Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Rab27a

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes RAB27A
- Mouse genes Rab27a
- Rat genes Rab27a
- Zfish genes rab27a
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Rab27a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0019003	GDP binding	RAB27A	IDA		Human	PMID:20937701
Molecular Function	GO:0005525	GTP binding	RAB27A	IDA		Human	PMID:9066979
Molecular Function	GO:0005525	GTP binding	Rab27a	IDA		Mouse	MGI:MGI:4412435\|PMID:18940603
Molecular Function	GO:0003924	GTPase activity	Rab27a	IDA		Mouse	MGI:MGI:4412435\|PMID:18940603
Molecular Function	GO:0031489	myosin V binding	Rab27a	IPI	PR:Q99104	Mouse	PMID:11266470
Molecular Function	GO:0005515	protein binding	RAB27A	IPI	UniProtKB:Q9BV36	Human	PMID:12897212
Molecular Function	GO:0005515	protein binding	RAB27A	IPI	UniProtKB:P26374	Human	PMID:15186776
Molecular Function	GO:0005515	protein binding	RAB27A	IPI	UniProtKB:Q70J99	Human	PMID:15548590
Molecular Function	GO:0005515	protein binding	RAB27A	IPI	UniProtKB:Q70J99	Human	PMID:16278825
Molecular Function	GO:0005515	protein binding	RAB27A	IPI	UniProtKB:Q9BV36	Human	PMID:17045265
Molecular Function	GO:0005515	protein binding	RAB27A	IPI	UniProtKB:Q8IYJ3	Human	PMID:18266782
Molecular Function	GO:0005515	protein binding	RAB27A	IPI	UniProtKB:Q9HCH5	Human	PMID:18812475
Molecular Function	GO:0005515	protein binding	RAB27A	IPI	UniProtKB:Q70J99	Human	PMID:22899725
Molecular Function	GO:0005515	protein binding	RAB27A	IPI	UniProtKB:Q70J99	Human	PMID:25312756
Molecular Function	GO:0005515	protein binding	RAB27A	IPI	UniProtKB:Q9BV36	Human	PMID:25312756
Molecular Function	GO:0005515	protein binding	RAB27A	IPI	UniProtKB:Q8TCE6	Human	PMID:30771381
Molecular Function	GO:0005515	protein binding	RAB27A	IPI	UniProtKB:Q4VX76	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RAB27A	IPI	UniProtKB:Q8IYJ3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RAB27A	IPI	UniProtKB:Q8NFW9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RAB27A	IPI	UniProtKB:Q8TDW5-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RAB27A	IPI	UniProtKB:Q96C24	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Rab27a	IPI	UniProtKB:Q9IV27	Mouse	MGI:MGI:2176311\|PMID:11773082
Molecular Function	GO:0005515	protein binding	Rab27a	IPI	UniProtKB:Q91V27	Mouse	MGI:MGI:2176311\|PMID:11773082
Molecular Function	GO:0005515	protein binding	Rab27a	IPI	UniProtKB:Q0VAV2	Mouse	MGI:MGI:2176311\|PMID:11773082
Molecular Function	GO:0005515	protein binding	Rab27a	IPI	UniProtKB:B2RUP2	Mouse	MGI:MGI:3778349\|PMID:18354201
Molecular Function	GO:0005515	protein binding	Rab27a	IPI	UniProtKB:P47708\|UniProtKB:Q99N48\|UniProtKB:Q99N50\|UniProtKB:Q99N80\|UniProtKB:Q9R0Q1	Mouse	MGI:MGI:2176311\|PMID:11773082
Molecular Function	GO:0005515	protein binding	Rab27a	IPI	UniProtKB:Q91V27	Mouse	MGI:MGI:4412434\|PMID:18940604
Molecular Function	GO:0005515	protein binding	Rab27a	IPI	UniProtKB:P47708	Mouse	MGI:MGI:4839453\|PMID:14722103
Molecular Function	GO:0005515	protein binding	Rab27a	IPI	UniProtKB:Q99N50\|UniProtKB:Q99N80	Mouse	MGI:MGI:3852304\|PMID:18266782
Molecular Function	GO:0005515	protein binding	Rab27a	IPI	UniProtKB:Q8NFW9	Mouse	MGI:MGI:2180422\|PMID:11964381
Molecular Function	GO:0005515	protein binding	Rab27a	IPI	UniProtKB:P47708\|UniProtKB:Q91V27	Mouse	MGI:MGI:2176311\|PMID:11773082
Molecular Function	GO:0005515	protein binding	Rab27a	IPI	UniProtKB:Q8TDW5	Mouse	MGI:MGI:4942255\|PMID:12051743
Molecular Function	GO:0005515	protein binding	Rab27a	IPI	UniProtKB:Q9HCH5\|UniProtKB:Q9R0Q1-1	Mouse	MGI:MGI:4412435\|PMID:18940603
Molecular Function	GO:0005515	protein binding	Rab27a	IPI	UniProtKB:Q9HCH5	Mouse	MGI:MGI:4412435\|PMID:18940603
Molecular Function	GO:0005515	protein binding	Rab27a	IPI	MGI:MGI:1350931	Mouse	PMID:29712939
Molecular Function	GO:0005515	protein binding	Rab27a	IPI	PR:Q99N48	Mouse	PMID:12590134
Molecular Function	GO:0005515	protein binding	Rab27a	IPI	PR:Q9R0Q1	Mouse	PMID:12590134
Molecular Function	GO:0005515	protein binding	Rab27a	IPI	PR:Q768S4	Mouse	PMID:12578829
Molecular Function	GO:0005515	protein binding	Rab27a	IPI	PR:Q80T23	Mouse	PMID:12590134
Molecular Function	GO:0005515	protein binding	Rab27a	IPI	PR:Q8K3I4	Mouse	PMID:12590134
Molecular Function	GO:0005515	protein binding	Rab27a	IPI	PR:Q99104	Mouse	PMID:14730011
Molecular Function	GO:0005515	protein binding	Rab27a	IPI	PR:Q99N80	Mouse	PMID:12590134
Molecular Function	GO:0005515	protein binding	Rab27a	IPI	RGD:620918\|RGD:620114	Rat	PMID:15039459\|RGD:4892230
Molecular Function	GO:0019904	protein domain specific binding	Rab27a	IPI	UniProtKB:Q8NEV8	Rat	PMID:16880209\|RGD:8554515
Cellular Component	GO:0016324	apical plasma membrane	Rab27a	IDA		Rat	PMID:17067543\|RGD:1601610
Cellular Component	GO:0030425	dendrite	RAB27A	IDA		Human	PMID:11266474
Cellular Component	GO:0070382	exocytic vesicle	RAB27A	IDA		Human	PMID:17237785
Cellular Component	GO:0070382	exocytic vesicle	RAB27A	IDA		Human	PMID:18812475
Cellular Component	GO:0070062	extracellular exosome	RAB27A	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	RAB27A	HDA		Human	PMID:23533145
Cellular Component	GO:0005794	Golgi apparatus	Rab27a	IDA		Mouse	PMID:14724135
Cellular Component	GO:0005770	late endosome	RAB27A	IDA		Human	PMID:17237785
Cellular Component	GO:0005770	late endosome	RAB27A	IDA		Human	PMID:30771381
Cellular Component	GO:0005764	lysosome	RAB27A	IDA		Human	PMID:15548590
Cellular Component	GO:0042470	melanosome	RAB27A	IDA		Human	PMID:11266474
Cellular Component	GO:0042470	melanosome	RAB27A	IDA		Human	PMID:11980908
Cellular Component	GO:0042470	melanosome	Rab27a	IDA		Mouse	MGI:MGI:2180422\|PMID:11964381
Cellular Component	GO:0042470	melanosome	Rab27a	IDA		Mouse	PMID:22275436
Cellular Component	GO:0042470	melanosome	Rab27a	IDA		Rat	PMID:17043139\|RGD:152025192
Cellular Component	GO:0032585	multivesicular body membrane	RAB27A	IDA		Human	PMID:19966785
Cellular Component	GO:0001750	photoreceptor outer segment	Rab27a	IDA		Mouse	MGI:MGI:2180422\|PMID:11964381
Cellular Component	GO:0030141	secretory granule	Rab27a	IMP	MGI:MGI:1856656	Mouse	PMID:11266473
Cellular Component	GO:0030141	secretory granule	Rab27a	IDA		Rat	PMID:15465017\|RGD:1601609
Cellular Component	GO:0030141	secretory granule	Rab27a	IDA		Rat	PMID:17311845\|RGD:14390061
Cellular Component	GO:0030667	secretory granule membrane	Rab27a	IDA		Rat	PMID:17067543\|RGD:1601610
Cellular Component	GO:0033093	Weibel-Palade body	Rab27a	IDA		Rat	PMID:22899725\|RGD:10047177
Biological Process	GO:0019882	antigen processing and presentation	RAB27A	IMP		Human	PMID:19717423
Biological Process	GO:0007596	blood coagulation	Rab27a	IMP	MGI:MGI:1856656	Mouse	PMID:10859366
Biological Process	GO:0097278	complement-dependent cytotoxicity	RAB27A	IMP		Human	PMID:24404184
Biological Process	GO:0043316	cytotoxic T cell degranulation	Rab27a	IMP	MGI:MGI:1856656	Mouse	PMID:11266473
Biological Process	GO:0006887	exocytosis	RAB27A	IDA		Human	PMID:18812475
Biological Process	GO:1990182	exosomal secretion	RAB27A	IMP		Human	PMID:23092844
Biological Process	GO:0030318	melanocyte differentiation	Rab27a	IMP	MGI:MGI:1856656	Mouse	PMID:2379821
Biological Process	GO:0030318	melanocyte differentiation	Rab27a	IMP	MGI:MGI:1856656	Mouse	MGI:MGI:52947
Biological Process	GO:0032400	melanosome localization	RAB27A	IMP		Human	PMID:15357836
Biological Process	GO:0032402	melanosome transport	Rab27a	IMP	MGI:MGI:1856656	Mouse	PMID:11266473
Biological Process	GO:0036257	multivesicular body organization	RAB27A	IMP		Human	PMID:23092844
Biological Process	GO:0071985	multivesicular body sorting pathway	RAB27A	IMP		Human	PMID:19966785
Biological Process	GO:0043320	natural killer cell degranulation	Rab27a	IMP	MGI:MGI:1856656	Mouse	PMID:11266473
Biological Process	GO:0051875	pigment granule localization	Rab27a	IMP	MGI:MGI:1856656	Mouse	PMID:14978221
Biological Process	GO:0051875	pigment granule localization	Rab27a	IMP	MGI:MGI:1856656	Mouse	PMID:15572405
Biological Process	GO:0051904	pigment granule transport	Rab27a	IMP	MGI:MGI:1856656	Mouse	PMID:15572405
Biological Process	GO:0043473	pigmentation	Rab27a	IMP	MGI:MGI:1856656	Mouse	PMID:2379821
Biological Process	GO:1903435	positive regulation of constitutive secretory pathway	RAB27A	IMP		Human	PMID:22899725
Biological Process	GO:0045921	positive regulation of exocytosis	RAB27A	IMP		Human	PMID:19966785
Biological Process	GO:0010628	positive regulation of gene expression	RAB27A	IMP		Human	PMID:23092844
Biological Process	GO:0050766	positive regulation of phagocytosis	RAB27A	IMP		Human	PMID:24404184
Biological Process	GO:1903428	positive regulation of reactive oxygen species biosynthetic process	RAB27A	IMP		Human	PMID:24404184
Biological Process	GO:1903307	positive regulation of regulated secretory pathway	RAB27A	IGI	UniProtKB:P59190	Human	PMID:22899725
Biological Process	GO:1903307	positive regulation of regulated secretory pathway	RAB27A	IMP		Human	PMID:22899725
Biological Process	GO:0016192	vesicle-mediated transport	Rab27a	IMP	MGI:MGI:1856656	Mouse	PMID:10859366

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.