Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes RAC2
  • Mouse genes Rac2
  • Rat genes Rac2
  • Zfish genes rac2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Rac2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005525	GTP binding	RAC2	IMP		Human	PMID:19625648
Molecular Function	GO:0003924	GTPase activity	Rac2	IDA		Mouse	PMID:15249579
Molecular Function	GO:0005515	protein binding	RAC2	IPI	UniProtKB:O14939	Human	PMID:22106281
Molecular Function	GO:0005515	protein binding	RAC2	IPI	UniProtKB:Q6P589	Human	PMID:22949657
Molecular Function	GO:0005515	protein binding	RAC2	IPI	UniProtKB:P53365	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RAC2	IPI	UniProtKB:Q8WUI4-6	Human	PMID:32296183
Molecular Function	GO:0019887	protein kinase regulator activity	Rac2	IMP		Mouse	MGI:MGI:3655336|PMID:10843388
Cellular Component	GO:0005884	actin filament	RAC2	IDA		Human	PMID:19625648
Cellular Component	GO:0005737	cytoplasm	Rac2	IDA		Mouse	PMID:12176888
Cellular Component	GO:0005737	cytoplasm	rac2	IDA		Zfish	PMID:22992407
Cellular Component	GO:0005829	cytosol	RAC2	IDA		Human	PMID:19625648
Cellular Component	GO:0070062	extracellular exosome	RAC2	HDA		Human	PMID:20458337
Cellular Component	GO:0070062	extracellular exosome	RAC2	HDA		Human	PMID:23533145
Cellular Component	GO:0005925	focal adhesion	RAC2	HDA		Human	PMID:21423176
Cellular Component	GO:0030027	lamellipodium	RAC2	IDA		Human	PMID:19625648
Cellular Component	GO:0016020	membrane	Rac2	IDA		Mouse	PMID:12176888
Cellular Component	GO:0005635	nuclear envelope	Rac2	IDA		Mouse	PMID:12176888
Biological Process	GO:0030036	actin cytoskeleton organization	Rac2	IDA		Mouse	PMID:12176888
Biological Process	GO:0030036	actin cytoskeleton organization	Rac2	IDA		Rat	PMID:10350213|RGD:1599401
Biological Process	GO:0007015	actin filament organization	RAC2	IMP		Human	PMID:21167572
Biological Process	GO:0045453	bone resorption	Rac2	IDA		Rat	PMID:10350213|RGD:1599401
Biological Process	GO:0008283	cell population proliferation	Rac2	IMP	MGI:MGI:1857701	Mouse	PMID:11435472
Biological Process	GO:0008283	cell population proliferation	Rac2	IGI	MGI:MGI:97306	Mouse	PMID:11435472
Biological Process	GO:0030031	cell projection assembly	Rac2	IDA		Mouse	PMID:12176888
Biological Process	GO:0006935	chemotaxis	Rac2	IDA		Mouse	PMID:12176888
Biological Process	GO:0042742	defense response to bacterium	rac2	IMP	ZFIN:ZDB-GENO-170504-15	Zfish	PMID:27837107
Biological Process	GO:0050832	defense response to fungus	rac2	IMP	ZFIN:ZDB-GENO-170504-15	Zfish	PMID:27837107
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	Rac2	IGI	MGI:MGI:3040696	Mouse	PMID:21178006
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	Rac2	IGI	MGI:MGI:98923	Mouse	PMID:21178006
Biological Process	GO:0071593	lymphocyte aggregation	RAC2	IMP		Human	PMID:21167572
Biological Process	GO:0048246	macrophage chemotaxis	rac2	IMP	ZFIN:ZDB-GENO-170504-15	Zfish	PMID:27837107
Biological Process	GO:1905517	macrophage migration	rac2	IMP	ZFIN:ZDB-GENO-170504-15	Zfish	PMID:27837107
Biological Process	GO:0070662	mast cell proliferation	Rac2	IMP	MGI:MGI:1857701	Mouse	PMID:11435472
Biological Process	GO:0070662	mast cell proliferation	Rac2	IGI	MGI:MGI:97306	Mouse	PMID:11435472
Biological Process	GO:0030593	neutrophil chemotaxis	rac2	IGI	ZFIN:ZDB-GENE-030131-5415	Zfish	PMID:27837107
Biological Process	GO:0030593	neutrophil chemotaxis	rac2	IMP	ZFIN:ZDB-GENO-170504-15	Zfish	PMID:27837107
Biological Process	GO:0001780	neutrophil homeostasis	rac2	IMP	ZFIN:ZDB-GENO-120814-4	Zfish	PMID:22014524
Biological Process	GO:0002446	neutrophil mediated immunity	rac2	IMP	ZFIN:ZDB-GENO-120814-2	Zfish	PMID:22014524
Biological Process	GO:0002446	neutrophil mediated immunity	rac2	IMP	ZFIN:ZDB-MRPHLNO-111103-1	Zfish	PMID:22014524
Biological Process	GO:1990266	neutrophil migration	rac2	IMP	ZFIN:ZDB-GENO-170504-15	Zfish	PMID:27837107
Biological Process	GO:0010592	positive regulation of lamellipodium assembly	RAC2	IMP		Human	PMID:19625648
Biological Process	GO:0010592	positive regulation of lamellipodium assembly	Rac2	IMP		Mouse	MGI:MGI:4355276|PMID:19625648
Biological Process	GO:0070668	positive regulation of mast cell proliferation	Rac2	IGI	MGI:MGI:97306	Mouse	PMID:11435472
Biological Process	GO:0070668	positive regulation of mast cell proliferation	Rac2	IMP	MGI:MGI:1857701	Mouse	PMID:11435472
Biological Process	GO:0090023	positive regulation of neutrophil chemotaxis	RAC2	IMP		Human	PMID:19625648
Biological Process	GO:0090023	positive regulation of neutrophil chemotaxis	Rac2	IMP		Mouse	MGI:MGI:4355276|PMID:19625648
Biological Process	GO:2000391	positive regulation of neutrophil extravasation	rac2	IMP	ZFIN:ZDB-GENO-120814-4	Zfish	PMID:22014524
Biological Process	GO:1903955	positive regulation of protein targeting to mitochondrion	RAC2	HMP		Human	PMID:24270810
Biological Process	GO:0002572	pro-T cell differentiation	rac2	IMP	ZFIN:ZDB-MRPHLNO-201217-3,ZFIN:ZDB-MRPHLNO-111103-1	Zfish	PMID:32198141
Biological Process	GO:0010810	regulation of cell-substrate adhesion	RAC2	IMP		Human	PMID:21167572
Biological Process	GO:0032878	regulation of establishment or maintenance of cell polarity	rac2	IMP	ZFIN:ZDB-GENO-120814-6	Zfish	PMID:22014524
Biological Process	GO:0032878	regulation of establishment or maintenance of cell polarity	rac2	IMP	ZFIN:ZDB-GENO-120814-8	Zfish	PMID:22014524
Biological Process	GO:0002685	regulation of leukocyte migration	rac2	IMP	ZFIN:ZDB-GENO-120815-2	Zfish	PMID:22014524
Biological Process	GO:0060753	regulation of mast cell chemotaxis	Rac2	IMP		Mouse	MGI:MGI:3655336|PMID:10843388
Biological Process	GO:0043304	regulation of mast cell degranulation	Rac2	IMP		Mouse	MGI:MGI:3655336|PMID:10843388
Biological Process	GO:0090022	regulation of neutrophil chemotaxis	rac2	IGI	ZFIN:ZDB-GENO-180226-4	Zfish	PMID:28954734
Biological Process	GO:1902622	regulation of neutrophil migration	RAC2	IMP		Human	PMID:21167572
Biological Process	GO:0060263	regulation of respiratory burst	RAC2	IDA		Human	PMID:16636067
Biological Process	GO:0042129	regulation of T cell proliferation	Rac2	IMP		Mouse	MGI:MGI:3702218|PMID:11581314
Biological Process	GO:0009611	response to wounding	rac2	IMP	ZFIN:ZDB-MRPHLNO-111103-1	Zfish	PMID:22014524
Biological Process	GO:0009611	response to wounding	rac2	IMP	ZFIN:ZDB-GENO-120814-2	Zfish	PMID:22014524

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern