Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes RBP4
  • Mouse genes Rbp4
  • Rat genes Rbp4
  • Zfish genes rbp4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Rbp4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	RBP4	IPI	UniProtKB:B7ZS96	Human	PMID:11080066
Molecular Function	GO:0005515	protein binding	RBP4	IPI	UniProtKB:O55245	Human	PMID:12228058
Molecular Function	GO:0005515	protein binding	RBP4	IPI	UniProtKB:O55245	Human	PMID:21777382
Molecular Function	GO:0005515	protein binding	RBP4	IPI	UniProtKB:P02766	Human	PMID:21777382
Molecular Function	GO:0005515	protein binding	RBP4	IPI	UniProtKB:P02766	Human	PMID:29997244
Molecular Function	GO:0005515	protein binding	RBP4	IPI	UniProtKB:P27731	Human	PMID:986177
Molecular Function	GO:0005515	protein binding	Rbp4	IPI	PR:O70491	Mouse	PMID:23105095
Molecular Function	GO:0005515	protein binding	Rbp4	IPI	PR:P07309	Mouse	PMID:23105095
Molecular Function	GO:0005515	protein binding	Rbp4	IPI	PR:Q9DBN1	Mouse	PMID:23105095
Molecular Function	GO:0044877	protein-containing complex binding	Rbp4	IDA		Rat	PMID:9260907|RGD:6484695
Molecular Function	GO:0019841	retinol binding	RBP4	IDA		Human	PMID:571335
Molecular Function	GO:0019841	retinol binding	Rbp4	IDA		Mouse	PMID:12484775
Molecular Function	GO:0019841	retinol binding	Rbp4	IDA		Rat	PMID:4708098|RGD:11567252
Molecular Function	GO:0019841	retinol binding	Rbp4	IDA		Rat	PMID:9260907|RGD:6484695
Cellular Component	GO:0070062	extracellular exosome	RBP4	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	RBP4	HDA		Human	PMID:23533145
Cellular Component	GO:0005615	extracellular space	RBP4	IDA		Human	PMID:12237133
Cellular Component	GO:0005615	extracellular space	RBP4	IDA		Human	PMID:17003346
Cellular Component	GO:0005615	extracellular space	RBP4	IDA		Human	PMID:5132677
Cellular Component	GO:0005615	extracellular space	Rbp4	IDA		Mouse	MGI:MGI:3584329|PMID:16034410
Cellular Component	GO:0005615	extracellular space	Rbp4	IDA		Rat	PMID:18819112|RGD:2302015
Cellular Component	GO:0005615	extracellular space	Rbp4	IDA		Rat	PMID:4708098|RGD:11567252
Cellular Component	GO:0032991	protein-containing complex	Rbp4	IDA		Rat	PMID:9260907|RGD:6484695
Biological Process	GO:0048738	cardiac muscle tissue development	Rbp4	IMP		Mouse	MGI:MGI:2655947|PMID:12663486
Biological Process	GO:0050908	detection of light stimulus involved in visual perception	Rbp4	IMP	MGI:MGI:2445721	Mouse	PMID:12484775
Biological Process	GO:0009790	embryo development	Rbp4	IGI	MGI:MGI:1891259	Mouse	PMID:18093970
Biological Process	GO:0048562	embryonic organ morphogenesis	Rbp4	IMP		Mouse	MGI:MGI:3604178|PMID:15994349
Biological Process	GO:0060059	embryonic retina morphogenesis in camera-type eye	Rbp4	IMP		Mouse	MGI:MGI:1344892|PMID:10469643
Biological Process	GO:0048706	embryonic skeletal system development	Rbp4	IMP		Mouse	MGI:MGI:3604178|PMID:15994349
Biological Process	GO:0001654	eye development	RBP4	IMP		Human	PMID:10232633
Biological Process	GO:0001654	eye development	Rbp4	IMP		Mouse	MGI:MGI:3604178|PMID:15994349
Biological Process	GO:0048807	female genitalia morphogenesis	Rbp4	IMP		Mouse	MGI:MGI:3604178|PMID:15994349
Biological Process	GO:0006094	gluconeogenesis	RBP4	IMP		Human	PMID:18466349
Biological Process	GO:0006094	gluconeogenesis	Rbp4	IMP		Mouse	MGI:MGI:3584329|PMID:16034410
Biological Process	GO:0042593	glucose homeostasis	RBP4	IDA		Human	PMID:17003346
Biological Process	GO:0007507	heart development	Rbp4	IMP		Mouse	MGI:MGI:3604178|PMID:15994349
Biological Process	GO:0060347	heart trabecula formation	Rbp4	IMP		Mouse	MGI:MGI:2655947|PMID:12663486
Biological Process	GO:0001889	liver development	rbp4	IMP	ZFIN:ZDB-MRPHLNO-080516-1	Zfish	PMID:17945029
Biological Process	GO:0001889	liver development	rbp4	IMP	ZFIN:ZDB-MRPHLNO-080516-2	Zfish	PMID:17945029
Biological Process	GO:0030324	lung development	Rbp4	IMP		Mouse	MGI:MGI:3604178|PMID:15994349
Biological Process	GO:0030277	maintenance of gastrointestinal epithelium	RBP4	IDA		Human	PMID:10944490
Biological Process	GO:0008584	male gonad development	Rbp4	IMP	MGI:MGI:3625605	Mouse	PMID:16586441
Biological Process	GO:0060044	negative regulation of cardiac muscle cell proliferation	Rbp4	IMP		Mouse	MGI:MGI:2655947|PMID:12663486
Biological Process	GO:0002639	positive regulation of immunoglobulin production	Rbp4	IDA		Mouse	MGI:MGI:3796317|PMID:10944490
Biological Process	GO:0032024	positive regulation of insulin secretion	RBP4	IMP		Human	PMID:16034410
Biological Process	GO:0045471	response to ethanol	Rbp4	IEP		Rat	PMID:17624994|RGD:2302017
Biological Process	GO:0032868	response to insulin	Rbp4	IMP	MGI:MGI:2445721	Mouse	PMID:16034410
Biological Process	GO:0032526	response to retinoic acid	RBP4	IDA		Human	PMID:571335
Biological Process	GO:0032526	response to retinoic acid	rbp4	IDA		Zfish	PMID:17945029
Biological Process	GO:0060041	retina development in camera-type eye	Rbp4	IMP	MGI:MGI:2445721	Mouse	PMID:11562477
Biological Process	GO:0042574	retinal metabolic process	Rbp4	IMP	MGI:MGI:2445721	Mouse	PMID:11562477
Biological Process	GO:0042572	retinol metabolic process	RBP4	IMP		Human	PMID:10232633
Biological Process	GO:0042572	retinol metabolic process	Rbp4	IGI	MGI:MGI:1891259	Mouse	PMID:18093970
Biological Process	GO:0034633	retinol transport	Rbp4	IMP	MGI:MGI:3625605	Mouse	PMID:16586441
Biological Process	GO:0034633	retinol transport	Rbp4	IGI	MGI:MGI:1921402	Mouse	PMID:23105095
Biological Process	GO:0034633	retinol transport	Rbp4	IMP	MGI:MGI:2445721	Mouse	PMID:15314099
Biological Process	GO:0034633	retinol transport	Rbp4	IMP	MGI:MGI:2445721	Mouse	PMID:11562477
Biological Process	GO:0034633	retinol transport	Rbp4	IMP	MGI:MGI:2445721	Mouse	PMID:18093970
Biological Process	GO:0034633	retinol transport	Rbp4	IMP	MGI:MGI:2445721	Mouse	PMID:12484775
Biological Process	GO:0034633	retinol transport	Rbp4	IDA		Rat	PMID:9260907|RGD:6484695
Biological Process	GO:0007283	spermatogenesis	Rbp4	IMP	MGI:MGI:3625605	Mouse	PMID:16586441
Biological Process	GO:0060157	urinary bladder development	Rbp4	IMP		Mouse	MGI:MGI:3604178|PMID:15994349
Biological Process	GO:0060065	uterus development	Rbp4	IMP		Mouse	MGI:MGI:3604178|PMID:15994349
Biological Process	GO:0060068	vagina development	Rbp4	IMP		Mouse	MGI:MGI:3604178|PMID:15994349
Biological Process	GO:0071939	vitamin A import into cell	Rbp4	IMP	MGI:MGI:2445721	Mouse	PMID:12484775

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern