Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes RACK1
  • Mouse genes Rack1
  • Rat genes Rack1
  • Zfish genes rack1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Rack1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0051434	BH3 domain binding	RACK1	IDA		Human	PMID:20541605
Molecular Function	GO:0045296	cadherin binding	RACK1	HDA		Human	PMID:25468996
Molecular Function	GO:0030332	cyclin binding	RACK1	IPI	UniProtKB:P78396	Human	PMID:15159402
Molecular Function	GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process	RACK1	IMP		Human	PMID:19767770
Molecular Function	GO:0019899	enzyme binding	RACK1	IPI	UniProtKB:Q08499-6	Human	PMID:20819076
Molecular Function	GO:0008200	ion channel inhibitor activity	Rack1	IDA		Mouse	MGI:MGI:3793387|PMID:18258429
Molecular Function	GO:0005515	protein binding	RACK1	IPI	UniProtKB:P03206	Human	PMID:10849009
Molecular Function	GO:0005515	protein binding	RACK1	IPI	UniProtKB:P48551	Human	PMID:11046044
Molecular Function	GO:0005515	protein binding	RACK1	IPI	UniProtKB:P00523	Human	PMID:11279199
Molecular Function	GO:0005515	protein binding	RACK1	IPI	UniProtKB:P03404	Human	PMID:11312657
Molecular Function	GO:0005515	protein binding	RACK1	IPI	UniProtKB:Q9Y561	Human	PMID:12809483
Molecular Function	GO:0005515	protein binding	RACK1	IPI	UniProtKB:P01112	Human	PMID:14500341
Molecular Function	GO:0005515	protein binding	RACK1	IPI	UniProtKB:P10275	Human	PMID:17108144
Molecular Function	GO:0005515	protein binding	RACK1	IPI	UniProtKB:Q8IVB4	Human	PMID:18057008
Molecular Function	GO:0005515	protein binding	RACK1	IPI	UniProtKB:Q92581	Human	PMID:18057008
Molecular Function	GO:0005515	protein binding	RACK1	IPI	UniProtKB:P22303	Human	PMID:18194455
Molecular Function	GO:0005515	protein binding	RACK1	IPI	UniProtKB:O43521	Human	PMID:18420585
Molecular Function	GO:0005515	protein binding	RACK1	IPI	UniProtKB:O54918-1	Human	PMID:18420585
Molecular Function	GO:0005515	protein binding	RACK1	IPI	UniProtKB:P63167	Human	PMID:18420585
Molecular Function	GO:0005515	protein binding	RACK1	IPI	UniProtKB:Q14899	Human	PMID:18816594
Molecular Function	GO:0005515	protein binding	RACK1	IPI	UniProtKB:Q96FW1	Human	PMID:18954305
Molecular Function	GO:0005515	protein binding	RACK1	IPI	UniProtKB:P21439	Human	PMID:19674157
Molecular Function	GO:0005515	protein binding	RACK1	IPI	UniProtKB:Q9P126	Human	PMID:19785988
Molecular Function	GO:0005515	protein binding	RACK1	IPI	UniProtKB:O75131	Human	PMID:20010870
Molecular Function	GO:0005515	protein binding	RACK1	IPI	UniProtKB:O75530	Human	PMID:20080539
Molecular Function	GO:0005515	protein binding	RACK1	IPI	UniProtKB:O75460	Human	PMID:20103773
Molecular Function	GO:0005515	protein binding	RACK1	IPI	UniProtKB:Q07812	Human	PMID:20541605
Molecular Function	GO:0005515	protein binding	RACK1	IPI	UniProtKB:Q07817	Human	PMID:20541605
Molecular Function	GO:0005515	protein binding	RACK1	IPI	UniProtKB:P40337	Human	PMID:20871634
Molecular Function	GO:0005515	protein binding	RACK1	IPI	UniProtKB:Q71RC2	Human	PMID:21098120
Molecular Function	GO:0005515	protein binding	RACK1	IPI	UniProtKB:Q08752	Human	PMID:21146485
Molecular Function	GO:0005515	protein binding	RACK1	IPI	UniProtKB:Q56935	Human	PMID:21347310
Molecular Function	GO:0005515	protein binding	RACK1	IPI	UniProtKB:Q9UKV8	Human	PMID:21525958
Molecular Function	GO:0005515	protein binding	RACK1	IPI	UniProtKB:Q0VD86	Human	PMID:21750715
Molecular Function	GO:0005515	protein binding	RACK1	IPI	UniProtKB:Q92615	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	RACK1	IPI	UniProtKB:O75928	Human	PMID:22210188
Molecular Function	GO:0005515	protein binding	RACK1	IPI	UniProtKB:Q9UKT8	Human	PMID:23651062
Molecular Function	GO:0005515	protein binding	RACK1	IPI	UniProtKB:P07948	Human	PMID:23866081
Molecular Function	GO:0005515	protein binding	RACK1	IPI	UniProtKB:Q9NWQ8	Human	PMID:23866081
Molecular Function	GO:0005515	protein binding	RACK1	IPI	UniProtKB:Q14940	Human	PMID:24006492
Molecular Function	GO:0005515	protein binding	RACK1	IPI	UniProtKB:Q99497	Human	PMID:24947010
Molecular Function	GO:0005515	protein binding	RACK1	IPI	UniProtKB:P35609	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	RACK1	IPI	UniProtKB:Q92615	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	RACK1	IPI	UniProtKB:Q9R1N3-2	Human	PMID:29743600
Molecular Function	GO:0005515	protein binding	RACK1	IPI	UniProtKB:O43309	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RACK1	IPI	UniProtKB:Q0P631	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RACK1	IPI	UniProtKB:Q13895	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RACK1	IPI	UniProtKB:Q14194	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RACK1	IPI	UniProtKB:Q14694	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RACK1	IPI	UniProtKB:Q70EL1-9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RACK1	IPI	UniProtKB:Q86UU5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RACK1	IPI	UniProtKB:Q86WP2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RACK1	IPI	UniProtKB:Q92615	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RACK1	IPI	UniProtKB:Q96B67	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RACK1	IPI	UniProtKB:Q9H000	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RACK1	IPI	UniProtKB:Q9NZN8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Rack1	IPI	UniProtKB:Q9BX84	Mouse	MGI:MGI:3793387|PMID:18258429
Molecular Function	GO:0005515	protein binding	Rack1	IPI	UniProtKB:O88351	Mouse	MGI:MGI:3688344|PMID:15102471
Molecular Function	GO:0005515	protein binding	Rack1	IPI	UniProtKB:Q91ZD4	Mouse	MGI:MGI:4939857|PMID:21262816
Molecular Function	GO:0005515	protein binding	Rack1	IPI	UniProtKB:Q99LX0	Mouse	MGI:MGI:5574514|PMID:24947010
Molecular Function	GO:0005515	protein binding	Rack1	IPI	UniProtKB:D4A7H1	Rat	PMID:21858920|RGD:155663534
Molecular Function	GO:0005515	protein binding	Rack1	IPI	RGD:619754	Rat	PMID:24007266|RGD:9588303
Molecular Function	GO:0042803	protein homodimerization activity	RACK1	IDA		Human	PMID:24947010
Molecular Function	GO:0005080	protein kinase C binding	RACK1	IDA		Human	PMID:11279199
Molecular Function	GO:0005080	protein kinase C binding	Rack1	IDA		Rat	PMID:8302854|RGD:68785
Molecular Function	GO:0019903	protein phosphatase binding	RACK1	IPI	UniProtKB:P28827	Human	PMID:11278757
Molecular Function	GO:0030292	protein tyrosine kinase inhibitor activity	RACK1	IDA		Human	PMID:9584165
Molecular Function	GO:0030971	receptor tyrosine kinase binding	RACK1	IDA		Human	PMID:9584165
Molecular Function	GO:0043022	ribosome binding	RACK1	IDA		Human	PMID:28132843
Molecular Function	GO:0003723	RNA binding	RACK1	HDA		Human	PMID:22658674
Molecular Function	GO:0003723	RNA binding	RACK1	HDA		Human	PMID:22681889
Molecular Function	GO:0042169	SH2 domain binding	RACK1	IDA		Human	PMID:11279199
Molecular Function	GO:0042169	SH2 domain binding	RACK1	IDA		Human	PMID:9584165
Molecular Function	GO:0035591	signaling adaptor activity	RACK1	IMP		Human	PMID:20103773
Cellular Component	GO:0044297	cell body	Rack1	IDA		Mouse	MGI:MGI:5574514|PMID:24947010
Cellular Component	GO:0005737	cytoplasm	RACK1	IDA		Human	PMID:10849009
Cellular Component	GO:0005737	cytoplasm	RACK1	IDA		Human	PMID:19785988
Cellular Component	GO:0005737	cytoplasm	RACK1	IDA		Human	PMID:29743600
Cellular Component	GO:0005737	cytoplasm	Rack1	IDA		Mouse	PMID:12826667
Cellular Component	GO:0005737	cytoplasm	rack1	IDA		Zfish	PMID:21262816
Cellular Component	GO:0005829	cytosol	RACK1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	RACK1	IMP		Human	PMID:19767770
Cellular Component	GO:0030425	dendrite	Rack1	IDA		Mouse	MGI:MGI:3616942|PMID:16414032
Cellular Component	GO:0070062	extracellular exosome	RACK1	HDA		Human	PMID:19056867
Cellular Component	GO:1990630	IRE1-RACK1-PP2A complex	RACK1	IDA		Human	PMID:20103773
Cellular Component	GO:0016020	membrane	Rack1	HDA		Rat	PMID:16210410|RGD:8655526
Cellular Component	GO:0030496	midbody	RACK1	IDA		Human	PMID:15166316
Cellular Component	GO:0005739	mitochondrion	RACK1	IMP		Human	PMID:19767770
Cellular Component	GO:0043005	neuron projection	Rack1	IDA		Mouse	MGI:MGI:5574514|PMID:24947010
Cellular Component	GO:0043025	neuronal cell body	Rack1	IDA		Mouse	PMID:16414032
Cellular Component	GO:0005654	nucleoplasm	RACK1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	RACK1	IDA		Human	PMID:10849009
Cellular Component	GO:0005634	nucleus	RACK1	IDA		Human	PMID:17108144
Cellular Component	GO:0048471	perinuclear region of cytoplasm	RACK1	IDA		Human	PMID:11279199
Cellular Component	GO:0001891	phagocytic cup	RACK1	IDA		Human	PMID:21347310
Cellular Component	GO:0015935	small ribosomal subunit	Rack1	IDA		Mouse	MGI:MGI:7432473|PMID:36517592
Cellular Component	GO:0015935	small ribosomal subunit	Rack1	IDA		Rat	PMID:15340087|RGD:8553695
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	RACK1	IMP		Human	PMID:19767770
Biological Process	GO:0001525	angiogenesis	rack1	IMP	ZFIN:ZDB-MRPHLNO-090824-17,ZFIN:ZDB-MRPHLNO-090824-18	Zfish	PMID:19389629
Biological Process	GO:0001525	angiogenesis	rack1	IMP	ZFIN:ZDB-MRPHLNO-090824-18	Zfish	PMID:19389629
Biological Process	GO:0001525	angiogenesis	rack1	IMP	ZFIN:ZDB-MRPHLNO-090824-17	Zfish	PMID:19389629
Biological Process	GO:0071333	cellular response to glucose stimulus	RACK1	IDA		Human	PMID:20103773
Biological Process	GO:0071363	cellular response to growth factor stimulus	RACK1	IDA		Human	PMID:20010870
Biological Process	GO:0060027	convergent extension involved in gastrulation	rack1	IGI	ZFIN:ZDB-MRPHLNO-041217-5,ZFIN:ZDB-MRPHLNO-110222-3	Zfish	PMID:21262816
Biological Process	GO:0060027	convergent extension involved in gastrulation	rack1	IMP	ZFIN:ZDB-MRPHLNO-110222-3	Zfish	PMID:21262816
Biological Process	GO:0030308	negative regulation of cell growth	RACK1	IDA		Human	PMID:9584165
Biological Process	GO:0010629	negative regulation of gene expression	RACK1	IMP		Human	PMID:19451233
Biological Process	GO:1903208	negative regulation of hydrogen peroxide-induced neuron death	RACK1	IGI	UniProtKB:Q99497	Human	PMID:24947010
Biological Process	GO:1903208	negative regulation of hydrogen peroxide-induced neuron death	Rack1	IGI	UniProtKB:Q99497	Mouse	MGI:MGI:5574514|PMID:24947010
Biological Process	GO:0033137	negative regulation of peptidyl-serine phosphorylation	RACK1	IMP		Human	PMID:20103773
Biological Process	GO:0050765	negative regulation of phagocytosis	RACK1	IMP		Human	PMID:21347310
Biological Process	GO:0032091	negative regulation of protein binding	RACK1	IDA		Human	PMID:20541605
Biological Process	GO:0051898	negative regulation of protein kinase B signaling	RACK1	IMP		Human	PMID:19767770
Biological Process	GO:0045879	negative regulation of smoothened signaling pathway	RACK1	IDA		Human	PMID:32467643
Biological Process	GO:0017148	negative regulation of translation	Rack1	IMP		Rat	PMID:15340087|RGD:8553695
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	rack1	IMP		Zfish	PMID:21262816|ZFIN:ZDB-PUB-110131-13
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	rack1	IMP	ZFIN:ZDB-MRPHLNO-110222-3	Zfish	PMID:21262816
Biological Process	GO:0001649	osteoblast differentiation	Rack1	HDA		Rat	PMID:16210410|RGD:8655526
Biological Process	GO:0043473	pigmentation	Rack1	IMP	MGI:MGI:5660834	Mouse	PMID:23212600
Biological Process	GO:0043065	positive regulation of apoptotic process	RACK1	IMP		Human	PMID:19767770
Biological Process	GO:0043065	positive regulation of apoptotic process	RACK1	IDA		Human	PMID:20541605
Biological Process	GO:0030335	positive regulation of cell migration	RACK1	IDA		Human	PMID:20499158
Biological Process	GO:0051343	positive regulation of cyclic-nucleotide phosphodiesterase activity	RACK1	IMP		Human	PMID:20819076
Biological Process	GO:2000543	positive regulation of gastrulation	rack1	IMP		Zfish	PMID:21262816|ZFIN:ZDB-PUB-110131-13
Biological Process	GO:0042998	positive regulation of Golgi to plasma membrane protein transport	RACK1	IMP		Human	PMID:19674157
Biological Process	GO:0043547	positive regulation of GTPase activity	RACK1	IDA		Human	PMID:20499158
Biological Process	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	RACK1	IMP		Human	PMID:19767770
Biological Process	GO:0051901	positive regulation of mitochondrial depolarization	RACK1	IMP		Human	PMID:19767770
Biological Process	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	RACK1	IDA		Human	PMID:19785988
Biological Process	GO:0001934	positive regulation of protein phosphorylation	RACK1	IDA		Human	PMID:11312657
Biological Process	GO:0001934	positive regulation of protein phosphorylation	RACK1	IDA		Human	PMID:17108144
Biological Process	GO:0031334	positive regulation of protein-containing complex assembly	RACK1	IDA		Human	PMID:20541605
Biological Process	GO:0016567	protein ubiquitination	RACK1	IMP		Human	PMID:28132843
Biological Process	GO:0051726	regulation of cell cycle	RACK1	IDA		Human	PMID:9584165
Biological Process	GO:0051302	regulation of cell division	rack1	IMP		Zfish	PMID:21262816|ZFIN:ZDB-PUB-110131-13
Biological Process	GO:0051302	regulation of cell division	rack1	IMP	ZFIN:ZDB-MRPHLNO-110222-3	Zfish	PMID:21262816
Biological Process	GO:2000114	regulation of establishment of cell polarity	rack1	IMP		Zfish	PMID:21262816|ZFIN:ZDB-PUB-110131-13
Biological Process	GO:2000114	regulation of establishment of cell polarity	rack1	IMP	ZFIN:ZDB-MRPHLNO-110222-3	Zfish	PMID:21262816
Biological Process	GO:0032880	regulation of protein localization	rack1	IMP		Zfish	PMID:21262816|ZFIN:ZDB-PUB-110131-13
Biological Process	GO:0032880	regulation of protein localization	rack1	IMP	ZFIN:ZDB-MRPHLNO-110222-3	Zfish	PMID:21262816
Biological Process	GO:1903076	regulation of protein localization to plasma membrane	Rack1	IMP		Rat	PMID:16797713|RGD:5131886
Biological Process	GO:0072344	rescue of stalled ribosome	RACK1	IMP		Human	PMID:28132843
Biological Process	GO:0006412	translation	Rack1	IMP	MGI:MGI:5660834	Mouse	PMID:23212600

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern