Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes RAB5C
  • Mouse genes Rab5c
  • Rat genes Rab5c
  • Zfish genes rab5c
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Rab5c

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0019003	GDP binding	RAB5C	IDA		Human	PMID:20937701
Molecular Function	GO:0003924	GTPase activity	RAB5C	IDA		Human	PMID:17562788
Molecular Function	GO:0005515	protein binding	RAB5C	IPI	UniProtKB:Q96HU1	Human	PMID:17562788
Molecular Function	GO:0005515	protein binding	RAB5C	IPI	UniProtKB:Q0VD86	Human	PMID:21750715
Molecular Function	GO:0005515	protein binding	RAB5C	IPI	UniProtKB:Q15075	Human	PMID:25114243
Molecular Function	GO:0005515	protein binding	RAB5C	IPI	UniProtKB:Q5ZRP9	Human	PMID:25114243
Molecular Function	GO:0005515	protein binding	RAB5C	IPI	UniProtKB:Q15075	Human	PMID:25266290
Molecular Function	GO:0005515	protein binding	RAB5C	IPI	UniProtKB:Q8NEU8	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	RAB5C	IPI	UniProtKB:Q8NEU8	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	RAB5C	IPI	UniProtKB:Q60I27	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RAB5C	IPI	UniProtKB:Q8NEU8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Rab5c	IPI	PR:Q80Y56	Mouse	PMID:20534488
Molecular Function	GO:0005515	protein binding	Rab5c	IPI	PR:Q8BL66	Mouse	PMID:20534488
Molecular Function	GO:0005515	protein binding	rab5c	IPI	UniProtKB:B2XCL9	Zfish	PMID:18455989
Molecular Function	GO:0005515	protein binding	rab5c	IPI	UniProtKB:B2XCM0	Zfish	PMID:18455989
Cellular Component	GO:0031410	cytoplasmic vesicle	Rab5c	IDA		Rat	PMID:12051767|RGD:704352
Cellular Component	GO:0005769	early endosome	rab5c	IDA		Zfish	PMID:21976318
Cellular Component	GO:0030139	endocytic vesicle	Rab5c	IDA		Mouse	PMID:7789520
Cellular Component	GO:0005768	endosome	RAB5C	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005768	endosome	rab5c	IDA		Zfish	PMID:18455989
Cellular Component	GO:0070062	extracellular exosome	RAB5C	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	RAB5C	HDA		Human	PMID:19199708
Cellular Component	GO:0070062	extracellular exosome	RAB5C	HDA		Human	PMID:20458337
Cellular Component	GO:0070062	extracellular exosome	RAB5C	HDA		Human	PMID:23533145
Cellular Component	GO:0005811	lipid droplet	RAB5C	IDA		Human	PMID:14741744
Cellular Component	GO:0005765	lysosomal membrane	RAB5C	HDA		Human	PMID:17897319
Cellular Component	GO:0030672	synaptic vesicle membrane	Rab5c	EXP		Rat	PMID:20926670|RGD:13432355
Cellular Component	GO:0030672	synaptic vesicle membrane	Rab5c	IDA		Rat	PMID:20926670|RGD:13432355
Biological Process	GO:0001525	angiogenesis	rab5c	IMP	ZFIN:ZDB-MRPHLNO-090824-14	Zfish	PMID:19389629
Biological Process	GO:0001525	angiogenesis	rab5c	IMP	ZFIN:ZDB-MRPHLNO-090824-13,ZFIN:ZDB-MRPHLNO-090824-14	Zfish	PMID:19389629
Biological Process	GO:0001525	angiogenesis	rab5c	IMP	ZFIN:ZDB-MRPHLNO-090824-13	Zfish	PMID:19389629
Biological Process	GO:0098609	cell-cell adhesion	rab5c	IMP	ZFIN:ZDB-MRPHLNO-060206-2	Zfish	PMID:16198297
Biological Process	GO:0007032	endosome organization	Rab5c	IDA		Mouse	PMID:7789520
Biological Process	GO:0120084	endothelial tip cell filopodium assembly	rab5c	IMP	ZFIN:ZDB-MRPHLNO-060206-2	Zfish	PMID:33983539
Biological Process	GO:0001702	gastrulation with mouth forming second	rab5c	IMP	ZFIN:ZDB-MRPHLNO-060206-2	Zfish	PMID:16198297
Biological Process	GO:0071425	hematopoietic stem cell proliferation	rab5c	IMP	ZFIN:ZDB-GENO-220429-5	Zfish	PMID:32275659
Biological Process	GO:0048227	plasma membrane to endosome transport	RAB5C	IMP		Human	PMID:17562788
Biological Process	GO:0090049	regulation of cell migration involved in sprouting angiogenesis	rab5c	IMP	ZFIN:ZDB-MRPHLNO-060206-2	Zfish	PMID:33983539
Biological Process	GO:0090049	regulation of cell migration involved in sprouting angiogenesis	rab5c	IMP	ZFIN:ZDB-GENO-220908-5	Zfish	PMID:33983539
Biological Process	GO:0030100	regulation of endocytosis	Rab5c	IDA		Mouse	PMID:7789520
Biological Process	GO:0030100	regulation of endocytosis	rab5c	IMP	ZFIN:ZDB-MRPHLNO-060206-2	Zfish	PMID:16198297
Biological Process	GO:0008593	regulation of Notch signaling pathway	rab5c	IMP	ZFIN:ZDB-MRPHLNO-060206-2	Zfish	PMID:33983539
Biological Process	GO:0030947	regulation of vascular endothelial growth factor receptor signaling pathway	rab5c	IMP	ZFIN:ZDB-MRPHLNO-060206-2	Zfish	PMID:33983539

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern