Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PTPRJ
  • Mouse genes Ptprj
  • Rat genes Ptprj
  • Zfish genes ptprja,ptprjb.1,ptprjb.2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ptprj

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008013	beta-catenin binding	PTPRJ	IPI	UniProtKB:P35222	Human	PMID:12370829
Molecular Function	GO:0045296	cadherin binding	PTPRJ	IPI	UniProtKB:P33151	Human	PMID:28926625
Molecular Function	GO:0070097	delta-catenin binding	PTPRJ	IPI	UniProtKB:O60716	Human	PMID:12370829
Molecular Function	GO:0070097	delta-catenin binding	PTPRJ	IPI	UniProtKB:O60716	Human	PMID:19332538
Molecular Function	GO:0045295	gamma-catenin binding	PTPRJ	IPI	UniProtKB:P14923	Human	PMID:12370829
Molecular Function	GO:0051019	mitogen-activated protein kinase binding	PTPRJ	IPI	UniProtKB:P28482	Human	PMID:19494114
Molecular Function	GO:0016791	phosphatase activity	PTPRJ	IMP		Human	PMID:11259588
Molecular Function	GO:0016791	phosphatase activity	PTPRJ	IDA		Human	PMID:12062403
Molecular Function	GO:0016791	phosphatase activity	PTPRJ	IDA		Human	PMID:12370829
Molecular Function	GO:0016791	phosphatase activity	PTPRJ	IDA		Human	PMID:19494114
Molecular Function	GO:0016791	phosphatase activity	PTPRJ	IMP		Human	PMID:19836242
Molecular Function	GO:0005161	platelet-derived growth factor receptor binding	PTPRJ	IPI	UniProtKB:P09619	Human	PMID:10821867
Molecular Function	GO:0005515	protein binding	PTPRJ	IPI	UniProtKB:P09619	Human	PMID:10821867
Molecular Function	GO:0005515	protein binding	PTPRJ	IPI	UniProtKB:O60716	Human	PMID:12370829
Molecular Function	GO:0005515	protein binding	PTPRJ	IPI	UniProtKB:P35222	Human	PMID:12370829
Molecular Function	GO:0005515	protein binding	PTPRJ	IPI	UniProtKB:O60716	Human	PMID:12475979
Molecular Function	GO:0005515	protein binding	PTPRJ	IPI	UniProtKB:P08581	Human	PMID:12475979
Molecular Function	GO:0005515	protein binding	PTPRJ	IPI	UniProtKB:Q13480	Human	PMID:12475979
Molecular Function	GO:0005515	protein binding	PTPRJ	IPI	UniProtKB:P17948	Human	PMID:12771128
Molecular Function	GO:0005515	protein binding	PTPRJ	IPI	UniProtKB:P17948	Human	PMID:16893970
Molecular Function	GO:0005515	protein binding	PTPRJ	IPI	UniProtKB:P35968	Human	PMID:18936167
Molecular Function	GO:0005515	protein binding	PTPRJ	IPI	UniProtKB:P04626	Human	PMID:19167335
Molecular Function	GO:0005515	protein binding	PTPRJ	IPI	UniProtKB:P08581	Human	PMID:19167335
Molecular Function	GO:0005515	protein binding	PTPRJ	IPI	UniProtKB:P09619	Human	PMID:19167335
Molecular Function	GO:0005515	protein binding	PTPRJ	IPI	UniProtKB:P10912	Human	PMID:19167335
Molecular Function	GO:0005515	protein binding	PTPRJ	IPI	UniProtKB:P27361	Human	PMID:19167335
Molecular Function	GO:0005515	protein binding	PTPRJ	IPI	UniProtKB:P35222	Human	PMID:19167335
Molecular Function	GO:0005515	protein binding	PTPRJ	IPI	UniProtKB:Q02763	Human	PMID:19167335
Molecular Function	GO:0005515	protein binding	PTPRJ	IPI	UniProtKB:Q13480	Human	PMID:19167335
Molecular Function	GO:0005515	protein binding	PTPRJ	IPI	UniProtKB:P27361	Human	PMID:19494114
Molecular Function	GO:0005515	protein binding	PTPRJ	IPI	UniProtKB:P28482	Human	PMID:19494114
Molecular Function	GO:0019901	protein kinase binding	PTPRJ	IPI	UniProtKB:P12931	Human	PMID:19332538
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	PTPRJ	IDA		Human	PMID:10821867
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	PTPRJ	IMP		Human	PMID:12475979
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	PTPRJ	IDA		Human	PMID:12913111
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	PTPRJ	IDA		Human	PMID:18348712
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	PTPRJ	IDA		Human	PMID:18936167
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	PTPRJ	IDA		Human	PMID:19332538
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	PTPRJ	IDA		Human	PMID:9531590
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	PTPRJ	IMP		Human	PMID:9780142
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	Ptprj	IMP		Mouse	MGI:MGI:4942251|PMID:12771128
Cellular Component	GO:0009986	cell surface	PTPRJ	IDA		Human	PMID:12913111
Cellular Component	GO:0005911	cell-cell junction	PTPRJ	IDA		Human	PMID:12370829
Cellular Component	GO:0005911	cell-cell junction	PTPRJ	IDA		Human	PMID:19332538
Cellular Component	GO:0070062	extracellular exosome	PTPRJ	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	PTPRJ	HDA		Human	PMID:23533145
Cellular Component	GO:0001772	immunological synapse	PTPRJ	IDA		Human	PMID:12913111
Cellular Component	GO:0001772	immunological synapse	Ptprj	IDA		Mouse	MGI:MGI:4942249|PMID:12913111
Cellular Component	GO:0005886	plasma membrane	PTPRJ	IDA		Human	PMID:18348712
Cellular Component	GO:0005886	plasma membrane	PTPRJ	IDA		Human	PMID:19836242
Cellular Component	GO:0005886	plasma membrane	PTPRJ	IDA		Human	PMID:9531590
Cellular Component	GO:0005886	plasma membrane	Ptprj	IDA		Mouse	MGI:MGI:3850609|PMID:19268662
Cellular Component	GO:0032587	ruffle membrane	Ptprj	IDA		Mouse	MGI:MGI:3850609|PMID:19268662
Biological Process	GO:0048844	artery morphogenesis	ptprja	IMP	ZFIN:ZDB-MRPHLNO-090304-3	Zfish	PMID:18835554
Biological Process	GO:0048844	artery morphogenesis	ptprja	IMP	ZFIN:ZDB-MRPHLNO-090304-2	Zfish	PMID:18835554
Biological Process	GO:0048844	artery morphogenesis	ptprja	IMP	ZFIN:ZDB-MRPHLNO-090304-2,ZFIN:ZDB-MRPHLNO-090304-3	Zfish	PMID:18835554
Biological Process	GO:0048844	artery morphogenesis	ptprjb.1	IMP	ZFIN:ZDB-MRPHLNO-090304-1	Zfish	PMID:18835554
Biological Process	GO:0030183	B cell differentiation	Ptprj	IMP		Mouse	MGI:MGI:3774343|PMID:18249142
Biological Process	GO:0007596	blood coagulation	Ptprj	IMP		Mouse	MGI:MGI:3847185|PMID:19246339
Biological Process	GO:0035584	calcium-mediated signaling using intracellular calcium source	Ptprj	IGI	UniProtKB:P06800	Mouse	MGI:MGI:3774343|PMID:18249142
Biological Process	GO:0042593	glucose homeostasis	Ptprj	IMP		Mouse	MGI:MGI:6379079|PMID:26063811
Biological Process	GO:0007507	heart development	Ptprj	IMP	MGI:MGI:2653313	Mouse	PMID:12588999
Biological Process	GO:0030308	negative regulation of cell growth	PTPRJ	IDA		Human	PMID:14709717
Biological Process	GO:0030336	negative regulation of cell migration	PTPRJ	IDA		Human	PMID:16682945
Biological Process	GO:0030336	negative regulation of cell migration	Ptprj	IDA		Mouse	MGI:MGI:4942250|PMID:12833140
Biological Process	GO:0008285	negative regulation of cell population proliferation	PTPRJ	IDA		Human	PMID:14709717
Biological Process	GO:0008285	negative regulation of cell population proliferation	PTPRJ	IDA		Human	PMID:16682945
Biological Process	GO:0008285	negative regulation of cell population proliferation	Ptprj	IMP		Mouse	MGI:MGI:4942251|PMID:12771128
Biological Process	GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway	PTPRJ	IMP		Human	PMID:19836242
Biological Process	GO:0046627	negative regulation of insulin receptor signaling pathway	Ptprj	IMP		Mouse	MGI:MGI:6379079|PMID:26063811
Biological Process	GO:0043407	negative regulation of MAP kinase activity	PTPRJ	IDA		Human	PMID:19494114
Biological Process	GO:0043407	negative regulation of MAP kinase activity	Ptprj	IDA		Mouse	MGI:MGI:4942250|PMID:12833140
Biological Process	GO:0010642	negative regulation of platelet-derived growth factor receptor signaling pathway	PTPRJ	IDA		Human	PMID:14709717
Biological Process	GO:0010642	negative regulation of platelet-derived growth factor receptor signaling pathway	Ptprj	IDA		Mouse	MGI:MGI:4942250|PMID:12833140
Biological Process	GO:0051898	negative regulation of protein kinase B signaling	PTPRJ	IMP		Human	PMID:19922411
Biological Process	GO:2000272	negative regulation of signaling receptor activity	Ptprj	IMP		Mouse	MGI:MGI:4942251|PMID:12771128
Biological Process	GO:0050860	negative regulation of T cell receptor signaling pathway	PTPRJ	IMP		Human	PMID:11259588
Biological Process	GO:0050860	negative regulation of T cell receptor signaling pathway	PTPRJ	IDA		Human	PMID:12913111
Biological Process	GO:0050860	negative regulation of T cell receptor signaling pathway	PTPRJ	IMP		Human	PMID:9780142
Biological Process	GO:0050860	negative regulation of T cell receptor signaling pathway	Ptprj	IDA		Mouse	MGI:MGI:4942249|PMID:12913111
Biological Process	GO:0043116	negative regulation of vascular permeability	PTPRJ	IDA		Human	PMID:19332538
Biological Process	GO:0048709	oligodendrocyte differentiation	Ptprj	IMP		Mouse	PMID:19139271
Biological Process	GO:0035335	peptidyl-tyrosine dephosphorylation	PTPRJ	IDA		Human	PMID:10821867
Biological Process	GO:0035335	peptidyl-tyrosine dephosphorylation	PTPRJ	IMP		Human	PMID:12475979
Biological Process	GO:0035335	peptidyl-tyrosine dephosphorylation	PTPRJ	IDA		Human	PMID:12913111
Biological Process	GO:0035335	peptidyl-tyrosine dephosphorylation	PTPRJ	IDA		Human	PMID:18348712
Biological Process	GO:0035335	peptidyl-tyrosine dephosphorylation	PTPRJ	IDA		Human	PMID:18936167
Biological Process	GO:0035335	peptidyl-tyrosine dephosphorylation	PTPRJ	IDA		Human	PMID:19332538
Biological Process	GO:0035335	peptidyl-tyrosine dephosphorylation	PTPRJ	IDA		Human	PMID:9531590
Biological Process	GO:0035335	peptidyl-tyrosine dephosphorylation	PTPRJ	IMP		Human	PMID:9780142
Biological Process	GO:1990264	peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity	Ptprj	IMP		Mouse	MGI:MGI:6379079|PMID:26063811
Biological Process	GO:0048008	platelet-derived growth factor receptor signaling pathway	PTPRJ	IMP		Human	PMID:21091576
Biological Process	GO:0050918	positive chemotaxis	PTPRJ	IDA		Human	PMID:14709717
Biological Process	GO:0045785	positive regulation of cell adhesion	PTPRJ	IMP		Human	PMID:21091576
Biological Process	GO:0001954	positive regulation of cell-matrix adhesion	Ptprj	IDA		Mouse	MGI:MGI:4942250|PMID:12833140
Biological Process	GO:1905451	positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis	Ptprj	IGI	UniProtKB:P06800	Mouse	MGI:MGI:3774343|PMID:18249142
Biological Process	GO:0051894	positive regulation of focal adhesion assembly	PTPRJ	IMP		Human	PMID:21091576
Biological Process	GO:0010759	positive regulation of macrophage chemotaxis	Ptprj	IDA		Mouse	MGI:MGI:3850609|PMID:19268662
Biological Process	GO:0043410	positive regulation of MAPK cascade	Ptprj	IGI	UniProtKB:P06800	Mouse	MGI:MGI:3774343|PMID:18249142
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	Ptprj	IGI	UniProtKB:P06800	Mouse	MGI:MGI:3774343|PMID:18249142
Biological Process	GO:0010572	positive regulation of platelet activation	Ptprj	IMP		Mouse	MGI:MGI:3847185|PMID:19246339
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	PTPRJ	IMP		Human	PMID:18936167
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	Ptprj	IGI	UniProtKB:P06800	Mouse	MGI:MGI:3774343|PMID:18249142
Biological Process	GO:0030155	regulation of cell adhesion	PTPRJ	IMP		Human	PMID:12370829
Biological Process	GO:0002574	thrombocyte differentiation	ptprja	IMP	ZFIN:ZDB-CRISPR-210610-4	Zfish	PMID:30591527
Biological Process	GO:0002574	thrombocyte differentiation	ptprja	IMP	ZFIN:ZDB-CRISPR-210610-3	Zfish	PMID:30591527
Biological Process	GO:0001570	vasculogenesis	Ptprj	IMP	MGI:MGI:2653313	Mouse	PMID:12588999

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern