Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes RAB4A
  • Mouse genes Rab4a
  • Rat genes Rab4a
  • Zfish genes rab4a
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Rab4a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001671	ATPase activator activity	Rab4a	IDA		Rat	PMID:11062069|RGD:633463
Molecular Function	GO:0051117	ATPase binding	Rab4a	IPI	RGD:621594	Rat	PMID:11062069|RGD:633463
Molecular Function	GO:0019003	GDP binding	RAB4A	IDA		Human	PMID:15907487
Molecular Function	GO:0019003	GDP binding	RAB4A	IDA		Human	PMID:16034420
Molecular Function	GO:0005525	GTP binding	RAB4A	IDA		Human	PMID:15907487
Molecular Function	GO:0005525	GTP binding	RAB4A	IDA		Human	PMID:16034420
Molecular Function	GO:0005525	GTP binding	Rab4a	IDA		Rat	PMID:11063739|RGD:2306283
Molecular Function	GO:0005525	GTP binding	Rab4a	IDA		Rat	PMID:8037667|RGD:2304043
Molecular Function	GO:0005525	GTP binding	Rab4a	IDA		Rat	PMID:8807639|RGD:2306441
Molecular Function	GO:0005525	GTP binding	Rab4a	IDA		Rat	PMID:9169411|RGD:2306443
Molecular Function	GO:0003924	GTPase activity	RAB4A	IDA		Human	PMID:15907487
Molecular Function	GO:0003924	GTPase activity	RAB4A	IDA		Human	PMID:16034420
Molecular Function	GO:0003924	GTPase activity	RAB4A	IDA		Human	PMID:17562788
Molecular Function	GO:0003924	GTPase activity	Rab4a	IDA		Rat	PMID:11063739|RGD:2306283
Molecular Function	GO:0003924	GTPase activity	Rab4a	IDA		Rat	PMID:9169411|RGD:2306443
Molecular Function	GO:0035255	ionotropic glutamate receptor binding	Rab4a	IPI	RGD:621531	Rat	PMID:17194442|RGD:2304049
Molecular Function	GO:0005515	protein binding	RAB4A	IPI	UniProtKB:Q9H1K0	Human	PMID:16034420
Molecular Function	GO:0005515	protein binding	RAB4A	IPI	UniProtKB:Q9Y3P9	Human	PMID:17562788
Molecular Function	GO:0005515	protein binding	RAB4A	IPI	UniProtKB:P31150	Human	PMID:19570034
Molecular Function	GO:0005515	protein binding	RAB4A	IPI	UniProtKB:Q4V328	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	RAB4A	IPI	UniProtKB:O00471	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	RAB4A	IPI	UniProtKB:Q8N1B4	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	RAB4A	IPI	UniProtKB:P31150	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	RAB4A	IPI	UniProtKB:P31150	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	RAB4A	IPI	UniProtKB:Q9H1K0	Human	PMID:29997244
Molecular Function	GO:0005515	protein binding	RAB4A	IPI	UniProtKB:Q8N1B4	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	RAB4A	IPI	UniProtKB:O00471	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RAB4A	IPI	UniProtKB:Q15276	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RAB4A	IPI	UniProtKB:Q4V328	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RAB4A	IPI	UniProtKB:Q8IYU2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RAB4A	IPI	UniProtKB:Q8NEG0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RAB4A	IPI	UniProtKB:Q96MP8-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RAB4A	IPI	UniProtKB:Q9H1K0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Rab4a	IPI	PR:Q8BIJ7	Mouse	PMID:11172003
Molecular Function	GO:0005515	protein binding	Rab4a	IPI	UniProtKB:Q9Y2I1	Rat	PMID:23386062|RGD:8693353
Molecular Function	GO:0019905	syntaxin binding	Rab4a	IPI	RGD:621019	Rat	PMID:11063739|RGD:2306283
Cellular Component	GO:0005737	cytoplasm	Rab4a	IDA		Mouse	PMID:18656450
Cellular Component	GO:0005829	cytosol	Rab4a	IDA		Rat	PMID:7575448|RGD:735238
Cellular Component	GO:0005829	cytosol	Rab4a	IDA		Rat	PMID:8037667|RGD:2304043
Cellular Component	GO:0005829	cytosol	Rab4a	IDA		Rat	PMID:8366094|RGD:2306265
Cellular Component	GO:0005768	endosome	Rab4a	IDA		Mouse	PMID:11172003
Cellular Component	GO:0070062	extracellular exosome	RAB4A	IDA		Human	PMID:15326289
Cellular Component	GO:0032593	insulin-responsive compartment	Rab4a	IDA		Rat	PMID:8366094|RGD:2306265
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	Rab4a	IDA		Rat	PMID:11063739|RGD:2306283
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	Rab4a	IDA		Rat	PMID:8037667|RGD:2304043
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	Rab4a	IDA		Rat	PMID:8366094|RGD:2306265
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	Rab4a	IDA		Rat	PMID:8536622|RGD:2306442
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	Rab4a	IDA		Rat	PMID:9169411|RGD:2306443
Cellular Component	GO:0016020	membrane	Rab4a	IDA		Rat	PMID:8807639|RGD:2306441
Cellular Component	GO:0048471	perinuclear region of cytoplasm	RAB4A	IDA		Human	PMID:19590752
Cellular Component	GO:0005886	plasma membrane	Rab4a	IDA		Rat	PMID:11063739|RGD:2306283
Cellular Component	GO:0005886	plasma membrane	Rab4a	IDA		Rat	PMID:7575448|RGD:735238
Cellular Component	GO:0005886	plasma membrane	Rab4a	IDA		Rat	PMID:8037667|RGD:2304043
Cellular Component	GO:0005886	plasma membrane	Rab4a	IDA		Rat	PMID:8366094|RGD:2306265
Cellular Component	GO:0098837	postsynaptic recycling endosome	Rab4a	IDA		Rat	PMID:20098723|RGD:12050105
Cellular Component	GO:0055037	recycling endosome	Rab4a	IDA		Rat	PMID:10468577|RGD:4892345
Cellular Component	GO:0055037	recycling endosome	Rab4a	IDA		Rat	PMID:25799061|RGD:11053432
Cellular Component	GO:0030672	synaptic vesicle membrane	Rab4a	IDA		Rat	PMID:20926670|RGD:13432355
Cellular Component	GO:0031982	vesicle	RAB4A	IDA		Human	PMID:19590752
Biological Process	GO:0019882	antigen processing and presentation	RAB4A	IMP		Human	PMID:19717423
Biological Process	GO:0015031	protein transport	Rab4a	IDA		Mouse	PMID:11172003
Biological Process	GO:0032482	Rab protein signal transduction	Rab4a	IMP		Rat	PMID:9169411|RGD:2306443
Biological Process	GO:0030100	regulation of endocytosis	Rab4a	IDA		Mouse	PMID:11172003
Biological Process	GO:0007264	small GTPase mediated signal transduction	Rab4a	IDA		Mouse	PMID:11172003
Biological Process	GO:0001944	vasculature development	rab4a	IMP	ZFIN:ZDB-MRPHLNO-140929-6	Zfish	PMID:24785348

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern