Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes RAD50
  • Mouse genes Rad50
  • Rat genes Rad50
  • Zfish genes rad50
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Rad50

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008408	3'-5' exonuclease activity	RAD50	IDA		Human	PMID:9705271
Molecular Function	GO:0003677	DNA binding	RAD50	IDA		Human	PMID:15790808
Molecular Function	GO:0003678	DNA helicase activity	RAD50	IMP		Human	PMID:15790808
Molecular Function	GO:0003690	double-stranded DNA binding	Rad50	IDA		Rat	PMID:21956462|RGD:9831191
Molecular Function	GO:0042802	identical protein binding	RAD50	IPI	UniProtKB:Q92878	Human	PMID:28134932
Molecular Function	GO:0005515	protein binding	RAD50	IPI	UniProtKB:Q6NUQ1	Human	PMID:11096100
Molecular Function	GO:0005515	protein binding	RAD50	IPI	UniProtKB:Q99708	Human	PMID:18716619
Molecular Function	GO:0005515	protein binding	RAD50	IPI	UniProtKB:O75943	Human	PMID:24534091
Molecular Function	GO:0005515	protein binding	RAD50	IPI	UniProtKB:P46100	Human	PMID:24651726
Molecular Function	GO:0005515	protein binding	RAD50	IPI	UniProtKB:Q61687	Human	PMID:24651726
Molecular Function	GO:0005515	protein binding	RAD50	IPI	UniProtKB:Q6NTE8	Human	PMID:27568553
Molecular Function	GO:0005515	protein binding	Rad50	IPI	UniProtKB:Q8BHZ5	Mouse	MGI:MGI:6202149|PMID:30017584
Molecular Function	GO:0005515	protein binding	Rad50	IPI	RGD:1309376	Rat	PMID:12615909|RGD:2300255
Molecular Function	GO:0044877	protein-containing complex binding	Rad50	IDA		Rat	PMID:18212738|RGD:2300253
Molecular Function	GO:0030674	protein-macromolecule adaptor activity	RAD50	IDA		Human	PMID:12152085
Molecular Function	GO:0000014	single-stranded DNA endodeoxyribonuclease activity	RAD50	IDA		Human	PMID:9705271
Cellular Component	GO:0070533	BRCA1-C complex	RAD50	IPI		Human	PMID:16391231
Cellular Component	GO:0000785	chromatin	Rad50	IDA		Rat	PMID:10855503|RGD:2300257
Cellular Component	GO:0000781	chromosome, telomeric region	RAD50	IDA		Human	PMID:24270157
Cellular Component	GO:0000781	chromosome, telomeric region	RAD50	IDA		Human	PMID:10888888
Cellular Component	GO:0000781	chromosome, telomeric region	RAD50	HDA		Human	PMID:19135898
Cellular Component	GO:0000794	condensed nuclear chromosome	Rad50	IDA		Rat	PMID:10855503|RGD:2300257
Cellular Component	GO:0016234	inclusion body	Rad50	IDA		Rat	PMID:18212738|RGD:2300253
Cellular Component	GO:0016020	membrane	RAD50	HDA		Human	PMID:19946888
Cellular Component	GO:0030870	Mre11 complex	RAD50	IPI		Human	PMID:31147924
Cellular Component	GO:0030870	Mre11 complex	RAD50	IDA		Human	PMID:10888888
Cellular Component	GO:0030870	Mre11 complex	RAD50	IDA		Human	PMID:19151086
Cellular Component	GO:0030870	Mre11 complex	RAD50	IDA		Human	PMID:9590181
Cellular Component	GO:0005654	nucleoplasm	Rad50	IDA		Rat	PMID:18212738|RGD:2300253
Cellular Component	GO:0005634	nucleus	Rad50	IDA		Mouse	PMID:17982445
Cellular Component	GO:0005634	nucleus	Rad50	IDA		Mouse	PMID:19001091
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Rad50	IDA		Rat	PMID:18212738|RGD:2300253
Cellular Component	GO:0045120	pronucleus	Rad50	IDA		Mouse	PMID:17982445
Cellular Component	GO:0035861	site of double-strand break	RAD50	IDA		Human	PMID:15916964
Biological Process	GO:0051276	chromosome organization	Rad50	IMP	MGI:MGI:2387852	Mouse	PMID:19001091
Biological Process	GO:0051276	chromosome organization	Rad50	IMP	MGI:MGI:3832533	Mouse	PMID:19001091
Biological Process	GO:0070192	chromosome organization involved in meiotic cell cycle	Rad50	IMP	MGI:MGI:2387852	Mouse	PMID:19001091
Biological Process	GO:0006974	DNA damage response	RAD50	IDA		Human	PMID:17500065
Biological Process	GO:0006974	DNA damage response	Rad50	IEP		Rat	PMID:11056294|RGD:727220
Biological Process	GO:0032508	DNA duplex unwinding	RAD50	IMP		Human	PMID:15790808
Biological Process	GO:0006310	DNA recombination	RAD50	IDA		Human	PMID:9705271
Biological Process	GO:0006281	DNA repair	RAD50	IDA		Human	PMID:9705271
Biological Process	GO:0006302	double-strand break repair	RAD50	IMP		Human	PMID:9590181
Biological Process	GO:0007507	heart development	Rad50	IEP		Rat	PMID:10908350|RGD:68816
Biological Process	GO:1904354	negative regulation of telomere capping	RAD50	IDA		Human	PMID:17694070
Biological Process	GO:0046597	negative regulation of viral entry into host cell	Rad50	IMP		Rat	PMID:22850678|RGD:8693392
Biological Process	GO:0033674	positive regulation of kinase activity	RAD50	IDA		Human	PMID:15790808
Biological Process	GO:0031954	positive regulation of protein autophosphorylation	RAD50	IDA		Human	PMID:15790808
Biological Process	GO:0032206	positive regulation of telomere maintenance	RAD50	IMP		Human	PMID:16374507
Biological Process	GO:0007346	regulation of mitotic cell cycle	Rad50	IMP	MGI:MGI:2387852	Mouse	PMID:19001091
Biological Process	GO:0007346	regulation of mitotic cell cycle	Rad50	IMP	MGI:MGI:3832533	Mouse	PMID:19001091
Biological Process	GO:0000019	regulation of mitotic recombination	RAD50	IDA		Human	PMID:8756642
Biological Process	GO:0044752	response to human chorionic gonadotropin	Rad50	IEP		Rat	PMID:23239112|RGD:9831388
Biological Process	GO:0007004	telomere maintenance via telomerase	RAD50	IDA		Human	PMID:9705271
Biological Process	GO:0031860	telomeric 3' overhang formation	RAD50	IMP		Human	PMID:16374507

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern