Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PTPRT
  • Mouse genes Ptprt
  • Rat genes Ptprt
  • Zfish genes ptprt
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ptprt

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0051393	alpha-actinin binding	Ptprt	IDA		Mouse	PMID:16973135
Molecular Function	GO:0045294	alpha-catenin binding	PTPRT	IDA		Human	PMID:16973135
Molecular Function	GO:0045294	alpha-catenin binding	Ptprt	IDA		Mouse	PMID:16973135
Molecular Function	GO:0008013	beta-catenin binding	PTPRT	IPI	UniProtKB:Q02248	Human	PMID:16973135
Molecular Function	GO:0008013	beta-catenin binding	Ptprt	IDA		Mouse	PMID:16973135
Molecular Function	GO:0045296	cadherin binding	PTPRT	IPI	UniProtKB:P09803	Human	PMID:16973135
Molecular Function	GO:0045296	cadherin binding	PTPRT	IPI	UniProtKB:P15116	Human	PMID:16973135
Molecular Function	GO:0045296	cadherin binding	PTPRT	IPI	UniProtKB:P55284	Human	PMID:16973135
Molecular Function	GO:0045296	cadherin binding	Ptprt	IPI	PR:P09803	Mouse	PMID:16973135
Molecular Function	GO:0045296	cadherin binding	Ptprt	IPI	PR:P15116	Mouse	PMID:16973135
Molecular Function	GO:0045296	cadherin binding	Ptprt	IPI	PR:P55284	Mouse	PMID:16973135
Molecular Function	GO:0070097	delta-catenin binding	PTPRT	IPI	UniProtKB:P30999	Human	PMID:16973135
Molecular Function	GO:0070097	delta-catenin binding	Ptprt	IPI	PR:P30999	Mouse	PMID:16973135
Molecular Function	GO:0045295	gamma-catenin binding	PTPRT	IDA		Human	PMID:16973135
Molecular Function	GO:0045295	gamma-catenin binding	Ptprt	IPI	PR:Q02257	Mouse	PMID:16973135
Molecular Function	GO:0005515	protein binding	PTPRT	IPI	UniProtKB:Q16849	Human	PMID:16273344
Molecular Function	GO:0005515	protein binding	PTPRT	IPI	UniProtKB:Q69ZK9	Human	PMID:19816407
Molecular Function	GO:0005515	protein binding	PTPRT	IPI	UniProtKB:Q6P9K9	Human	PMID:19816407
Molecular Function	GO:0005515	protein binding	PTPRT	IPI	UniProtKB:Q99K10	Human	PMID:19816407
Molecular Function	GO:0005515	protein binding	PTPRT	IPI	UniProtKB:Q9CS84	Human	PMID:19816407
Molecular Function	GO:0005515	protein binding	PTPRT	IPI	UniProtKB:P62993	Human	PMID:21725282
Molecular Function	GO:0005515	protein binding	PTPRT	IPI	UniProtKB:P17931	Human	PMID:24846175
Molecular Function	GO:0042803	protein homodimerization activity	PTPRT	IPI	UniProtKB:O14522	Human	PMID:24846175
Molecular Function	GO:0019903	protein phosphatase binding	PTPRT	IPI	UniProtKB:O14522	Human	PMID:24846175
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	PTPRT	IMP		Human	PMID:16973135
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	PTPRT	IMP		Human	PMID:17360477
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	Ptprt	IMP		Mouse	PMID:16973135
Molecular Function	GO:0097677	STAT family protein binding	PTPRT	IPI	UniProtKB:P40763	Human	PMID:17360477
Molecular Function	GO:0016790	thiolester hydrolase activity	Ptprt	IDA		Mouse	PMID:16973135
Molecular Function	GO:0005001	transmembrane receptor protein tyrosine phosphatase activity	PTPRT	IDA		Human	PMID:24846175
Cellular Component	GO:0009986	cell surface	PTPRT	IDA		Human	PMID:18644975
Cellular Component	GO:0098978	glutamatergic synapse	Ptprt	IDA		Rat	PMID:19816407|RGD:13702429
Cellular Component	GO:0098978	glutamatergic synapse	Ptprt	IMP		Rat	PMID:19816407|RGD:13702429
Cellular Component	GO:0005886	plasma membrane	PTPRT	IDA		Human	PMID:18644975
Cellular Component	GO:0005886	plasma membrane	PTPRT	IDA		Human	PMID:24846175
Cellular Component	GO:0098839	postsynaptic density membrane	Ptprt	IDA		Rat	PMID:19816407|RGD:13702429
Biological Process	GO:0071354	cellular response to interleukin-6	PTPRT	IDA		Human	PMID:17360477
Biological Process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	PTPRT	IDA		Human	PMID:18644975
Biological Process	GO:0030336	negative regulation of cell migration	PTPRT	IMP		Human	PMID:24846175
Biological Process	GO:1904893	negative regulation of receptor signaling pathway via STAT	PTPRT	IDA		Human	PMID:17360477
Biological Process	GO:1904893	negative regulation of receptor signaling pathway via STAT	PTPRT	IMP		Human	PMID:24846175
Biological Process	GO:0035335	peptidyl-tyrosine dephosphorylation	PTPRT	IDA		Human	PMID:17360477
Biological Process	GO:1990264	peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity	PTPRT	IDA		Human	PMID:24846175
Biological Process	GO:0006470	protein dephosphorylation	PTPRT	IDA		Human	PMID:16973135
Biological Process	GO:0006470	protein dephosphorylation	Ptprt	IDA		Mouse	PMID:16973135
Biological Process	GO:0050807	regulation of synapse organization	Ptprt	IDA		Rat	PMID:19816407|RGD:13702429
Biological Process	GO:0050807	regulation of synapse organization	Ptprt	IMP		Rat	PMID:19816407|RGD:13702429
Biological Process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	PTPRT	IMP		Human	PMID:16973135

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern