Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes RECK
  • Mouse genes Reck
  • Rat genes Reck
  • Zfish genes reck
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Reck

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:1904928	coreceptor activity involved in canonical Wnt signaling pathway	Reck	IDA		Mouse	MGI:MGI:6255947|PMID:30026314
Molecular Function	GO:0004866	endopeptidase inhibitor activity	RECK	IDA		Human	PMID:9789069
Molecular Function	GO:0004866	endopeptidase inhibitor activity	Reck	IDA		Mouse	PMID:11747814
Molecular Function	GO:0008191	metalloendopeptidase inhibitor activity	RECK	IDA		Human	PMID:18194466
Molecular Function	GO:0005515	protein binding	RECK	IPI	UniProtKB:P04626	Human	PMID:21255571
Molecular Function	GO:0005515	protein binding	Reck	IPI	UniProtKB:O00755|UniProtKB:P56706	Mouse	MGI:MGI:6255947|PMID:30026314
Molecular Function	GO:0017147	Wnt-protein binding	Reck	IPI	UniProtKB:O00755	Mouse	MGI:MGI:6255947|PMID:30026314
Cellular Component	GO:0005886	plasma membrane	RECK	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	Reck	IDA		Mouse	MGI:MGI:6255947|PMID:30026314
Cellular Component	GO:0005886	plasma membrane	Reck	IDA		Mouse	MGI:MGI:6114565|PMID:28803732
Cellular Component	GO:0005886	plasma membrane	reck	IDA		Zfish	PMID:27979830|ZFIN:ZDB-PUB-161217-10
Cellular Component	GO:1990909	Wnt signalosome	Reck	IDA		Mouse	MGI:MGI:6255947|PMID:30026314
Biological Process	GO:0001955	blood vessel maturation	Reck	IGI	MGI:MGI:97009	Mouse	PMID:11747814
Biological Process	GO:0001955	blood vessel maturation	Reck	IMP	MGI:MGI:3623517	Mouse	PMID:11747814
Biological Process	GO:1990791	dorsal root ganglion development	reck	IMP	ZFIN:ZDB-MRPHLNO-120319-9	Zfish	PMID:26051822
Biological Process	GO:0007566	embryo implantation	Reck	IDA		Mouse	PMID:18556655
Biological Process	GO:0035115	embryonic forelimb morphogenesis	Reck	IMP	MGI:MGI:4830337	Mouse	PMID:23213437
Biological Process	GO:0030198	extracellular matrix organization	Reck	IMP	MGI:MGI:3623517	Mouse	PMID:11747814
Biological Process	GO:0030336	negative regulation of cell migration	RECK	IMP		Human	PMID:18591254
Biological Process	GO:1904684	negative regulation of metalloendopeptidase activity	RECK	IDA		Human	PMID:18194466
Biological Process	GO:1904684	negative regulation of metalloendopeptidase activity	Reck	IMP		Mouse	MGI:MGI:5659805|PMID:24812324
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	Reck	IDA		Mouse	MGI:MGI:6255947|PMID:30026314
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	Reck	IDA		Mouse	MGI:MGI:6114565|PMID:28803732
Biological Process	GO:0045765	regulation of angiogenesis	Reck	IMP		Mouse	MGI:MGI:6114565|PMID:28803732
Biological Process	GO:0060828	regulation of canonical Wnt signaling pathway	reck	IMP	ZFIN:ZDB-GENO-160526-1	Zfish	PMID:26657775
Biological Process	GO:0051726	regulation of cell cycle	reck	IGI	ZFIN:ZDB-GENO-200625-7	Zfish	PMID:29805750
Biological Process	GO:0090049	regulation of cell migration involved in sprouting angiogenesis	reck	IMP	ZFIN:ZDB-GENO-160526-1	Zfish	PMID:26657775
Biological Process	GO:0090210	regulation of establishment of blood-brain barrier	Reck	IMP		Mouse	MGI:MGI:6114565|PMID:28803732
Biological Process	GO:0002040	sprouting angiogenesis	reck	IMP	ZFIN:ZDB-MRPHLNO-120319-9	Zfish	PMID:26051822
Biological Process	GO:0001944	vasculature development	reck	IMP	ZFIN:ZDB-MRPHLNO-120319-9	Zfish	PMID:26051822
Biological Process	GO:0016055	Wnt signaling pathway	reck	IMP	ZFIN:ZDB-MRPHLNO-120319-9	Zfish	PMID:26051822

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern