Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes RAPGEF1
  • Mouse genes Rapgef1
  • Rat genes Rapgef1
  • Zfish genes rapgef1a,rapgef1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Rapgef1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	RAPGEF1	IDA		Human	PMID:10548487
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	RAPGEF1	IMP		Human	PMID:21840392
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	Rapgef1	IDA		Mouse	PMID:12671687
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	Rapgef1	IDA		Mouse	PMID:14712229
Molecular Function	GO:0005515	protein binding	RAPGEF1	IPI	UniProtKB:P00519	Human	PMID:16443220
Molecular Function	GO:0005515	protein binding	RAPGEF1	IPI	UniProtKB:P46109	Human	PMID:16443220
Molecular Function	GO:0005515	protein binding	RAPGEF1	IPI	UniProtKB:P00519	Human	PMID:17474147
Molecular Function	GO:0005515	protein binding	RAPGEF1	IPI	UniProtKB:P06241	Human	PMID:17474147
Molecular Function	GO:0005515	protein binding	RAPGEF1	IPI	UniProtKB:P12931	Human	PMID:17474147
Molecular Function	GO:0005515	protein binding	RAPGEF1	IPI	UniProtKB:P16333	Human	PMID:17474147
Molecular Function	GO:0005515	protein binding	RAPGEF1	IPI	UniProtKB:P27986	Human	PMID:17474147
Molecular Function	GO:0005515	protein binding	RAPGEF1	IPI	UniProtKB:P46108	Human	PMID:17474147
Molecular Function	GO:0005515	protein binding	RAPGEF1	IPI	UniProtKB:P46108	Human	PMID:17515907
Molecular Function	GO:0005515	protein binding	RAPGEF1	IPI	UniProtKB:P46108-1	Human	PMID:17515907
Molecular Function	GO:0005515	protein binding	RAPGEF1	IPI	UniProtKB:P46108-1	Human	PMID:19001122
Molecular Function	GO:0005515	protein binding	RAPGEF1	IPI	UniProtKB:P46108	Human	PMID:19380743
Molecular Function	GO:0005515	protein binding	RAPGEF1	IPI	UniProtKB:P46109	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	RAPGEF1	IPI	UniProtKB:P46108	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	RAPGEF1	IPI	UniProtKB:P56945	Human	PMID:9748234
Molecular Function	GO:0005515	protein binding	RAPGEF1	IPI	UniProtKB:Q6P5Z4	Human	PMID:9748234
Molecular Function	GO:0005515	protein binding	Rapgef1	IPI	UniProtKB:Q60631	Mouse	MGI:MGI:3688344|PMID:15102471
Molecular Function	GO:0005515	protein binding	Rapgef1	IPI	PR:P47941	Mouse	PMID:12697763
Molecular Function	GO:0005515	protein binding	Rapgef1	IPI	PR:P47941	Mouse	PMID:12671687
Molecular Function	GO:0005515	protein binding	Rapgef1	IPI	RGD:1308531	Rat	PMID:20190816|RGD:9835044
Cellular Component	GO:0005737	cytoplasm	RAPGEF1	IDA		Human	PMID:17515907
Cellular Component	GO:0005769	early endosome	RAPGEF1	IDA		Human	PMID:17724123
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	RAPGEF1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Rapgef1	IDA		Rat	PMID:18832707|RGD:9835043
Cellular Component	GO:0030670	phagocytic vesicle membrane	Rapgef1	IDA		Rat	PMID:18832707|RGD:9835043
Cellular Component	GO:0032991	protein-containing complex	Rapgef1	IDA		Rat	PMID:20190816|RGD:9835044
Biological Process	GO:0090630	activation of GTPase activity	Rapgef1	IGI	MGI:MGI:88508	Mouse	PMID:25621495
Biological Process	GO:0090630	activation of GTPase activity	Rapgef1	IGI	MGI:MGI:104686	Mouse	PMID:25621495
Biological Process	GO:0090630	activation of GTPase activity	Rapgef1	IGI	MGI:MGI:97302	Mouse	PMID:25621495
Biological Process	GO:0007409	axonogenesis	rapgef1a	IMP	ZFIN:ZDB-MRPHLNO-221128-1	Zfish	PMID:33834495
Biological Process	GO:0007409	axonogenesis	rapgef1a	IMP	ZFIN:ZDB-MRPHLNO-221128-2	Zfish	PMID:33834495
Biological Process	GO:0001568	blood vessel development	Rapgef1	IMP	MGI:MGI:2445403	Mouse	PMID:12466202
Biological Process	GO:0060070	canonical Wnt signaling pathway	Rapgef1	IGI	MGI:MGI:95516	Mouse	PMID:16858399
Biological Process	GO:0098609	cell-cell adhesion	Rapgef1	IMP	MGI:MGI:2445403	Mouse	PMID:12466202
Biological Process	GO:0071320	cellular response to cAMP	RAPGEF1	IDA		Human	PMID:21840392
Biological Process	GO:1990090	cellular response to nerve growth factor stimulus	RAPGEF1	IDA		Human	PMID:17724123
Biological Process	GO:0070371	ERK1 and ERK2 cascade	Rapgef1	IGI	MGI:MGI:95516	Mouse	PMID:16858399
Biological Process	GO:0061028	establishment of endothelial barrier	RAPGEF1	IMP		Human	PMID:21840392
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	Rapgef1	IGI	MGI:MGI:95516	Mouse	PMID:16858399
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	Rapgef1	IGI	MGI:MGI:95516	Mouse	PMID:16858399
Biological Process	GO:2000178	negative regulation of neural precursor cell proliferation	Rapgef1	IMP	MGI:MGI:2445403	Mouse	PMID:16858399
Biological Process	GO:0051898	negative regulation of protein kinase B signaling	Rapgef1	IGI	MGI:MGI:95516	Mouse	PMID:16858399
Biological Process	GO:0046580	negative regulation of Ras protein signal transduction	Rapgef1	IMP	MGI:MGI:2445403	Mouse	PMID:16858399
Biological Process	GO:0038180	nerve growth factor signaling pathway	RAPGEF1	IDA		Human	PMID:17724123
Biological Process	GO:0061351	neural precursor cell proliferation	Rapgef1	IMP	MGI:MGI:2445403	Mouse	PMID:16858399
Biological Process	GO:0048008	platelet-derived growth factor receptor signaling pathway	Rapgef1	IMP	MGI:MGI:2445403	Mouse	PMID:12466202
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	Rapgef1	IMP		Rat	PMID:16507992|RGD:11534985
Biological Process	GO:1905451	positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis	Rapgef1	IMP		Rat	PMID:18832707|RGD:9835043
Biological Process	GO:0043547	positive regulation of GTPase activity	RAPGEF1	IDA		Human	PMID:10548487
Biological Process	GO:0043547	positive regulation of GTPase activity	RAPGEF1	IMP		Human	PMID:21840392
Biological Process	GO:0010976	positive regulation of neuron projection development	RAPGEF1	IMP		Human	PMID:17724123
Biological Process	GO:0010976	positive regulation of neuron projection development	Rapgef1	IMP		Rat	PMID:20190816|RGD:9835044
Biological Process	GO:0043491	protein kinase B signaling	Rapgef1	IGI	MGI:MGI:95516	Mouse	PMID:16858399
Biological Process	GO:0032486	Rap protein signal transduction	RAPGEF1	IMP		Human	PMID:21840392
Biological Process	GO:0007265	Ras protein signal transduction	Rapgef1	IMP	MGI:MGI:2445403	Mouse	PMID:16858399
Biological Process	GO:1901888	regulation of cell junction assembly	RAPGEF1	IMP		Human	PMID:21840392
Biological Process	GO:0046328	regulation of JNK cascade	Rapgef1	IMP		Rat	PMID:10811109|RGD:11534984
Biological Process	GO:0001756	somitogenesis	rapgef1a	IMP	ZFIN:ZDB-MRPHLNO-221128-2	Zfish	PMID:33834495
Biological Process	GO:0001756	somitogenesis	rapgef1a	IMP	ZFIN:ZDB-MRPHLNO-221128-1	Zfish	PMID:33834495
Biological Process	GO:0001570	vasculogenesis	rapgef1a	IMP	ZFIN:ZDB-MRPHLNO-221128-2	Zfish	PMID:33834495
Biological Process	GO:0001570	vasculogenesis	rapgef1a	IMP	ZFIN:ZDB-MRPHLNO-221128-1	Zfish	PMID:33834495

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern