Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PTPRO
  • Mouse genes Ptpro
  • Rat genes Ptpro
  • Zfish genes ptpro
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ptpro

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0045296	cadherin binding	PTPRO	IPI	UniProtKB:P33151	Human	PMID:28926625
Molecular Function	GO:0005515	protein binding	PTPRO	IPI	UniProtKB:P04626	Human	PMID:19167335
Molecular Function	GO:0005515	protein binding	PTPRO	IPI	UniProtKB:P08581	Human	PMID:19167335
Molecular Function	GO:0005515	protein binding	PTPRO	IPI	UniProtKB:Q02763	Human	PMID:19167335
Molecular Function	GO:0005515	protein binding	PTPRO	IPI	UniProtKB:P08581	Human	PMID:28330616
Molecular Function	GO:0005515	protein binding	Ptpro	IPI	UniProtKB:P27467	Mouse	MGI:MGI:4833733|PMID:20804755
Molecular Function	GO:0005515	protein binding	Ptpro	IPI	UniProtKB:Q60631	Mouse	MGI:MGI:4941445|PMID:20398064
Molecular Function	GO:0005515	protein binding	Ptpro	IPI	UniProtKB:Q99J85	Mouse	MGI:MGI:3577156|PMID:15673668
Molecular Function	GO:0042803	protein homodimerization activity	Ptpro	IDA		Mouse	MGI:MGI:4357718|PMID:19573017
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	PTPRO	IDA		Human	PMID:19167335
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	PTPRO	IMP		Human	PMID:19233845
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	Ptpro	IDA		Mouse	MGI:MGI:3577156|PMID:15673668
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	Ptpro	IDA		Rat	PMID:9032477|RGD:61725
Molecular Function	GO:0017147	Wnt-protein binding	Ptpro	IDA		Mouse	MGI:MGI:4833733|PMID:20804755
Cellular Component	GO:0016324	apical plasma membrane	Ptpro	IDA		Mouse	MGI:MGI:5306556|PMID:20633639
Cellular Component	GO:0043197	dendritic spine	Ptpro	IDA		Mouse	MGI:MGI:4819945|PMID:19924828
Cellular Component	GO:0070062	extracellular exosome	PTPRO	HDA		Human	PMID:19056867
Cellular Component	GO:0098982	GABA-ergic synapse	Ptpro	IDA		Mouse	PMID:28871037
Cellular Component	GO:0098982	GABA-ergic synapse	Ptpro	IMP		Mouse	PMID:28871037
Cellular Component	GO:0098978	glutamatergic synapse	Ptpro	IMP		Mouse	PMID:28871037
Cellular Component	GO:0098978	glutamatergic synapse	Ptpro	IDA		Mouse	PMID:28871037
Cellular Component	GO:0016328	lateral plasma membrane	Ptpro	IDA		Mouse	MGI:MGI:5306556|PMID:20633639
Cellular Component	GO:0005886	plasma membrane	Ptpro	IDA		Mouse	MGI:MGI:3577156|PMID:15673668
Cellular Component	GO:0098839	postsynaptic density membrane	Ptpro	IDA		Mouse	PMID:28871037
Cellular Component	GO:0098839	postsynaptic density membrane	Ptpro	IEP		Mouse	PMID:28871037
Biological Process	GO:0007411	axon guidance	Ptpro	IMP		Mouse	MGI:MGI:5306568|PMID:19800005
Biological Process	GO:0000902	cell morphogenesis	Ptpro	IMP		Mouse	MGI:MGI:4941445|PMID:20398064
Biological Process	GO:0007417	central nervous system development	ptpro	IMP	ZFIN:ZDB-MRPHLNO-130628-2	Zfish	PMID:23361036
Biological Process	GO:0021587	cerebellum morphogenesis	ptpro	IMP	ZFIN:ZDB-MRPHLNO-130628-1	Zfish	PMID:23361036
Biological Process	GO:0032835	glomerulus development	PTPRO	IMP		Human	PMID:21722858
Biological Process	GO:0030032	lamellipodium assembly	Ptpro	IMP		Mouse	MGI:MGI:4941445|PMID:20398064
Biological Process	GO:0002548	monocyte chemotaxis	PTPRO	IMP		Human	PMID:19233845
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	Ptpro	IDA		Mouse	MGI:MGI:4833733|PMID:20804755
Biological Process	GO:0003105	negative regulation of glomerular filtration	Ptpro	IMP		Rat	PMID:19403647|RGD:8554129
Biological Process	GO:0035335	peptidyl-tyrosine dephosphorylation	PTPRO	IMP		Human	PMID:19233845
Biological Process	GO:0035335	peptidyl-tyrosine dephosphorylation	Ptpro	IDA		Mouse	MGI:MGI:3577156|PMID:15673668
Biological Process	GO:1990264	peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity	Ptpro	IDA		Mouse	MGI:MGI:6379079|PMID:26063811
Biological Process	GO:0072112	podocyte differentiation	Ptpro	IMP		Mouse	MGI:MGI:1927435|PMID:11086029
Biological Process	GO:0040036	regulation of fibroblast growth factor receptor signaling pathway	ptpro	IMP	ZFIN:ZDB-MRPHLNO-130628-1	Zfish	PMID:23361036
Biological Process	GO:0003093	regulation of glomerular filtration	Ptpro	IMP		Mouse	MGI:MGI:1927435|PMID:11086029
Biological Process	GO:0050807	regulation of synapse organization	Ptpro	IDA		Mouse	PMID:28871037
Biological Process	GO:0050807	regulation of synapse organization	Ptpro	IMP		Mouse	PMID:28871037
Biological Process	GO:0036060	slit diaphragm assembly	Ptpro	IMP		Mouse	MGI:MGI:1927435|PMID:11086029

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern