Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes RASGRP1
  • Mouse genes Rasgrp1
  • Rat genes Rasgrp1
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Rasgrp1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005509	calcium ion binding	RASGRP1	IMP		Human	PMID:23908768
Molecular Function	GO:0019992	diacylglycerol binding	RASGRP1	IMP		Human	PMID:23908768
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	RASGRP1	IMP		Human	PMID:23908768
Molecular Function	GO:0042802	identical protein binding	RASGRP1	IPI	UniProtKB:O95267	Human	PMID:23908768
Molecular Function	GO:0031210	phosphatidylcholine binding	RASGRP1	IMP		Human	PMID:23908768
Molecular Function	GO:0008270	zinc ion binding	RASGRP1	IMP		Human	PMID:23908768
Cellular Component	GO:0005829	cytosol	RASGRP1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005794	Golgi apparatus	RASGRP1	IDA		Human	PMID:21968647
Cellular Component	GO:0005886	plasma membrane	RASGRP1	IDA		Human	GO_REF:0000052
Biological Process	GO:0090630	activation of GTPase activity	RASGRP1	IDA		Human	PMID:10807788
Biological Process	GO:0090630	activation of GTPase activity	RASGRP1	IMP		Human	PMID:12845332
Biological Process	GO:0090630	activation of GTPase activity	Rasgrp1	IMP		Mouse	MGI:MGI:1891792|PMID:11017103
Biological Process	GO:0090630	activation of GTPase activity	Rasgrp1	IMP	MGI:MGI:2386261	Mouse	PMID:17190838
Biological Process	GO:0042113	B cell activation	RASGRP1	IMP		Human	PMID:27776107
Biological Process	GO:0042113	B cell activation	RASGRP1	IMP		Human	PMID:29155103
Biological Process	GO:0042100	B cell proliferation	RASGRP1	IMP		Human	PMID:27776107
Biological Process	GO:0002437	inflammatory response to antigenic stimulus	Rasgrp1	IMP	MGI:MGI:2386261	Mouse	PMID:17190838
Biological Process	GO:0032762	mast cell cytokine production	Rasgrp1	IMP	MGI:MGI:2386261	Mouse	PMID:17190838
Biological Process	GO:0043303	mast cell degranulation	Rasgrp1	IMP	MGI:MGI:2386261	Mouse	PMID:17190838
Biological Process	GO:0030101	natural killer cell activation	RASGRP1	IMP		Human	PMID:27776107
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	RASGRP1	IMP		Human	PMID:19933860
Biological Process	GO:0032725	positive regulation of granulocyte macrophage colony-stimulating factor production	RASGRP1	IMP		Human	PMID:19933860
Biological Process	GO:0043547	positive regulation of GTPase activity	RASGRP1	IMP		Human	PMID:23908768
Biological Process	GO:0046330	positive regulation of JNK cascade	RASGRP1	IMP		Human	PMID:19933860
Biological Process	GO:0043406	positive regulation of MAP kinase activity	RASGRP1	IMP		Human	PMID:15899849
Biological Process	GO:0032816	positive regulation of natural killer cell activation	Rasgrp1	IMP		Mouse	MGI:MGI:5302428|PMID:21957144
Biological Process	GO:0032825	positive regulation of natural killer cell differentiation	Rasgrp1	IMP		Mouse	MGI:MGI:5302428|PMID:21957144
Biological Process	GO:0045954	positive regulation of natural killer cell mediated cytotoxicity	RASGRP1	IMP		Human	PMID:19933860
Biological Process	GO:0001934	positive regulation of protein phosphorylation	RASGRP1	IDA		Human	PMID:21968647
Biological Process	GO:0001934	positive regulation of protein phosphorylation	RASGRP1	IMP		Human	PMID:23908768
Biological Process	GO:0046579	positive regulation of Ras protein signal transduction	RASGRP1	IMP		Human	PMID:19933860
Biological Process	GO:0033089	positive regulation of T cell differentiation in thymus	Rasgrp1	IMP		Mouse	MGI:MGI:1891792|PMID:11017103
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	RASGRP1	IMP		Human	PMID:19933860
Biological Process	GO:0032729	positive regulation of type II interferon production	RASGRP1	IMP		Human	PMID:19933860
Biological Process	GO:0070372	regulation of ERK1 and ERK2 cascade	RASGRP1	IMP		Human	PMID:23908768
Biological Process	GO:0014066	regulation of phosphatidylinositol 3-kinase signaling	Rasgrp1	IMP	MGI:MGI:2386261	Mouse	PMID:17190838
Biological Process	GO:0032252	secretory granule localization	Rasgrp1	IMP	MGI:MGI:2386261	Mouse	PMID:17190838
Biological Process	GO:0042110	T cell activation	RASGRP1	IMP		Human	PMID:27776107
Biological Process	GO:0042110	T cell activation	RASGRP1	IMP		Human	PMID:29155103
Biological Process	GO:0042098	T cell proliferation	RASGRP1	IMP		Human	PMID:29155103
Biological Process	GO:0047496	vesicle transport along microtubule	Rasgrp1	IMP	MGI:MGI:2386261	Mouse	PMID:17190838

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern