Comparative GO Graph (mouse, human, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes RC3H1
  • Mouse genes Rc3h1
  • Rat genes
  • Zfish genes rc3h1a,rc3h1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Rc3h1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:1905762	CCR4-NOT complex binding	RC3H1	IMP		Human	PMID:31636267
Molecular Function	GO:0003725	double-stranded RNA binding	RC3H1	IDA		Human	PMID:25026078
Molecular Function	GO:0003725	double-stranded RNA binding	RC3H1	IDA		Human	PMID:25504471
Molecular Function	GO:0035198	miRNA binding	Rc3h1	IDA		Mouse	MGI:MGI:5641569|PMID:25697406
Molecular Function	GO:0003730	mRNA 3'-UTR binding	Rc3h1	IDA		Mouse	MGI:MGI:5751631|PMID:26255671
Molecular Function	GO:0003730	mRNA 3'-UTR binding	Rc3h1	IDA		Mouse	MGI:MGI:4819285|PMID:20639877
Molecular Function	GO:0003730	mRNA 3'-UTR binding	Rc3h1	IDA		Mouse	MGI:MGI:5706859|PMID:26000482
Molecular Function	GO:0003729	mRNA binding	Rc3h1	IDA		Mouse	PMID:23583643
Molecular Function	GO:0005515	protein binding	RC3H1	IPI	UniProtKB:Q9UKV8	Human	PMID:25697406
Molecular Function	GO:0005515	protein binding	Rc3h1	IPI	UniProtKB:Q3UJB9	Mouse	MGI:MGI:4819285|PMID:20639877
Molecular Function	GO:0005515	protein binding	Rc3h1	IPI	UniProtKB:Q8CJG0	Mouse	MGI:MGI:5641569|PMID:25697406
Molecular Function	GO:0005515	protein binding	Rc3h1	IPI	PR:Q3UJB9	Mouse	PMID:23583643
Molecular Function	GO:0003723	RNA binding	RC3H1	HDA		Human	PMID:22658674
Molecular Function	GO:0003723	RNA binding	RC3H1	HDA		Human	PMID:22681889
Molecular Function	GO:0035613	RNA stem-loop binding	RC3H1	IDA		Human	PMID:25504471
Molecular Function	GO:0035613	RNA stem-loop binding	Rc3h1	IDA		Mouse	MGI:MGI:6154479|PMID:25026077
Molecular Function	GO:0035613	RNA stem-loop binding	Rc3h1	IDA		Mouse	MGI:MGI:5706859|PMID:26000482
Molecular Function	GO:0035613	RNA stem-loop binding	Rc3h1	IDA		Mouse	MGI:MGI:5751631|PMID:26255671
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	RC3H1	IDA		Human	PMID:26489670
Molecular Function	GO:0008270	zinc ion binding	Rc3h1	IDA		Mouse	MGI:MGI:5641569|PMID:25697406
Cellular Component	GO:0005737	cytoplasm	Rc3h1	IDA		Mouse	PMID:15917799
Cellular Component	GO:0010494	cytoplasmic stress granule	Rc3h1	IDA		Mouse	MGI:MGI:5706859|PMID:26000482
Cellular Component	GO:0010494	cytoplasmic stress granule	Rc3h1	IDA		Mouse	MGI:MGI:3580753|PMID:15917799
Cellular Component	GO:0010494	cytoplasmic stress granule	Rc3h1	IDA		Mouse	MGI:MGI:4819285|PMID:20639877
Cellular Component	GO:0010494	cytoplasmic stress granule	Rc3h1	IDA		Mouse	MGI:MGI:5751631|PMID:26255671
Cellular Component	GO:0000932	P-body	RC3H1	IMP		Human	PMID:31636267
Cellular Component	GO:0000932	P-body	Rc3h1	IDA		Mouse	MGI:MGI:5751631|PMID:26255671
Cellular Component	GO:0000932	P-body	Rc3h1	IDA		Mouse	MGI:MGI:4819285|PMID:20639877
Cellular Component	GO:0000932	P-body	Rc3h1	IDA		Mouse	MGI:MGI:5706859|PMID:26000482
Biological Process	GO:0061158	3'-UTR-mediated mRNA destabilization	Rc3h1	IDA		Mouse	MGI:MGI:5751631|PMID:26255671
Biological Process	GO:0061158	3'-UTR-mediated mRNA destabilization	Rc3h1	IDA		Mouse	MGI:MGI:5706859|PMID:26000482
Biological Process	GO:0001782	B cell homeostasis	Rc3h1	IGI	MGI:MGI:2442789	Mouse	PMID:23583643
Biological Process	GO:0071347	cellular response to interleukin-1	Rc3h1	IDA		Mouse	MGI:MGI:5751631|PMID:26255671
Biological Process	GO:0048535	lymph node development	Rc3h1	IGI	MGI:MGI:2442789	Mouse	PMID:23583643
Biological Process	GO:0046007	negative regulation of activated T cell proliferation	Rc3h1	IMP		Mouse	MGI:MGI:5284769|PMID:18172933
Biological Process	GO:0030889	negative regulation of B cell proliferation	Rc3h1	IMP		Mouse	MGI:MGI:5284769|PMID:18172933
Biological Process	GO:0002635	negative regulation of germinal center formation	Rc3h1	IMP		Mouse	MGI:MGI:5284769|PMID:18172933
Biological Process	GO:2000320	negative regulation of T-helper 17 cell differentiation	Rc3h1	IMP		Mouse	MGI:MGI:6142401|PMID:25282160
Biological Process	GO:0045623	negative regulation of T-helper cell differentiation	Rc3h1	IMP	MGI:MGI:3581675	Mouse	PMID:15917799
Biological Process	GO:0000956	nuclear-transcribed mRNA catabolic process	RC3H1	IDA		Human	PMID:25026078
Biological Process	GO:0000956	nuclear-transcribed mRNA catabolic process	Rc3h1	IMP		Mouse	MGI:MGI:4819285|PMID:20639877
Biological Process	GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	Rc3h1	IMP		Mouse	MGI:MGI:5751631|PMID:26255671
Biological Process	GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	Rc3h1	IMP		Mouse	MGI:MGI:5706859|PMID:26000482
Biological Process	GO:0033962	P-body assembly	Rc3h1	IMP		Mouse	MGI:MGI:4819285|PMID:20639877
Biological Process	GO:0061014	positive regulation of mRNA catabolic process	Rc3h1	IDA		Mouse	MGI:MGI:5751631|PMID:26255671
Biological Process	GO:0061014	positive regulation of mRNA catabolic process	Rc3h1	IDA		Mouse	MGI:MGI:5706859|PMID:26000482
Biological Process	GO:0061014	positive regulation of mRNA catabolic process	Rc3h1	IMP		Mouse	MGI:MGI:6154479|PMID:25026077
Biological Process	GO:1901224	positive regulation of NIK/NF-kappaB signaling	Rc3h1	IDA		Mouse	PMID:23583643
Biological Process	GO:0010608	post-transcriptional regulation of gene expression	Rc3h1	IMP		Mouse	MGI:MGI:6154479|PMID:25026077
Biological Process	GO:0010608	post-transcriptional regulation of gene expression	Rc3h1	IMP		Mouse	MGI:MGI:4819285|PMID:20639877
Biological Process	GO:0010608	post-transcriptional regulation of gene expression	Rc3h1	IDA		Mouse	PMID:23583643
Biological Process	GO:0000209	protein polyubiquitination	RC3H1	IDA		Human	PMID:26489670
Biological Process	GO:0010468	regulation of gene expression	Rc3h1	IDA		Mouse	PMID:23583643
Biological Process	GO:0002634	regulation of germinal center formation	Rc3h1	IMP		Mouse	MGI:MGI:3580753|PMID:15917799
Biological Process	GO:0002634	regulation of germinal center formation	Rc3h1	IMP		Mouse	MGI:MGI:3838060|PMID:19217324
Biological Process	GO:2000628	regulation of miRNA metabolic process	Rc3h1	IMP		Mouse	MGI:MGI:5641569|PMID:25697406
Biological Process	GO:2000628	regulation of miRNA metabolic process	Rc3h1	IMP		Mouse	MGI:MGI:6377925|PMID:31636267
Biological Process	GO:0043488	regulation of mRNA stability	Rc3h1	IMP		Mouse	MGI:MGI:5284769|PMID:18172933
Biological Process	GO:1900151	regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	RC3H1	IMP		Human	PMID:31636267
Biological Process	GO:0050856	regulation of T cell receptor signaling pathway	Rc3h1	IMP		Mouse	MGI:MGI:3580753|PMID:15917799
Biological Process	GO:0048536	spleen development	Rc3h1	IGI	MGI:MGI:2442789	Mouse	PMID:23583643
Biological Process	GO:0043029	T cell homeostasis	Rc3h1	IGI	MGI:MGI:2442789	Mouse	PMID:23583643
Biological Process	GO:0042098	T cell proliferation	Rc3h1	IGI	MGI:MGI:2442789	Mouse	PMID:23583643
Biological Process	GO:0050852	T cell receptor signaling pathway	Rc3h1	IMP		Mouse	MGI:MGI:6142401|PMID:25282160
Biological Process	GO:0061470	T follicular helper cell differentiation	Rc3h1	IGI	MGI:MGI:2442789	Mouse	PMID:23583643

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern