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Comparative GO Graph (mouse, human, rat, zebrafish)
Source
Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Pxn

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

Molecular Function


Cellular Component


Biological Process



Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pxn
Category ID Classification term Gene Evidence Inferred from Organism Reference
Molecular FunctionGO:0008013beta-catenin bindingPXNIPIUniProtKB:P35222HumanPMID:17513457
Molecular FunctionGO:0051435BH4 domain bindingPxnIPIPR:Q64373MousePMID:14699151
Molecular FunctionGO:0051435BH4 domain bindingPxnIPIPR:P70345MousePMID:14699151
Molecular FunctionGO:0051435BH4 domain bindingPxnIPIPR:P10417MousePMID:14699151
Molecular FunctionGO:0005178integrin bindingPxnIPIRGD:2927RatPMID:16935300|RGD:2325674
Molecular FunctionGO:0005078MAP-kinase scaffold activityPxnIDAMousePMID:14636584
Molecular FunctionGO:0038191neuropilin bindingPXNIPIUniProtKB:O14786HumanPMID:24863063
Molecular FunctionGO:0038191neuropilin bindingPxnIPIUniProtKB:P97333MouseMGI:MGI:5588737|PMID:24863063
Molecular FunctionGO:0005515protein bindingPXNIPIUniProtKB:P05556-1HumanPMID:10604475
Molecular FunctionGO:0005515protein bindingPXNIPIUniProtKB:P13612HumanPMID:10604475
Molecular FunctionGO:0005515protein bindingPXNIPIUniProtKB:P06931HumanPMID:10814581
Molecular FunctionGO:0005515protein bindingPXNIPIUniProtKB:P13688HumanPMID:11035932
Molecular FunctionGO:0005515protein bindingPXNIPIUniProtKB:Q09463HumanPMID:12861019
Molecular FunctionGO:0005515protein bindingPXNIPIUniProtKB:Q99942HumanPMID:12861019
Molecular FunctionGO:0005515protein bindingPXNIPIUniProtKB:P41240HumanPMID:14665621
Molecular FunctionGO:0005515protein bindingPXNIPIUniProtKB:Q06124HumanPMID:14665621
Molecular FunctionGO:0005515protein bindingPXNIPIUniProtKB:Q13480HumanPMID:14665621
Molecular FunctionGO:0005515protein bindingPXNIPIUniProtKB:Q15654HumanPMID:14688263
Molecular FunctionGO:0005515protein bindingPXNIPIUniProtKB:Q13882HumanPMID:15572663
Molecular FunctionGO:0005515protein bindingPXNIPIUniProtKB:Q14161HumanPMID:16628223
Molecular FunctionGO:0005515protein bindingPXNIPIUniProtKB:Q9Y2X7HumanPMID:16628223
Molecular FunctionGO:0005515protein bindingPXNIPIUniProtKB:Q62417-2HumanPMID:17082770
Molecular FunctionGO:0005515protein bindingPXNIPIUniProtKB:Q05209HumanPMID:19167335
Molecular FunctionGO:0005515protein bindingPXNIPIUniProtKB:Q9BUL8HumanPMID:20489202
Molecular FunctionGO:0005515protein bindingPXNIPIUniProtKB:Q05397HumanPMID:21034468
Molecular FunctionGO:0005515protein bindingPXNIPIUniProtKB:P13612HumanPMID:21173240
Molecular FunctionGO:0005515protein bindingPXNIPIUniProtKB:Q05397HumanPMID:21741599
Molecular FunctionGO:0005515protein bindingPXNIPIUniProtKB:Q05397HumanPMID:22270917
Molecular FunctionGO:0005515protein bindingPXNIPIUniProtKB:P35222HumanPMID:22728435
Molecular FunctionGO:0005515protein bindingPXNIPIUniProtKB:Q14161HumanPMID:22728435
Molecular FunctionGO:0005515protein bindingPXNIPIUniProtKB:P06931HumanPMID:23393263
Molecular FunctionGO:0005515protein bindingPXNIPIUniProtKB:Q06124HumanPMID:23397142
Molecular FunctionGO:0005515protein bindingPXNIPIUniProtKB:Q9UHB6HumanPMID:24694988
Molecular FunctionGO:0005515protein bindingPXNIPIUniProtKB:P49023HumanPMID:24863063
Molecular FunctionGO:0005515protein bindingPXNIPIUniProtKB:Q05209HumanPMID:27880917
Molecular FunctionGO:0005515protein bindingPXNIPIUniProtKB:P41240HumanPMID:31980649
Molecular FunctionGO:0005515protein bindingPXNIPIUniProtKB:Q05397HumanPMID:31980649
Molecular FunctionGO:0005515protein bindingPXNIPIUniProtKB:Q14161HumanPMID:31980649
Molecular FunctionGO:0005515protein bindingPXNIPIUniProtKB:Q9Y2X7HumanPMID:31980649
Molecular FunctionGO:0005515protein bindingPXNIPIUniProtKB:Q05397HumanPMID:32707033
Molecular FunctionGO:0005515protein bindingPXNIPIUniProtKB:Q05397HumanPMID:7561682
Molecular FunctionGO:0005515protein bindingPXNIPIUniProtKB:Q05397HumanPMID:9756887
Molecular FunctionGO:0005515protein bindingPxnIPIUniProtKB:P34152MouseMGI:MGI:6294183|PMID:15138291
Molecular FunctionGO:0005515protein bindingPxnIPIUniProtKB:P18031MouseMGI:MGI:5508311|PMID:9418872
Molecular FunctionGO:0005515protein bindingPxnIPIUniProtKB:P11627MouseMGI:MGI:3796794|PMID:18464795
Molecular FunctionGO:0005515protein bindingPxnIPIUniProtKB:P34152MouseMGI:MGI:3694172|PMID:16298995
Molecular FunctionGO:0005515protein bindingPxnIPIUniProtKB:P34152MouseMGI:MGI:5508567|PMID:20308429
Molecular FunctionGO:0005515protein bindingPxnIPIUniProtKB:Q64727MouseMGI:MGI:5508567|PMID:20308429
Molecular FunctionGO:0005515protein bindingPxnIPIPR:O55222MousePMID:14699151
Molecular FunctionGO:0005515protein bindingPxnIPIPR:Q8BGS1MousePMID:18794329
Molecular FunctionGO:0005515protein bindingPxnIPIPR:P53668MousePMID:16399995
Molecular FunctionGO:0005515protein bindingPxnIPIUniProtKB:Q9Z272RatPMID:12473661|RGD:9850090
Molecular FunctionGO:0005515protein bindingPxnIPIRGD:69331RatPMID:12629171|RGD:152995492
Molecular FunctionGO:0005515protein bindingPxnIPIRGD:2405RatPMID:14622258|RGD:1298804
Molecular FunctionGO:0019901protein kinase bindingPxnIPIRGD:620063RatPMID:14581460|RGD:2302070
Molecular FunctionGO:0019903protein phosphatase bindingPXNIPIUniProtKB:P51452HumanPMID:28759036
Molecular FunctionGO:0044877protein-containing complex bindingPxnIPIRGD:2927|RGD:1306247|RGD:3443RatPMID:16935300|RGD:2325674
Molecular FunctionGO:0017166vinculin bindingPXNIPIUniProtKB:P18206HumanPMID:9054445
Cellular ComponentGO:0031252cell leading edgePxnIDAMousePMID:18794329
Cellular ComponentGO:0005911cell-cell junctionPXNIMPHumanPMID:25753039
Cellular ComponentGO:0005829cytosolPXNIDAHumanGO_REF:0000052
Cellular ComponentGO:0005829cytosolPxnIDARatPMID:12629171|RGD:152995492
Cellular ComponentGO:0005925focal adhesionPXNIDAHumanGO_REF:0000052
Cellular ComponentGO:0005925focal adhesionPXNIDAHumanPMID:12686598
Cellular ComponentGO:0005925focal adhesionPXNIDAHumanPMID:20086044
Cellular ComponentGO:0005925focal adhesionPXNHDAHumanPMID:21423176
Cellular ComponentGO:0005925focal adhesionPXNIDAHumanPMID:23574715
Cellular ComponentGO:0005925focal adhesionPXNIDAHumanPMID:24863063
Cellular ComponentGO:0005925focal adhesionPXNIMPHumanPMID:25705373
Cellular ComponentGO:0005925focal adhesionPxnIDAMouseMGI:MGI:5588737|PMID:24863063
Cellular ComponentGO:0005925focal adhesionPxnIDAMousePMID:11807098
Cellular ComponentGO:0005925focal adhesionPxnIDAMousePMID:15728191
Cellular ComponentGO:0005925focal adhesionPxnIDAMousePMID:10809671
Cellular ComponentGO:0005925focal adhesionPxnIDAMousePMID:16399995
Cellular ComponentGO:0005925focal adhesionPxnIDAMousePMID:14636584
Cellular ComponentGO:0005925focal adhesionPxnIDAMousePMID:25217619
Cellular ComponentGO:0005925focal adhesionPxnIDAMousePMID:24841562
Cellular ComponentGO:0005925focal adhesionPxnIDAMousePMID:15889232
Cellular ComponentGO:0005925focal adhesionPxnIDAMousePMID:18794329
Cellular ComponentGO:0005925focal adhesionPxnIDARatPMID:14581460|RGD:2302070
Cellular ComponentGO:0030027lamellipodiumPXNIDAHumanPMID:12686598
Cellular ComponentGO:0030027lamellipodiumPxnIDAMousePMID:14636584
Cellular ComponentGO:0005886plasma membranePXNIDAHumanPMID:17449030
Cellular ComponentGO:0001725stress fiberPXNIDAHumanPMID:24036928
Biological ProcessGO:0048754branching morphogenesis of an epithelial tubePxnIDAMousePMID:14636584
Biological ProcessGO:0016477cell migrationPXNIMPHumanPMID:23275153
Biological ProcessGO:0016477cell migrationPXNIMPHumanPMID:26693054
Biological ProcessGO:0034614cellular response to reactive oxygen speciesPXNIEPHumanPMID:12686598
Biological ProcessGO:0043009chordate embryonic developmentpxnaIEPZfishPMID:12925747
Biological ProcessGO:0007010cytoskeleton organizationPxnIMPMGI:MGI:2158458MousePMID:11784865
Biological ProcessGO:0043542endothelial cell migrationPXNIMPHumanPMID:24863063
Biological ProcessGO:0048041focal adhesion assemblyPxnIDAMousePMID:14636584
Biological ProcessGO:0060396growth hormone receptor signaling pathwayPXNIDAHumanPMID:10925297
Biological ProcessGO:0007229integrin-mediated signaling pathwayPxnIMPMGI:MGI:2158458MousePMID:11784865
Biological ProcessGO:0030032lamellipodium assemblyPxnIDAMousePMID:14636584
Biological ProcessGO:0061055myotome developmentpxnaIGIZFIN:ZDB-GENO-170728-2ZfishPMID:28315297
Biological ProcessGO:0061055myotome developmentpxnbIGIZFIN:ZDB-GENO-170728-2ZfishPMID:28315297
Biological ProcessGO:0018108peptidyl-tyrosine phosphorylationPxnIDAMousePMID:15467718
Biological ProcessGO:0045766positive regulation of angiogenesisPxnIMPMouseMGI:MGI:5588737|PMID:24863063
Biological ProcessGO:0045860positive regulation of protein kinase activityPxnIMPMousePMID:23658024
Biological ProcessGO:0051496positive regulation of stress fiber assemblyPXNIMPHumanPMID:24863063
Biological ProcessGO:0008360regulation of cell shapePxnIMPMousePMID:23658024
Biological ProcessGO:0032880regulation of protein localizationpxnaIMPZFIN:ZDB-MRPHLNO-171206-1ZfishPMID:26954676
Biological ProcessGO:1901652response to peptidePxnIPIRGD:2405RatPMID:14622258|RGD:1298804
Biological ProcessGO:0007519skeletal muscle tissue developmentpxnaIGIZFIN:ZDB-GENO-101229-1,ZFIN:ZDB-MRPHLNO-051215-1ZfishPMID:23109907
Biological ProcessGO:0001756somitogenesispxnaIEPZfishPMID:12925747
Biological ProcessGO:0034446substrate adhesion-dependent cell spreadingPxnIMPMousePMID:23658024
Biological ProcessGO:0007179transforming growth factor beta receptor signaling pathwayPXNIDAHumanPMID:24036928
Biological ProcessGO:0007179transforming growth factor beta receptor signaling pathwayPxnIDAMouseMGI:MGI:5582864|PMID:24036928

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IDA Inferred from direct assay
  IEP Inferred from expression pattern
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  HTP Inferred from High Throughput Experiment
  HDA Inferred from High Throughput Direct Assay
  HMP Inferred from High Throughput Mutant Phenotype
  HGI Inferred from High Throughput Genetic Interaction
  HEP Inferred from High Throughput Expression Pattern

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
08/02/2024
MGI 6.24
The Jackson Laboratory