Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes RC3H2
  • Mouse genes Rc3h2
  • Rat genes Rc3h2
  • Zfish genes rc3h2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Rc3h2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003677	DNA binding	RC3H2	IDA		Human	PMID:10938276
Molecular Function	GO:0003725	double-stranded RNA binding	RC3H2	IDA		Human	PMID:26489670
Molecular Function	GO:0003729	mRNA binding	Rc3h2	IDA		Mouse	PMID:23583643
Molecular Function	GO:0005515	protein binding	Rc3h2	IPI	PR:Q3UJB9	Mouse	PMID:23583643
Molecular Function	GO:0003723	RNA binding	RC3H2	HDA		Human	PMID:22658674
Molecular Function	GO:0003723	RNA binding	RC3H2	HDA		Human	PMID:22681889
Molecular Function	GO:0035613	RNA stem-loop binding	RC3H2	IDA		Human	PMID:26249698
Molecular Function	GO:0035613	RNA stem-loop binding	RC3H2	IDA		Human	PMID:26489670
Molecular Function	GO:0061630	ubiquitin protein ligase activity	RC3H2	IDA		Human	PMID:24448648
Molecular Function	GO:0061630	ubiquitin protein ligase activity	RC3H2	IDA		Human	PMID:26489670
Cellular Component	GO:0009986	cell surface	RC3H2	IDA		Human	PMID:10938276
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	RC3H2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016020	membrane	RC3H2	IDA		Human	PMID:10938276
Biological Process	GO:0001782	B cell homeostasis	Rc3h2	IGI	MGI:MGI:2685397	Mouse	PMID:23583643
Biological Process	GO:0060173	limb development	Rc3h2	IMP	MGI:MGI:4364357	Mouse	PMID:23583643
Biological Process	GO:0048286	lung alveolus development	Rc3h2	IMP	MGI:MGI:4364357	Mouse	PMID:23583643
Biological Process	GO:0048535	lymph node development	Rc3h2	IGI	MGI:MGI:2685397	Mouse	PMID:23583643
Biological Process	GO:0035264	multicellular organism growth	Rc3h2	IMP	MGI:MGI:4364357	Mouse	PMID:23583643
Biological Process	GO:2000320	negative regulation of T-helper 17 cell differentiation	Rc3h2	IMP		Mouse	MGI:MGI:6142401|PMID:25282160
Biological Process	GO:1901224	positive regulation of NIK/NF-kappaB signaling	Rc3h2	IDA		Mouse	PMID:23583643
Biological Process	GO:0009791	post-embryonic development	Rc3h2	IMP	MGI:MGI:4364357	Mouse	PMID:23583643
Biological Process	GO:0010608	post-transcriptional regulation of gene expression	Rc3h2	IDA		Mouse	PMID:23583643
Biological Process	GO:0000209	protein polyubiquitination	RC3H2	IMP		Human	PMID:24448648
Biological Process	GO:0000209	protein polyubiquitination	RC3H2	IDA		Human	PMID:26489670
Biological Process	GO:0010468	regulation of gene expression	Rc3h2	IDA		Mouse	PMID:23583643
Biological Process	GO:2000628	regulation of miRNA metabolic process	Rc3h2	IMP		Mouse	MGI:MGI:5641569|PMID:25697406
Biological Process	GO:0048536	spleen development	Rc3h2	IGI	MGI:MGI:2685397	Mouse	PMID:23583643
Biological Process	GO:0043029	T cell homeostasis	Rc3h2	IGI	MGI:MGI:2685397	Mouse	PMID:23583643
Biological Process	GO:0042098	T cell proliferation	Rc3h2	IGI	MGI:MGI:2685397	Mouse	PMID:23583643
Biological Process	GO:0050852	T cell receptor signaling pathway	Rc3h2	IMP		Mouse	MGI:MGI:6142401|PMID:25282160
Biological Process	GO:0061470	T follicular helper cell differentiation	Rc3h2	IGI	MGI:MGI:2685397	Mouse	PMID:23583643

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern