Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PTPRF
  • Mouse genes Ptprf
  • Rat genes Ptprf
  • Zfish genes ptprfa,ptprfb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ptprf

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0050839	cell adhesion molecule binding	PTPRF	IPI	UniProtKB:Q9HCJ2	Human	PMID:23986473
Molecular Function	GO:0035373	chondroitin sulfate proteoglycan binding	Ptprf	IPI	PR:Q62059	Mouse	PMID:21976490
Molecular Function	GO:0005158	insulin receptor binding	Ptprf	IDA		Rat	PMID:7711057|RGD:2293185
Molecular Function	GO:0042301	phosphate ion binding	Ptprf	IDA		Rat	PMID:1918076|RGD:633829
Molecular Function	GO:0005515	protein binding	Ptprf	IPI	RGD:69331	Rat	PMID:12629171|RGD:152995492
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	PTPRF	IDA		Human	PMID:10338209
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	PTPRF	IMP		Human	PMID:23358419
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	Ptprf	IDA		Rat	PMID:8068021|RGD:69951
Molecular Function	GO:0044877	protein-containing complex binding	Ptprf	IDA		Mouse	PMID:23791195
Molecular Function	GO:0030971	receptor tyrosine kinase binding	Ptprf	IPI	RGD:3082	Rat	PMID:16415345|RGD:1642742
Molecular Function	GO:0005001	transmembrane receptor protein tyrosine phosphatase activity	Ptprf	IDA		Rat	PMID:7711057|RGD:2293185
Cellular Component	GO:0005768	endosome	Ptprf	IDA		Rat	PMID:16269466|RGD:1642745
Cellular Component	GO:0060076	excitatory synapse	Ptprf	IDA		Rat	PMID:15750591|RGD:1642736
Cellular Component	GO:0070062	extracellular exosome	PTPRF	HDA		Human	PMID:19199708
Cellular Component	GO:0030426	growth cone	Ptprf	IDA		Rat	PMID:9604206|RGD:1642752
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	Ptprf	IDA		Rat	PMID:10692429|RGD:1642747
Cellular Component	GO:0016020	membrane	Ptprf	IDA		Rat	PMID:12365558|RGD:1642746
Cellular Component	GO:0043005	neuron projection	Ptprf	IDA		Mouse	PMID:21976490
Cellular Component	GO:0043005	neuron projection	Ptprf	IDA		Mouse	PMID:11438588
Cellular Component	GO:0043005	neuron projection	Ptprf	IDA		Rat	PMID:9748473|RGD:1642751
Cellular Component	GO:0043025	neuronal cell body	Ptprf	IDA		Mouse	PMID:21976490
Cellular Component	GO:0043025	neuronal cell body	Ptprf	IDA		Rat	PMID:9748473|RGD:1642751
Cellular Component	GO:0005886	plasma membrane	Ptprf	IDA		Rat	PMID:10692429|RGD:1642747
Cellular Component	GO:0098839	postsynaptic density membrane	Ptprf	IDA		Rat	PMID:15750591|RGD:1642736
Biological Process	GO:0016477	cell migration	PTPRF	IMP		Human	PMID:23358419
Biological Process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	Ptprf	IDA		Rat	PMID:12716943|RGD:633826
Biological Process	GO:0008285	negative regulation of cell population proliferation	Ptprf	IMP		Rat	PMID:16415345|RGD:1642742
Biological Process	GO:0031345	negative regulation of cell projection organization	Ptprf	IMP		Rat	PMID:10699984|RGD:1642748
Biological Process	GO:0001960	negative regulation of cytokine-mediated signaling pathway	Ptprf	IMP		Rat	PMID:16415345|RGD:1642742
Biological Process	GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway	Ptprf	IMP		Rat	PMID:8557682|RGD:1642757
Biological Process	GO:0046627	negative regulation of insulin receptor signaling pathway	Ptprf	IMP		Rat	PMID:8557682|RGD:1642757
Biological Process	GO:0051387	negative regulation of neurotrophin TRK receptor signaling pathway	Ptprf	IMP		Rat	PMID:10699984|RGD:1642748
Biological Process	GO:1900121	negative regulation of receptor binding	PTPRF	IMP		Human	PMID:23358419
Biological Process	GO:0007399	nervous system development	Ptprf	IDA		Rat	PMID:12716943|RGD:633826
Biological Process	GO:0031102	neuron projection regeneration	Ptprf	IMP	MGI:MGI:2156205	Mouse	PMID:11438588
Biological Process	GO:0035335	peptidyl-tyrosine dephosphorylation	PTPRF	IMP		Human	PMID:23358419
Biological Process	GO:0043065	positive regulation of apoptotic process	Ptprf	IDA		Rat	PMID:9501065|RGD:1642754
Biological Process	GO:0050775	positive regulation of dendrite morphogenesis	Ptprf	IMP		Rat	PMID:15750591|RGD:1642736
Biological Process	GO:0043525	positive regulation of neuron apoptotic process	Ptprf	IMP		Rat	PMID:10699984|RGD:1642748
Biological Process	GO:0006470	protein dephosphorylation	Ptprf	IDA		Rat	PMID:7711057|RGD:2293185
Biological Process	GO:0006470	protein dephosphorylation	Ptprf	IDA		Rat	PMID:8068021|RGD:69951
Biological Process	GO:0048679	regulation of axon regeneration	Ptprf	IMP		Mouse	PMID:21976490
Biological Process	GO:0010975	regulation of neuron projection development	Ptprf	IMP	MGI:MGI:2156205	Mouse	PMID:21976490
Biological Process	GO:0099175	regulation of postsynapse organization	Ptprf	IDA		Rat	PMID:15750591|RGD:1642736
Biological Process	GO:0099175	regulation of postsynapse organization	Ptprf	IMP		Rat	PMID:15750591|RGD:1642736
Biological Process	GO:0050803	regulation of synapse structure or activity	Ptprf	IMP		Rat	PMID:15750591|RGD:1642736
Biological Process	GO:0097374	sensory neuron axon guidance	ptprfa	IGI	ZFIN:ZDB-MRPHLNO-120419-1,ZFIN:ZDB-MRPHLNO-120419-2	Zfish	PMID:22326027
Biological Process	GO:0097374	sensory neuron axon guidance	ptprfa	IMP	ZFIN:ZDB-MRPHLNO-120419-1,ZFIN:ZDB-MRPHLNO-120419-3	Zfish	PMID:22326027
Biological Process	GO:0097374	sensory neuron axon guidance	ptprfa	IGI	ZFIN:ZDB-MRPHLNO-120419-3,ZFIN:ZDB-MRPHLNO-120419-4	Zfish	PMID:22326027
Biological Process	GO:0097374	sensory neuron axon guidance	ptprfb	IGI	ZFIN:ZDB-GENO-130821-6,ZFIN:ZDB-MRPHLNO-120419-2	Zfish	PMID:22326027
Biological Process	GO:0097374	sensory neuron axon guidance	ptprfb	IGI	ZFIN:ZDB-GENO-130821-6,ZFIN:ZDB-MRPHLNO-120419-4	Zfish	PMID:22326027
Biological Process	GO:0097374	sensory neuron axon guidance	ptprfb	IGI	ZFIN:ZDB-MRPHLNO-120419-1,ZFIN:ZDB-MRPHLNO-120419-2	Zfish	PMID:22326027
Biological Process	GO:0097374	sensory neuron axon guidance	ptprfb	IGI	ZFIN:ZDB-MRPHLNO-120419-3,ZFIN:ZDB-MRPHLNO-120419-4	Zfish	PMID:22326027
Biological Process	GO:0097374	sensory neuron axon guidance	ptprfb	IMP	ZFIN:ZDB-MRPHLNO-120419-4	Zfish	PMID:22326027
Biological Process	GO:0099560	synaptic membrane adhesion	PTPRF	IDA		Human	PMID:26321637
Biological Process	GO:0099560	synaptic membrane adhesion	PTPRF	IMP		Human	PMID:26321637
Biological Process	GO:0099560	synaptic membrane adhesion	Ptprf	IDA		Rat	PMID:20139422|RGD:13702345
Biological Process	GO:0099560	synaptic membrane adhesion	Ptprf	IMP		Rat	PMID:20139422|RGD:13702345
Biological Process	GO:0099560	synaptic membrane adhesion	Ptprf	IDA		Rat	PMID:27225731|RGD:13702436
Biological Process	GO:0099560	synaptic membrane adhesion	Ptprf	IMP		Rat	PMID:27225731|RGD:13702436

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern