Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PURB
  • Mouse genes Purb
  • Rat genes Purb
  • Zfish genes purba,purbb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Purb

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Purb	IDA		Mouse	PMID:15282343
Molecular Function	GO:0140297	DNA-binding transcription factor binding	Purb	IPI	UniProtKB:P42669	Mouse	MGI:MGI:1336864|PMID:10318844
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Purb	IDA		Mouse	MGI:MGI:3513643|PMID:15282343
Molecular Function	GO:0003690	double-stranded DNA binding	Purb	IDA		Mouse	PMID:15282343
Molecular Function	GO:0003729	mRNA binding	Purb	IDA		Mouse	MGI:MGI:3688338|PMID:12933792
Molecular Function	GO:0000900	mRNA regulatory element binding translation repressor activity	Purb	IDA		Rat	PMID:12933792|RGD:1581942
Molecular Function	GO:0005515	protein binding	PURB	IPI	UniProtKB:Q6ZNH5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PURB	IPI	UniProtKB:Q8TBB1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PURB	IPI	UniProtKB:Q96AH0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PURB	IPI	UniProtKB:Q9BXS5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PURB	IPI	UniProtKB:Q9UBB5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PURB	IPI	UniProtKB:Q9Y5E9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Purb	IPI	PR:Q8BUN5	Mouse	PMID:15282343
Molecular Function	GO:0005515	protein binding	Purb	IPI	PR:P97471	Mouse	PMID:15282343
Molecular Function	GO:0005515	protein binding	Purb	IPI	PR:O89090	Mouse	PMID:15282343
Molecular Function	GO:0005515	protein binding	Purb	IPI	PR:Q62432	Mouse	PMID:15282343
Molecular Function	GO:0032422	purine-rich negative regulatory element binding	Purb	IDA		Rat	PMID:12933792|RGD:1581942
Molecular Function	GO:0003723	RNA binding	PURB	HDA		Human	PMID:22658674
Molecular Function	GO:0003723	RNA binding	PURB	HDA		Human	PMID:22681889
Molecular Function	GO:0003723	RNA binding	Purb	IDA		Mouse	PMID:23723417
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	Purb	IDA		Mouse	MGI:MGI:3513643|PMID:15282343
Molecular Function	GO:0003697	single-stranded DNA binding	Purb	IDA		Mouse	MGI:MGI:3688338|PMID:12933792
Molecular Function	GO:0003697	single-stranded DNA binding	Purb	IDA		Mouse	MGI:MGI:1336864|PMID:10318844
Molecular Function	GO:0003697	single-stranded DNA binding	Purb	IDA		Rat	PMID:12933792|RGD:1581942
Molecular Function	GO:0046332	SMAD binding	Purb	IDA		Mouse	PMID:15282343
Cellular Component	GO:0005654	nucleoplasm	PURB	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	Purb	IDA		Mouse	PMID:15282343
Cellular Component	GO:0005634	nucleus	Purb	IDA		Rat	PMID:12933792|RGD:1581942
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Purb	IDA		Mouse	PMID:15282343
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Purb	IDA		Rat	PMID:12933792|RGD:1581942
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Purb	IDA		Mouse	MGI:MGI:3513643|PMID:15282343
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Purb	IGI	MGI:MGI:3705267	Mouse	PMID:23723417

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern