Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes RAP1GAP
  • Mouse genes Rap1gap
  • Rat genes Rap1gap
  • Zfish genes rap1gapa,rap1gapb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Rap1gap

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005096	GTPase activator activity	RAP1GAP	IDA		Human	PMID:15141215
Molecular Function	GO:0005096	GTPase activator activity	RAP1GAP	EXP		Human	PMID:16076873
Molecular Function	GO:0005515	protein binding	RAP1GAP	IPI	UniProtKB:P61224	Human	PMID:18309292
Molecular Function	GO:0005515	protein binding	RAP1GAP	IPI	UniProtKB:P07949	Human	PMID:20877310
Molecular Function	GO:0005515	protein binding	RAP1GAP	IPI	UniProtKB:O14645	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	RAP1GAP	IPI	UniProtKB:O14901	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Rap1gap	IPI	PR:Q69Z36	Mouse	PMID:24803656
Molecular Function	GO:0005515	protein binding	Rap1gap	IPI	RGD:3556	Rat	PMID:20877310|RGD:9835042
Molecular Function	GO:0042803	protein homodimerization activity	RAP1GAP	IPI	UniProtKB:P47736	Human	PMID:18309292
Molecular Function	GO:0031267	small GTPase binding	RAP1GAP	IPI	UniProtKB:P61224	Human	PMID:18309292
Cellular Component	GO:0030424	axon	Rap1gap	IDA		Rat	PMID:20877310|RGD:9835042
Cellular Component	GO:0005829	cytosol	RAP1GAP	IDA		Human	PMID:10476970
Cellular Component	GO:0005829	cytosol	Rap1gap	IDA		Rat	PMID:12198116|RGD:1359795
Cellular Component	GO:0030425	dendrite	Rap1gap	IDA		Rat	PMID:20877310|RGD:9835042
Cellular Component	GO:0005769	early endosome	Rap1gap	IDA		Rat	PMID:20877310|RGD:9835042
Cellular Component	GO:0016020	membrane	RAP1GAP	IDA		Human	PMID:10476970
Cellular Component	GO:0016020	membrane	Rap1gap	IDA		Rat	PMID:12198116|RGD:1359795
Cellular Component	GO:0043025	neuronal cell body	Rap1gap	IDA		Rat	PMID:20877310|RGD:9835042
Biological Process	GO:0098609	cell-cell adhesion	Rap1gap	IMP		Mouse	PMID:24803656
Biological Process	GO:1990792	cellular response to glial cell derived neurotrophic factor	Rap1gap	IDA		Rat	PMID:20877310|RGD:9835042
Biological Process	GO:0051649	establishment of localization in cell	Rap1gap	IMP		Mouse	PMID:24803656
Biological Process	GO:1904425	negative regulation of GTP binding	Rap1gap	IMP		Rat	PMID:19066305|RGD:9835342
Biological Process	GO:1903697	negative regulation of microvillus assembly	RAP1GAP	IMP		Human	PMID:22797597
Biological Process	GO:0045665	negative regulation of neuron differentiation	Rap1gap	IMP		Rat	PMID:20877310|RGD:9835042
Biological Process	GO:1904442	negative regulation of thyroid gland epithelial cell proliferation	Rap1gap	IMP		Rat	PMID:17646383|RGD:9835038
Biological Process	GO:0006909	phagocytosis	Rap1gap	IMP		Mouse	PMID:24803656
Biological Process	GO:0022409	positive regulation of cell-cell adhesion	Rap1gap	IMP		Mouse	PMID:24803656
Biological Process	GO:0043547	positive regulation of GTPase activity	RAP1GAP	IDA		Human	PMID:15141215
Biological Process	GO:0050766	positive regulation of phagocytosis	Rap1gap	IMP		Mouse	PMID:24803656
Biological Process	GO:0043087	regulation of GTPase activity	RAP1GAP	IDA		Human	PMID:18309292

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern