Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Rapgef4

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes RAPGEF4
- Mouse genes Rapgef4
- Rat genes Rapgef4
- Zfish genes rapgef4a,rapgef4b
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Rapgef4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0030552	cAMP binding	Rapgef4	IDA		Mouse	MGI:MGI:4412439\|PMID:18660803
Molecular Function	GO:0030552	cAMP binding	Rapgef4	IDA		Rat	PMID:9856955\|RGD:632397
Molecular Function	GO:0005096	GTPase activator activity	Rapgef4	IDA		Mouse	PMID:18660803
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	RAPGEF4	EXP		Human	PMID:15334074
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	RAPGEF4	EXP		Human	PMID:16076873
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	Rapgef4	IDA		Mouse	PMID:18660803
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	Rapgef4	IDA		Mouse	PMID:11056535
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	Rapgef4	IDA		Rat	PMID:9856955\|RGD:632397
Molecular Function	GO:0140677	molecular function activator activity	Rapgef4	IDA		Mouse	PMID:11056535
Molecular Function	GO:0005515	protein binding	RAPGEF4	IPI	UniProtKB:Q86UR5	Human	PMID:11438518
Molecular Function	GO:0005515	protein binding	RAPGEF4	IPI	UniProtKB:Q96MC5	Human	PMID:24722188
Molecular Function	GO:0005515	protein binding	RAPGEF4	IPI	UniProtKB:Q9UH65	Human	PMID:24722188
Molecular Function	GO:0005515	protein binding	RAPGEF4	IPI	UniProtKB:Q96MC5	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	RAPGEF4	IPI	UniProtKB:Q9H4E7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RAPGEF4	IPI	UniProtKB:P05455	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	RAPGEF4	IPI	UniProtKB:P42858	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	RAPGEF4	IPI	UniProtKB:P49459	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	RAPGEF4	IPI	UniProtKB:Q9UH65	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Rapgef4	IPI	UniProtKB:P61224	Mouse	MGI:MGI:4412439\|PMID:18660803
Molecular Function	GO:0005515	protein binding	Rapgef4	IPI	UniProtKB:P61224	Mouse	MGI:MGI:5917821\|PMID:16452984
Molecular Function	GO:0005515	protein binding	Rapgef4	IPI	UniProtKB:P01112	Mouse	MGI:MGI:3694182\|PMID:16316996
Molecular Function	GO:0005515	protein binding	Rapgef4	IPI	PR:Q9QYX7	Mouse	PMID:12401793
Molecular Function	GO:0005515	protein binding	Rapgef4	IPI	PR:Q9EQZ7	Mouse	PMID:12401793
Molecular Function	GO:0005515	protein binding	Rapgef4	IPI	RGD:3042	Rat	PMID:15202935\|RGD:2314804
Molecular Function	GO:0005515	protein binding	Rapgef4	IPI	RGD:621117\|RGD:621118\|RGD:621119	Rat	PMID:19734897\|RGD:2314692
Molecular Function	GO:0044877	protein-containing complex binding	Rapgef4	IDA		Rat	PMID:19734897\|RGD:2314692
Molecular Function	GO:0030674	protein-macromolecule adaptor activity	Rapgef4	IDA		Mouse	PMID:11056535
Molecular Function	GO:0031267	small GTPase binding	Rapgef4	IPI	UniProtKB:P61224	Mouse	MGI:MGI:4412439\|PMID:18660803
Cellular Component	GO:0016324	apical plasma membrane	Rapgef4	IDA		Rat	PMID:18495799\|RGD:2314762
Cellular Component	GO:0030424	axon	Rapgef4	IDA		Rat	PMID:19734897\|RGD:2314692
Cellular Component	GO:0016323	basolateral plasma membrane	Rapgef4	IDA		Rat	PMID:18495799\|RGD:2314762
Cellular Component	GO:0005903	brush border	Rapgef4	IDA		Rat	PMID:18495799\|RGD:2314762
Cellular Component	GO:0005929	cilium	Rapgef4	IDA		Rat	PMID:18687752\|RGD:9850084
Cellular Component	GO:0044316	cone cell pedicle	Rapgef4	IDA		Rat	PMID:19883736\|RGD:2314691
Cellular Component	GO:0005829	cytosol	Rapgef4	IDA		Mouse	PMID:11056535
Cellular Component	GO:0030425	dendrite	Rapgef4	IDA		Rat	PMID:19734897\|RGD:2314692
Cellular Component	GO:0043197	dendritic spine	Rapgef4	IDA		Rat	PMID:19734897\|RGD:2314692
Cellular Component	GO:0060076	excitatory synapse	Rapgef4	IDA		Rat	PMID:19734897\|RGD:2314692
Cellular Component	GO:0098978	glutamatergic synapse	Rapgef4	IDA		Rat	PMID:19734897\|RGD:2314692
Cellular Component	GO:0098978	glutamatergic synapse	Rapgef4	IMP		Rat	PMID:19734897\|RGD:2314692
Cellular Component	GO:0030426	growth cone	Rapgef4	IDA		Rat	PMID:18583150\|RGD:9835386
Cellular Component	GO:0098686	hippocampal mossy fiber to CA3 synapse	Rapgef4	IDA		Mouse	PMID:25904804
Cellular Component	GO:0098686	hippocampal mossy fiber to CA3 synapse	Rapgef4	IMP		Mouse	PMID:25904804
Cellular Component	GO:0043025	neuronal cell body	Rapgef4	IDA		Rat	PMID:19883736\|RGD:2314691
Cellular Component	GO:0001917	photoreceptor inner segment	Rapgef4	IDA		Rat	PMID:19883736\|RGD:2314691
Cellular Component	GO:0001750	photoreceptor outer segment	Rapgef4	IDA		Rat	PMID:19883736\|RGD:2314691
Cellular Component	GO:0005886	plasma membrane	Rapgef4	IDA		Rat	PMID:19734897\|RGD:2314692
Cellular Component	GO:0014069	postsynaptic density	Rapgef4	IDA		Rat	PMID:19734897\|RGD:2314692
Cellular Component	GO:0032991	protein-containing complex	Rapgef4	IDA		Rat	PMID:19734897\|RGD:2314692
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	Rapgef4	IMP		Mouse	PMID:11598134
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	Rapgef4	IDA		Mouse	PMID:12401793
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	Rapgef4	IDA		Mouse	PMID:11598134
Biological Process	GO:0007188	adenylate cyclase-modulating G protein-coupled receptor signaling pathway	Rapgef4	IDA		Mouse	PMID:11056535
Biological Process	GO:0007420	brain development	Rapgef4	IEP		Rat	PMID:18583150\|RGD:9835386
Biological Process	GO:0017156	calcium-ion regulated exocytosis	Rapgef4	IDA		Mouse	PMID:11056535
Biological Process	GO:1990090	cellular response to nerve growth factor stimulus	Rapgef4	IEP		Rat	PMID:25126967\|RGD:9850100
Biological Process	GO:0061548	ganglion development	Rapgef4	IEP		Rat	PMID:18583150\|RGD:9835386
Biological Process	GO:0007507	heart development	Rapgef4	IEP		Rat	PMID:18697745\|RGD:2314761
Biological Process	GO:0046879	hormone secretion	Rapgef4	IMP	MGI:MGI:3767602	Mouse	PMID:23542788
Biological Process	GO:0030073	insulin secretion	Rapgef4	IDA		Mouse	PMID:11598134
Biological Process	GO:0030073	insulin secretion	Rapgef4	IDA		Mouse	PMID:12401793
Biological Process	GO:0050805	negative regulation of synaptic transmission	Rapgef4	IDA		Rat	PMID:19734897\|RGD:2314692
Biological Process	GO:0032024	positive regulation of insulin secretion	Rapgef4	IMP		Mouse	PMID:11598134
Biological Process	GO:1904457	positive regulation of neuronal action potential	Rapgef4	IMP		Rat	PMID:25126967\|RGD:9850100
Biological Process	GO:0050714	positive regulation of protein secretion	Rapgef4	IMP		Rat	PMID:25126967\|RGD:9850100
Biological Process	GO:0014911	positive regulation of smooth muscle cell migration	Rapgef4	IDA		Rat	PMID:18697745\|RGD:2314761
Biological Process	GO:0050773	regulation of dendrite development	Rapgef4	IMP		Rat	PMID:19734897\|RGD:2314692
Biological Process	GO:0017157	regulation of exocytosis	Rapgef4	IDA		Mouse	PMID:12401793
Biological Process	GO:0098696	regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	Rapgef4	IDA		Rat	PMID:19734897\|RGD:2314692
Biological Process	GO:0098696	regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	Rapgef4	IMP		Rat	PMID:19734897\|RGD:2314692
Biological Process	GO:0099175	regulation of postsynapse organization	Rapgef4	IDA		Rat	PMID:19734897\|RGD:2314692
Biological Process	GO:0099175	regulation of postsynapse organization	Rapgef4	IMP		Rat	PMID:19734897\|RGD:2314692
Biological Process	GO:0098693	regulation of synaptic vesicle cycle	Rapgef4	IMP		Mouse	PMID:25904804
Biological Process	GO:0098693	regulation of synaptic vesicle cycle	Rapgef4	IDA		Mouse	PMID:25904804
Biological Process	GO:1901423	response to benzene	Rapgef4	IEP		Rat	PMID:15468289\|RGD:9835385
Biological Process	GO:0007165	signal transduction	Rapgef4	IDA		Rat	PMID:9856955\|RGD:632397
Biological Process	GO:0021510	spinal cord development	Rapgef4	IEP		Rat	PMID:18583150\|RGD:9835386

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/18/2025 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.