Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PTPRN
  • Mouse genes Ptprn
  • Rat genes Ptprn
  • Zfish genes ptprna,ptprnb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ptprn

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0051020	GTPase binding	Ptprn	IPI	RGD:71096	Rat	PMID:16413169|RGD:1625628
Molecular Function	GO:0005515	protein binding	PTPRN	IPI	UniProtKB:Q9H254	Human	PMID:11086001
Molecular Function	GO:0005515	protein binding	PTPRN	IPI	UniProtKB:O14522	Human	PMID:16273344
Molecular Function	GO:0005515	protein binding	PTPRN	IPI	UniProtKB:P62937	Human	PMID:16273344
Molecular Function	GO:0005515	protein binding	PTPRN	IPI	UniProtKB:Q13332	Human	PMID:16273344
Molecular Function	GO:0005515	protein binding	PTPRN	IPI	UniProtKB:Q8WXG6	Human	PMID:16273344
Molecular Function	GO:0005515	protein binding	PTPRN	IPI	UniProtKB:Q92543	Human	PMID:16273344
Molecular Function	GO:0005515	protein binding	Ptprn	IPI	UniProtKB:P18052|UniProtKB:P80560	Mouse	MGI:MGI:5508281|PMID:12364328
Molecular Function	GO:0030507	spectrin binding	PTPRN	IPI	UniProtKB:Q9H254	Human	PMID:11086001
Molecular Function	GO:0008134	transcription factor binding	PTPRN	IDA		Human	PMID:16622421
Molecular Function	GO:0044389	ubiquitin-like protein ligase binding	PTPRN	IDA		Human	PMID:15596545
Cellular Component	GO:0043679	axon terminus	Ptprn	IDA		Rat	PMID:8641276|RGD:10402034
Cellular Component	GO:0005768	endosome	Ptprn	IDA		Rat	PMID:8641276|RGD:10402034
Cellular Component	GO:0005794	Golgi apparatus	Ptprn	IDA		Rat	PMID:8641276|RGD:10402034
Cellular Component	GO:0016020	membrane	Ptprn	IDA		Rat	PMID:11043403|RGD:1625632
Cellular Component	GO:0043025	neuronal cell body	Ptprn	IDA		Rat	PMID:8641276|RGD:10402034
Cellular Component	GO:0005634	nucleus	PTPRN	IDA		Human	PMID:15596545
Cellular Component	GO:0005886	plasma membrane	Ptprn	IDA		Rat	PMID:8641276|RGD:10402034
Cellular Component	GO:0030141	secretory granule	Ptprn	IDA		Rat	PMID:8641276|RGD:10402034
Cellular Component	GO:0045202	synapse	Ptprn	IDA		Rat	PMID:8641276|RGD:10402034
Biological Process	GO:0019221	cytokine-mediated signaling pathway	Ptprn	IDA		Rat	PMID:12239095|RGD:628454
Biological Process	GO:1990502	dense core granule maturation	PTPRN	IGI	UniProtKB:Q6P4T1	Human	PMID:24843546
Biological Process	GO:0030073	insulin secretion	PTPRN	IGI	UniProtKB:Q6P4T1	Human	PMID:24843546
Biological Process	GO:0035773	insulin secretion involved in cellular response to glucose stimulus	Ptprn	IMP		Mouse	MGI:MGI:3624867|PMID:12031972
Biological Process	GO:0035773	insulin secretion involved in cellular response to glucose stimulus	Ptprn	IMP		Mouse	MGI:MGI:5141326|PMID:21732083
Biological Process	GO:0001553	luteinization	Ptprn	IMP		Mouse	MGI:MGI:3769282|PMID:16269463
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	PTPRN	IDA		Human	PMID:15596545
Biological Process	GO:1904692	positive regulation of type B pancreatic cell proliferation	PTPRN	IDA		Human	PMID:18178618
Biological Process	GO:1904692	positive regulation of type B pancreatic cell proliferation	Ptprn	IMP		Mouse	MGI:MGI:3772720|PMID:18178618
Biological Process	GO:1904692	positive regulation of type B pancreatic cell proliferation	Ptprn	IMP		Rat	PMID:18178618|RGD:11535096
Biological Process	GO:0051591	response to cAMP	Ptprn	IEP		Rat	PMID:12351437|RGD:1625631
Biological Process	GO:0043627	response to estrogen	Ptprn	IEP		Rat	PMID:9607778|RGD:1625635
Biological Process	GO:0009749	response to glucose	Ptprn	IEP		Rat	PMID:12351437|RGD:1625631
Biological Process	GO:0032868	response to insulin	Ptprn	IEP		Rat	PMID:12351437|RGD:1625631
Biological Process	GO:0000302	response to reactive oxygen species	PTPRN	IDA		Human	PMID:18048354

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern