Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PTPRK
  • Mouse genes Ptprk
  • Rat genes Ptprk
  • Zfish genes ptprk
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ptprk

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008013	beta-catenin binding	PTPRK	IPI	UniProtKB:P35222	Human	PMID:8663237
Molecular Function	GO:0045295	gamma-catenin binding	PTPRK	IPI	UniProtKB:P14923	Human	PMID:8663237
Molecular Function	GO:0005515	protein binding	PTPRK	IPI	UniProtKB:P00533	Human	PMID:15899872
Molecular Function	GO:0005515	protein binding	PTPRK	IPI	UniProtKB:P04626	Human	PMID:19167335
Molecular Function	GO:0005515	protein binding	PTPRK	IPI	UniProtKB:Q02763	Human	PMID:19167335
Molecular Function	GO:0005515	protein binding	PTPRK	IPI	UniProtKB:P28300	Human	PMID:21690299
Molecular Function	GO:0019901	protein kinase binding	PTPRK	IPI	UniProtKB:P04626	Human	PMID:15899872
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	PTPRK	IDA		Human	PMID:16263724
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	PTPRK	IDA		Human	PMID:16849327
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	PTPRK	IDA		Human	PMID:8663237
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	Ptprk	IDA		Mouse	PMID:8474452
Cellular Component	GO:0030424	axon	Ptprk	IDA		Mouse	PMID:18308476
Cellular Component	GO:0030054	cell junction	PTPRK	IDA		Human	GO_REF:0000052
Cellular Component	GO:0009986	cell surface	PTPRK	IDA		Human	PMID:18276111
Cellular Component	GO:0005911	cell-cell junction	PTPRK	IDA		Human	PMID:8663237
Cellular Component	GO:0030425	dendrite	Ptprk	IDA		Mouse	PMID:18308476
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	PTPRK	IDA		Human	GO_REF:0000052
Cellular Component	GO:0031256	leading edge membrane	PTPRK	IDA		Human	PMID:15899872
Cellular Component	GO:0043025	neuronal cell body	Ptprk	IDA		Mouse	PMID:18308476
Cellular Component	GO:0001750	photoreceptor outer segment	Ptprk	IDA		Mouse	PMID:18308476
Cellular Component	GO:0005886	plasma membrane	PTPRK	IDA		Human	GO_REF:0000052
Biological Process	GO:0007155	cell adhesion	PTPRK	IMP		Human	PMID:15899872
Biological Process	GO:0007155	cell adhesion	Ptprk	IDA		Rat	PMID:10383829|RGD:634006
Biological Process	GO:0016477	cell migration	PTPRK	IMP		Human	PMID:15899872
Biological Process	GO:0034614	cellular response to reactive oxygen species	PTPRK	IDA		Human	PMID:16849327
Biological Process	GO:0034644	cellular response to UV	PTPRK	IDA		Human	PMID:16849327
Biological Process	GO:0048041	focal adhesion assembly	PTPRK	IMP		Human	PMID:15899872
Biological Process	GO:0045786	negative regulation of cell cycle	PTPRK	IDA		Human	PMID:15899872
Biological Process	GO:0030336	negative regulation of cell migration	PTPRK	IDA		Human	PMID:18276111
Biological Process	GO:0008285	negative regulation of cell population proliferation	PTPRK	IDA		Human	PMID:15899872
Biological Process	GO:0008285	negative regulation of cell population proliferation	PTPRK	IDA		Human	PMID:18276111
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	PTPRK	IDA		Human	PMID:18276111
Biological Process	GO:0010839	negative regulation of keratinocyte proliferation	PTPRK	IDA		Human	PMID:16263724
Biological Process	GO:0031175	neuron projection development	Ptprk	IMP		Rat	PMID:10383829|RGD:634006
Biological Process	GO:0006470	protein dephosphorylation	PTPRK	IDA		Human	PMID:16263724
Biological Process	GO:0006470	protein dephosphorylation	Ptprk	IDA		Mouse	PMID:8474452
Biological Process	GO:0034394	protein localization to cell surface	PTPRK	IDA		Human	PMID:18276111
Biological Process	GO:0007165	signal transduction	PTPRK	IDA		Human	PMID:16849327
Biological Process	GO:0030217	T cell differentiation	Ptprk	IEP		Rat	PMID:17434290|RGD:15036800
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	PTPRK	IDA		Human	PMID:15899872

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern