Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Rapgef2

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes RAPGEF2
- Mouse genes Rapgef2
- Rat genes Rapgef2
- Zfish genes rapgef2a,rapgef2b
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Rapgef2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0031697	beta-1 adrenergic receptor binding	RAPGEF2	IDA		Human	PMID:12391161
Molecular Function	GO:0030552	cAMP binding	RAPGEF2	IDA		Human	PMID:10801446
Molecular Function	GO:0005096	GTPase activator activity	RAPGEF2	IDA		Human	PMID:10934204
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	RAPGEF2	IDA		Human	PMID:10608883
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	RAPGEF2	IDA		Human	PMID:10801446
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	RAPGEF2	IDA		Human	PMID:12391161
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	RAPGEF2	IDA		Human	PMID:16272156
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	Rapgef2	IMP		Mouse	MGI:MGI:5499726\|PMID:16272156
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	Rapgef2	IMP		Mouse	MGI:MGI:4359570\|PMID:19635461
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	Rapgef2	IDA		Mouse	MGI:MGI:5514088\|PMID:23800469
Molecular Function	GO:0030165	PDZ domain binding	RAPGEF2	IDA		Human	PMID:10548487
Molecular Function	GO:0030165	PDZ domain binding	RAPGEF2	IDA		Human	PMID:11168587
Molecular Function	GO:0030165	PDZ domain binding	RAPGEF2	IDA		Human	PMID:12391161
Molecular Function	GO:0070300	phosphatidic acid binding	RAPGEF2	IDA		Human	PMID:22797597
Molecular Function	GO:0005515	protein binding	RAPGEF2	IPI	UniProtKB:Q86UL8	Human	PMID:10548487
Molecular Function	GO:0005515	protein binding	RAPGEF2	IPI	UniProtKB:P01112	Human	PMID:10608844
Molecular Function	GO:0005515	protein binding	RAPGEF2	IPI	UniProtKB:P62834	Human	PMID:10608844
Molecular Function	GO:0005515	protein binding	RAPGEF2	IPI	UniProtKB:Q96QZ7	Human	PMID:11168587
Molecular Function	GO:0005515	protein binding	RAPGEF2	IPI	UniProtKB:Q96QZ7-3	Human	PMID:11168587
Molecular Function	GO:0005515	protein binding	RAPGEF2	IPI	UniProtKB:P62834	Human	PMID:11359771
Molecular Function	GO:0005515	protein binding	RAPGEF2	IPI	UniProtKB:P01112	Human	PMID:11598133
Molecular Function	GO:0005515	protein binding	RAPGEF2	IPI	UniProtKB:P46934	Human	PMID:11598133
Molecular Function	GO:0005515	protein binding	RAPGEF2	IPI	UniProtKB:P08588	Human	PMID:12391161
Molecular Function	GO:0005515	protein binding	RAPGEF2	IPI	UniProtKB:Q9Y624	Human	PMID:23885123
Molecular Function	GO:0005515	protein binding	Rapgef2	IPI	UniProtKB:O88382	Rat	PMID:10548487\|RGD:8554081
Molecular Function	GO:0005515	protein binding	Rapgef2	IPI	UniProtKB:O88382	Rat	PMID:17724123\|RGD:8554481
Molecular Function	GO:0005515	protein binding	Rapgef2	IPI	UniProtKB:P35739	Rat	PMID:17724123\|RGD:8554481
Molecular Function	GO:0005515	protein binding	Rapgef2	IPI	UniProtKB:Q9EQG6	Rat	PMID:17724123\|RGD:8554481
Molecular Function	GO:0019901	protein kinase binding	Rapgef2	IPI	UniProtKB:Q9R012	Rat	PMID:21382555\|RGD:7241548
Molecular Function	GO:0050699	WW domain binding	RAPGEF2	IDA		Human	PMID:10548487
Molecular Function	GO:0050699	WW domain binding	RAPGEF2	IDA		Human	PMID:11598133
Cellular Component	GO:0016324	apical plasma membrane	RAPGEF2	IDA		Human	PMID:22797597
Cellular Component	GO:0005923	bicellular tight junction	RAPGEF2	IDA		Human	PMID:23885123
Cellular Component	GO:0005737	cytoplasm	RAPGEF2	IDA		Human	PMID:11359771
Cellular Component	GO:0005737	cytoplasm	RAPGEF2	IDA		Human	PMID:17724123
Cellular Component	GO:0005829	cytosol	RAPGEF2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	RAPGEF2	IDA		Human	PMID:22797597
Cellular Component	GO:0030139	endocytic vesicle	RAPGEF2	IDA		Human	PMID:22797597
Cellular Component	GO:0005770	late endosome	RAPGEF2	IDA		Human	PMID:17724123
Cellular Component	GO:0016020	membrane	RAPGEF2	IDA		Human	PMID:10608883
Cellular Component	GO:0043005	neuron projection	Rapgef2	IDA		Rat	PMID:10801446\|RGD:8554829
Cellular Component	GO:0043025	neuronal cell body	Rapgef2	IDA		Rat	PMID:10548487\|RGD:8554081
Cellular Component	GO:0048471	perinuclear region of cytoplasm	RAPGEF2	IDA		Human	PMID:11359771
Cellular Component	GO:0005886	plasma membrane	RAPGEF2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	Rapgef2	IDA		Rat	PMID:12391161\|RGD:8554163
Cellular Component	GO:0032991	protein-containing complex	Rapgef2	IDA		Rat	PMID:17724123\|RGD:8554481
Cellular Component	GO:0045202	synapse	Rapgef2	IDA		Rat	PMID:10548487\|RGD:8554081
Biological Process	GO:0071880	adenylate cyclase-activating adrenergic receptor signaling pathway	RAPGEF2	IDA		Human	PMID:12391161
Biological Process	GO:0001568	blood vessel development	Rapgef2	IMP		Mouse	MGI:MGI:3757825\|PMID:17826737
Biological Process	GO:0031547	brain-derived neurotrophic factor receptor signaling pathway	Rapgef2	IMP		Rat	PMID:17724123\|RGD:8554481
Biological Process	GO:0019933	cAMP-mediated signaling	RAPGEF2	IDA		Human	PMID:23800469
Biological Process	GO:0019933	cAMP-mediated signaling	Rapgef2	IDA		Mouse	MGI:MGI:5514088\|PMID:23800469
Biological Process	GO:0071320	cellular response to cAMP	RAPGEF2	IDA		Human	PMID:10801446
Biological Process	GO:0071320	cellular response to cAMP	RAPGEF2	IDA		Human	PMID:16272156
Biological Process	GO:0071320	cellular response to cAMP	RAPGEF2	IDA		Human	PMID:21840392
Biological Process	GO:0071320	cellular response to cAMP	RAPGEF2	IDA		Human	PMID:23800469
Biological Process	GO:0071320	cellular response to cAMP	Rapgef2	IMP		Mouse	MGI:MGI:5499726\|PMID:16272156
Biological Process	GO:0071320	cellular response to cAMP	Rapgef2	IDA		Mouse	MGI:MGI:5514088\|PMID:23800469
Biological Process	GO:0071321	cellular response to cGMP	RAPGEF2	IDA		Human	PMID:10801446
Biological Process	GO:1990090	cellular response to nerve growth factor stimulus	Rapgef2	IDA		Rat	PMID:17724123\|RGD:8554481
Biological Process	GO:0061028	establishment of endothelial barrier	RAPGEF2	IMP		Human	PMID:21840392
Biological Process	GO:0090557	establishment of endothelial intestinal barrier	RAPGEF2	IMP		Human	PMID:23885123
Biological Process	GO:0021884	forebrain neuron development	Rapgef2	IMP		Mouse	MGI:MGI:3848551\|PMID:19453629
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	RAPGEF2	IDA		Human	PMID:23800469
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	Rapgef2	IDA		Mouse	MGI:MGI:5514088\|PMID:23800469
Biological Process	GO:0030033	microvillus assembly	RAPGEF2	IGI	UniProtKB:Q8TEU7	Human	PMID:22797597
Biological Process	GO:0008285	negative regulation of cell population proliferation	RAPGEF2	IDA		Human	PMID:16272156
Biological Process	GO:0008285	negative regulation of cell population proliferation	Rapgef2	IMP		Mouse	MGI:MGI:5499726\|PMID:16272156
Biological Process	GO:0050774	negative regulation of dendrite morphogenesis	RAPGEF2	IDA		Human	PMID:16272156
Biological Process	GO:0050774	negative regulation of dendrite morphogenesis	Rapgef2	IMP		Mouse	MGI:MGI:5499726\|PMID:16272156
Biological Process	GO:0048022	negative regulation of melanin biosynthetic process	Rapgef2	IMP		Mouse	MGI:MGI:5499726\|PMID:16272156
Biological Process	GO:0038180	nerve growth factor signaling pathway	Rapgef2	IDA		Rat	PMID:17724123\|RGD:8554481
Biological Process	GO:0001764	neuron migration	Rapgef2	IMP		Mouse	MGI:MGI:5300001\|PMID:21864586
Biological Process	GO:0031175	neuron projection development	RAPGEF2	IDA		Human	PMID:23800469
Biological Process	GO:0031175	neuron projection development	Rapgef2	IMP		Mouse	MGI:MGI:5514088\|PMID:23800469
Biological Process	GO:0007218	neuropeptide signaling pathway	RAPGEF2	IDA		Human	PMID:23800469
Biological Process	GO:0007218	neuropeptide signaling pathway	Rapgef2	IDA		Mouse	MGI:MGI:5514088\|PMID:23800469
Biological Process	GO:2000481	positive regulation of cAMP-dependent protein kinase activity	RAPGEF2	IDA		Human	PMID:16272156
Biological Process	GO:2000481	positive regulation of cAMP-dependent protein kinase activity	Rapgef2	IMP		Mouse	MGI:MGI:5499726\|PMID:16272156
Biological Process	GO:0043950	positive regulation of cAMP-mediated signaling	RAPGEF2	IDA		Human	PMID:12391161
Biological Process	GO:2000670	positive regulation of dendritic cell apoptotic process	RAPGEF2	IDA		Human	PMID:16272156
Biological Process	GO:2000670	positive regulation of dendritic cell apoptotic process	Rapgef2	IMP		Mouse	MGI:MGI:5499726\|PMID:16272156
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	RAPGEF2	IDA		Human	PMID:16272156
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	RAPGEF2	IDA		Human	PMID:23800469
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	Rapgef2	IDA		Mouse	MGI:MGI:5514088\|PMID:23800469
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	Rapgef2	IMP		Mouse	MGI:MGI:5499726\|PMID:16272156
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	Rapgef2	IMP		Rat	PMID:17724123\|RGD:8554481
Biological Process	GO:0043547	positive regulation of GTPase activity	RAPGEF2	IDA		Human	PMID:10548487
Biological Process	GO:0043547	positive regulation of GTPase activity	RAPGEF2	IDA		Human	PMID:10608844
Biological Process	GO:0043547	positive regulation of GTPase activity	RAPGEF2	IDA		Human	PMID:10801446
Biological Process	GO:0043547	positive regulation of GTPase activity	RAPGEF2	IDA		Human	PMID:11359771
Biological Process	GO:0043547	positive regulation of GTPase activity	RAPGEF2	IDA		Human	PMID:16272156
Biological Process	GO:0043547	positive regulation of GTPase activity	RAPGEF2	IDA		Human	PMID:17724123
Biological Process	GO:0043547	positive regulation of GTPase activity	RAPGEF2	IMP		Human	PMID:21840392
Biological Process	GO:0043547	positive regulation of GTPase activity	RAPGEF2	IMP		Human	PMID:22797597
Biological Process	GO:0043547	positive regulation of GTPase activity	RAPGEF2	IDA		Human	PMID:23800469
Biological Process	GO:0043547	positive regulation of GTPase activity	Rapgef2	IDA		Mouse	MGI:MGI:5514088\|PMID:23800469
Biological Process	GO:0043547	positive regulation of GTPase activity	Rapgef2	IMP		Mouse	MGI:MGI:5499726\|PMID:16272156
Biological Process	GO:0043547	positive regulation of GTPase activity	Rapgef2	IMP		Mouse	MGI:MGI:4359570\|PMID:19635461
Biological Process	GO:0043547	positive regulation of GTPase activity	Rapgef2	IMP		Rat	PMID:17724123\|RGD:8554481
Biological Process	GO:0043547	positive regulation of GTPase activity	Rapgef2	IDA		Rat	PMID:21382555\|RGD:7241548
Biological Process	GO:2001224	positive regulation of neuron migration	Rapgef2	IMP		Mouse	MGI:MGI:3848551\|PMID:19453629
Biological Process	GO:0010976	positive regulation of neuron projection development	Rapgef2	IMP		Rat	PMID:17724123\|RGD:8554481
Biological Process	GO:0032092	positive regulation of protein binding	Rapgef2	IDA		Mouse	MGI:MGI:5514088\|PMID:23800469
Biological Process	GO:0045860	positive regulation of protein kinase activity	RAPGEF2	IDA		Human	PMID:11359771
Biological Process	GO:0045860	positive regulation of protein kinase activity	RAPGEF2	IDA		Human	PMID:23800469
Biological Process	GO:0045860	positive regulation of protein kinase activity	Rapgef2	IDA		Mouse	MGI:MGI:5514088\|PMID:23800469
Biological Process	GO:0045860	positive regulation of protein kinase activity	Rapgef2	IMP		Rat	PMID:17724123\|RGD:8554481
Biological Process	GO:2001214	positive regulation of vasculogenesis	Rapgef2	IMP		Mouse	MGI:MGI:4359570\|PMID:19635461
Biological Process	GO:0072659	protein localization to plasma membrane	RAPGEF2	IMP		Human	PMID:22797597
Biological Process	GO:0032486	Rap protein signal transduction	RAPGEF2	IMP		Human	PMID:21840392
Biological Process	GO:1901888	regulation of cell junction assembly	RAPGEF2	IMP		Human	PMID:21840392
Biological Process	GO:0048167	regulation of synaptic plasticity	Rapgef2	IDA		Rat	PMID:21382555\|RGD:7241548
Biological Process	GO:0021591	ventricular system development	Rapgef2	IMP		Mouse	MGI:MGI:3757825\|PMID:17826737

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 07/02/2024 MGI 6.13

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.