Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes RAG2
  • Mouse genes Rag2
  • Rat genes Rag2
  • Zfish genes rag2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Rag2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	Rag2	IDA		Mouse	MGI:MGI:4441253|PMID:18025461
Molecular Function	GO:0003682	chromatin binding	Rag2	IDA		Mouse	MGI:MGI:4441252|PMID:18033247
Molecular Function	GO:1990238	double-stranded DNA endonuclease activity	rag2	IGI	ZFIN:ZDB-GENE-990415-234	Zfish	PMID:30061602
Molecular Function	GO:0035064	methylated histone binding	Rag2	IDA		Mouse	MGI:MGI:4441253|PMID:18025461
Molecular Function	GO:0035064	methylated histone binding	Rag2	IDA		Mouse	MGI:MGI:4441252|PMID:18033247
Molecular Function	GO:0035091	phosphatidylinositol binding	Rag2	IDA		Mouse	MGI:MGI:4441252|PMID:18033247
Molecular Function	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding	Rag2	IDA		Mouse	MGI:MGI:4441271|PMID:15964836
Molecular Function	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding	Rag2	IDA		Mouse	MGI:MGI:4441271|PMID:15964836
Molecular Function	GO:0080025	phosphatidylinositol-3,5-bisphosphate binding	Rag2	IDA		Mouse	MGI:MGI:4441271|PMID:15964836
Molecular Function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	Rag2	IDA		Mouse	MGI:MGI:4441271|PMID:15964836
Molecular Function	GO:0005515	protein binding	Rag2	IPI	UniProtKB:P15919	Mouse	MGI:MGI:5919821|PMID:25707801
Molecular Function	GO:0005515	protein binding	Rag2	IPI	UniProtKB:P15919	Mouse	MGI:MGI:4441118|PMID:19396172
Molecular Function	GO:0005515	protein binding	Rag2	IPI	UniProtKB:P15919	Mouse	MGI:MGI:5914716|PMID:21149691
Molecular Function	GO:0005515	protein binding	rag2	IPI	ZFIN:ZDB-GENE-990415-234,ZFIN:ZDB-GENE-990415-235	Zfish	PMID:26548953
Molecular Function	GO:0043565	sequence-specific DNA binding	rag2	IPI	ZFIN:ZDB-GENE-990415-234,ZFIN:ZDB-GENE-990415-235	Zfish	PMID:26548953
Molecular Function	GO:0008270	zinc ion binding	Rag2	IDA		Mouse	MGI:MGI:4441252|PMID:18033247
Molecular Function	GO:0008270	zinc ion binding	Rag2	IDA		Mouse	MGI:MGI:4441253|PMID:18025461
Molecular Function	GO:0008270	zinc ion binding	Rag2	IDA		Mouse	MGI:MGI:4441271|PMID:15964836
Cellular Component	GO:0097519	DNA recombinase complex	rag2	IPI	ZFIN:ZDB-GENE-990415-234,ZFIN:ZDB-GENE-990415-235	Zfish	PMID:26548953
Cellular Component	GO:1905347	endodeoxyribonuclease complex	rag2	IPI	ZFIN:ZDB-GENE-990415-234	Zfish	PMID:30061602
Biological Process	GO:0030183	B cell differentiation	Rag2	IMP		Mouse	MGI:MGI:50458|PMID:1547488
Biological Process	GO:0030183	B cell differentiation	Rag2	IMP		Mouse	MGI:MGI:50459|PMID:1547487
Biological Process	GO:0030183	B cell differentiation	Rag2	IMP	MGI:MGI:1858556	Mouse	PMID:11980719
Biological Process	GO:0030183	B cell differentiation	Rag2	IMP	MGI:MGI:1858556	Mouse	PMID:14595002
Biological Process	GO:0002358	B cell homeostatic proliferation	Rag2	IMP	MGI:MGI:1858556	Mouse	PMID:9052834
Biological Process	GO:0002326	B cell lineage commitment	Rag2	IMP	MGI:MGI:1858556	Mouse	PMID:8788039
Biological Process	GO:0042742	defense response to bacterium	Rag2	IGI	MGI:MGI:1342279	Mouse	PMID:14766966
Biological Process	GO:1904155	DN2 thymocyte differentiation	Rag2	IMP	MGI:MGI:1858556	Mouse	PMID:9875844
Biological Process	GO:0048534	hematopoietic or lymphoid organ development	rag2	IMP	ZFIN:ZDB-GENO-150115-3	Zfish	PMID:25042784
Biological Process	GO:0033152	immunoglobulin V(D)J recombination	rag2	IDA		Zfish	PMID:32139788
Biological Process	GO:0030098	lymphocyte differentiation	rag2	IMP	ZFIN:ZDB-GENO-150115-3	Zfish	PMID:25042784
Biological Process	GO:0002313	mature B cell differentiation involved in immune response	Rag2	IMP		Rat	PMID:30206106|RGD:38508903
Biological Process	GO:0033085	negative regulation of T cell differentiation in thymus	Rag2	IMP		Rat	PMID:30206106|RGD:38508903
Biological Process	GO:0035265	organ growth	Rag2	IMP		Mouse	PMID:9252127
Biological Process	GO:0035265	organ growth	Rag2	IGI	MGI:MGI:96561	Mouse	PMID:9252127
Biological Process	GO:0046622	positive regulation of organ growth	Rag2	IGI	MGI:MGI:96561	Mouse	PMID:9252127
Biological Process	GO:0046622	positive regulation of organ growth	Rag2	IMP		Mouse	PMID:9252127
Biological Process	GO:0002331	pre-B cell allelic exclusion	Rag2	IMP		Mouse	MGI:MGI:3848557|PMID:19448632
Biological Process	GO:0065004	protein-DNA complex assembly	rag2	IPI	ZFIN:ZDB-GENE-990415-234,ZFIN:ZDB-GENE-990415-235	Zfish	PMID:26548953
Biological Process	GO:0030217	T cell differentiation	Rag2	IMP	MGI:MGI:1858556	Mouse	PMID:14595002
Biological Process	GO:0030217	T cell differentiation	Rag2	IMP	MGI:MGI:1858556	Mouse	PMID:11980719
Biological Process	GO:0030217	T cell differentiation	rag2	IMP	ZFIN:ZDB-GENO-150115-3	Zfish	PMID:27810924
Biological Process	GO:0033077	T cell differentiation in thymus	Rag2	IMP		Mouse	MGI:MGI:50458|PMID:1547488
Biological Process	GO:0002360	T cell lineage commitment	Rag2	IMP	MGI:MGI:1858556	Mouse	PMID:8788039
Biological Process	GO:0048538	thymus development	rag2	IMP	ZFIN:ZDB-GENO-150115-3	Zfish	PMID:25042784
Biological Process	GO:0033151	V(D)J recombination	Rag2	IMP		Mouse	MGI:MGI:50458|PMID:1547488
Biological Process	GO:0033151	V(D)J recombination	Rag2	IMP		Mouse	MGI:MGI:4441252|PMID:18033247
Biological Process	GO:0033151	V(D)J recombination	Rag2	IGI	MGI:MGI:97848	Mouse	PMID:2360047
Biological Process	GO:0033151	V(D)J recombination	rag2	IPI	ZFIN:ZDB-GENE-990415-234,ZFIN:ZDB-GENE-990415-235	Zfish	PMID:26548953
Biological Process	GO:0033151	V(D)J recombination	rag2	IPI	ZFIN:ZDB-GENE-990415-234	Zfish	PMID:30061602

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern