Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes RALA
  • Mouse genes Rala
  • Rat genes Rala
  • Zfish genes ralaa,ralab
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Rala

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0051117	ATPase binding	RALA	IPI	UniProtKB:Q15311	Human	PMID:24056301
Molecular Function	GO:0031755	Edg-2 lysophosphatidic acid receptor binding	RALA	IDA		Human	PMID:19306925
Molecular Function	GO:0019003	GDP binding	RALA	IDA		Human	PMID:24056301
Molecular Function	GO:0005525	GTP binding	RALA	IDA		Human	PMID:24056301
Molecular Function	GO:0003924	GTPase activity	RALA	IMP		Human	PMID:30500825
Molecular Function	GO:0003924	GTPase activity	Rala	EXP		Mouse	MGI:MGI:5770072|PMID:17765682
Molecular Function	GO:0003924	GTPase activity	Rala	EXP		Mouse	MGI:MGI:5317053|PMID:21148297
Molecular Function	GO:0017022	myosin binding	RALA	IPI	UniProtKB:O00159	Human	PMID:24056301
Molecular Function	GO:0005515	protein binding	RALA	IPI	UniProtKB:P21333	Human	PMID:10051605
Molecular Function	GO:0005515	protein binding	RALA	IPI	UniProtKB:O54921	Human	PMID:12839989
Molecular Function	GO:0005515	protein binding	RALA	IPI	UniProtKB:P21333	Human	PMID:16291724
Molecular Function	GO:0005515	protein binding	RALA	IPI	UniProtKB:P30154	Human	PMID:17540176
Molecular Function	GO:0005515	protein binding	RALA	IPI	UniProtKB:P01112	Human	PMID:19222999
Molecular Function	GO:0005515	protein binding	RALA	IPI	UniProtKB:P25098	Human	PMID:19306925
Molecular Function	GO:0005515	protein binding	RALA	IPI	UniProtKB:Q92633	Human	PMID:19306925
Molecular Function	GO:0005515	protein binding	RALA	IPI	UniProtKB:Q9HBW0	Human	PMID:19306925
Molecular Function	GO:0005515	protein binding	RALA	IPI	UniProtKB:O54921	Human	PMID:21241894
Molecular Function	GO:0005515	protein binding	RALA	IPI	UniProtKB:Q15311	Human	PMID:21822277
Molecular Function	GO:0005515	protein binding	RALA	IPI	UniProtKB:O00471	Human	PMID:24056301
Molecular Function	GO:0005515	protein binding	RALA	IPI	UniProtKB:Q8IYI6	Human	PMID:24056301
Molecular Function	GO:0005515	protein binding	RALA	IPI	UniProtKB:Q8WWB5	Human	PMID:24056301
Molecular Function	GO:0005515	protein binding	RALA	IPI	UniProtKB:Q96A65	Human	PMID:24056301
Molecular Function	GO:0005515	protein binding	RALA	IPI	UniProtKB:Q96KP1	Human	PMID:24056301
Molecular Function	GO:0005515	protein binding	RALA	IPI	UniProtKB:Q9BZG1	Human	PMID:24056301
Molecular Function	GO:0005515	protein binding	RALA	IPI	UniProtKB:Q9Y333	Human	PMID:24056301
Molecular Function	GO:0005515	protein binding	RALA	IPI	UniProtKB:Q15311	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	RALA	IPI	UniProtKB:Q15311	Human	PMID:28851898
Molecular Function	GO:0005515	protein binding	RALA	IPI	UniProtKB:P01112	Human	PMID:30194290
Molecular Function	GO:0005515	protein binding	RALA	IPI	UniProtKB:Q15311	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	RALA	IPI	UniProtKB:Q15311	Human	PMID:7673236
Molecular Function	GO:0005515	protein binding	Rala	IPI	UniProtKB:Q62172	Mouse	MGI:MGI:1195509|PMID:8570186
Molecular Function	GO:0005515	protein binding	Rala	IPI	UniProtKB:P23298	Mouse	MGI:MGI:5306545|PMID:21346190
Molecular Function	GO:0005515	protein binding	Rala	IPI	PR:O35382	Mouse	PMID:21148297
Molecular Function	GO:0005515	protein binding	Rala	IPI	PR:P62835	Mouse	PMID:14712229
Molecular Function	GO:0005515	protein binding	Rala	IPI	PR:O35250	Mouse	PMID:21148297
Molecular Function	GO:0005515	protein binding	Rala	IPI	UniProtKB:Q62796	Rat	PMID:7623849|RGD:633902
Molecular Function	GO:0031625	ubiquitin protein ligase binding	RALA	IPI	UniProtKB:Q8TEY7	Human	PMID:24056301
Molecular Function	GO:0031625	ubiquitin protein ligase binding	RALA	IPI	UniProtKB:Q9H4P4	Human	PMID:24056301
Cellular Component	GO:0009986	cell surface	RALA	IDA		Human	PMID:19306925
Cellular Component	GO:0032154	cleavage furrow	RALA	IDA		Human	PMID:18756269
Cellular Component	GO:0030139	endocytic vesicle	RALA	IDA		Human	PMID:19306925
Cellular Component	GO:0070062	extracellular exosome	RALA	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	RALA	HDA		Human	PMID:19199708
Cellular Component	GO:0070062	extracellular exosome	RALA	HDA		Human	PMID:20458337
Cellular Component	GO:0070062	extracellular exosome	RALA	HDA		Human	PMID:23533145
Cellular Component	GO:0005925	focal adhesion	RALA	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005925	focal adhesion	RALA	HDA		Human	PMID:21423176
Cellular Component	GO:0005739	mitochondrion	RALA	IDA		Human	PMID:21822277
Cellular Component	GO:0043209	myelin sheath	Rala	HDA		Mouse	MGI:MGI:3834050|PMID:17634366
Cellular Component	GO:0005886	plasma membrane	RALA	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	RALA	IDA		Human	PMID:17875936
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	Rala	EXP		Rat	PMID:19823667|RGD:2324918
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	Rala	IDA		Rat	PMID:19823667|RGD:2324918
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	Rala	IMP		Rat	PMID:19823667|RGD:2324918
Cellular Component	GO:0097060	synaptic membrane	Rala	IDA		Rat	PMID:19823667|RGD:2324918
Biological Process	GO:0031532	actin cytoskeleton reorganization	RALA	IDA		Human	PMID:10051605
Biological Process	GO:0072655	establishment of protein localization to mitochondrion	RALA	IMP		Human	PMID:21822277
Biological Process	GO:0051665	membrane raft localization	RALA	IDA		Human	PMID:20005108
Biological Process	GO:0051665	membrane raft localization	Rala	IDA		Mouse	MGI:MGI:4421258|PMID:20005108
Biological Process	GO:0001843	neural tube closure	Rala	IMP		Mouse	MGI:MGI:5504565|PMID:23063435
Biological Process	GO:0045742	positive regulation of epidermal growth factor receptor signaling pathway	RALA	IGI	UniProtKB:P11234	Human	PMID:34096503
Biological Process	GO:0051491	positive regulation of filopodium assembly	RALA	IDA		Human	PMID:10051605
Biological Process	GO:0090141	positive regulation of mitochondrial fission	RALA	IMP		Human	PMID:21822277
Biological Process	GO:0007265	Ras protein signal transduction	RALA	IMP		Human	PMID:30500825
Biological Process	GO:0031623	receptor internalization	RALA	IGI	UniProtKB:P11234	Human	PMID:34096503
Biological Process	GO:0017157	regulation of exocytosis	RALA	IDA		Human	PMID:20005108
Biological Process	GO:0017157	regulation of exocytosis	Rala	IDA		Mouse	MGI:MGI:4421258|PMID:20005108
Biological Process	GO:0099149	regulation of postsynaptic neurotransmitter receptor internalization	Rala	EXP		Rat	PMID:19823667|RGD:2324918
Biological Process	GO:0099149	regulation of postsynaptic neurotransmitter receptor internalization	Rala	IDA		Rat	PMID:19823667|RGD:2324918
Biological Process	GO:0099149	regulation of postsynaptic neurotransmitter receptor internalization	Rala	IMP		Rat	PMID:19823667|RGD:2324918

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern