Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Ptprs

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes PTPRS
- Mouse genes Ptprs
- Rat genes Ptprs
- Zfish genes ptprsa
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ptprs

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0035374	chondroitin sulfate binding	Ptprs	IDA		Mouse	MGI:MGI:5461303\|PMID:22406547
Molecular Function	GO:0008201	heparin binding	Ptprs	IDA		Mouse	MGI:MGI:5461303\|PMID:22406547
Molecular Function	GO:0004721	phosphoprotein phosphatase activity	PTPRS	IDA		Human	PMID:8524829
Molecular Function	GO:0005515	protein binding	PTPRS	IPI	UniProtKB:Q16849	Human	PMID:16273344
Molecular Function	GO:0005515	protein binding	Ptprs	IPI	PR:Q62468	Mouse	PMID:24385580
Molecular Function	GO:0005515	protein binding	Ptprs	IPI	UniProtKB:P15311	Mouse	PMID:24385580
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	Ptprs	IDA		Mouse	MGI:MGI:70512\|PMID:7529177
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	Ptprs	IDA		Mouse	PMID:24385580
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	Ptprs	IDA		Rat	PMID:8068021\|RGD:69951
Cellular Component	GO:0005829	cytosol	PTPRS	IDA		Human	GO_REF:0000052
Cellular Component	GO:0070062	extracellular exosome	PTPRS	HDA		Human	PMID:23533145
Cellular Component	GO:0098978	glutamatergic synapse	Ptprs	IMP		Mouse	PMID:21262467
Cellular Component	GO:0098978	glutamatergic synapse	Ptprs	IDA		Mouse	PMID:21262467
Cellular Component	GO:0098978	glutamatergic synapse	Ptprs	IDA		Mouse	PMID:32142410
Cellular Component	GO:0098978	glutamatergic synapse	Ptprs	IMP		Mouse	PMID:32142410
Cellular Component	GO:0098978	glutamatergic synapse	Ptprs	EXP		Rat	PMID:21262467\|RGD:13702219
Cellular Component	GO:0098978	glutamatergic synapse	Ptprs	IDA		Rat	PMID:21262467\|RGD:13702219
Cellular Component	GO:0098978	glutamatergic synapse	Ptprs	IMP		Rat	PMID:21262467\|RGD:13702219
Cellular Component	GO:0005886	plasma membrane	PTPRS	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	PTPRS	IDA		Human	PMID:26231120
Cellular Component	GO:0005886	plasma membrane	Ptprs	IDA		Mouse	MGI:MGI:5780783\|PMID:26231120
Cellular Component	GO:0098839	postsynaptic density membrane	Ptprs	IDA		Rat	PMID:22519304\|RGD:12790648
Cellular Component	GO:0042734	presynaptic membrane	Ptprs	IDA		Mouse	PMID:21262467
Cellular Component	GO:0042734	presynaptic membrane	Ptprs	IDA		Rat	PMID:21262467\|RGD:13702219
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	Ptprs	IDA		Mouse	PMID:22519304
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	Ptprs	IMP		Mouse	PMID:22519304
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	Ptprs	IDA		Mouse	PMID:32142410
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	Ptprs	IMP		Mouse	PMID:32142410
Cellular Component	GO:0030672	synaptic vesicle membrane	Ptprs	IDA		Rat	PMID:22519304\|RGD:12790648
Biological Process	GO:0021549	cerebellum development	Ptprs	IMP	MGI:MGI:2158734	Mouse	PMID:15842738
Biological Process	GO:0021987	cerebral cortex development	Ptprs	IMP	MGI:MGI:2158734	Mouse	PMID:15842738
Biological Process	GO:0022038	corpus callosum development	Ptprs	IMP	MGI:MGI:2158734	Mouse	PMID:15842738
Biological Process	GO:0090557	establishment of endothelial intestinal barrier	Ptprs	IMP	MGI:MGI:2158734	Mouse	PMID:24385580
Biological Process	GO:0021766	hippocampus development	Ptprs	IMP	MGI:MGI:2158734	Mouse	PMID:15842738
Biological Process	GO:0050804	modulation of chemical synaptic transmission	Ptprs	IMP		Mouse	PMID:22519304
Biological Process	GO:0050804	modulation of chemical synaptic transmission	Ptprs	IDA		Mouse	PMID:22519304
Biological Process	GO:0030517	negative regulation of axon extension	Ptprs	IMP		Mouse	MGI:MGI:4880863\|PMID:19780196
Biological Process	GO:0048681	negative regulation of axon regeneration	Ptprs	IMP		Mouse	MGI:MGI:5461303\|PMID:22406547
Biological Process	GO:0048681	negative regulation of axon regeneration	Ptprs	IMP		Mouse	MGI:MGI:4880863\|PMID:19780196
Biological Process	GO:0048671	negative regulation of collateral sprouting	Ptprs	IMP		Mouse	MGI:MGI:5431284\|PMID:22519304
Biological Process	GO:0061000	negative regulation of dendritic spine development	Ptprs	IMP		Mouse	MGI:MGI:5431284\|PMID:22519304
Biological Process	GO:0032687	negative regulation of interferon-alpha production	PTPRS	IMP		Human	PMID:26231120
Biological Process	GO:0032688	negative regulation of interferon-beta production	PTPRS	IMP		Human	PMID:26231120
Biological Process	GO:0010977	negative regulation of neuron projection development	Ptprs	IMP		Mouse	MGI:MGI:5461303\|PMID:22406547
Biological Process	GO:0034164	negative regulation of toll-like receptor 9 signaling pathway	PTPRS	IMP		Human	PMID:26231120
Biological Process	GO:0021772	olfactory bulb development	ptprsa	IMP	ZFIN:ZDB-GENO-111111-4	Zfish	PMID:21812780
Biological Process	GO:0035335	peptidyl-tyrosine dephosphorylation	Ptprs	IDA		Mouse	MGI:MGI:70512\|PMID:7529177
Biological Process	GO:0035335	peptidyl-tyrosine dephosphorylation	Ptprs	IMP	MGI:MGI:2158734	Mouse	PMID:24385580
Biological Process	GO:0099054	presynapse assembly	Ptprs	EXP		Rat	PMID:21262467\|RGD:13702219
Biological Process	GO:0099054	presynapse assembly	Ptprs	IDA		Rat	PMID:21262467\|RGD:13702219
Biological Process	GO:0099054	presynapse assembly	Ptprs	IMP		Rat	PMID:21262467\|RGD:13702219
Biological Process	GO:0006470	protein dephosphorylation	PTPRS	IDA		Human	PMID:8524829
Biological Process	GO:0099151	regulation of postsynaptic density assembly	Ptprs	IDA		Mouse	PMID:21262467
Biological Process	GO:0099151	regulation of postsynaptic density assembly	Ptprs	IMP		Mouse	PMID:21262467
Biological Process	GO:0099151	regulation of postsynaptic density assembly	Ptprs	EXP		Rat	PMID:21262467\|RGD:13702219
Biological Process	GO:0099151	regulation of postsynaptic density assembly	Ptprs	IDA		Rat	PMID:21262467\|RGD:13702219
Biological Process	GO:0099151	regulation of postsynaptic density assembly	Ptprs	IMP		Rat	PMID:21262467\|RGD:13702219
Biological Process	GO:0021510	spinal cord development	Ptprs	IMP	MGI:MGI:2158734	Mouse	PMID:15842738
Biological Process	GO:0050808	synapse organization	Ptprs	IDA		Mouse	PMID:22519304
Biological Process	GO:0050808	synapse organization	Ptprs	IMP		Mouse	PMID:22519304
Biological Process	GO:0099560	synaptic membrane adhesion	PTPRS	IDA		Human	PMID:23345436
Biological Process	GO:0099560	synaptic membrane adhesion	PTPRS	IMP		Human	PMID:23345436
Biological Process	GO:0099560	synaptic membrane adhesion	Ptprs	IDA		Rat	PMID:20139422\|RGD:13702345
Biological Process	GO:0099560	synaptic membrane adhesion	Ptprs	IMP		Rat	PMID:20139422\|RGD:13702345
Biological Process	GO:0099560	synaptic membrane adhesion	Ptprs	IDA		Rat	PMID:27225731\|RGD:13702436
Biological Process	GO:0099560	synaptic membrane adhesion	Ptprs	IMP		Rat	PMID:27225731\|RGD:13702436
Biological Process	GO:0099537	trans-synaptic signaling	Ptprs	IMP		Mouse	PMID:32142410
Biological Process	GO:0099537	trans-synaptic signaling	Ptprs	IDA		Mouse	PMID:32142410

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.