immune response mediated by circulating immunoglobulinPtpn6IMPMGI:MGI:1856074MousePMID:9254656
Biological ProcessGO:0106015negative regulation of inflammatory response to woundingPtpn6IDAMousePMID:27830702
Biological ProcessGO:0032715negative regulation of interleukin-6 productionPtpn6IGIUniProtKB:P97797MouseMGI:MGI:3760575|PMID:17954568
Biological ProcessGO:0043407negative regulation of MAP kinase activityPtpn6IMPMGI:MGI:1856074MousePMID:9254656
Biological ProcessGO:0043407negative regulation of MAP kinase activityPtpn6IMPMGI:MGI:1856074MousePMID:9064344
Biological ProcessGO:0043409negative regulation of MAPK cascadePtpn6IMPMGI:MGI:1856074MousePMID:9254656
Biological ProcessGO:0043409negative regulation of MAPK cascadePtpn6IMPMGI:MGI:1856074MousePMID:9064344
Biological ProcessGO:0033007negative regulation of mast cell activation involved in immune responsePtpn6IDAMouseMGI:MGI:6827314|PMID:10026201
Biological ProcessGO:0050732negative regulation of peptidyl-tyrosine phosphorylationPTPN6IMPHumanPMID:19749791
Biological ProcessGO:0050732negative regulation of peptidyl-tyrosine phosphorylationPtpn6IMPMGI:MGI:1856074MousePMID:9254656
Biological ProcessGO:0042130negative regulation of T cell proliferationPtpn6IMPMGI:MGI:1856073MousePMID:9064344
Biological ProcessGO:0042130negative regulation of T cell proliferationPtpn6IMPMGI:MGI:1856074MousePMID:9064344
Biological ProcessGO:0050860negative regulation of T cell receptor signaling pathwayPtpn6IMPMGI:MGI:1856074MousePMID:9064344
Biological ProcessGO:0032720negative regulation of tumor necrosis factor productionPtpn6IGIUniProtKB:P97797MouseMGI:MGI:3760575|PMID:17954568
Biological ProcessGO:0035335peptidyl-tyrosine dephosphorylationPTPN6IMPHumanPMID:17562706
Biological ProcessGO:0018108peptidyl-tyrosine phosphorylationPTPN6IDAHumanPMID:18802077
Biological ProcessGO:0018108peptidyl-tyrosine phosphorylationPTPN6IDAHumanPMID:9285411
Biological ProcessGO:0018108peptidyl-tyrosine phosphorylationPtpn6IMPMGI:MGI:1856074MousePMID:9254656
Biological ProcessGO:0070527platelet aggregationPtpn6IMPMGI:MGI:3719625MousePMID:23509158
Biological ProcessGO:0030220platelet formationPtpn6IGIMGI:MGI:2146995MousePMID:23509158
Biological ProcessGO:0030220platelet formationPtpn6IGIMGI:MGI:99511MousePMID:23509158
Biological ProcessGO:0033630positive regulation of cell adhesion mediated by integrinPtpn6IMPMGI:MGI:3719625MousePMID:23509158
Biological ProcessGO:0008284positive regulation of cell population proliferationPTPN6IMPHumanPMID:19749791
Biological ProcessGO:0008284positive regulation of cell population proliferationPTPN6IMPHumanPMID:19838216
Biological ProcessGO:0014068positive regulation of phosphatidylinositol 3-kinase signalingPTPN6IMPHumanPMID:19838216
Biological ProcessGO:0006470protein dephosphorylationPTPN6IDAHumanPMID:11266449
Biological ProcessGO:0006470protein dephosphorylationPtpn6IDAMousePMID:9064344
Biological ProcessGO:0006470protein dephosphorylationPtpn6IDAMousePMID:8632004
Biological ProcessGO:0006470protein dephosphorylationPtpn6IMPMGI:MGI:1856073MousePMID:9064344
Biological ProcessGO:0006470protein dephosphorylationPtpn6IMPMGI:MGI:1856074MousePMID:9064344
Biological ProcessGO:0045577regulation of B cell differentiationPtpn6IMPMGI:MGI:1856074MousePMID:9254656
Biological ProcessGO:0070372regulation of ERK1 and ERK2 cascadePTPN6IDAHumanPMID:11266449
Biological ProcessGO:2000045regulation of G1/S transition of mitotic cell cyclePTPN6IMPHumanPMID:19838216
Biological ProcessGO:0051279regulation of release of sequestered calcium ion into cytosolPtpn6IGIMGI:MGI:3053558MousePMID:23509253
Biological ProcessGO:0048678response to axon injuryPtpn6IEPRatPMID:11157073|RGD:1302222
Biological ProcessGO:0009611response to woundingPtpn6IEPRatPMID:11157073|RGD:1302222
Biological ProcessGO:0042098T cell proliferationPtpn6IMPMGI:MGI:1856074MousePMID:9064344
Biological ProcessGO:0042098T cell proliferationPtpn6IMPMGI:MGI:1856073MousePMID:9064344
Biological ProcessGO:0050852T cell receptor signaling pathwayPtpn6IMPMGI:MGI:1856074MousePMID:9064344

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IDA Inferred from direct assay
  IEP Inferred from expression pattern
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  HTP Inferred from High Throughput Experiment
  HDA Inferred from High Throughput Direct Assay
  HMP Inferred from High Throughput Mutant Phenotype
  HGI Inferred from High Throughput Genetic Interaction
  HEP Inferred from High Throughput Expression Pattern

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
12/10/2024
MGI 6.24
The Jackson Laboratory