Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes RAPGEF3
  • Mouse genes Rapgef3
  • Rat genes Rapgef3
  • Zfish genes rapgef3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Rapgef3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0030552	cAMP binding	Rapgef3	IPI	CHEBI:17489	Rat	PMID:16244178|RGD:9850088
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	RAPGEF3	EXP		Human	PMID:15334074
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	RAPGEF3	EXP		Human	PMID:16076873
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	RAPGEF3	IMP		Human	PMID:21840392
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	Rapgef3	IDA		Mouse	PMID:14712229
Molecular Function	GO:0005515	protein binding	RAPGEF3	IPI	UniProtKB:Q13370	Human	PMID:21393242
Molecular Function	GO:0005515	protein binding	Rapgef3	IPI	UniProtKB:E9Q9K8	Mouse	MGI:MGI:5491968|PMID:23540699
Molecular Function	GO:0005515	protein binding	Rapgef3	IPI	RGD:3042	Rat	PMID:15202935|RGD:2314804
Molecular Function	GO:0005515	protein binding	Rapgef3	IPI	RGD:3043	Rat	PMID:16244178|RGD:9850088
Molecular Function	GO:0019904	protein domain specific binding	RAPGEF3	IPI	UniProtKB:P26043	Human	PMID:21047789
Molecular Function	GO:0044325	transmembrane transporter binding	Rapgef3	IPI	RGD:3787	Rat	PMID:19491242|RGD:9850103
Cellular Component	GO:0045177	apical part of cell	Rapgef3	IDA		Rat	PMID:18495799|RGD:2314762
Cellular Component	GO:0043679	axon terminus	Rapgef3	IDA		Rat	PMID:21653844|RGD:10041044
Cellular Component	GO:0009925	basal plasma membrane	Rapgef3	IDA		Rat	PMID:15464734|RGD:9835384
Cellular Component	GO:1990794	basolateral part of cell	Rapgef3	IDA		Rat	PMID:18495799|RGD:2314762
Cellular Component	GO:0031526	brush border membrane	Rapgef3	IDA		Rat	PMID:18495799|RGD:2314762
Cellular Component	GO:0071944	cell periphery	Rapgef3	IDA		Rat	PMID:22056318|RGD:9850102
Cellular Component	GO:0030864	cortical actin cytoskeleton	RAPGEF3	IDA		Human	PMID:21047789
Cellular Component	GO:0030864	cortical actin cytoskeleton	Rapgef3	IDA		Rat	PMID:21047789|RGD:10054076
Cellular Component	GO:0070062	extracellular exosome	RAPGEF3	HDA		Human	PMID:19056867
Cellular Component	GO:0030175	filopodium	RAPGEF3	IDA		Human	PMID:21047789
Cellular Component	GO:0030175	filopodium	Rapgef3	IDA		Rat	PMID:21047789|RGD:10054076
Cellular Component	GO:0030426	growth cone	Rapgef3	IDA		Rat	PMID:18583150|RGD:9835386
Cellular Component	GO:0030027	lamellipodium	RAPGEF3	IDA		Human	PMID:21047789
Cellular Component	GO:0030027	lamellipodium	Rapgef3	IDA		Rat	PMID:21047789|RGD:10054076
Cellular Component	GO:0005902	microvillus	RAPGEF3	IDA		Human	PMID:21047789
Cellular Component	GO:0005902	microvillus	Rapgef3	IDA		Rat	PMID:21047789|RGD:10054076
Cellular Component	GO:0043025	neuronal cell body	Rapgef3	IDA		Rat	PMID:19883736|RGD:2314691
Cellular Component	GO:0031090	organelle membrane	Rapgef3	IDA		Rat	PMID:15464734|RGD:9835384
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Rapgef3	IDA		Rat	PMID:22056318|RGD:9850102
Cellular Component	GO:1990796	photoreceptor cell terminal bouton	Rapgef3	IDA		Rat	PMID:19883736|RGD:2314691
Cellular Component	GO:0005886	plasma membrane	RAPGEF3	IDA		Human	PMID:21047789
Cellular Component	GO:0005886	plasma membrane	Rapgef3	IDA		Rat	PMID:21047789|RGD:10054076
Cellular Component	GO:0097470	ribbon synapse	Rapgef3	IDA		Rat	PMID:19883736|RGD:2314691
Cellular Component	GO:1990795	rod bipolar cell terminal bouton	Rapgef3	IDA		Rat	PMID:19883736|RGD:2314691
Biological Process	GO:0060840	artery development	Rapgef3	IEP		Rat	PMID:18697745|RGD:2314761
Biological Process	GO:0008306	associative learning	Rapgef3	IMP	MGI:MGI:5425762	Mouse	PMID:26158416
Biological Process	GO:0007420	brain development	Rapgef3	IEP		Rat	PMID:18583150|RGD:9835386
Biological Process	GO:0071320	cellular response to cAMP	RAPGEF3	IDA		Human	PMID:21840392
Biological Process	GO:1904474	cellular response to L-dopa	Rapgef3	IEP		Rat	PMID:25044243|RGD:10041045
Biological Process	GO:0071407	cellular response to organic cyclic compound	Rapgef3	IEP		Rat	PMID:18276108|RGD:9835371
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	Rapgef3	IEP		Rat	PMID:23845590|RGD:9835377
Biological Process	GO:0071466	cellular response to xenobiotic stimulus	Rapgef3	IEP		Rat	PMID:18276108|RGD:9835371
Biological Process	GO:1990791	dorsal root ganglion development	Rapgef3	IEP		Rat	PMID:18583150|RGD:9835386
Biological Process	GO:0061028	establishment of endothelial barrier	RAPGEF3	IMP		Human	PMID:21840392
Biological Process	GO:0097421	liver regeneration	Rapgef3	IEP		Rat	PMID:22227930|RGD:9850085
Biological Process	GO:0010667	negative regulation of cardiac muscle cell apoptotic process	Rapgef3	IMP		Rat	PMID:18276108|RGD:9835371
Biological Process	GO:0032966	negative regulation of collagen biosynthetic process	Rapgef3	IMP		Rat	PMID:22012077|RGD:9850086
Biological Process	GO:0034242	negative regulation of syncytium formation by plasma membrane fusion	RAPGEF3	IMP		Human	PMID:23867755
Biological Process	GO:0045766	positive regulation of angiogenesis	RAPGEF3	IMP		Human	PMID:21393242
Biological Process	GO:1904427	positive regulation of calcium ion transmembrane transport	Rapgef3	IMP		Rat	PMID:22910094|RGD:9835378
Biological Process	GO:0045793	positive regulation of cell size	Rapgef3	IMP		Rat	PMID:18323524|RGD:9835356
Biological Process	GO:1904426	positive regulation of GTP binding	Rapgef3	IMP		Rat	PMID:18689492|RGD:9835375
Biological Process	GO:0043547	positive regulation of GTPase activity	RAPGEF3	IMP		Human	PMID:21840392
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	RAPGEF3	IDA		Human	PMID:23867755
Biological Process	GO:1904453	positive regulation of potassium:proton exchanging ATPase activity	Rapgef3	IMP		Rat	PMID:11897793|RGD:625394
Biological Process	GO:1901985	positive regulation of protein acetylation	RAPGEF3	IMP		Human	PMID:23867755
Biological Process	GO:0046827	positive regulation of protein export from nucleus	RAPGEF3	IDA		Human	PMID:23867755
Biological Process	GO:0001934	positive regulation of protein phosphorylation	Rapgef3	IMP		Rat	PMID:18276108|RGD:9835371
Biological Process	GO:0014911	positive regulation of smooth muscle cell migration	Rapgef3	IMP		Rat	PMID:18697745|RGD:2314761
Biological Process	GO:0051496	positive regulation of stress fiber assembly	RAPGEF3	IMP		Human	PMID:21840392
Biological Process	GO:0060143	positive regulation of syncytium formation by plasma membrane fusion	RAPGEF3	IMP		Human	PMID:23867755
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Rapgef3	IMP		Rat	PMID:18323524|RGD:9835356
Biological Process	GO:0032486	Rap protein signal transduction	RAPGEF3	IMP		Human	PMID:21840392
Biological Process	GO:0032956	regulation of actin cytoskeleton organization	Rapgef3	IMP		Rat	PMID:18323524|RGD:9835356
Biological Process	GO:2000249	regulation of actin cytoskeleton reorganization	RAPGEF3	IMP		Human	PMID:21840392
Biological Process	GO:0045765	regulation of angiogenesis	RAPGEF3	IMP		Human	PMID:21840392
Biological Process	GO:0014066	regulation of phosphatidylinositol 3-kinase signaling	RAPGEF3	IMP		Human	PMID:21840392
Biological Process	GO:0035094	response to nicotine	Rapgef3	IEP		Rat	PMID:11478936|RGD:2316519
Biological Process	GO:0021510	spinal cord development	Rapgef3	IEP		Rat	PMID:18583150|RGD:9835386

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern