Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes REC8
  • Mouse genes Rec8
  • Rat genes Rec8
  • Zfish genes rec8b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Rec8

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	REC8	IPI	UniProtKB:O95816	Human	PMID:24981860
Molecular Function	GO:0005515	protein binding	REC8	IPI	UniProtKB:Q9UNE7	Human	PMID:24981860
Molecular Function	GO:0005515	protein binding	REC8	IPI	UniProtKB:O95816	Human	PMID:25036637
Molecular Function	GO:0005515	protein binding	REC8	IPI	UniProtKB:Q9UNE7	Human	PMID:25036637
Molecular Function	GO:0005515	protein binding	Rec8	IPI	UniProtKB:P70281,UniProtKB:Q61545,UniProtKB:Q62209,UniProtKB:Q96EQ9|UniProtKB:P70281,UniProtKB:Q62209,UniProtKB:Q96EQ9|UniProtKB:Q61545	Mouse	MGI:MGI:6355525|PMID:27932493
Molecular Function	GO:0005515	protein binding	Rec8	IPI	PR:Q9CW03	Mouse	PMID:12759374
Molecular Function	GO:0005515	protein binding	Rec8	IPI	PR:P70281	Mouse	PMID:12759374
Molecular Function	GO:0005515	protein binding	Rec8	IPI	PR:Q920F6	Mouse	PMID:12759374
Molecular Function	GO:0005515	protein binding	Rec8	IPI	RGD:621542	Rat	PMID:12615909|RGD:2300255
Cellular Component	GO:0000793	condensed chromosome	Rec8	IDA		Mouse	PMID:21795393
Cellular Component	GO:0000779	condensed chromosome, centromeric region	Rec8	IDA		Mouse	PMID:21743440
Cellular Component	GO:0000779	condensed chromosome, centromeric region	Rec8	IDA		Mouse	PMID:18084284
Cellular Component	GO:0000794	condensed nuclear chromosome	Rec8	IDA		Mouse	PMID:18084284
Cellular Component	GO:0000794	condensed nuclear chromosome	Rec8	IDA		Mouse	PMID:24797475
Cellular Component	GO:0000794	condensed nuclear chromosome	Rec8	IDA		Mouse	PMID:22164254
Cellular Component	GO:0000776	kinetochore	Rec8	IDA		Mouse	PMID:18765791
Cellular Component	GO:0000800	lateral element	Rec8	IDA		Mouse	PMID:15870106
Cellular Component	GO:0000800	lateral element	Rec8	IDA		Mouse	PMID:32328639
Cellular Component	GO:0001673	male germ cell nucleus	Rec8	IDA		Mouse	PMID:17696610
Cellular Component	GO:0030893	meiotic cohesin complex	Rec8	IDA		Mouse	PMID:22164254
Cellular Component	GO:0030893	meiotic cohesin complex	Rec8	IDA		Mouse	PMID:21743440
Cellular Component	GO:0030893	meiotic cohesin complex	Rec8	IDA		Mouse	PMID:17696610
Cellular Component	GO:0030893	meiotic cohesin complex	Rec8	IDA		Mouse	PMID:22854038
Cellular Component	GO:0005634	nucleus	Rec8	IDA		Mouse	PMID:12759374
Cellular Component	GO:0000795	synaptonemal complex	Rec8	IDA		Mouse	PMID:12759374
Biological Process	GO:0000724	double-strand break repair via homologous recombination	Rec8	IGI	MGI:MGI:3652039	Mouse	PMID:22711701
Biological Process	GO:0009566	fertilization	Rec8	IMP	MGI:MGI:3512754	Mouse	PMID:22711701
Biological Process	GO:0007129	homologous chromosome pairing at meiosis	Rec8	IMP	MGI:MGI:3512754	Mouse	PMID:17696610
Biological Process	GO:0007141	male meiosis I	Rec8	IMP	MGI:MGI:3512754	Mouse	PMID:17696610
Biological Process	GO:0051321	meiotic cell cycle	Rec8	IPI	PR:P70281	Mouse	PMID:12759374
Biological Process	GO:0001556	oocyte maturation	Rec8	IGI	MGI:MGI:1916966	Mouse	PMID:17696610
Biological Process	GO:0001556	oocyte maturation	Rec8	IMP	MGI:MGI:3512754	Mouse	PMID:17696610
Biological Process	GO:0072520	seminiferous tubule development	Rec8	IGI	MGI:MGI:3652039	Mouse	PMID:22711701
Biological Process	GO:0007286	spermatid development	Rec8	IMP	MGI:MGI:3512754	Mouse	PMID:17696610
Biological Process	GO:0007130	synaptonemal complex assembly	Rec8	IGI	MGI:MGI:3652039	Mouse	PMID:22711701
Biological Process	GO:0007130	synaptonemal complex assembly	Rec8	IGI	MGI:MGI:1349669	Mouse	PMID:24589552
Biological Process	GO:0007130	synaptonemal complex assembly	Rec8	IGI	MGI:MGI:3652039	Mouse	PMID:24589552

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern