Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes RAP2B
  • Mouse genes Rap2b
  • Rat genes Rap2b
  • Zfish genes rap2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Rap2b

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0019003	GDP binding	RAP2B	IDA		Human	PMID:16213650
Molecular Function	GO:0005525	GTP binding	RAP2B	IDA		Human	PMID:16213650
Molecular Function	GO:0005525	GTP binding	RAP2B	IDA		Human	PMID:18582561
Molecular Function	GO:0005515	protein binding	RAP2B	IPI	UniProtKB:Q59EK9	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	RAP2B	IPI	UniProtKB:Q13554	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	RAP2B	IPI	UniProtKB:Q59EK9	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	RAP2B	IPI	UniProtKB:Q8WWW0	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	RAP2B	IPI	UniProtKB:P52306-5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RAP2B	IPI	UniProtKB:Q13554-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RAP2B	IPI	UniProtKB:Q59EK9-3	Human	PMID:32296183
Molecular Function	GO:0019904	protein domain specific binding	Rap2b	IPI	PR:Q9D394	Mouse	PMID:16928684
Cellular Component	GO:0005923	bicellular tight junction	RAP2B	IDA		Human	PMID:23885123
Cellular Component	GO:0044291	cell-cell contact zone	RAP2B	IDA		Human	PMID:23885123
Cellular Component	GO:0005829	cytosol	RAP2B	IDA		Human	PMID:18582561
Cellular Component	GO:0005829	cytosol	Rap2b	IDA		Mouse	PMID:19061864
Cellular Component	GO:0070062	extracellular exosome	RAP2B	IDA		Human	PMID:16540189
Cellular Component	GO:0070062	extracellular exosome	RAP2B	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	RAP2B	HDA		Human	PMID:20458337
Cellular Component	GO:0016020	membrane	RAP2B	IMP		Human	PMID:18582561
Cellular Component	GO:0016020	membrane	Rap2b	IDA		Mouse	PMID:19061864
Cellular Component	GO:0045121	membrane raft	RAP2B	IMP		Human	PMID:18582561
Cellular Component	GO:0005886	plasma membrane	RAP2B	IDA		Human	PMID:16213650
Cellular Component	GO:0005886	plasma membrane	RAP2B	IDA		Human	PMID:16540189
Cellular Component	GO:0055037	recycling endosome	Rap2b	IDA		Mouse	PMID:19061864
Cellular Component	GO:0055038	recycling endosome membrane	Rap2b	IDA		Mouse	MGI:MGI:3822406|PMID:19061864
Biological Process	GO:0030336	negative regulation of cell migration	Rap2b	IDA		Mouse	PMID:19061864
Biological Process	GO:0030168	platelet activation	RAP2B	IDA		Human	PMID:18582561
Biological Process	GO:0070527	platelet aggregation	RAP2B	IDA		Human	PMID:18582561
Biological Process	GO:0031954	positive regulation of protein autophosphorylation	Rap2b	IDA		Mouse	PMID:19061864
Biological Process	GO:0032486	Rap protein signal transduction	Rap2b	IDA		Mouse	MGI:MGI:3822406|PMID:19061864
Biological Process	GO:0061097	regulation of protein tyrosine kinase activity	Rap2b	IDA		Mouse	MGI:MGI:3822406|PMID:19061864

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern