Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes RAG1
  • Mouse genes Rag1
  • Rat genes Rag1
  • Zfish genes rag1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Rag1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:1990238	double-stranded DNA endonuclease activity	rag1	IGI	ZFIN:ZDB-GENE-990415-235	Zfish	PMID:30061602
Molecular Function	GO:0004519	endonuclease activity	Rag1	IMP		Mouse	MGI:MGI:4441118|PMID:19396172
Molecular Function	GO:0004519	endonuclease activity	Rag1	IMP		Mouse	MGI:MGI:4441148|PMID:10601033
Molecular Function	GO:0042393	histone binding	Rag1	IDA		Mouse	MGI:MGI:4441018|PMID:20122409
Molecular Function	GO:0042802	identical protein binding	Rag1	IPI	UniProtKB:P15919	Mouse	MGI:MGI:5914716|PMID:21149691
Molecular Function	GO:0042802	identical protein binding	Rag1	IPI	UniProtKB:P15919	Mouse	MGI:MGI:4441118|PMID:19396172
Molecular Function	GO:0000287	magnesium ion binding	rag1	IDA		Zfish	PMID:26548953
Molecular Function	GO:0046872	metal ion binding	Rag1	IMP		Mouse	MGI:MGI:4441148|PMID:10601033
Molecular Function	GO:0005515	protein binding	RAG1	IPI	UniProtKB:P16333	Human	PMID:17474147
Molecular Function	GO:0005515	protein binding	Rag1	IPI	UniProtKB:P21784	Mouse	MGI:MGI:4441118|PMID:19396172
Molecular Function	GO:0005515	protein binding	Rag1	IPI	UniProtKB:P21784	Mouse	MGI:MGI:5919821|PMID:25707801
Molecular Function	GO:0005515	protein binding	Rag1	IPI	UniProtKB:P21784	Mouse	MGI:MGI:5914716|PMID:21149691
Molecular Function	GO:0005515	protein binding	Rag1	IPI	PR:Q9JL60	Mouse	PMID:19324890
Molecular Function	GO:0005515	protein binding	Rag1	IPI	MGI:MGI:104912	Mouse	PMID:19324890
Molecular Function	GO:0005515	protein binding	Rag1	IPI	PR:P52293	Mouse	PMID:19324890
Molecular Function	GO:0005515	protein binding	rag1	IPI	ZFIN:ZDB-GENE-990415-234,ZFIN:ZDB-GENE-990415-235	Zfish	PMID:26548953
Molecular Function	GO:0042803	protein homodimerization activity	Rag1	IDA		Mouse	MGI:MGI:4442154|PMID:9228952
Molecular Function	GO:0042803	protein homodimerization activity	Rag1	IDA		Mouse	MGI:MGI:4441118|PMID:19396172
Molecular Function	GO:0043565	sequence-specific DNA binding	Rag1	IDA		Mouse	MGI:MGI:4441118|PMID:19396172
Molecular Function	GO:0043565	sequence-specific DNA binding	Rag1	IMP		Mouse	MGI:MGI:4441148|PMID:10601033
Molecular Function	GO:0043565	sequence-specific DNA binding	rag1	IPI	ZFIN:ZDB-GENE-990415-234,ZFIN:ZDB-GENE-990415-235	Zfish	PMID:26548953
Molecular Function	GO:0061630	ubiquitin protein ligase activity	Rag1	IDA		Mouse	PMID:20122409
Molecular Function	GO:0061630	ubiquitin protein ligase activity	Rag1	IDA		Mouse	PMID:14671314
Molecular Function	GO:0061630	ubiquitin protein ligase activity	Rag1	IDA		Mouse	PMID:12629039
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	Rag1	IDA		Mouse	MGI:MGI:4441135|PMID:12629039
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	Rag1	IDA		Mouse	MGI:MGI:4441018|PMID:20122409
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	Rag1	IDA		Mouse	MGI:MGI:3029666|PMID:14671314
Molecular Function	GO:0008270	zinc ion binding	Rag1	IDA		Mouse	MGI:MGI:4442154|PMID:9228952
Cellular Component	GO:0097519	DNA recombinase complex	rag1	IPI	ZFIN:ZDB-GENE-990415-234,ZFIN:ZDB-GENE-990415-235	Zfish	PMID:26548953
Cellular Component	GO:1905347	endodeoxyribonuclease complex	rag1	IPI	ZFIN:ZDB-GENE-990415-235	Zfish	PMID:30061602
Cellular Component	GO:0005634	nucleus	Rag1	IDA		Mouse	MGI:MGI:64624|PMID:8284210
Biological Process	GO:0002250	adaptive immune response	Rag1	IMP	MGI:MGI:1857241	Mouse	PMID:22801499
Biological Process	GO:0030183	B cell differentiation	Rag1	IMP		Mouse	MGI:MGI:50458|PMID:1547488
Biological Process	GO:0030183	B cell differentiation	Rag1	IDA		Mouse	PMID:11976687
Biological Process	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	Rag1	IMP		Mouse	PMID:15728238
Biological Process	GO:0070233	negative regulation of T cell apoptotic process	Rag1	IGI	MGI:MGI:1353616	Mouse	PMID:18684012
Biological Process	GO:0070244	negative regulation of thymocyte apoptotic process	Rag1	IMP		Mouse	PMID:15728238
Biological Process	GO:0045582	positive regulation of T cell differentiation	Rag1	IMP		Mouse	MGI:MGI:50458|PMID:1547488
Biological Process	GO:0002331	pre-B cell allelic exclusion	Rag1	IMP		Mouse	MGI:MGI:3848557|PMID:19448632
Biological Process	GO:0051865	protein autoubiquitination	Rag1	IDA		Mouse	MGI:MGI:3029666|PMID:14671314
Biological Process	GO:0065004	protein-DNA complex assembly	rag1	IPI	ZFIN:ZDB-GENE-990415-234,ZFIN:ZDB-GENE-990415-235	Zfish	PMID:26548953
Biological Process	GO:2000822	regulation of behavioral fear response	Rag1	IMP		Rat	PMID:22964459|RGD:12907572
Biological Process	GO:0045580	regulation of T cell differentiation	Rag1	IGI	MGI:MGI:1353616	Mouse	PMID:18684012
Biological Process	GO:0002562	somatic diversification of immune receptors via germline recombination within a single locus	rag1	IMP	ZFIN:ZDB-GENO-100426-2	Zfish	PMID:28790360
Biological Process	GO:0033077	T cell differentiation in thymus	Rag1	IMP		Mouse	MGI:MGI:50458|PMID:1547488
Biological Process	GO:0033077	T cell differentiation in thymus	Rag1	IMP	MGI:MGI:2448994	Mouse	PMID:9215624
Biological Process	GO:0043029	T cell homeostasis	Rag1	IGI	MGI:MGI:1353616	Mouse	PMID:18684012
Biological Process	GO:0048538	thymus development	Rag1	IGI	MGI:MGI:1353616	Mouse	PMID:18684012
Biological Process	GO:0033151	V(D)J recombination	RAG1	IMP		Human	PMID:14670978
Biological Process	GO:0033151	V(D)J recombination	Rag1	IMP		Mouse	MGI:MGI:4441018|PMID:20122409
Biological Process	GO:0033151	V(D)J recombination	Rag1	IMP		Mouse	MGI:MGI:50458|PMID:1547488
Biological Process	GO:0033151	V(D)J recombination	Rag1	IMP		Mouse	MGI:MGI:64624|PMID:8284210
Biological Process	GO:0033151	V(D)J recombination	Rag1	IMP		Mouse	MGI:MGI:4441148|PMID:10601033
Biological Process	GO:0033151	V(D)J recombination	Rag1	IGI	MGI:MGI:97849	Mouse	PMID:2360047
Biological Process	GO:0033151	V(D)J recombination	rag1	IPI	ZFIN:ZDB-GENE-990415-234,ZFIN:ZDB-GENE-990415-235	Zfish	PMID:26548953
Biological Process	GO:0033151	V(D)J recombination	rag1	IPI	ZFIN:ZDB-GENE-990415-235	Zfish	PMID:30061602
Biological Process	GO:0008542	visual learning	Rag1	IMP		Rat	PMID:22964459|RGD:12907572

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern