Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes RAC3
  • Mouse genes Rac3
  • Rat genes Rac3
  • Zfish genes rac3a,rac3b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Rac3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0048306	calcium-dependent protein binding	RAC3	IPI	UniProtKB:Q99828	Human	PMID:11756406
Molecular Function	GO:0003924	GTPase activity	RAC3	IDA		Human	PMID:11956649
Molecular Function	GO:0005515	protein binding	RAC3	IPI	UniProtKB:Q9UHY1	Human	PMID:11956649
Molecular Function	GO:0005515	protein binding	RAC3	IPI	UniProtKB:P03372	Human	PMID:21217774
Molecular Function	GO:0005515	protein binding	RAC3	IPI	UniProtKB:P53365	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RAC3	IPI	UniProtKB:Q8WUI4-6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RAC3	IPI	UniProtKB:Q9BYG5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Rac3	IPI	UniProtKB:Q99PT1	Mouse	MGI:MGI:3688344|PMID:15102471
Molecular Function	GO:0005515	protein binding	Rac3	IPI	MGI:MGI:2442401	Mouse	PMID:16525025
Molecular Function	GO:0005515	protein binding	Rac3	IPI	PR:A6X8Z5	Mouse	PMID:16525025
Cellular Component	GO:0071944	cell periphery	RAC3	IDA		Human	PMID:11756406
Cellular Component	GO:0005856	cytoskeleton	Rac3	IDA		Rat	PMID:16525025|RGD:8554233
Cellular Component	GO:0005829	cytosol	Rac3	IDA		Rat	PMID:16525025|RGD:8554233
Cellular Component	GO:0012505	endomembrane system	RAC3	IDA		Human	PMID:11956649
Cellular Component	GO:0070062	extracellular exosome	RAC3	HDA		Human	PMID:23533145
Cellular Component	GO:0031941	filamentous actin	RAC3	IDA		Human	PMID:16525025
Cellular Component	GO:0098978	glutamatergic synapse	RAC3	IDA		Human	PMID:21297961
Cellular Component	GO:0098978	glutamatergic synapse	RAC3	IMP		Human	PMID:21297961
Cellular Component	GO:0030426	growth cone	RAC3	IDA		Human	PMID:16525025
Cellular Component	GO:0030426	growth cone	Rac3	IDA		Rat	PMID:16525025|RGD:8554233
Cellular Component	GO:0043005	neuron projection	RAC3	IDA		Human	PMID:16525025
Cellular Component	GO:0043005	neuron projection	Rac3	IDA		Rat	PMID:16525025|RGD:8554233
Cellular Component	GO:0043025	neuronal cell body	RAC3	IDA		Human	PMID:16525025
Cellular Component	GO:0048471	perinuclear region of cytoplasm	RAC3	IDA		Human	PMID:11756406
Biological Process	GO:0030036	actin cytoskeleton organization	RAC3	IDA		Human	PMID:11956649
Biological Process	GO:0031032	actomyosin structure organization	rac3b	IMP	ZFIN:ZDB-GENO-200107-22	Zfish	PMID:29610331
Biological Process	GO:0031032	actomyosin structure organization	rac3b	IMP	ZFIN:ZDB-MRPHLNO-180824-2	Zfish	PMID:29610331
Biological Process	GO:0030031	cell projection assembly	RAC3	IDA		Human	PMID:11956649
Biological Process	GO:0021894	cerebral cortex GABAergic interneuron development	Rac3	IGI	MGI:MGI:97845	Mouse	PMID:23258346
Biological Process	GO:0048873	homeostasis of number of cells within a tissue	Rac3	IGI	MGI:MGI:97845	Mouse	PMID:23258346
Biological Process	GO:0050905	neuromuscular process	Rac3	IMP	MGI:MGI:3581887	Mouse	PMID:15964829
Biological Process	GO:0050885	neuromuscular process controlling balance	Rac3	IMP	MGI:MGI:3581887	Mouse	PMID:15964829
Biological Process	GO:0031175	neuron projection development	Rac3	IDA		Mouse	PMID:16525025
Biological Process	GO:0033630	positive regulation of cell adhesion mediated by integrin	RAC3	IDA		Human	PMID:11756406
Biological Process	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading	RAC3	IDA		Human	PMID:11756406
Biological Process	GO:0098974	postsynaptic actin cytoskeleton organization	RAC3	IDA		Human	PMID:21297961
Biological Process	GO:0098974	postsynaptic actin cytoskeleton organization	RAC3	IMP		Human	PMID:21297961
Biological Process	GO:0022604	regulation of cell morphogenesis	Rac3	IGI	MGI:MGI:97845	Mouse	PMID:23258346
Biological Process	GO:0014041	regulation of neuron maturation	Rac3	IGI	MGI:MGI:97845	Mouse	PMID:23258346
Biological Process	GO:0021654	rhombomere boundary formation	rac3b	IMP	ZFIN:ZDB-MRPHLNO-180824-2	Zfish	PMID:29610331
Biological Process	GO:0021654	rhombomere boundary formation	rac3b	IMP	ZFIN:ZDB-GENO-200107-22	Zfish	PMID:29610331
Biological Process	GO:0051932	synaptic transmission, GABAergic	Rac3	IGI	MGI:MGI:97845	Mouse	PMID:23258346
Biological Process	GO:0016055	Wnt signaling pathway	RAC3	IMP		Human	PMID:29276006

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern