Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes REG1A,REG1B
  • Mouse genes Reg1
  • Rat genes Reg1a
  • Zfish genes si:ch211-125e6.14
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Reg1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008083	growth factor activity	REG1A	IDA		Human	PMID:10526060
Molecular Function	GO:0008083	growth factor activity	Reg1a	IDA		Rat	PMID:10526060|RGD:8554818
Molecular Function	GO:0042802	identical protein binding	Reg1a	IPI	RGD:3552	Rat	PMID:11278730|RGD:9831423
Molecular Function	GO:0042802	identical protein binding	Reg1a	IPI	RGD:3552	Rat	PMID:22158612|RGD:9850120
Molecular Function	GO:0140678	molecular function inhibitor activity	REG1A	IDA		Human	PMID:1397886
Molecular Function	GO:0019902	phosphatase binding	Reg1a	IPI	RGD:1586212	Rat	PMID:18929742|RGD:10044027
Molecular Function	GO:0005515	protein binding	Reg1a	IPI	RGD:3254	Rat	PMID:10662590|RGD:10044032
Molecular Function	GO:0005515	protein binding	Reg1a	IPI	RGD:621204	Rat	PMID:18929742|RGD:10044027
Molecular Function	GO:0019903	protein phosphatase binding	Reg1a	IPI	RGD:620897	Rat	PMID:18929742|RGD:10044027
Molecular Function	GO:0005102	signaling receptor binding	Reg1a	IPI	RGD:62065	Rat	PMID:10753861|RGD:61576
Cellular Component	GO:0045178	basal part of cell	Reg1a	IDA		Rat	PMID:12764608|RGD:9831428
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Reg1	HDA		Mouse	MGI:MGI:6201853|PMID:28071719
Cellular Component	GO:0005829	cytosol	Reg1a	IDA		Rat	PMID:22158612|RGD:9850120
Cellular Component	GO:0032590	dendrite membrane	Reg1a	IDA		Rat	PMID:22158612|RGD:9850120
Cellular Component	GO:0070062	extracellular exosome	REG1A	HDA		Human	PMID:23533145
Cellular Component	GO:0070062	extracellular exosome	REG1B	HDA		Human	PMID:23533145
Cellular Component	GO:0005615	extracellular space	Reg1a	IDA		Rat	PMID:1886885|RGD:9850118
Cellular Component	GO:0030426	growth cone	Reg1a	IDA		Rat	PMID:22158612|RGD:9850120
Cellular Component	GO:0032809	neuronal cell body membrane	Reg1a	IDA		Rat	PMID:22158612|RGD:9850120
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Reg1a	IDA		Rat	PMID:22158612|RGD:9850120
Cellular Component	GO:0032991	protein-containing complex	Reg1a	IDA		Rat	PMID:11278730|RGD:9831423
Cellular Component	GO:0042588	zymogen granule	Reg1a	IDA		Rat	PMID:12764608|RGD:9831428
Biological Process	GO:0055074	calcium ion homeostasis	Reg1a	IDA		Rat	PMID:1886885|RGD:9850118
Biological Process	GO:1990869	cellular response to chemokine	Reg1a	IEP		Rat	PMID:11113082|RGD:10044028
Biological Process	GO:1990878	cellular response to gastrin	Reg1a	IEP		Rat	PMID:10348814|RGD:9850135
Biological Process	GO:0010467	gene expression	Reg1	IMP	MGI:MGI:2446480	Mouse	PMID:16405968
Biological Process	GO:0097421	liver regeneration	Reg1a	IEP		Rat	PMID:19284990|RGD:10044030
Biological Process	GO:0007494	midgut development	Reg1a	IEP		Rat	PMID:7720628|RGD:9850133
Biological Process	GO:0008285	negative regulation of cell population proliferation	Reg1a	IMP		Rat	PMID:18929742|RGD:10044027
Biological Process	GO:1990798	pancreas regeneration	Reg1	IMP	MGI:MGI:2446480	Mouse	PMID:16405968
Biological Process	GO:1990798	pancreas regeneration	Reg1a	IEP		Rat	PMID:1985964|RGD:729900
Biological Process	GO:0014065	phosphatidylinositol 3-kinase signaling	Reg1	IMP	MGI:MGI:2446480	Mouse	PMID:16405968
Biological Process	GO:1904699	positive regulation of acinar cell proliferation	Reg1a	IDA		Rat	PMID:9788538|RGD:9850126
Biological Process	GO:1903861	positive regulation of dendrite extension	Reg1a	IMP		Rat	PMID:22158612|RGD:9850120
Biological Process	GO:0010628	positive regulation of gene expression	Reg1a	IDA		Rat	PMID:18929742|RGD:10044027
Biological Process	GO:0001934	positive regulation of protein phosphorylation	Reg1	IMP	MGI:MGI:2446480	Mouse	PMID:16405968
Biological Process	GO:1904692	positive regulation of type B pancreatic cell proliferation	Reg1a	IMP		Rat	PMID:24055447|RGD:9850134
Biological Process	GO:1903492	response to acetylsalicylate	Reg1a	IEP		Rat	PMID:14563943|RGD:10044035
Biological Process	GO:1990867	response to gastrin	Reg1a	IEP		Rat	PMID:9834276|RGD:10044033
Biological Process	GO:1990864	response to growth hormone-releasing hormone	Reg1a	IEP		Rat	PMID:7720628|RGD:9850133
Biological Process	GO:0001666	response to hypoxia	Reg1a	IEP		Rat	PMID:24055447|RGD:9850134
Biological Process	GO:0031667	response to nutrient levels	Reg1a	IEP		Rat	PMID:1985964|RGD:729900
Biological Process	GO:0014070	response to organic cyclic compound	Reg1a	IEP		Rat	PMID:16874863|RGD:9850141
Biological Process	GO:1990785	response to water-immersion restraint stress	Reg1a	IEP		Rat	PMID:8698224|RGD:10402055
Biological Process	GO:0003309	type B pancreatic cell differentiation	Reg1	IMP	MGI:MGI:2446480	Mouse	PMID:16405968
Biological Process	GO:0042060	wound healing	Reg1a	IEP		Rat	PMID:11113082|RGD:10044028

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern