Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes RASA1
  • Mouse genes Rasa1
  • Rat genes Rasa1
  • Zfish genes rasa1a,rasa1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Rasa1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005096	GTPase activator activity	RASA1	EXP		Human	PMID:7478585
Molecular Function	GO:0005096	GTPase activator activity	Rasa1	IDA		Rat	PMID:8226805|RGD:9999452
Molecular Function	GO:0051020	GTPase binding	RASA1	IPI	UniProtKB:P01112	Human	PMID:2122974
Molecular Function	GO:0019900	kinase binding	Rasa1	IPI	UniprotKB:P00524	Rat	PMID:1704131|RGD:10002729
Molecular Function	GO:0001784	phosphotyrosine residue binding	RASA1	IPI	UniProtKB:O84462	Human	PMID:20624904
Molecular Function	GO:0001784	phosphotyrosine residue binding	RASA1	IPI	UniProtKB:Q6GX35	Human	PMID:20624904
Molecular Function	GO:0005161	platelet-derived growth factor receptor binding	Rasa1	IPI	RGD:3285	Rat	PMID:7489253|RGD:10002733
Molecular Function	GO:0005161	platelet-derived growth factor receptor binding	Rasa1	IDA		Rat	PMID:9612285|RGD:10002728
Molecular Function	GO:0005515	protein binding	RASA1	IPI	UniProtKB:P09619	Human	PMID:1314164
Molecular Function	GO:0005515	protein binding	RASA1	IPI	UniProtKB:P09619	Human	PMID:1375321
Molecular Function	GO:0005515	protein binding	RASA1	IPI	UniProtKB:Q05397	Human	PMID:15077193
Molecular Function	GO:0005515	protein binding	RASA1	IPI	UniProtKB:Q03135	Human	PMID:15504032
Molecular Function	GO:0005515	protein binding	RASA1	IPI	UniProtKB:Q13480	Human	PMID:15574420
Molecular Function	GO:0005515	protein binding	RASA1	IPI	UniProtKB:P00533	Human	PMID:16273093
Molecular Function	GO:0005515	protein binding	RASA1	IPI	UniProtKB:P04626	Human	PMID:16273093
Molecular Function	GO:0005515	protein binding	RASA1	IPI	UniProtKB:P21860	Human	PMID:16273093
Molecular Function	GO:0005515	protein binding	RASA1	IPI	UniProtKB:Q13017	Human	PMID:1689011
Molecular Function	GO:0005515	protein binding	RASA1	IPI	UniProtKB:P04632	Human	PMID:18761085
Molecular Function	GO:0005515	protein binding	RASA1	IPI	UniProtKB:Q96QB1	Human	PMID:19151751
Molecular Function	GO:0005515	protein binding	RASA1	IPI	UniProtKB:Q8IZP0	Human	PMID:20598684
Molecular Function	GO:0005515	protein binding	RASA1	IPI	UniProtKB:Q03135	Human	PMID:20808760
Molecular Function	GO:0005515	protein binding	RASA1	IPI	UniProtKB:P16333	Human	PMID:21664272
Molecular Function	GO:0005515	protein binding	RASA1	IPI	UniProtKB:P04626	Human	PMID:24412244
Molecular Function	GO:0005515	protein binding	RASA1	IPI	UniProtKB:Q96QB1	Human	PMID:24412244
Molecular Function	GO:0005515	protein binding	RASA1	IPI	UniProtKB:P08581	Human	PMID:24728074
Molecular Function	GO:0005515	protein binding	RASA1	IPI	UniProtKB:P10275	Human	PMID:24728074
Molecular Function	GO:0005515	protein binding	RASA1	IPI	UniProtKB:P10721	Human	PMID:24728074
Molecular Function	GO:0005515	protein binding	RASA1	IPI	UniProtKB:Q13480	Human	PMID:24728074
Molecular Function	GO:0005515	protein binding	RASA1	IPI	UniProtKB:P36888	Human	PMID:28086240
Molecular Function	GO:0005515	protein binding	RASA1	IPI	UniProtKB:P54760	Human	PMID:30578106
Molecular Function	GO:0005515	protein binding	RASA1	IPI	UniProtKB:Q96IK5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RASA1	IPI	UniProtKB:P42858	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	RASA1	IPI	UniProtKB:P09619	Human	PMID:8382774
Molecular Function	GO:0005515	protein binding	RASA1	IPI	UniProtKB:P06239	Human	PMID:8618896
Molecular Function	GO:0005515	protein binding	RASA1	IPI	UniProtKB:Q13501	Human	PMID:8618896
Molecular Function	GO:0005515	protein binding	RASA1	IPI	UniProtKB:Q13283	Human	PMID:8649363
Molecular Function	GO:0005515	protein binding	RASA1	IPI	UniProtKB:P01112	Human	PMID:9219684
Molecular Function	GO:0005515	protein binding	Rasa1	IPI	PR:P97465	Mouse	PMID:9008161
Molecular Function	GO:0005515	protein binding	Rasa1	IPI	PR:O70469	Mouse	PMID:9697832
Molecular Function	GO:0005515	protein binding	Rasa1	IPI	UniProtKB:Q8R500	Rat	PMID:15322553|RGD:1304351
Molecular Function	GO:0005515	protein binding	Rasa1	IPI	RGD:1308738	Rat	PMID:2005883|RGD:10002731
Molecular Function	GO:0005515	protein binding	Rasa1	IPI	RGD:621459	Rat	PMID:2005883|RGD:10002731
Molecular Function	GO:0005515	protein binding	Rasa1	IPI	UniProtKB:Q13480	Rat	PMID:31585087|RGD:21201274
Molecular Function	GO:0043422	protein kinase B binding	Rasa1	IPI	RGD:2081	Rat	PMID:14707121|RGD:9999423
Molecular Function	GO:1990782	protein tyrosine kinase binding	Rasa1	IPI	RGD:2641	Rat	PMID:10708762|RGD:1642649
Molecular Function	GO:0044877	protein-containing complex binding	Rasa1	IPI	RGD:628758|RGD:621172	Rat	PMID:10708762|RGD:1642649
Molecular Function	GO:0044877	protein-containing complex binding	Rasa1	IDA		Rat	PMID:2005883|RGD:10002731
Molecular Function	GO:0030971	receptor tyrosine kinase binding	Rasa1	IPI	RGD:628758	Rat	PMID:10708762|RGD:1642649
Molecular Function	GO:0005102	signaling receptor binding	RASA1	IPI	UniProtKB:P09619	Human	PMID:2157284
Molecular Function	GO:0005102	signaling receptor binding	RASA1	IPI	UniProtKB:P00533	Human	PMID:2176151
Molecular Function	GO:0044325	transmembrane transporter binding	Rasa1	IPI	RGD:621172	Rat	PMID:10708762|RGD:1642649
Cellular Component	GO:0005829	cytosol	Rasa1	IDA		Rat	PMID:8226805|RGD:9999452
Cellular Component	GO:0016020	membrane	Rasa1	IDA		Rat	PMID:2005883|RGD:10002731
Cellular Component	GO:0031965	nuclear membrane	Rasa1	IDA		Rat	PMID:1382416|RGD:10041028
Cellular Component	GO:0005886	plasma membrane	Rasa1	IDA		Mouse	PMID:15860730
Cellular Component	GO:0005886	plasma membrane	Rasa1	IDA		Rat	PMID:1382416|RGD:10041028
Cellular Component	GO:0001726	ruffle	Rasa1	IDA		Mouse	PMID:15860730
Biological Process	GO:0090630	activation of GTPase activity	Rasa1	IDA		Rat	PMID:8226805|RGD:9999452
Biological Process	GO:0001568	blood vessel development	rasa1a	IGI	ZFIN:ZDB-GENE-070713-2	Zfish	PMID:24837431
Biological Process	GO:0001568	blood vessel development	rasa1a	IGI	ZFIN:ZDB-GENE-990415-62	Zfish	PMID:24837431
Biological Process	GO:0001568	blood vessel development	rasa1a	IMP	ZFIN:ZDB-MRPHLNO-140709-3	Zfish	PMID:24837431
Biological Process	GO:0048514	blood vessel morphogenesis	RASA1	IMP		Human	PMID:23687085
Biological Process	GO:0071364	cellular response to epidermal growth factor stimulus	Rasa1	IDA		Rat	PMID:2005883|RGD:10002731
Biological Process	GO:0044344	cellular response to fibroblast growth factor stimulus	Rasa1	IEP		Rat	PMID:15530650|RGD:2324642
Biological Process	GO:0036120	cellular response to platelet-derived growth factor stimulus	Rasa1	IDA		Rat	PMID:9612285|RGD:10002728
Biological Process	GO:0048013	ephrin receptor signaling pathway	rasa1a	IGI	ZFIN:ZDB-GENE-070713-2	Zfish	PMID:24837431
Biological Process	GO:0048013	ephrin receptor signaling pathway	rasa1a	IGI	ZFIN:ZDB-GENE-990415-62	Zfish	PMID:24837431
Biological Process	GO:0030539	male genitalia development	Rasa1	IEP		Rat	PMID:20933506|RGD:9999420
Biological Process	GO:0043066	negative regulation of apoptotic process	RASA1	IDA		Human	PMID:15542850
Biological Process	GO:0007162	negative regulation of cell adhesion	RASA1	IDA		Human	PMID:8344248
Biological Process	GO:0001953	negative regulation of cell-matrix adhesion	RASA1	IDA		Human	PMID:8344248
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	Rasa1	IMP		Rat	PMID:7588705|RGD:10002727
Biological Process	GO:0046326	positive regulation of glucose import	Rasa1	IMP		Rat	PMID:7588705|RGD:10002727
Biological Process	GO:0043547	positive regulation of GTPase activity	Rasa1	IMP		Rat	PMID:14707121|RGD:9999423
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	Rasa1	IMP		Rat	PMID:7588705|RGD:10002727
Biological Process	GO:0001934	positive regulation of protein phosphorylation	Rasa1	IMP		Rat	PMID:14707121|RGD:9999423
Biological Process	GO:0030833	regulation of actin filament polymerization	RASA1	IDA		Human	PMID:8344248
Biological Process	GO:0032868	response to insulin	Rasa1	IEP		Rat	PMID:11208545|RGD:10002732
Biological Process	GO:0009410	response to xenobiotic stimulus	Rasa1	IDA		Rat	PMID:1382416|RGD:10041028
Biological Process	GO:0007165	signal transduction	RASA1	IDA		Human	PMID:1756860

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern