Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes RDH5
  • Mouse genes Rdh5
  • Rat genes Rdh5
  • Zfish genes rdh1,rdh5
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Rdh5

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0047044	androstan-3-alpha,17-beta-diol dehydrogenase activity	RDH5	IDA		Human	PMID:9931293
Molecular Function	GO:0047023	androsterone dehydrogenase activity	RDH5	IDA		Human	PMID:9931293
Molecular Function	GO:0004745	NAD-retinol dehydrogenase activity	RDH5	IDA		Human	PMID:11675386
Molecular Function	GO:0004745	NAD-retinol dehydrogenase activity	Rdh5	IDA		Mouse	MGI:MGI:1350674|PMID:10588954
Molecular Function	GO:0004745	NAD-retinol dehydrogenase activity	rdh1	IDA		Zfish	PMID:15358764
Molecular Function	GO:0042803	protein homodimerization activity	RDH5	IDA		Human	PMID:11675386
Cellular Component	GO:0044297	cell body	Rdh5	IDA		Rat	PMID:19180257|RGD:6893662
Cellular Component	GO:0005788	endoplasmic reticulum lumen	RDH5	IDA		Human	PMID:11675386
Cellular Component	GO:0005788	endoplasmic reticulum lumen	Rdh5	IDA		Mouse	MGI:MGI:1355159|PMID:10739682
Cellular Component	GO:0005788	endoplasmic reticulum lumen	Rdh5	IDA		Mouse	PMID:16223484
Cellular Component	GO:0005789	endoplasmic reticulum membrane	RDH5	IDA		Human	PMID:11675386
Biological Process	GO:0035050	embryonic heart tube development	rdh1	IDA		Zfish	PMID:15358764
Biological Process	GO:0035118	embryonic pectoral fin morphogenesis	rdh1	IMP		Zfish	PMID:15358764
Biological Process	GO:0031018	endocrine pancreas development	rdh1	IMP		Zfish	PMID:15358764
Biological Process	GO:0030855	epithelial cell differentiation	rdh1	IMP		Zfish	PMID:15358764
Biological Process	GO:0031017	exocrine pancreas development	rdh1	IMP		Zfish	PMID:15358764
Biological Process	GO:0001754	eye photoreceptor cell differentiation	rdh5	IMP	ZFIN:ZDB-MRPHLNO-060928-2	Zfish	PMID:16938888
Biological Process	GO:0001754	eye photoreceptor cell differentiation	rdh5	IMP	ZFIN:ZDB-MRPHLNO-060928-1	Zfish	PMID:16938888
Biological Process	GO:0060041	retina development in camera-type eye	rdh5	IMP	ZFIN:ZDB-MRPHLNO-060928-1	Zfish	PMID:16938888
Biological Process	GO:0060041	retina development in camera-type eye	rdh5	IMP	ZFIN:ZDB-MRPHLNO-060928-2	Zfish	PMID:16938888
Biological Process	GO:0042574	retinal metabolic process	rdh1	IDA		Zfish	PMID:15358764
Biological Process	GO:0001523	retinoid metabolic process	RDH5	IDA		Human	PMID:9931293
Biological Process	GO:0001523	retinoid metabolic process	Rdh5	IDA		Mouse	MGI:MGI:1350674|PMID:10588954
Biological Process	GO:0042572	retinol metabolic process	rdh1	IDA		Zfish	PMID:15358764
Biological Process	GO:0001501	skeletal system development	rdh1	IMP		Zfish	PMID:15358764
Biological Process	GO:0008202	steroid metabolic process	RDH5	IDA		Human	PMID:9931293
Biological Process	GO:0035238	vitamin A biosynthetic process	rdh5	IDA		Zfish	PMID:16938888

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern