Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes RAP1B,RAP1BL
  • Mouse genes Rap1b
  • Rat genes Rap1b
  • Zfish genes rap1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Rap1b

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003925	G protein activity	Rap1b	IDA		Mouse	PMID:11056535
Molecular Function	GO:0019003	GDP binding	RAP1B	IDA		Human	PMID:18309292
Molecular Function	GO:0005525	GTP binding	RAP1B	IDA		Human	PMID:18309292
Molecular Function	GO:0003924	GTPase activity	RAP1B	IDA		Human	PMID:18309292
Molecular Function	GO:0004708	MAP kinase kinase activity	rap1b	IGI	ZFIN:ZDB-MRPHLNO-070519-1,ZFIN:ZDB-MRPHLNO-070519-2	Zfish	PMID:26280580
Molecular Function	GO:0004708	MAP kinase kinase activity	rap1b	IGI	ZFIN:ZDB-MRPHLNO-070519-1,ZFIN:ZDB-MRPHLNO-070519-2,ZFIN:ZDB-MRPHLNO-151208-5	Zfish	PMID:26280580
Molecular Function	GO:0005515	protein binding	RAP1B	IPI	UniProtKB:Q9EQZ6-3	Human	PMID:16452984
Molecular Function	GO:0005515	protein binding	RAP1B	IPI	UniProtKB:P47736	Human	PMID:18309292
Molecular Function	GO:0005515	protein binding	RAP1B	IPI	UniProtKB:Q9EQZ6	Human	PMID:18660803
Molecular Function	GO:0005515	protein binding	RAP1B	IPI	UniProtKB:Q9EQZ6-3	Human	PMID:18660803
Molecular Function	GO:0005515	protein binding	RAP1B	IPI	UniProtKB:Q12967	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	RAP1B	IPI	UniProtKB:Q12967	Human	PMID:22705156
Molecular Function	GO:0005515	protein binding	RAP1B	IPI	UniProtKB:P52306	Human	PMID:24415755
Molecular Function	GO:0005515	protein binding	RAP1B	IPI	UniProtKB:Q8WWW0	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	RAP1B	IPI	UniProtKB:Q5U651	Human	PMID:26780829
Molecular Function	GO:0005515	protein binding	RAP1B	IPI	UniProtKB:Q12967-6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RAP1B	IPI	UniProtKB:Q5JR59-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RAP1B	IPI	UniProtKB:P27797	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	RAP1B	IPI	UniProtKB:P36957	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	RAP1B	IPI	UniProtKB:Q8TDX7	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Rap1b	IPI	PR:Q99N57	Mouse	PMID:14712229
Molecular Function	GO:0044877	protein-containing complex binding	RAP1B	IDA		Human	PMID:23209302
Cellular Component	GO:0005911	cell-cell junction	RAP1B	IDA		Human	PMID:20332120
Cellular Component	GO:0005911	cell-cell junction	rap1b	IMP	ZFIN:ZDB-MRPHLNO-090826-11	Zfish	PMID:19093037
Cellular Component	GO:0005829	cytosol	RAP1B	IDA		Human	PMID:18582561
Cellular Component	GO:0070062	extracellular exosome	RAP1B	HDA		Human	PMID:19199708
Cellular Component	GO:0070062	extracellular exosome	RAP1B	HDA		Human	PMID:20458337
Cellular Component	GO:0098978	glutamatergic synapse	Rap1b	IMP		Mouse	PMID:26844834
Cellular Component	GO:0098978	glutamatergic synapse	Rap1b	IDA		Mouse	PMID:26844834
Cellular Component	GO:0005811	lipid droplet	RAP1B	IDA		Human	PMID:14741744
Biological Process	GO:0017156	calcium-ion regulated exocytosis	Rap1b	IGI	MGI:MGI:97852	Mouse	PMID:23616533
Biological Process	GO:0060536	cartilage morphogenesis	rap1b	IGI	ZFIN:ZDB-MRPHLNO-070519-1,ZFIN:ZDB-MRPHLNO-070519-2	Zfish	PMID:26280580
Biological Process	GO:0008283	cell population proliferation	Rap1b	IPI	UniProtKB:Q91ZZ2	Mouse	PMID:14712229
Biological Process	GO:0008283	cell population proliferation	Rap1b	IPI	UniProtKB:Q8VCC8	Mouse	PMID:14712229
Biological Process	GO:0071320	cellular response to cAMP	RAP1B	IDA		Human	PMID:21840392
Biological Process	GO:0097211	cellular response to gonadotropin-releasing hormone	Rap1b	IEP		Rat	PMID:22127306|RGD:10041018
Biological Process	GO:0071407	cellular response to organic cyclic compound	Rap1b	IDA		Rat	PMID:10908723|RGD:10003157
Biological Process	GO:0071466	cellular response to xenobiotic stimulus	Rap1b	IDA		Rat	PMID:10908723|RGD:10003157
Biological Process	GO:0003428	chondrocyte intercalation involved in growth plate cartilage morphogenesis	rap1b	IGI	ZFIN:ZDB-MRPHLNO-070519-1,ZFIN:ZDB-MRPHLNO-070519-2	Zfish	PMID:26280580
Biological Process	GO:0060026	convergent extension	rap1b	IGI	ZFIN:ZDB-MRPHLNO-070519-1,ZFIN:ZDB-MRPHLNO-070519-2	Zfish	PMID:26280580
Biological Process	GO:0060026	convergent extension	rap1b	IMP	ZFIN:ZDB-MRPHLNO-070519-3	Zfish	PMID:17336901
Biological Process	GO:0060026	convergent extension	rap1b	IGI	ZFIN:ZDB-CRISPR-151208-1,ZFIN:ZDB-CRISPR-151208-2	Zfish	PMID:26280580
Biological Process	GO:0060026	convergent extension	rap1b	IGI	ZFIN:ZDB-MRPHLNO-070519-1,ZFIN:ZDB-MRPHLNO-070519-2,ZFIN:ZDB-MRPHLNO-151208-3	Zfish	PMID:26280580
Biological Process	GO:0060026	convergent extension	rap1b	IMP	ZFIN:ZDB-MRPHLNO-070519-2	Zfish	PMID:17336901
Biological Process	GO:0060027	convergent extension involved in gastrulation	rap1b	IGI	ZFIN:ZDB-CRISPR-151208-1,ZFIN:ZDB-CRISPR-151208-2	Zfish	PMID:30018450
Biological Process	GO:0048701	embryonic cranial skeleton morphogenesis	rap1b	IGI	ZFIN:ZDB-CRISPR-151208-1,ZFIN:ZDB-CRISPR-151208-2	Zfish	PMID:30018450
Biological Process	GO:0061028	establishment of endothelial barrier	RAP1B	IMP		Human	PMID:21840392
Biological Process	GO:0051649	establishment of localization in cell	Rap1b	IGI	MGI:MGI:97852	Mouse	PMID:23616533
Biological Process	GO:0007507	heart development	rap1b	IGI	ZFIN:ZDB-MRPHLNO-070519-1,ZFIN:ZDB-MRPHLNO-070519-3	Zfish	PMID:23226434
Biological Process	GO:0060218	hematopoietic stem cell differentiation	rap1b	IMP	ZFIN:ZDB-GENO-200409-12	Zfish	PMID:31006651
Biological Process	GO:0099010	modification of postsynaptic structure	Rap1b	IDA		Mouse	PMID:26844834
Biological Process	GO:0099010	modification of postsynaptic structure	Rap1b	IMP		Mouse	PMID:26844834
Biological Process	GO:0045955	negative regulation of calcium ion-dependent exocytosis	Rap1b	IGI	MGI:MGI:97852	Mouse	PMID:23616533
Biological Process	GO:2000301	negative regulation of synaptic vesicle exocytosis	Rap1b	IGI	MGI:MGI:97852	Mouse	PMID:23616533
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	Rap1b	IGI	MGI:MGI:97852	Mouse	PMID:23616533
Biological Process	GO:0033625	positive regulation of integrin activation	RAP1B	IMP		Human	PMID:19461049
Biological Process	GO:0032486	Rap protein signal transduction	RAP1B	IMP		Human	PMID:21840392
Biological Process	GO:1901888	regulation of cell junction assembly	RAP1B	IMP		Human	PMID:21840392
Biological Process	GO:2000114	regulation of establishment of cell polarity	RAP1B	IMP		Human	PMID:20332120
Biological Process	GO:0009743	response to carbohydrate	Rap1b	IEP		Rat	PMID:9149109|RGD:633760
Biological Process	GO:0007264	small GTPase mediated signal transduction	Rap1b	IDA		Mouse	PMID:14712229
Biological Process	GO:0032525	somite rostral/caudal axis specification	rap1b	IGI	ZFIN:ZDB-GENO-100512-3,ZFIN:ZDB-MRPHLNO-070519-3	Zfish	PMID:23192979
Biological Process	GO:0032525	somite rostral/caudal axis specification	rap1b	IGI	ZFIN:ZDB-GENO-100512-2,ZFIN:ZDB-MRPHLNO-070519-3	Zfish	PMID:23192979
Biological Process	GO:0001756	somitogenesis	rap1b	IGI	ZFIN:ZDB-GENO-100512-2,ZFIN:ZDB-MRPHLNO-070519-3	Zfish	PMID:23192979
Biological Process	GO:0001756	somitogenesis	rap1b	IGI	ZFIN:ZDB-GENO-100512-3,ZFIN:ZDB-MRPHLNO-070519-3	Zfish	PMID:23192979

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern