Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PXN
  • Mouse genes Pxn
  • Rat genes Pxn
  • Zfish genes pxna,pxnb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pxn

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008013	beta-catenin binding	PXN	IPI	UniProtKB:P35222	Human	PMID:17513457
Molecular Function	GO:0051435	BH4 domain binding	Pxn	IPI	PR:Q64373	Mouse	PMID:14699151
Molecular Function	GO:0051435	BH4 domain binding	Pxn	IPI	PR:P70345	Mouse	PMID:14699151
Molecular Function	GO:0051435	BH4 domain binding	Pxn	IPI	PR:P10417	Mouse	PMID:14699151
Molecular Function	GO:0005178	integrin binding	Pxn	IPI	RGD:2927	Rat	PMID:16935300|RGD:2325674
Molecular Function	GO:0005078	MAP-kinase scaffold activity	Pxn	IDA		Mouse	PMID:14636584
Molecular Function	GO:0038191	neuropilin binding	PXN	IPI	UniProtKB:O14786	Human	PMID:24863063
Molecular Function	GO:0038191	neuropilin binding	Pxn	IPI	UniProtKB:P97333	Mouse	MGI:MGI:5588737|PMID:24863063
Molecular Function	GO:0005515	protein binding	PXN	IPI	UniProtKB:P05556-1	Human	PMID:10604475
Molecular Function	GO:0005515	protein binding	PXN	IPI	UniProtKB:P13612	Human	PMID:10604475
Molecular Function	GO:0005515	protein binding	PXN	IPI	UniProtKB:P06931	Human	PMID:10814581
Molecular Function	GO:0005515	protein binding	PXN	IPI	UniProtKB:P13688	Human	PMID:11035932
Molecular Function	GO:0005515	protein binding	PXN	IPI	UniProtKB:Q09463	Human	PMID:12861019
Molecular Function	GO:0005515	protein binding	PXN	IPI	UniProtKB:Q99942	Human	PMID:12861019
Molecular Function	GO:0005515	protein binding	PXN	IPI	UniProtKB:P41240	Human	PMID:14665621
Molecular Function	GO:0005515	protein binding	PXN	IPI	UniProtKB:Q06124	Human	PMID:14665621
Molecular Function	GO:0005515	protein binding	PXN	IPI	UniProtKB:Q13480	Human	PMID:14665621
Molecular Function	GO:0005515	protein binding	PXN	IPI	UniProtKB:Q15654	Human	PMID:14688263
Molecular Function	GO:0005515	protein binding	PXN	IPI	UniProtKB:Q13882	Human	PMID:15572663
Molecular Function	GO:0005515	protein binding	PXN	IPI	UniProtKB:Q14161	Human	PMID:16628223
Molecular Function	GO:0005515	protein binding	PXN	IPI	UniProtKB:Q9Y2X7	Human	PMID:16628223
Molecular Function	GO:0005515	protein binding	PXN	IPI	UniProtKB:Q62417-2	Human	PMID:17082770
Molecular Function	GO:0005515	protein binding	PXN	IPI	UniProtKB:Q05209	Human	PMID:19167335
Molecular Function	GO:0005515	protein binding	PXN	IPI	UniProtKB:Q9BUL8	Human	PMID:20489202
Molecular Function	GO:0005515	protein binding	PXN	IPI	UniProtKB:Q05397	Human	PMID:21034468
Molecular Function	GO:0005515	protein binding	PXN	IPI	UniProtKB:P13612	Human	PMID:21173240
Molecular Function	GO:0005515	protein binding	PXN	IPI	UniProtKB:Q05397	Human	PMID:21741599
Molecular Function	GO:0005515	protein binding	PXN	IPI	UniProtKB:Q05397	Human	PMID:22270917
Molecular Function	GO:0005515	protein binding	PXN	IPI	UniProtKB:P35222	Human	PMID:22728435
Molecular Function	GO:0005515	protein binding	PXN	IPI	UniProtKB:Q14161	Human	PMID:22728435
Molecular Function	GO:0005515	protein binding	PXN	IPI	UniProtKB:P06931	Human	PMID:23393263
Molecular Function	GO:0005515	protein binding	PXN	IPI	UniProtKB:Q06124	Human	PMID:23397142
Molecular Function	GO:0005515	protein binding	PXN	IPI	UniProtKB:Q9UHB6	Human	PMID:24694988
Molecular Function	GO:0005515	protein binding	PXN	IPI	UniProtKB:P49023	Human	PMID:24863063
Molecular Function	GO:0005515	protein binding	PXN	IPI	UniProtKB:Q05209	Human	PMID:27880917
Molecular Function	GO:0005515	protein binding	PXN	IPI	UniProtKB:P41240	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	PXN	IPI	UniProtKB:Q05397	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	PXN	IPI	UniProtKB:Q14161	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	PXN	IPI	UniProtKB:Q9Y2X7	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	PXN	IPI	UniProtKB:Q05397	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	PXN	IPI	UniProtKB:Q05397	Human	PMID:7561682
Molecular Function	GO:0005515	protein binding	PXN	IPI	UniProtKB:Q05397	Human	PMID:9756887
Molecular Function	GO:0005515	protein binding	Pxn	IPI	UniProtKB:P34152	Mouse	MGI:MGI:6294183|PMID:15138291
Molecular Function	GO:0005515	protein binding	Pxn	IPI	UniProtKB:P18031	Mouse	MGI:MGI:5508311|PMID:9418872
Molecular Function	GO:0005515	protein binding	Pxn	IPI	UniProtKB:P11627	Mouse	MGI:MGI:3796794|PMID:18464795
Molecular Function	GO:0005515	protein binding	Pxn	IPI	UniProtKB:P34152	Mouse	MGI:MGI:3694172|PMID:16298995
Molecular Function	GO:0005515	protein binding	Pxn	IPI	UniProtKB:P34152	Mouse	MGI:MGI:5508567|PMID:20308429
Molecular Function	GO:0005515	protein binding	Pxn	IPI	UniProtKB:Q64727	Mouse	MGI:MGI:5508567|PMID:20308429
Molecular Function	GO:0005515	protein binding	Pxn	IPI	PR:O55222	Mouse	PMID:14699151
Molecular Function	GO:0005515	protein binding	Pxn	IPI	PR:Q8BGS1	Mouse	PMID:18794329
Molecular Function	GO:0005515	protein binding	Pxn	IPI	PR:P53668	Mouse	PMID:16399995
Molecular Function	GO:0005515	protein binding	Pxn	IPI	UniProtKB:Q9Z272	Rat	PMID:12473661|RGD:9850090
Molecular Function	GO:0005515	protein binding	Pxn	IPI	RGD:69331	Rat	PMID:12629171|RGD:152995492
Molecular Function	GO:0005515	protein binding	Pxn	IPI	RGD:2405	Rat	PMID:14622258|RGD:1298804
Molecular Function	GO:0019901	protein kinase binding	Pxn	IPI	RGD:620063	Rat	PMID:14581460|RGD:2302070
Molecular Function	GO:0019903	protein phosphatase binding	PXN	IPI	UniProtKB:P51452	Human	PMID:28759036
Molecular Function	GO:0044877	protein-containing complex binding	Pxn	IPI	RGD:2927|RGD:1306247|RGD:3443	Rat	PMID:16935300|RGD:2325674
Molecular Function	GO:0017166	vinculin binding	PXN	IPI	UniProtKB:P18206	Human	PMID:9054445
Cellular Component	GO:0031252	cell leading edge	Pxn	IDA		Mouse	PMID:18794329
Cellular Component	GO:0005911	cell-cell junction	PXN	IMP		Human	PMID:25753039
Cellular Component	GO:0005829	cytosol	PXN	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	Pxn	IDA		Rat	PMID:12629171|RGD:152995492
Cellular Component	GO:0005925	focal adhesion	PXN	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005925	focal adhesion	PXN	IDA		Human	PMID:12686598
Cellular Component	GO:0005925	focal adhesion	PXN	IDA		Human	PMID:20086044
Cellular Component	GO:0005925	focal adhesion	PXN	HDA		Human	PMID:21423176
Cellular Component	GO:0005925	focal adhesion	PXN	IDA		Human	PMID:23574715
Cellular Component	GO:0005925	focal adhesion	PXN	IDA		Human	PMID:24863063
Cellular Component	GO:0005925	focal adhesion	PXN	IMP		Human	PMID:25705373
Cellular Component	GO:0005925	focal adhesion	Pxn	IDA		Mouse	MGI:MGI:5588737|PMID:24863063
Cellular Component	GO:0005925	focal adhesion	Pxn	IDA		Mouse	PMID:11807098
Cellular Component	GO:0005925	focal adhesion	Pxn	IDA		Mouse	PMID:15728191
Cellular Component	GO:0005925	focal adhesion	Pxn	IDA		Mouse	PMID:10809671
Cellular Component	GO:0005925	focal adhesion	Pxn	IDA		Mouse	PMID:16399995
Cellular Component	GO:0005925	focal adhesion	Pxn	IDA		Mouse	PMID:14636584
Cellular Component	GO:0005925	focal adhesion	Pxn	IDA		Mouse	PMID:25217619
Cellular Component	GO:0005925	focal adhesion	Pxn	IDA		Mouse	PMID:24841562
Cellular Component	GO:0005925	focal adhesion	Pxn	IDA		Mouse	PMID:15889232
Cellular Component	GO:0005925	focal adhesion	Pxn	IDA		Mouse	PMID:18794329
Cellular Component	GO:0005925	focal adhesion	Pxn	IDA		Rat	PMID:14581460|RGD:2302070
Cellular Component	GO:0030027	lamellipodium	PXN	IDA		Human	PMID:12686598
Cellular Component	GO:0030027	lamellipodium	Pxn	IDA		Mouse	PMID:14636584
Cellular Component	GO:0005886	plasma membrane	PXN	IDA		Human	PMID:17449030
Cellular Component	GO:0001725	stress fiber	PXN	IDA		Human	PMID:24036928
Biological Process	GO:0048754	branching morphogenesis of an epithelial tube	Pxn	IDA		Mouse	PMID:14636584
Biological Process	GO:0016477	cell migration	PXN	IMP		Human	PMID:23275153
Biological Process	GO:0016477	cell migration	PXN	IMP		Human	PMID:26693054
Biological Process	GO:0034614	cellular response to reactive oxygen species	PXN	IEP		Human	PMID:12686598
Biological Process	GO:0043009	chordate embryonic development	pxna	IEP		Zfish	PMID:12925747
Biological Process	GO:0007010	cytoskeleton organization	Pxn	IMP	MGI:MGI:2158458	Mouse	PMID:11784865
Biological Process	GO:0043542	endothelial cell migration	PXN	IMP		Human	PMID:24863063
Biological Process	GO:0048041	focal adhesion assembly	Pxn	IDA		Mouse	PMID:14636584
Biological Process	GO:0060396	growth hormone receptor signaling pathway	PXN	IDA		Human	PMID:10925297
Biological Process	GO:0007229	integrin-mediated signaling pathway	Pxn	IMP	MGI:MGI:2158458	Mouse	PMID:11784865
Biological Process	GO:0030032	lamellipodium assembly	Pxn	IDA		Mouse	PMID:14636584
Biological Process	GO:0061055	myotome development	pxna	IGI	ZFIN:ZDB-GENO-170728-2	Zfish	PMID:28315297
Biological Process	GO:0061055	myotome development	pxnb	IGI	ZFIN:ZDB-GENO-170728-2	Zfish	PMID:28315297
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	Pxn	IDA		Mouse	PMID:15467718
Biological Process	GO:0045766	positive regulation of angiogenesis	Pxn	IMP		Mouse	MGI:MGI:5588737|PMID:24863063
Biological Process	GO:0045860	positive regulation of protein kinase activity	Pxn	IMP		Mouse	PMID:23658024
Biological Process	GO:0051496	positive regulation of stress fiber assembly	PXN	IMP		Human	PMID:24863063
Biological Process	GO:0008360	regulation of cell shape	Pxn	IMP		Mouse	PMID:23658024
Biological Process	GO:0032880	regulation of protein localization	pxna	IMP	ZFIN:ZDB-MRPHLNO-171206-1	Zfish	PMID:26954676
Biological Process	GO:1901652	response to peptide	Pxn	IPI	RGD:2405	Rat	PMID:14622258|RGD:1298804
Biological Process	GO:0007519	skeletal muscle tissue development	pxna	IGI	ZFIN:ZDB-GENO-101229-1,ZFIN:ZDB-MRPHLNO-051215-1	Zfish	PMID:23109907
Biological Process	GO:0001756	somitogenesis	pxna	IEP		Zfish	PMID:12925747
Biological Process	GO:0034446	substrate adhesion-dependent cell spreading	Pxn	IMP		Mouse	PMID:23658024
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	PXN	IDA		Human	PMID:24036928
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	Pxn	IDA		Mouse	MGI:MGI:5582864|PMID:24036928

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern