Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes RABGEF1
  • Mouse genes Rabgef1
  • Rat genes Rabgef1
  • Zfish genes rabgef1,rabgef1l
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Rabgef1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	RABGEF1	IDA		Human	PMID:20937701
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	RABGEF1	IMP		Human	PMID:23382462
Molecular Function	GO:0005515	protein binding	RABGEF1	IPI	UniProtKB:Q9BQD3	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	RABGEF1	IPI	UniProtKB:P00533	Human	PMID:16499958
Molecular Function	GO:0005515	protein binding	RABGEF1	IPI	UniProtKB:P0CG47	Human	PMID:16499958
Molecular Function	GO:0005515	protein binding	RABGEF1	IPI	UniProtKB:Q9UL25	Human	PMID:17450153
Molecular Function	GO:0005515	protein binding	RABGEF1	IPI	UniProtKB:D3DUQ6	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	RABGEF1	IPI	UniProtKB:Q15038	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	RABGEF1	IPI	UniProtKB:Q53FD0	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	RABGEF1	IPI	UniProtKB:Q96C32	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	RABGEF1	IPI	UniProtKB:Q96FV9	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	RABGEF1	IPI	UniProtKB:Q99757	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	RABGEF1	IPI	UniProtKB:Q9BYV2	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	RABGEF1	IPI	UniProtKB:Q9C019	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	RABGEF1	IPI	UniProtKB:Q9C0C6	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	RABGEF1	IPI	UniProtKB:Q9UL45	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	Rabgef1	IPI	UniProtKB:P97492	Mouse	MGI:MGI:5009199|PMID:10926822
Molecular Function	GO:0005515	protein binding	Rabgef1	IPI	PR:O35551	Mouse	PMID:17341663
Molecular Function	GO:0005515	protein binding	Rabgef1	IPI	PR:Q61411	Mouse	PMID:15235600
Molecular Function	GO:0031267	small GTPase binding	RABGEF1	IPI	UniProtKB:P20339	Human	PMID:23382462
Molecular Function	GO:0061630	ubiquitin protein ligase activity	Rabgef1	IDA		Mouse	PMID:17341663
Cellular Component	GO:0005829	cytosol	RABGEF1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0030425	dendrite	Rabgef1	IPI		Mouse	MGI:MGI:6832479|PMID:23430262
Cellular Component	GO:0005769	early endosome	RABGEF1	IMP		Human	PMID:23382462
Cellular Component	GO:0005730	nucleolus	RABGEF1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0031982	vesicle	Rabgef1	IDA		Mouse	PMID:17341663
Biological Process	GO:0098935	dendritic transport	Rabgef1	IPI		Mouse	PMID:23430262
Biological Process	GO:0098935	dendritic transport	Rabgef1	IMP		Mouse	PMID:23430262
Biological Process	GO:0098935	dendritic transport	Rabgef1	IDA		Mouse	PMID:23430262
Biological Process	GO:0051649	establishment of localization in cell	Rabgef1	IMP	MGI:MGI:3051384	Mouse	PMID:16533754
Biological Process	GO:0032635	interleukin-6 production	Rabgef1	IMP	MGI:MGI:3051384	Mouse	PMID:16533754
Biological Process	GO:0038109	Kit signaling pathway	Rabgef1	IMP	MGI:MGI:3051384	Mouse	PMID:16533754
Biological Process	GO:0032762	mast cell cytokine production	Rabgef1	IMP	MGI:MGI:3051384	Mouse	PMID:16533754
Biological Process	GO:0043303	mast cell degranulation	Rabgef1	IMP	MGI:MGI:3051384	Mouse	PMID:15235600
Biological Process	GO:0097531	mast cell migration	Rabgef1	IMP	MGI:MGI:3051384	Mouse	PMID:16533754
Biological Process	GO:0050728	negative regulation of inflammatory response	Rabgef1	IMP	MGI:MGI:3051384	Mouse	PMID:15235600
Biological Process	GO:0032715	negative regulation of interleukin-6 production	Rabgef1	IMP	MGI:MGI:3051384	Mouse	PMID:16533754
Biological Process	GO:1900235	negative regulation of Kit signaling pathway	Rabgef1	IMP	MGI:MGI:3051384	Mouse	PMID:16533754
Biological Process	GO:0002686	negative regulation of leukocyte migration	Rabgef1	IMP	MGI:MGI:3051384	Mouse	PMID:16533754
Biological Process	GO:0033004	negative regulation of mast cell activation	Rabgef1	IMP	MGI:MGI:3051384	Mouse	PMID:15235600
Biological Process	GO:0032764	negative regulation of mast cell cytokine production	Rabgef1	IMP	MGI:MGI:3051384	Mouse	PMID:16533754
Biological Process	GO:0043305	negative regulation of mast cell degranulation	Rabgef1	IMP	MGI:MGI:3051384	Mouse	PMID:15235600
Biological Process	GO:0001933	negative regulation of protein phosphorylation	Rabgef1	IMP	MGI:MGI:3051384	Mouse	PMID:16533754
Biological Process	GO:0046580	negative regulation of Ras protein signal transduction	Rabgef1	IMP		Mouse	PMID:15235600
Biological Process	GO:0048261	negative regulation of receptor-mediated endocytosis	Rabgef1	IMP	MGI:MGI:3051384	Mouse	PMID:16533754
Biological Process	GO:0006468	protein phosphorylation	Rabgef1	IMP	MGI:MGI:3051384	Mouse	PMID:16533754
Biological Process	GO:0006612	protein targeting to membrane	RABGEF1	IMP		Human	PMID:23382462
Biological Process	GO:0007265	Ras protein signal transduction	Rabgef1	IMP		Mouse	PMID:15235600
Biological Process	GO:0006898	receptor-mediated endocytosis	Rabgef1	IMP	MGI:MGI:3051384	Mouse	PMID:16533754
Biological Process	GO:0060368	regulation of Fc receptor mediated stimulatory signaling pathway	Rabgef1	IDA		Mouse	PMID:17341663
Biological Process	GO:0060368	regulation of Fc receptor mediated stimulatory signaling pathway	Rabgef1	IMP		Mouse	PMID:15235600

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern