Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes RAB21
  • Mouse genes Rab21
  • Rat genes Rab21
  • Zfish genes rab21
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Rab21

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0019003	GDP binding	RAB21	IDA		Human	PMID:16034420
Molecular Function	GO:0019003	GDP binding	RAB21	IDA		Human	PMID:20937701
Molecular Function	GO:0005525	GTP binding	RAB21	IMP		Human	PMID:15561770
Molecular Function	GO:0005525	GTP binding	RAB21	IDA		Human	PMID:16034420
Molecular Function	GO:0003924	GTPase activity	RAB21	IDA		Human	PMID:16034420
Molecular Function	GO:0005515	protein binding	RAB21	IPI	UniProtKB:Q96NW4	Human	PMID:16525121
Molecular Function	GO:0005515	protein binding	RAB21	IPI	UniProtKB:Q9UJ41	Human	PMID:17450153
Molecular Function	GO:0005515	protein binding	RAB21	IPI	UniProtKB:Q9UJ41-2	Human	PMID:17450153
Molecular Function	GO:0005515	protein binding	RAB21	IPI	UniProtKB:Q9UKG1	Human	PMID:17581628
Molecular Function	GO:0005515	protein binding	RAB21	IPI	UniProtKB:Q9UJ41-2	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	RAB21	IPI	UniProtKB:P49755	Human	PMID:31455601
Molecular Function	GO:0005515	protein binding	Rab21	IPI	UniProtKB:P05556|UniProtKB:P17301	Mouse	MGI:MGI:4456942|PMID:16754960
Molecular Function	GO:0005515	protein binding	Rab21	IPI	PR:Q9R0M3	Mouse	PMID:19368996
Cellular Component	GO:0098559	cytoplasmic side of early endosome membrane	RAB21	IDA		Human	PMID:15561770
Cellular Component	GO:0009898	cytoplasmic side of plasma membrane	RAB21	IDA		Human	PMID:15561770
Cellular Component	GO:0005768	endosome	RAB21	IDA		Human	GO_REF:0000054
Cellular Component	GO:0070062	extracellular exosome	RAB21	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	RAB21	HDA		Human	PMID:20458337
Cellular Component	GO:0070062	extracellular exosome	RAB21	HDA		Human	PMID:23533145
Cellular Component	GO:0005925	focal adhesion	RAB21	HDA		Human	PMID:21423176
Cellular Component	GO:0032580	Golgi cisterna membrane	RAB21	IDA		Human	PMID:15561770
Cellular Component	GO:0043005	neuron projection	Rab21	IDA		Mouse	MGI:MGI:5607233|PMID:19745841
Cellular Component	GO:0043005	neuron projection	Rab21	IDA		Rat	PMID:19745841|RGD:8554110
Cellular Component	GO:0045202	synapse	Rab21	EXP		Rat	PMID:24876496|RGD:10047219
Cellular Component	GO:0045202	synapse	Rab21	IDA		Rat	PMID:24876496|RGD:10047219
Cellular Component	GO:0005802	trans-Golgi network	RAB21	IDA		Human	PMID:19745841
Cellular Component	GO:0012506	vesicle membrane	RAB21	IDA		Human	PMID:15561770
Biological Process	GO:0008089	anterograde axonal transport	RAB21	IDA		Human	PMID:22705394
Biological Process	GO:0008089	anterograde axonal transport	RAB21	IMP		Human	PMID:22705394
Biological Process	GO:0008089	anterograde axonal transport	Rab21	IDA		Rat	PMID:22705394|RGD:10047362
Biological Process	GO:0050775	positive regulation of dendrite morphogenesis	Rab21	IMP		Mouse	MGI:MGI:5490454|PMID:22171327
Biological Process	GO:2000643	positive regulation of early endosome to late endosome transport	RAB21	IMP		Human	PMID:15561770
Biological Process	GO:0048260	positive regulation of receptor-mediated endocytosis	RAB21	IMP		Human	PMID:15561770
Biological Process	GO:0050821	protein stabilization	RAB21	IMP		Human	PMID:31455601
Biological Process	GO:0030516	regulation of axon extension	Rab21	IDA		Rat	PMID:19745841|RGD:8554110
Biological Process	GO:0017157	regulation of exocytosis	RAB21	IDA		Human	PMID:22705394

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern